Analysis of Cardiac Substructure Dose in a Large, Multi-Centre Danish Breast Cancer Cohort (the DBCG HYPO trial): Trends and Predictive Modelling

Analysis of Cardiac Substructure Dose in a Large, Multi-Centre Danish Breast Cancer Cohort (the DBCG HYPO trial): Trends and Predictive Modelling: Background and purposeRadiotherapy for breast cancer can increase the risks of heart disease. Patient-specific risk assessment may be improved with the inclusion of doses to cardiac substructures. The purpose of this work was to use automatic segmentation to evaluate substructure doses and develop predictive models for these based on the dose to the whole heart.Material and methodsAutomatic segmentation was used to delineate cardiac substructures in a Danish breast cancer trial (DBCG HYPO) dataset comprising over 1500 Danish women treated between 2009 and 2014.