IJERPH, Vol. 17, Pages 6545: Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17186545 Authors: Teodora-Irina Adam-Bonci Paraschiva Cherecheș-Panța Eduard-Alexandru Bonci Sorin Claudiu Man Ancuța Cutaș-Benedec Tudor Drugan Raluca Maria Pop Alexandru Irimie...
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IJMS, Vol. 21, Pages 6577: Discovery of epi-Enprioline as a Novel Drug for the Treatment of Vincristine Resistant Neuroblastoma International Journal of Molecular Sciences doi: 10.3390/ijms21186577 Authors: Wondossen Sime Mohamed Jemaà Yasmin Abassi Vito Alessandro Lasorsa Julie Bonne Køhler Karin Hansson Daniel Bexell Martin Michaelis Jindrich Cinatl Daniel Strand Mario Capasso Ramin Massoumi Neuroblastoma is a childhood solid tumour originating from...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6570: iRhom2: An Emerging Adaptor Regulating Immunity and Disease International Journal of Molecular Sciences doi: 10.3390/ijms21186570 Authors: Mazin A. Al-Salihi Philipp A. Lang The rhomboid family are evolutionary conserved intramembrane proteases. Their inactive members, iRhom in Drosophila melanogaster and iRhom1 and iRhom2 in mammals, lack the catalytic center and are hence labelled “inactive” rhomboid family members. In mammals, both...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6575: Small Molecules and Peptides Targeting Glial Cell Line-Derived Neurotrophic Factor Receptors for the Treatment of Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21186575 Authors: Yulia A. Sidorova Mart Saarma Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) are able to promote the survival of multiple neuronal populations in the body and, therefore, hold considerable promise for disease-modifying treatments...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6576: Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor Archon2 International Journal of Molecular Sciences doi: 10.3390/ijms21186576 Authors: Alfons Penzkofer Arita Silapetere Peter Hegemann Archon2 is a fluorescent voltage sensor derived from Archaerhodopsin 3 (Arch) of Halorubrum sodomense using robotic multidimensional directed evolution approach. Here we report absorption...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6573: An Update on Vitamin D Metabolism International Journal of Molecular Sciences doi: 10.3390/ijms21186573 Authors: Federica Saponaro Alessandro Saba Riccardo Zucchi Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6572: The Impact of Insertion Sequences on O-Serotype Phenotype and Its O-Locus-Based Prediction in Klebsiella pneumoniae O2 and O1 International Journal of Molecular Sciences doi: 10.3390/ijms21186572 Authors: Daria Artyszuk Radosław Izdebski Anna Maciejewska Marta Kaszowska Aleksandra Herud Valeria Szijártó Marek Gniadkowski Jolanta Lukasiewicz Klebsiella pneumoniae is a nosocomial pathogen, pointed out by the World Helth Organisation (WHO)...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6569: Cerebral Vasodilator Property of Poly(ADP-Ribose) Polymerase Inhibitor (PJ34) in the Neonatal and Adult Mouse Is Mediated by the Nitric Oxide Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21186569 Authors: Philippe Bonnin Christiane Charriaut-Marlangue Julien Pansiot Alexandre Boutigny Jean-Marie Launay Valérie C. Besson The poly(ADP-ribose) polymerase (PARP) inhibitor PJ34 has been reported to improve endothelial dysfunction...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6574: Research Progress on the Roles of Cytokinin in Plant Response to Stress International Journal of Molecular Sciences doi: 10.3390/ijms21186574 Authors: Yun Liu Mingjing Zhang Zhe Meng Baoshan Wang Min Chen Cytokinins promote plant growth and development under normal plant growth conditions and also play an important role in plant resistance to stress. Understanding the working mechanisms of cytokinins under adverse conditions will help to make full...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6568: Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation International Journal of Molecular Sciences doi: 10.3390/ijms21186568 Authors: Marc Melià-Sorolla Carlos Castaño Núria DeGregorio-Rocasolano Luis Rodríguez-Esparragoza Antoni Dávalos Octavi Martí-Sistac Teresa Gasull In the search of animal stroke models providing translational advantages for biomedical research, pigs are large mammals...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6567: CCL4 Inhibition in Atherosclerosis: Effects on Plaque Stability, Endothelial Cell Adhesiveness, and Macrophages Activation International Journal of Molecular Sciences doi: 10.3390/ijms21186567 Authors: Ting-Ting Chang Hsin-Ying Yang Ching Chen Jaw-Wen Chen Atherosclerosis is an arterial inflammatory disease. The circulating level of the C-C chemokine ligand (CCL4) is increased in atherosclerotic patients. This study aimed to investigate whether CCL4...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6560: Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces International Journal of Molecular Sciences doi: 10.3390/ijms21186560 Authors: Maud Bongaerts Koceila Aizel Emilie Secret Audric Jan Tasmin Nahar Fabian Raudzus Sebastian Neumann Neil Telling Rolf Heumann Jean-Michel Siaugue Christine Ménager Jérôme Fresnais Catherine Villard Alicia El Haj Jacob Piehler Monte A. Gates Mathieu...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6559: Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore International Journal of Molecular Sciences doi: 10.3390/ijms21186559 Authors: Konstantin N. Belosludtsev Natalia V. Belosludtseva Mikhail V. Dubinin Diabetes mellitus is one of the most common metabolic diseases in the developed world, and is associated either with the impaired secretion of insulin or with the resistance of cells to the actions of this hormone...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6566: Ivabradine-Stimulated Microvesicle Release Induces Cardiac Protection against Acute Myocardial Infarction International Journal of Molecular Sciences doi: 10.3390/ijms21186566 Authors: Rafael Ramirez-Carracedo Laura Tesoro Ignacio Hernandez Javier Diez-Mata Laura Botana Marta Saura Marcelo Sanmartin Jose Luis Zamorano Carlos Zaragoza Ivabradine can reduce heart rate through inhibition of the current I(f) by still unexplored mechanisms....
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6565: Molecular and Cellular Mechanisms of Arthritis in Children and Adults: New Perspectives on Applied Photobiomodulation International Journal of Molecular Sciences doi: 10.3390/ijms21186565 Authors: Ailioaie Litscher Juvenile idiopathic arthritis and adult rheumatoid arthritis are two major groups with chronic joint pain and inflammation, extra-articular manifestations, and high risk of comorbidities, which can cause physical and ocular disability, as well...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6563: Characterization of Integrin αIIbβ3-Mediated Outside-in Signaling by Protein Kinase Cδ in Platelets International Journal of Molecular Sciences doi: 10.3390/ijms21186563 Authors: Preeti Kumari Chaudhary Sanggu Kim Youngheun Jee Seung-Hun Lee Soochong Kim Engagement of integrin αIIbβ3 promotes platelet–platelet interaction and stimulates outside-in signaling that amplifies activation. Protein kinase Cδ (PKCδ)...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6562: An Increased Burden of Highly Active Retrotransposition Competent L1s Is Associated with Parkinson’s Disease Risk and Progression in the PPMI Cohort International Journal of Molecular Sciences doi: 10.3390/ijms21186562 Authors: Abigail L. Pfaff Vivien J. Bubb John P. Quinn Sulev Koks Long interspersed element-1 (LINE-1/L1s) contributes 17% of the human genome with more than 1 million elements present; however, fewer than 100 of these have evidence...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6564: Development and Technical Validation of an Immunoassay for the Detection of APP669–711 (Aβ−3–40) in Biological Samples International Journal of Molecular Sciences doi: 10.3390/ijms21186564 Authors: Hans W. Klafki Petra Rieper Anja Matzen Silvia Zampar Oliver Wirths Jonathan Vogelgsang Dirk Osterloh Lara Rohdenburg Timo J. Oberstein Olaf Jahn Isaak Beyer Ingolf Lachmann Hans-Joachim Knölker Jens Wiltfang The ratio of amyloid...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6558: The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition International Journal of Molecular Sciences doi: 10.3390/ijms21186558 Authors: Michela Pucci Inês Gomes Ferreira Nadia Malagolini Manuela Ferracin Fabio Dall’Olio Background: The Sda antigen and its biosynthetic enzyme B4GALNT2 are highly expressed in healthy colon but undergo a variable down-regulation in colon cancer....
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6561: Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis? International Journal of Molecular Sciences doi: 10.3390/ijms21186561 Authors: Christine C. Krieger Susanne Neumann Marvin C. Gershengorn In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6557: FACS-Based Proteomics Enables Profiling of Proteins in Rare Cell Populations International Journal of Molecular Sciences doi: 10.3390/ijms21186557 Authors: Evelyne Maes Nathalie Cools Hanny Willems Geert Baggerman Understanding disease pathology often does not require an overall proteomic analysis of clinical samples but rather the analysis of different, often rare, subpopulations of cells in a heterogeneous mixture of cell types. For the isolation...
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6556: Ponatinib and other CML Tyrosine Kinase Inhibitors in Thrombosis International Journal of Molecular Sciences doi: 10.3390/ijms21186556 Authors: Peng Zeng Alvin Schmaier Abl1 kinase has important biological roles. The Bcr-Abl1 fusion protein creates undesired kinase activity and is pathogenic in 95% of chronic myeloid leukemia (CML) and 30% of acute lymphoblastic leukemia (ALL) patients. Targeted therapies to these diseases are tyrosine kinase inhibitors....
Tue Sep 08, 2020 03:00
IJMS, Vol. 21, Pages 6555: Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21186555 Authors: K.V. Surangi Dharmawansa David W. Hoskin H. P. Vasantha Rupasinghe Anthocyanins are a group of dietary polyphenols, abundant mainly in fruits and their products. Dietary interventions of anthocyanins are being studied extensively related to the prevention...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2906: Parkinson Network Eastern Saxony (PANOS): Reaching Consensus for a Regional Intersectoral Integrated Care Concept for Patients with Parkinson’s Disease in the Region of Eastern Saxony, Germany Journal of Clinical Medicine doi: 10.3390/jcm9092906 Authors: Kai F. Loewenbrück Doron B. Stein Volker E. Amelung Robert Bitterlich Martin Brumme Björn Falkenburger Annekathrin Fehre Tim Feige Anika Frank Carola Gißke Claudia Helmert Linda Kerkemeyer...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2905: Key Strategies to Optimize Outcomes in Mild-to-Moderate Ulcerative Colitis Journal of Clinical Medicine doi: 10.3390/jcm9092905 Authors: Virginia Solitano Ferdinando D’Amico Gionata Fiorino Kristine Paridaens Laurent Peyrin-Biroulet Silvio Danese Mesalamine (5-ASA) is the mainstay therapy in patients with mild-to-moderate active ulcerative colitis (UC). However, non-adherence to therapy and practice variability among gastroenterologists represent...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2904: A Two-Year Follow-Up Cohort Study—Improved Clinical Control over CVD Risk Factors through Weight Loss in Middle-Aged and Older Adults Journal of Clinical Medicine doi: 10.3390/jcm9092904 Authors: Pawel Macek Malgorzata Terek-Derszniak Malgorzata Biskup Halina Krol Jolanta Smok-Kalwat Stanislaw Gozdz Marek Zak Modest weight loss enhances clinical control over cardiovascular disease (CVD) risk factors in overweight and obese individuals. This...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2903: Overview of the Side-Effects of FDA- and/or EMA-Approved Targeted Therapies for the Treatment of Hematological Malignancies Journal of Clinical Medicine doi: 10.3390/jcm9092903 Authors: Catalin Constantinescu Sergiu Pasca Alina-Andreea Zimta Tiberiu Tat Ioana Rus Patric Teodorescu Sabina Iluta Alina Tanase Anca Colita Olafur Sigurjonsson Hermann Einsele Ciprian Tomuleasa In the last decade there has been tremendous effort in offering...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2902: Resistance Exercise, Electrical Muscle Stimulation, and Whole-Body Vibration in Older Adults: Systematic Review and Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9092902 Authors: Nejc Šarabon Žiga Kozinc Stefan Löfler Christian Hofer It has been shown that resistance exercise (RT) is one of the most effective approaches to counteract the physical and functional changes associated with aging. This systematic...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2901: Is There a Role for Spacer Exchange in Two-Stage Exchange Arthroplasty for Periprosthetic Joint Infection? Journal of Clinical Medicine doi: 10.3390/jcm9092901 Authors: Elie Kozaily Emanuele Chisari Javad Parvizi Periprosthetic joint infection (PJI) continues to be one of the most serious complications after hip and knee arthroplasty. The choice of surgical treatment depends on a multitude of factors like chronicity of infection, host factors, and institutional...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2897: Effect of CYP3A5 on the Once-Daily Tacrolimus Conversion in Stable Liver Transplant Patients Journal of Clinical Medicine doi: 10.3390/jcm9092897 Authors: Jong Man Kim Je Ho Ryu Kwang-Woong Lee Suk Kyun Hong Kwangho Yang Gyu-Seong Choi Young-Ae Kim Ju-Yeun Lee Nam-Joon Yi Choon Hyuck David Kwon Chong Woo Chu Kyung-Suk Suh Jae-Won Joh Cytochrome P450 (CYP) 3A5 polymorphism influences tacrolimus metabolism, but its effect on...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2900: Severe Acute Kidney Injury in Cardiovascular Surgery: Thrombotic Microangiopathy as a Differential Diagnosis to Ischemia Reperfusion Injury. A Retrospective Study Journal of Clinical Medicine doi: 10.3390/jcm9092900 Authors: Melissa Grigorescu Christine-Elena Kamla Dietmar Wassilowsky Dominik Joskowiak Sven Peterss Stephan Kemmner Maximilian Pichlmaier Christian Hagl Michael Fischereder Ulf Schönermarck Background: Acute kidney injury...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2899: Machine Learning-Based Predictive Modeling of Postpartum Depression Journal of Clinical Medicine doi: 10.3390/jcm9092899 Authors: Dayeon Shin Kyung Ju Lee Temidayo Adeluwa Junguk Hur Postpartum depression is a serious health issue beyond the mental health problems that affect mothers after childbirth. There are no predictive tools available to screen postpartum depression that also allow early interventions. We aimed to develop predictive models for...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2898: Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor in Uterine Sarcoma Journal of Clinical Medicine doi: 10.3390/jcm9092898 Authors: Min Jin Jeong Jung Hyun Park Soo Young Hur Chan Joo Kim Hae Seong Nam Yong Seok Lee Background: Recent studies have demonstrated that the tumor microenvironment, known to be influenced by inflammatory cells, plays a crucial role in cancer progression and clinical outcome of patients. The objective of...
Tue Sep 08, 2020 03:00
JCM, Vol. 9, Pages 2896: Time Trends of Crohn’s Disease in Catalonia from 2011 to 2017. Increasing Use of Biologics Correlates with a Reduced Need for Surgery Journal of Clinical Medicine doi: 10.3390/jcm9092896 Authors: Eduard Brunet Emili Vela Luigi Melcarne Montserrat Clèries Caridad Pontes Laura Patricia Llovet Pilar García-Iglesias Marta Gallach Albert Villòria Mercedes Vergara Xavier Calvet Background and Aims: Data from clinical trials suggest that...
Tue Sep 08, 2020 03:00
JoF, Vol. 6, Pages 165: Heterogeneity of Clinical Presentations and Paraclinical Explorations to Diagnose Disseminated Histoplasmosis in Patients with Advanced HIV: 34 Years of Experience in French Guiana Journal of Fungi doi: 10.3390/jof6030165 Authors: Mathieu Nacher Audrey Valdes Antoine Adenis Romain Blaizot Philippe Abboud Magalie Demar Félix Djossou Loïc Epelboin Kinan Drak Alsibai Caroline Misslin Balthazar Ntab Pierre Couppié We aimed to describe...
Tue Sep 08, 2020 03:00
J. Imaging, Vol. 6, Pages 92: Comparative Study of First Order Optimizers for Image Classification Using Convolutional Neural Networks on Histopathology Images Journal of Imaging doi: 10.3390/jimaging6090092 Authors: Ibrahem Kandel Mauro Castelli Aleš Popovič The classification of histopathology images requires an experienced physician with years of experience to classify the histopathology images accurately. In this study, an algorithm was developed to assist physicians in classifying...
Tue Sep 08, 2020 03:00
J. Imaging, Vol. 6, Pages 91: On the Use of Deep Active Semi-Supervised Learning for Fast Rendering in Global Illumination Journal of Imaging doi: 10.3390/jimaging6090091 Authors: Ibtissam Constantin Joseph Constantin André Bigand Convolution neural networks usually require large labeled data-sets to construct accurate models. However, in many real-world scenarios, such as global illumination, labeling data are a time-consuming and costly human intelligent task. Semi-supervised...
Tue Sep 08, 2020 03:00
JPM, Vol. 10, Pages 116: Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: Sensitivity, Specificity and Potential for Clinical Use Journal of Personalized Medicine doi: 10.3390/jpm10030116 Authors: Cristina d’Abramo Luciano D’Adamio Luca Giliberto Alzheimer’s disease (AD) is the most common type of dementia, affecting more than 5 million Americans, with steadily increasing mortality and incredible socio-economic burden. Not only have therapeutic...
Tue Sep 08, 2020 03:00
Life, Vol. 10, Pages 185: An Overview of Bioinformatics Tools for DNA Meta-Barcoding Analysis of Microbial Communities of Bioaerosols: Digest for Microbiologists Life doi: 10.3390/life10090185 Authors: Hamza Mbareche Nathan Dumont-Leblond Guillaume J. Bilodeau Caroline Duchaine High-throughput DNA sequencing (HTS) has changed our understanding of the microbial composition present in a wide range of environments. Applying HTS methods to air samples from different environments...
Tue Sep 08, 2020 03:00
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