Background One important anti‐predator strategy adopted by birds involves nest site selection and timing of breeding. Nest-site selection by marsh-nesting birds often involves nest concealment and water depth as key features influencing nest survival. Marsh Harrier (Circus aeruginosus) is an obligate ground nester, which sets it apart from other raptors. The aim of the present study was to identify for the first time possible temporal and habitat factors affecting nest survival in Marsh Harrier....
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Background The outbreak of coronavirus disease 2019 (COVID-19) that occurred in Wuhan, China, has become a global public health threat. It is necessary to identify indicators that can be used as optimal predictors for clinical outcomes of COVID-19 patients. Methods The clinical information from 126 patients diagnosed with COVID-19 were collected from Wuhan Fourth Hospital. Specific clinical characteristics, laboratory findings, treatments and clinical outcomes were analyzed from patients...
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Abstract Background This study aimed to investigate the antitumor activity of paclitaxel with radiation and sorafenib in anaplastic thyroid cancer (ATC) cells in vitro and in vivo. Methods The 8505C ATC cell line was exposed to radiation, sorafenib, and paclitaxel each or in combination. The effects of combined treatment on the cell cycle and intracellular signaling pathways were assessed using flow cytometry and western blot analysis. An ATC cell line xenograft model was used to examine...
Tue Sep 08, 2020 11:10
Abstract Introduction Our purpose is to review the role radiotherapy (RT) in the treatment of glottic squamous cell carcinoma (SCC). Methods A concise review of the pertinent literature. Results RT cure rates are Tis‐ T1N0, 90% to 95%; T2N0, 70% to 80%; low‐volume T3‐T4a, 65% to 70%. Concomitant cisplatin is given for T3‐T4a SCCs. Severe complications occur in 1% to 2% for Tis‐T2N0 and 10% for T3‐T4a SCCs. Patients with high‐volume T3‐T4 SCCs undergo total laryngectomy, neck dissection,...
Tue Sep 08, 2020 11:09
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue Sep 08, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Fri Sep 04, 2020 10:00
Inferences about past processes of adaptation and speciation require a gene-scale and genome-wide understanding of the evolutionary history of diverging taxa. In this study, we use genome-wide capture of nuclear gene sequences, plus skimming of organellar sequences, to investigate the phylogenomics of monkeyflowers in Mimulus section Erythranthe (27 accessions from seven species). Taxa within Erythranthe, particularly the parapatric and putatively sister species M. lewisii (bee-pollinated) and M....
Tue Sep 08, 2020 03:00
Alternative spicing is an integral part of gene expression in multicellular organisms that allows for diverse mRNA transcripts and proteins to be produced from a single gene. However, most existing analyses have focused on macro-evolution, with only limited research on splice site evolution over shorter term, micro-evolutionary time scales. Here we examine splicing evolution that has occurred during domestication and observe 45 novel splice forms with strongly transgressive isoform compositions,...
Tue Sep 08, 2020 03:00
Abstract Background IL-4 is known to present abnormal expression in thyroid tumors and SNPs in the IL-4 and its receptor IL-4R genes are associated to risk and mortality of various types of cancer. Methods In order to evaluate their role in differentiated thyroid cancer (DTC), we investigated genetic frequencies of two IL-4 promoter SNPs (rs2070874...
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One of the central problems of vertebrate evolution is understanding the relationship among the distal portions of fins and limbs. This region forms the digits of tetrapods and the distal radials and rays of fish fins. Lacking comparable morphological markers of these regions in fish and tetrapods, these relationships have remained uncertain for the past century. Here we show that Gli3 roles in controlling the proliferative expansion of distal progenitors are shared among median and paired fins as...
Tue Sep 08, 2020 03:00
Related Articles [Logistic precautions in preparation and administration of allergen immunotherapy during the COVID-19 pandemic in Mexico]. Rev Alerg Mex. 2020 Apr-Jun;67(2):199-201 Authors: Larenas-Linnemann D, Del Río-Navarro BE, Luna-Pech J, Navarrete-Rodríguez EM, Pozo-Beltrán CF, Arias-Cruz A, Costa-Domínguez MC, Rodríguez-González M, Blandón-Vijil MV, Estrada-Cardona A, Gereda JE, Ortega-Martell JA, Rodríguez-Pérez N, Rojo-Gutiérrez MI, Espinosa-Rosales...
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Related Articles [Doctor Ernesto Guevara before he became "El Che Guevara". His work in the General Hospital of Mexico]. Rev Alerg Mex. 2020 Apr-Jun;67(2):196-198 Authors: Velázquez-Sámano G, Hernández-Solís A, Cicero-Sabido R PMID: 32892534 [PubMed - in process]
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Related Articles [Drug provocation tests to identify analgesic alternatives for an infant with Stevens-Johnson syndrome caused by ibuprofen-acetaminophen]. Rev Alerg Mex. 2020 Apr-Jun;67(2):189-195 Authors: Abreu S, Castelblanco-Arango IY, Gómez-Pineda PA, Cardona R Abstract BACKGROUND: The Stevens-Johnson syndrome is a serious skin reaction to drugs, and it is potentially life-threatening. Its handling involves the strict restriction of the...
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Related Articles [Hemophagocytic syndrome associated with Hodgkin lymphoma and Epstein-Barr virus infection. A case report]. Rev Alerg Mex. 2020 Apr-Jun;67(2):183-188 Authors: Noyola-García M, González-Ríos RD, Olascoaga-Lugo A, Rodríguez-Florido MA, Rubio-Anguiano BL Abstract BACKGROUND: Hodgkin lymphoma is a malignant neoplasm of B lymphoid cells whose histologic characteristic is the presence of Reed-Sternberg cells in an inflammatory environment....
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Related Articles [Giant coronary aneurysms in infant with Kawasaki disease shock syndrome]. Rev Alerg Mex. 2020 Apr-Jun;67(2):174-182 Authors: García-Domínguez M, Riviera-Navarro D, Quibrera J, Pérez-Gaxiola G Abstract BACKGROUND: Kawasaki disease shock syndrome is a rare presentation of Kawasaki disease, in which cardiovascular manifestations associated with elevated inflammation biomarkers that develop hypotension are observed. It is preceded...
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Related Articles [Biases in diagnostic test studies: impact on estimating sensitivity and specificity]. Rev Alerg Mex. 2020 Apr-Jun;67(2):165-173 Authors: Rendón-Macías ME, Valenzuela M, Villasís-Keever MÁ Abstract Diagnostic tests make it possible to determine whether a person has a disease or not. Before incorporating a new diagnostic test in the clinical setting, it is necessary to define its validity through its indicators of performance,...
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Related Articles [General concepts of humoral immune deficiencies]. Rev Alerg Mex. 2020 Apr-Jun;67(2):142-164 Authors: Velásquez-Ortiz MG, O'Farrill-Romanillos PM, Berrón-Ruiz L Abstract Humoral immune deficiencies (HID) comprise a group of diseases characterized by the impossibility to develop an effective immune response mediated by immunoglobulins (Ig). Patients with HID have infections caused by capped extracellular bacteria, mainly in the...
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Related Articles [Emollients: benefits, key elements, and clinical application]. Rev Alerg Mex. 2020 Apr-Jun;67(2):128-141 Authors: Gil-Castaño G, Cardona R Abstract The skin is the largest organ in the human body. Among other components, it contains epidermal cells, which are modified epithelial cells that rest on a basal membrane that separates them from the dermis. When the epidermis presents variations in its structural composition and the...
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Related Articles [Reactivity to antigens of the microbiome of the respiratory tract in patients with respiratory allergic diseases]. Rev Alerg Mex. 2020 Apr-Jun;67(2):119-127 Authors: Trejo-Tapia D, Henández-Ortega MM, Valadez-Carmona L, Ochoa-Juárez DB, Suárez-Souto MA, Gómez-Orozco LT Abstract BACKGROUND: The prevalence of allergic diseases has increased worldwide. Recent studies have informed that the dysbiosis of some specific members of...
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Related Articles [Activity of chronic spontaneous urticaria in euthyroid vs hypothyroid patients]. Rev Alerg Mex. 2020 Apr-Jun;67(2):112-118 Authors: Herrera-Sánchez DA, Álvarez-Chávez FE, O Farrill-Romanillos PM Abstract BACKGROUND: Chronic urticaria (CU) affects 5 % of the general population and it is associated with thyroid disease in up to 54 % of patients. There is scarce information on the activity of urticaria in patients with and without...
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Related Articles [Hereditary angioedema in Costa Rica]. Rev Alerg Mex. 2020 Apr-Jun;67(2):102-111 Authors: Alfaro-Murillo AJ, Martínez-Alfonso M, Castro-Cordero J, León-Bratti MP, Ivankovich-Escoto G, Espinoza-Mora MR Abstract BACKGROUND: Hereditary angioedema is classified as a primary immunodeficiency of the complement system because it is characterized by the absence of C1 esterase inhibitor (C1-INH) and by the periodic edema of any region...
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Related Articles [The frequency of adverse reactions to sulfamethoxazole with trimethoprim and risk factors in HIV patients]. Rev Alerg Mex. 2020 Apr-Jun;67(2):96-101 Authors: Martínez-Martínez MC, Hernández-Morales MR, Mancilla-Hernández E Abstract BACKGROUND: Trimethoprim-sulfamethoxazole (TMP-SMZ) is the long-term use antimicrobial of choice in the prevention and treatment of opportunistic germs in patients with acquired immunodeficiency...
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This report documents a rare case of an extracranial meningioma on the posterior scalp without apparent dural connection. Additionally, a sebaceous steatocystoma of the anterior scalp presented alongside the meningioma. A steatocystoma localized to the scalp is also remarkably rare. To our knowledge, this is the first report documenting both an extracranial meningioma and a steatocystoma presenting concurrently on the scalp. A male patient in his thirties presented with a mass lesion on the scalp....
Tue Sep 08, 2020 18:35
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mon Sep 07, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mon Sep 07, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mon Sep 07, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Sep 04, 2020 10:00
Allopolyploidization, which involves hybridization and genome doubling, is a key driving force in higher plant evolution. The transcriptome reprogramming that accompanies allopolyploidization can cause extensive phenotypic variations, and thus confers allopolyploids higher evolutionary potential than their diploid progenitors. Despite many studies, little is known about the interplay between hybridization and genome doubling in transcriptome reprogramming during allopolyploidization. Here, we performed...
Tue Sep 08, 2020 03:00
Surgical Infections, Ahead of Print.
Tue Sep 08, 2020 10:00
Surgical Infections, Ahead of Print.
Thu Sep 03, 2020 10:00
British Journal of Cancer, Published online: 09 September 2020; doi:10.1038/s41416-020-01051-9Development of a non-invasive exhaled breath test for the diagnosis of head and neck cancer
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British Journal of Cancer, Published online: 09 September 2020; doi:10.1038/s41416-020-01038-6Cancer health disparities in racial/ethnic minorities in the United States
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British Journal of Cancer, Published online: 09 September 2020; doi:10.1038/s41416-020-01052-8EGFR as a stable marker of prostate cancer dissemination to bones
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British Journal of Cancer, Published online: 09 September 2020; doi:10.1038/s41416-020-01043-9Bisphosphonates and risk of cancers: a systematic review and meta-analysis
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In recent months, epidemiologists in the United States and throughout the world have been asked the same question by clinicians, journalists, and members of the public, "When will we have a vaccine?" The obvious answer to this question would be, "When a candidate vaccine is demonstrated to be safe,…
Tue Sep 08, 2020 03:00
Abstract Purpose of Review Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with a large clinical burden and high rates of treatment failure with first-line treatment options. Literature for combination antimicrobial therapies for initial treatment or salvage therapy in the setting of persistent bacteremia is developing. Recent Findings...
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Thyroid, Ahead of Print.
Tue Sep 08, 2020 10:00
Thyroid, Ahead of Print.
Tue Sep 08, 2020 10:00
Thyroid, Ahead of Print.
Tue Sep 08, 2020 10:00
Thyroid, Ahead of Print.
Mon Sep 07, 2020 10:00
Thyroid, Ahead of Print.
Thu Sep 03, 2020 10:00
An international team of scientists has identified at least 11 species of fish suspected to have land-walking abilities.
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An integrative analysis focused on multi-tissue transcriptomics has not been done for asthma. Tissue-specific DEGs remain undetected in many multi-tissue analyses, which influences identification of disease-relevant pathways and potential drug candidates. Transcriptome data from 609 cases and 196 controls, generated using airway epithelium, bronchial, nasal, airway macrophages, distal lung fibroblasts, proximal lung fibroblasts, CD4+ lymphocytes, CD8+ lymphocytes from whole blood and induced sputum...
Tue Sep 08, 2020 22:58
As a class of transcription regulators, numerous miRNAs have been verified to participate in regulating ovary follicular development in chickens (Gallus gallus). Previously we showed that gga-miR-135a-5p has significant differential expression between high and low-yield chicken ovaries, and the abundance of gga-miR-135a-5p is significantly higher in follicular theca cells than in granulosa cells. However, the exact role of gga-miR-135a-5p in chicken follicular theca cells is unclear. In this study,...
Tue Sep 08, 2020 22:58
Plant breeding leads to the genetic improvement of target traits by selecting a small number of genotypes from among typically large numbers of candidate genotypes after careful evaluation. In this study, we first investigated how mutations at conserved nucleotide sites normally viewed as deleterious, such as nonsynonymous sites, accumulated in a wheat, Triticum aestivum, breeding lineage. By comparing a 150 year old ancestral and modern cultivar, we found recent nucleotide polymorphisms altered...
Tue Sep 08, 2020 22:58
Ewen's sampling formula is a foundational theoretical result that connects probability and number theory with molecular genetics and molecular evolution; it was the analytical result required for testing the neutral theory of evolution, and has since been directly or indirectly utilized in a number of population genetics statistics. Ewen's sampling formula, in turn, is deeply connected to Stirling numbers of the first kind. Here, we explore the cumulative distribution function of these Stirling numbers,...
Tue Sep 08, 2020 22:58
Various Hydra species have been employed as model organisms since the 18th century. Introduction of transgenic and knock-down technologies made them ideal experimental systems for studying cellular and molecular mechanisms involved in regeneration, body-axis formation, senescence, symbiosis, and holobiosis. In order to provide an important reference for genetic studies, the Hydra magnipapillata genome (species name has been changed to H. vulgaris) was sequenced a decade ago (Chapman et al., 2010)...
Tue Sep 08, 2020 22:58
Abstract Introduction In FRESCO (Fruquintinib Efficacy and Safety in 3+ Line Colorectal Cancer Patients) trial, fruquintinib demonstrated a statistically significant and clinically meaningful overall survival benefit in Chinese patients with metastatic colorectal cancer (mCRC). However, its safety profile, including adverse events of special interest (AESIs) and treatment-emergent adverse events (TEAEs) by age, sex, and body mass index...
Tue Sep 08, 2020 03:00
Purpose: Medulloblastoma (MB) is an important cause of mortality and morbidity in pediatric oncology. Here we investigated whether the DNA repair inhibitor AsiDNA could help address a significant unmet clinical need in MB care, by improving radiotherapy efficacy without increasing radiation-associated toxicity. Experimental Design: To evaluate the brain permeability to AsiDNA upon systemic delivery, we injected intraperitoneally a fluorescent form of AsiDNA in models harboring brain tumors and in...
Tue Sep 08, 2020 16:09
Purpose: KRAS is among the most commonly mutated oncogene in cancer including non-small cell lung cancer (NSCLC). In early clinical trials, inhibitors targeting G12C mutant KRAS have achieved responses in some patients with NSCLC. Possible intrinsic and acquired resistance mechanisms to KRAS G12C inhibitors are not fully elucidated and will likely become important to identify. Experimental Design: To identify potential resistance mechanisms, we defined the sensitivity of a panel of KRAS G12C mutant...
Tue Sep 08, 2020 16:09
Purpose: No effective therapy is available for unresectable soft tissue sarcomas (STS). This unmet clinical need has prompted us to test whether chondroitin sulfate proteoglycan 4 (CSPG4)-specific CAR-redirected cytokine-induced killer lymphocytes (CAR.CIK) are effective in eliminating tumor cells derived from multiple STS histotypes in vitro and in immunodeficient mice. Experimental Design: The experimental platform included patient-derived CAR.CIK and cell lines established from multiple STS histotypes....
Tue Sep 08, 2020 16:09
Purpose:Intraoperative image guidance may aid in clinical decision making during surgical treatment of colorectal cancer. We developed the dual-labeled CEA-targeting tracer [111In]In-DTPA-SGM-101 for pre- and intraoperative imaging of colorectal cancer. Subsequently we investigated the tracer in preclinical biodistribution and multimodal image-guided surgery studies, and assessed the clinical feasibility on patient derived colorectal cancer samples, paving the way for rapid clinical translation....
Tue Sep 08, 2020 16:09
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01489C, PaperXuejiao Fang, Yuhang Song, Yi Huang, Guo-Hai Yang, Caiqin Han, Haitao Li, Lu-Lu QuThe ultrathin two-dimensional MXene nanosheets were decorated on the surface of silver nanorods (AgNRs) through a facile modification strategy to prepare highly sensitive and reproducible SERS substrates (AgNR/MXene substrate). The...The content of this RSS Feed (c) The Royal Society of Chemistry
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Background and purposeRadiotherapy for breast cancer can increase the risks of heart disease. Patient-specific risk assessment may be improved with the inclusion of doses to cardiac substructures. The purpose of this work was to use automatic segmentation to evaluate substructure doses and develop predictive models for these based on the dose to the whole heart.Material and methodsAutomatic segmentation was used to delineate cardiac substructures in a Danish breast cancer trial (DBCG HYPO) dataset...
Tue Sep 08, 2020 03:00
Low absolute lymphocyte counts (ALCs) during therapy have been linked not only with the risk of opportunistic infections (e.g. radiation-induced pneumonia) [1,2] but also with worse survival in patients receiving radiation therapy [3–9]. Moreover, the emergence of immunotherapy has greatly improved outcomes in some patients with lung cancer and has become a treatment option in major guidelines. Lymphocytes have crucial roles in cancer immunity, and severe lymphopenia resulting from current standard...
Tue Sep 08, 2020 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02896
Tue Sep 08, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01490
Tue Sep 08, 2020 07:00
To assess and compare volumetric and shape changes of the orbital cavity in patients treated with tooth-borne (TB) and bone-borne (BB) rapid maxillary expansion (RME).
Tue Sep 08, 2020 03:00
As a front-line healthcare worker, I witnessed many of my colleagues get COVID-19 infection, some of whom required intensive care support. I was heartened by the solidarity and support from my community and by the additional resources provided by the government in the first surge of this pandemic. I am now also aware of many of those who have recovered from the acute COVID-19 infection, who suffer now from a debilitating Post COVID Syndrome (PCS). They are not able to return to work due to significant...
Tue Sep 08, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04917
Tue Sep 08, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06858
Tue Sep 08, 2020 07:00
Abstract Ecosystems worldwide are exposed to pollutants connected to the industrial production of pharmaceuticals. The objective of this study was to study the composition and characteristics of the soil microbial communities that had been exposed to long-term selection pressure caused by the industrial production of penicillin G. Soil samples from four sites among the penicillin G production plant were analysed using 16S rRNA profiling via Illumina MiSeq platform and were compared...
Tue Sep 08, 2020 03:00
Horm Metab ResDOI: 10.1055/a-1227-6635The rapid spread of coronavirus disease (COVID-19) worldwide justifies global effort to combat the disease but also the need to review effective preventive strategies and medical management for potentially high-risk populations during the pandemic. Data regarding the COVID-19 manifestations in adults with underlying endocrine conditions, especially diabetes mellitus, are increasingly...
Tue Sep 08, 2020 02:00
Abstract Background Shunt insertion for hydrocephalus is a common paediatric neurosurgery procedure. Shunt complications are frequent with an estimated 20–40% failure rate within the first year, and 4.5% per year subsequently. We have an open-door ‘possible shunt malfunction’ pathway for children treated with a shunt or endoscopic third ventriculostomy, providing direct ward access to ensure rapid assessment and timely management of...
Tue Sep 08, 2020 03:00
Abstract Objective The purpose of this study was to analyze the anatomical structures relevant for endodontic microsurgery in the mandibular posterior teeth using a cone-beam computed tomography (CBCT). Material and methods A total of 963 mandibular posterior teeth were analyzed in CBCT scans from 133 patients. The buccolingual and mesiodistal dimensions...
Tue Sep 08, 2020 03:00
Abstract To evaluate the efficiency of photobiomodulation therapy (PBMT) in the midpalatal suture (MPS) and pain sensation in patients undergoing rapid palatal expansion (RPE). Thirty-four individuals with the diagnosis of skeletal maxillary hypoplasia were divided in two groups: laser (n = 18) and control (n = 16). Treatment plan consisted of the use of the Hyrax expander in all patients. Subjects in the laser group were irradiated with diode laser (980 nm, 0.3 W) in six spots...
Tue Sep 08, 2020 03:00
Abstract Objectives To assess patient needs and concerns after head and neck squamous cell carcinoma (HNSCC) treatment and their possible correlations with long-term quality of life (QoL) and to examine the potential impact of psychological distress on these results. Methods Alive and disease-free HNSCC patients at least 1 year after treatment were enrolled...
Tue Sep 08, 2020 03:00
Abstract Purpose To assess suspected acute stroke, the computed tomography (CT) protocol contains a non-contrast CT (NCCT), a CT angiography (CTA), and a CT perfusion (CTP). Due to assumably high radiation doses of the complete protocol, the aim of this study is to examine radiation exposure and to establish diagnostic reference levels (DRLs). Methods ...
Tue Sep 08, 2020 03:00
Clinical Thyroidology, Volume 32, Issue 9, Page 408-408, September 2020.
Wed Sep 02, 2020 10:00
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