Clinical Thyroidology, Volume 32, Issue 9, Page 440-442, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 410-411, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 433-435, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 412-414, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 447-449, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 415-417, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 430-432, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 418-421, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 436-439, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 422-425, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 443-446, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 426-429, September 2020.
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Clinical Thyroidology, Volume 32, Issue 9, Page 450-453, September 2020.
Wed Sep 02, 2020 10:00
The novel Coronavirus from Wuhan China discovered in December 2019 (nCOV-2019) has since developed into a global epidemic with major concerns about the possibility of the virus evolving into something even more sinister. In the present study we constructed the phylo-geo-network of nCOV-2019 genomes from across India to understand the viral evolution in the country. A total of 611 full length genomes were extracted from different states of India from the EpiCov repository of GISAID initiative and...
Tue Sep 08, 2020 03:00
Understanding the conservation and evolution of protein complexes is of critical value to decode their function in physiological and pathological processes. One prominent proposal posits gene duplication as a potential mechanism for protein complex evolution. In this study we take advantage of large-scale proteome expression datasets to systematically investigate the role of paralogues, and specifically self-interacting paralogues, in shaping the evolutionary trajectories of protein complexes. First,...
Tue Sep 08, 2020 03:00
Abstract Background Lung involvement in patients with coronavirus disease 2019 (COVID-19) undergoing PET-CT has been previously reported. However, FDG uptake outside lung parenchyma was poorly characterized in detail. We evaluated the extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia through 18F-FDG PET-CT. Methods ...
Tue Sep 08, 2020 03:00
The Value of Contrast-Enhanced Ultrasound versus Doppler Ultrasound in Grading Renal Artery Stenosis
Objective. This study is aimed at exploring the accuracy of contrast-enhanced ultrasound (CEUS) in grading renal artery stenosis. Methods. 122 renal arteries with suspected renal artery stenosis were selected. DSA, DUS, and CEUS were performed for all patients with suspected renal artery stenosis in the research. DSA was selected as the gold standard. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of CEUS or Doppler ultrasound (DUS) in...
Tue Sep 08, 2020 17:20
Abstract Purpose To clarify the association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) and sudden sensorineural hearing loss (SSNHL). Methods A systematic literature search of related studies up to August 30, 2019 in the PubMed and Embase databases was performed, and the results were displayed by odds ratios (ORs), and their...
Tue Sep 08, 2020 03:00
This article outlines the ways that transoral robotic surgery and transoral laser microsurgery relate to treatment de-escalation in the treatment of head and neck cancer. Treatment de-escalation has particular importance in context of human papillomavirus–related oropharynx squamous cell carcinoma, which responds well to therapy but leaves many survivors with decades of treatment-related sequelae. We compare these less invasive transoral approaches with previously used open approaches to the oropharynx....
Tue Sep 08, 2020 03:00
Robotic surgery has been shown to be feasible and successful in several areas of pediatric head and neck surgery. However, adoption has been limited. Robotic surgery may be better integrated into practice with advanced preoperative surgical planning and the design of new robotic platforms with instrumentation specific for the application. With continued investigations, computer-aided surgical planning techniques including three-dimensional printing, virtual reality, multiobjective cost function for...
Tue Sep 08, 2020 03:00
Oropharyngeal cancers and their treatment can exquisitely affect a patient’s quality of life and functional outcome. Transoral robotic surgery offers a minimally invasive surgical approach that mitigates injury from traditional open surgical approaches and offers a treatment more likely to have short-term side effects compared with nonsurgical treatment. Feeding tube dependence, oral intake, and swallowing questionnaires, in addition to swallowing evaluations provide a snapshot of a patient’s current...
Tue Sep 08, 2020 03:00
Transoral robotic surgery (TORS) is a rapidly growing diagnostic and therapeutic modality in otolaryngology–head and neck surgery, having already made a large impact in the short time since its inception. Cost-effectiveness analysis is complex, and a thorough cost-effectiveness inquiry should analyze not only financial consequences but also impact on the health state of the patient. The cost-effectiveness of TORS is still under scrutiny, but the early data suggest that TORS is a cost-effective method...
Tue Sep 08, 2020 03:00
This article summarizes major and minor complications following transoral robotic surgery in the head and neck. Overall, transoral robotic surgery is extremely safe; however, surgeons must recognize inherent risks associated with major and severe bleeding, dysphagia, and minor complications, including injury to nerves, mucosal surfaces, teeth, and the eyes. This article briefly discusses prevention and management strategies for common complications.
Tue Sep 08, 2020 03:00
Key Points miR-217 plays critical roles in both antibacterial and antiviral immunity in fish. TAK1 is a novel target for miR-217 in fish. miR-217 modulates TAK1-mediated NF-B and IRF3 signaling in fish.
Tue Sep 08, 2020 23:00
The evolution of the immune system, diet, and the microbiome are interconnected. Dietary metabolites modulate the cells of the immune system both directly and indirectly via shifts in the composition of the intestinal microbiota and its products. As a result, overconsumption and malnutrition can have substantial effects on immune responses and inflammation. In resource-rich nations, diets high in processed foods, fat, and sugar can contribute to chronic inflammatory conditions, which are on the rise...
Tue Sep 08, 2020 23:00
Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although most people are immunocompetent to the virus, a small group fail to mount an effective antiviral response and develop chronic infections that trigger hyperinflammation. This results in major complications, including acute respiratory distress syndrome, disseminated intravascular coagulation, and multiorgan failure, which all carry poor...
Tue Sep 08, 2020 23:00
Key Points Macrophage deletion of PPAR reduces inflammation/revascularization of injured muscle. PPAR expression is not required for M2 macrophage activation in injured muscle. IL-10 is required for M2 macrophage activation after sterile muscle injury.
Tue Sep 08, 2020 23:00
Key Points GSK3 inhibition promotes human IL-10+ FOXP3+ iTreg generation. Human IL-10+ FOXP3+ iTregs exhibited enhanced suppressive features and function. GSK3 inhibition upregulated the transcription of IL-10 in human FOXP3+ iTregs.
Tue Sep 08, 2020 23:00
Key Points Influenza enables noninvasive Streptococcus pneumoniae to cause deadly pneumonia. Influenza mainly predisposes hosts to airway, but not systemic, bacterial infection. Influenza temporally abolishes innate bacterial clearance by alveolar macrophages.
Tue Sep 08, 2020 23:00
Key Points CD8+ T cells produce TNF-α, IL-2, and IFN- with similar Ag thresholds. Costimulation decreases Ag thresholds similarly for different cytokines. A common rate-limiting switch downstream of the TCR can explain these findings.
Tue Sep 08, 2020 23:00
Key Points DUSP11 inhibits LPS-induced macrophage activation by dephosphorylating TAK1. Besides targeting RNAs, DUSP11 binds to and targets a protein substrate, TAK1.
Tue Sep 08, 2020 23:00
Key Points Ascorbic acid facilitates KIR promoter demethylation in human NK cells. Runx3, TET2, and TET3 are enriched within KIR promoters in response to ascorbic acid. KIR expression is driven by the combination of Runx3, TET3, and ascorbic acid.
Tue Sep 08, 2020 23:00
Key Points The innate lymphoid system promotes bacterial clearance from airspaces. The innate lymphoid system mediates Th2 responses in the Tg+ airspaces. Ablation of the innate lymphoid system abolishes MCM in the Tg+ airspaces.
Tue Sep 08, 2020 23:00
Key Points Shared bias of TRBV4-1 dominates the HLA-B7 EBVRPP–specific CD8+ T cell response. Key residues of TRBV4-1 CDR1/2 loops interact with the HLA-B7/EBVRPP complex.
Tue Sep 08, 2020 23:00
Key Points BMN from female versus male mice express higher surface levels of CR3. Serum from female versus male mice contains higher levels of C3. Higher levels of CR3 and C3 may contribute to greater bactericidal capacity of female murine BMN.
Tue Sep 08, 2020 23:00
Key Points C8α-– deficient African Americans share a G->A mutation in intron 6 of the C8A gene. This change creates a new, preferred 3' splice site causing a 10 nt mRNA insertion. The insertion shifts the reading frame, producing a premature stop codon downstream.
Tue Sep 08, 2020 23:00
Key Points CD4+ T cell exhaustion during malaria is associated with reduced mTOR activity. mTOR activity and glycolysis in CD4+ T cells are correlated with T-bet expression. Blocking T cell exhaustion increases T-bet expression and elevates glycolysis.
Tue Sep 08, 2020 23:00
Key Points 4-1BB signaling activates NF-B/cRel and is dependent on IBα nuclear export. IBα nuclear export is necessary for efficient IL-2 production and T cell immunity.
Tue Sep 08, 2020 23:00
Key Points Sectm1a enhances macrophage clearance of bacteria through activating GITR. Sectm1a deficiency worsens the outcome of polymicrobial sepsis.
Tue Sep 08, 2020 23:00
Key Points Diversity Outbred F1 HER2 transgenic mice recapitulate human genetic heterozygosity. Quantitative trait locus analysis reveals regulators of HER2 immunization response. MHC-IB–reactive NK cells promote immune activation, countering Treg suppression.
Tue Sep 08, 2020 23:00
Key Points FAP-α is involved in a nonapoptotic signaling pathway in neutrophils. FAP-α is activated in parallel with RIPK–MLKL signaling. FAP-α could be a potential drug target in neutrophilic inflammatory responses.
Tue Sep 08, 2020 23:00
Key Points MERS-CoV ORF8b protein functions as a type I IFN antagonist. ORF8b-deficient MERS-CoV induces IFN and ISG expression more robustly. ORF8b interacts with HSP70 chaperone to suppress its activation of IRF3 kinase IKK.
Tue Sep 08, 2020 23:00
Key Points hC4Nb8 is a potent cross-reactive inhibitor of CP and LP proconvertase formation. hC4Nb8 binds to a neoepitope exposed upon C4 activation and C4b generation. hC4Nb8 inhibits the CP of complement in vivo.
Tue Sep 08, 2020 23:00
Key Points TDM has an ambiguous impact on the macrophage response to IFN-. TDM impairs IFN-–induced Ag presentation via MHC-II and GBP1 expression. Inhibition by TDM does not affect STAT1 phosphorylation, but requires SOCS1.
Tue Sep 08, 2020 23:00
Key Points A novel method to generate mAb using tetramers and reporter cells is described. Ab against the MCMV immunoevasin m12 are generated and characterized. An mAb was identified that is capable of blocking m12-mediated NK inhibition.
Tue Sep 08, 2020 23:00
Over 300,000 women in the US are expected to be diagnosed with breast cancer this year, with an estimated 12,000 of those diagnosed expected to be under the age of 40. Early detection is pivotal to ensuring a high likelihood of survival, which is why the Keep A Breast Foundation is doubling down on the importance of self-checks with their enhanced mobile app. According to Keep A Breast Medical Director Dr. Joel Evans, “The breast self-check is the simplest and easiest way to protect your...
Tue Sep 08, 2020 23:46
On August 14, 2020, Arazy Group received its fastest Traditional 510(k) clearance via the FDA’s new expedited 30-day Triage Quick route. This is an option that the Triage Quick program is offering any Traditional 510(k) submission that meets its criteria. The Traditional 510(k) submission, K202068, which was sent for Triage Quick review on July 27, 2020 and was cleared only 18 days later. “Arazy Group’s clearance rate of eighty-four Traditional 510(k)s applications over the past 3 years is an average...
Fri Sep 04, 2020 21:10
Mutations are critical for evolutionary change. Although mutation spectra (mutational biases) vary greatly across organisms, we lack direct evidence of their evolutionary consequences. Here, we show experimentally that a biased spectrum alters the distribution of fitness effects in a bacterium, and should facilitate adaptation by increasing beneficial mutations and reducing genetic load. Adaptive walk simulations show that this advantage arises via better sampling of mutational classes that were...
Tue Sep 08, 2020 03:00
Abstract Purpose Due to an increased human life expectancy, the need to replace arthritic or dysfunctional joints by prosthetics is higher than ever before. Prosthetic joints are unfortunately inherently susceptible to bacterial infection accompanied by biofilm formation. Accurate and rapid diagnosis is vital to increase therapeutic success. Yet, established diagnostic modalities cannot directly detect bacterial biofilms on prostheses....
Tue Sep 08, 2020 03:00
This report highlights the utility of MatriStem Surgical Matrix Thick UBM™ (rebranded as Gentrix® ACell, Inc), a decellularised urinary bladder extracellular matrix in the reconstruction of a post-oncological maxillectomy defect. In utilising this biological construct to serve as a biological dressing, our patient underwent complete mucosalisation of his surgical site without the development of an oroantral fistula and with adequate maxillary vestibule to allow for definitive oral rehabilitation...
Tue Sep 08, 2020 03:00
The purpose of this study was to provide a United States perspective on alloplastic total joint replacement. We sought to estimate the inpatient burden and report the most common adverse events using two administrative datasets. The National Inpatient Sample was queried from October 2015 to December 2016 for total joint replacement admissions using International Classification of Diseases 10th revision codes, and the Manufacturer and User Facility Device Experience registry was queried from January...
Tue Sep 08, 2020 03:00
The contemporary literature is discordant regarding the role of delayed diagnosis in the prognosis of patients with oral cancer. This study examined data on a previously reported cohort of 101 patients with oral squamous cell carcinoma diagnosed at a single institution between 2008 and 2010. The time interval between symptom onset and initial histological diagnosis (diagnostic delay) was recorded for each patient, as were demographic data and cancer features such as T stage, nodal status, and smoking...
Tue Sep 08, 2020 03:00
To analyze the accuracy of traditional acoustic measurements (F0, perturbation, and noise) and formant measurements in discriminating between women with and without voice disorders, and with different laryngeal disorders.
Tue Sep 08, 2020 03:00
To explore the factors affecting the therapeutic efficacy of laryngeal contact granuloma.
Tue Sep 08, 2020 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02196
Tue Sep 08, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07995
Tue Sep 08, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05331
Tue Sep 08, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06605
Tue Sep 08, 2020 07:00
Abstract Aim In recent years, the clinical availability of scanners for integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) has enabled the practical potential of multimodal, combined metabolic-receptor, anatomical, and functional imaging to be explored. The present systematic review and meta-analysis summarize the diagnostic information provided by PET/MRI in patients with prostate cancer (PCa). ...
Tue Sep 08, 2020 03:00
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