Abstract Objectives To investigate the clinicopathological profile and risk factors of micro-invasive carcinoma within oral potentially malignant disorders (OPMD). Methods Micro-invasive carcinomas were identified in a large prospective series of OPMD patients (n = 810) from eastern China. Logistic regression was applied to evaluate odds ratios (OR) with...
03:00
Background The overall risk of postcontrast acute kidney injury (PC-AKI) after computerized tomography (CT) is negligible, likely because of the small volume of injected iodinated contrast media required. However, the safety of contrast media–enhanced CT in patients with advanced renal functional impairment, an established major risk factor for PC-AKI, is unknown. Materials and Methods This is a retrospective study using large data analysis of hospitalized patients at a single center. Adults...
10:34
Objectives The aim of the study was to reach homogeneous enhancement of the liver, irrespective of total body weight (TBW) or tube voltage. An easy-to-use rule of thumb, the 10-to-10 rule, which pairs a 10 kV reduction in tube voltage with a 10% decrease in contrast media (CM) dose, was evaluated. Materials and Methods A total of 256 patients scheduled for an abdominal CT in portal venous phase were randomly allocated to 1 of 4 groups. In group 1 (n = 64), a tube voltage of 120 kV and a TBW-adapted...
10:34
Objectives We used laser ablation inductively coupled plasma mass spectrometry to quantify gadolinium in hair samples from autopsy cases with gadolinium-based contrast agent (GBCA) exposure. Hair gadolinium data were correlated with gadolinium concentrations in brain, skin, and bone tissues from the same case to investigate a potential noninvasive method for gadolinium quantification and monitoring. Materials and Methods Medical records from autopsy cases at our institution were screened...
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Objectives Gadolinium deposition is widely believed to occur, but questions regarding accumulation pattern and permanence remain. We conducted a retrospective study of intracranial signal changes on monthly triple-dose contrast-enhanced magnetic resonance imaging (MRI) examinations from the previously published Betaseron vs. Copaxone in Multiple Sclerosis With Triple-Dose Gadolinium and 3-Tesla MRI Endpoints Trial (N = 67) to characterize the dynamics of gadolinium deposition in several deep brain...
10:34
Objectives Contrast enhanced ultrasound (CEUS) is now broadly used clinically for liver lesion detection and characterization. Obstacles to the efforts to quantify perfusion with CEUS have been the lack of a standardized approach and undocumented reproducibility. The use of multiple scanners and different analysis software packages compounds the degree of variability. Our objectives were to standardize a CEUS-based approach for quantification of perfusion-related parameters of liver lesions and...
10:34
The latest technical developments in CT have created the possibility for individualized scan protocols at variable kV settings. Lowering tube voltages closer to the K-edge of iodine increases attenuation. However, the latter is also influenced by patient characteristics such as total body weight. To maintain a robust contrast enhancement throughout the patient population in both vascular and parenchymal CT scans, one must adapt the contrast media administration protocols to both the selected kV setting...
10:34
Objectives The aim of this study was to evaluate the added value of ultrasound molecular imaging of the vascular growth factor receptor 2 (VEGFR2) expression, using the clinical grade contrast agent BR55, for the early evaluation of antiangiogenic treatment efficacy in a chemo-induced rat mammary tumor model. Materials and Methods In this preclinical study, chemo-induced rat mammary tumors were obtained after a single injection of N-nitroso-N-methylurea intraperitoneally in 46 prepubescent...
10:34
Objectives Dual-energy and multienergy computed tomography (DECT/MECT) has the potential to simultaneously visualize two contrast agents in the small bowel: arterial enhancement of iodine in the bowel wall and enteric enhancement of bismuth in the bowel lumen. The purpose of this study was to explore its feasibility in a swine study using a research whole-body photon-counting-detector (PCD) computed tomography (CT) system. Materials and Methods A phantom study was initially performed to evaluate...
10:34
Self-medication with antibiotics (SMA) is one of the most dangerous inappropriate antibiotic use behaviors. This study aims to investigate the impact of parental SMA for children before a consultation on their...
Mon Sep 07, 2020 03:00
Antimicrobial resistance (AMR) is one of the most urgent global health threats with low-resource countries being disproportionately affected. Targeted interventions require insight in antibiotic prescription p...
Mon Sep 07, 2020 03:00
Related Articles Noncystic cerebellopontine angle hemangioblastoma: A case of an atypical location. Int J Surg Case Rep. 2020 Aug 29;74:234-237 Authors: Pamela Ferreira Neto B, Martins Barreto Santana J, Dornellys da Silva Lapa J, Cristina de Souza Melo T, Maynart Pereira Oliveira A Abstract INTRODUCTION: Extra-axial cerebellopontine angle (CPA) hemangioblastoma is a rare condition in which the correct differential diagnosis from other CPA lesions...
Tue Sep 08, 2020 13:31
Related Articles Upper gastrointestinal bleeding due to hepatic artery aneurysm: Case report and literature review. Int J Surg Case Rep. 2020 Aug 29;74:230-233 Authors: Alonso-Lamberti Rizo L, Bustamante Recuenco C, Cuesta Pérez J, Ramos Rodríguez JL, Salazar Carrasco A, Valle Rubio A, Jiménez Carneros V, Jiménez Miramón FJ, Jover Navalón JM Abstract INTRODUCTION: Aneurysm of the hepatic artery is most of the time a rare and asymptomatic pathology,...
Tue Sep 08, 2020 13:31
Related Articles A rare case report of infant ileal atresia with double appendix. Int J Surg Case Rep. 2020 Aug 29;74:226-229 Authors: Dhar PP, Mohanty U Abstract INTRODUCTION: Small bowel atresia has quite an incidence in infants particularly in males. It is usually seen to be the most common cause of bowel obstruction in neonates since birth. It may be associated with other congenital anomalies. PRESENTATION OF THE CASE: A 4 day old...
Tue Sep 08, 2020 13:31
Related Articles Pneumoperitoneum and Pneumatosis cystoides intestinalis, a dangerous mixture. A case report. Int J Surg Case Rep. 2020 Aug 29;74:222-225 Authors: Moyon FX, Molina GA, Tufiño JF, Basantes VM, Espin DS, Moyon MA, Cevallos JM, Palacios NE, Parra RA, Eras KR Abstract BACKGROUND: Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by gas infiltration into the intestine wall. When gas is seen in the intestinal...
Tue Sep 08, 2020 13:31
Related Articles Benign multi-cystic peritoneal mesothelioma of the porta hepatis. Int J Surg Case Rep. 2020 Aug 29;74:218-221 Authors: Aziz H, Hao M, Merchant A, Alfson D, Foran C, Raashid Sheikh M Abstract INTRODUCTION: Our case report describes a patient where multiple laparoscopies five years from initial presentation of symptoms were performed prior to laparotomy for benign multi-cystic peritoneal mesothelioma (BMPM), which has not been...
Tue Sep 08, 2020 13:31
Related Articles Laparoscopic right hemicolectomy for metastatic renal cell carcinoma in the ascending colon: A case report. Int J Surg Case Rep. 2020 Aug 30;74:214-217 Authors: Kataoka M, Hirano Y, Kondo H, Ishikawa S, Yamaguchi S Abstract INTRODUCTION: Renal cell carcinoma (RCC) arises from the renal parenchyma and is the most common primary malignancy of the kidney. RCC frequently metastasizes to the lung, bone, lymph nodes, and other locations,...
Tue Sep 08, 2020 13:31
Related Articles Malignant metastatic melanoma to the gallbladder: Report of a PECULIAR case. Int J Surg Case Rep. 2020 Sep 01;: Authors: Di Buono G, Maienza E, Rinaldi G, Buscemi S, Romano G, Agrusa A Abstract INTRODUCTION: Melanoma is one of the most aggressive and one of the fastest growing types of cancer. The occurrence of a malignant melanoma in the gastrointestinal tract, either primary or metastatic, is a rare event. Metastatis from...
Tue Sep 08, 2020 13:31
Key points Nrf2 is a master regulator of endogenous cellular defenses, governing the expression of more than 200 cytoprotective proteins, including a panel of antioxidant enzymes. Nrf2 plays an important role in redox hemostasis of skeletal muscle in response to the increased generation of reactive oxygen species during contraction. Employing skeletal muscle specific transgenic mouse models with unbiased‐omic approaches, we uncovered new target proteins, downstream pathways, and molecular networks...
Mon Sep 07, 2020 14:04
Key points Muscle contractions increase protein synthesis in a mechanistic target of rapamycin (mTOR)‐dependent manner, yet it is unclear which/how mTOR complexes regulate muscle protein synthesis. We investigated the requirement of mTOR Complex 2 (mTORC2) in contraction‐stimulated muscle protein synthesis. mTORC2 inhibition by muscle‐specific Rictor knockout (Rictor mKO) did not prevent contraction‐induced muscle protein synthesis. Rapamycin prevented contraction‐induced muscle protein synthesis...
Mon Sep 07, 2020 14:04
Related Articles Significance of prophylactic urethrectomy at the time of radical cystectomy for bladder cancer. Jpn J Clin Oncol. 2020 Sep 07;: Authors: Hakozaki K, Kikuchi E, Ogihara K, Shigeta K, Abe T, Miyazaki Y, Kaneko G, Maeda T, Yoshimine S, Kanai K, Ide H, Shirotake S, Oyama M, Mizuno R, Oya M Abstract BACKGROUND: Prophylactic urethrectomy at the time of radical cystectomy is frequently recommended for patients with bladder cancer at...
Tue Sep 08, 2020 13:22
COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study.
Related Articles COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study. Int J Surg. 2020 Sep 03;: Authors: Hou J, Wan X, Shen Q, Zhu J, Leng Y, Zhao B, Xia Z, He Y, Wu Y Abstract BACKGROUND: This study aimed to describe the epidemiologic and clinical characteristics of coronavirus disease 2019 (COVID-19) in surgical patients and medical staff. METHODS: A single-center case series of...
Tue Sep 08, 2020 13:17
Related Articles Open abdomen management for severe peritonitis in elderly. Results from the prospective International Register of Open Abdomen (IROA): Cohort study. Int J Surg. 2020 Sep 03;: Authors: Rausei S, Pappalardo V, Ceresoli M, Catena F, Sartelli M, Chiarugi M, Kluger Y, Kirkpatrick A, Ansaloni L, Coccolini F, IROA study Group Abstract BACKGROUND: Analyzing the data of the International Register of Open Abdomen (IROA), the feasibility...
Tue Sep 08, 2020 13:17
Related Articles Comparison of navigated versus fluoroscopic guided pedicle screw placement accuracy and complication rate. World Neurosurg. 2020 Sep 03;: Authors: Budu A, Sims-Williams H, Radatz M, Bacon A, Bhattacharyya D, Athanassacopoulos M, Ivanov M PMID: 32891853 [PubMed - as supplied by publisher]
Tue Sep 08, 2020 13:16
Related Articles Diversity in Neurosurgery. World Neurosurg. 2020 Sep 03;: Authors: Kim EE, Klein AL, Lartigue JW, Hervey-Jumper SL, Rosseau G Abstract Over the past century, the field of neurosurgery has evolved and expanded in various directions. Neurosurgeons have continuously pushed the boundaries of the specialty with scientific discovery and innovation. A diverse array of neurosurgical techniques, treatments, and new areas of study have...
Tue Sep 08, 2020 13:16
Related Articles Patients Who Undergo Primary Lumbar Spine Fusion after Recent but Not Remote Total Hip Arthroplasty are at Increased Risk for Complications, Revision Surgery, and Prolonged Opioid-use. World Neurosurg. 2020 Sep 03;: Authors: Patel SA, Li NY, Yang DS, Reid DBC, Disilvestro KJ, Babu JM, Kuris EO, Barrett T, Daniels AH Abstract OBJECT: Evaluate the impacts of a recent history of Total Hip Arthroplasty (THA) on Primary Lumbar Spine...
Tue Sep 08, 2020 13:16
Related Articles COVID-19 impact on neurosurgical practice: lockdown attitude and experience of a European academic center. World Neurosurg. 2020 Sep 03;: Authors: Lubansu A, Assamadi M, Barrit S, Dembour V, Yao G, Hadwe SE, Witte O Abstract INTRODUCTION: The Coronavirus disease 2019 (COVID-19) pandemic is an unprecedented challenge. Different models of reorganization have been described aiming to preserve resources while ensuring optimal medical...
Tue Sep 08, 2020 13:16
Related Articles Anterior distraction and reduction with posterior stabilization for Basilar Invagination: A novel technique. World Neurosurg. 2020 Sep 03;: Authors: Rathod T, Marathe N, Sathe A, Mohanty SS, Reddy Mallepally A Abstract INTRODUCTION: Introduction of posterior spacer for atlantoaxial joint distraction followed by posterior stabilization is a commonly performed procedure for I-AAD. However, here we present a unique case where posterior...
Tue Sep 08, 2020 13:16
Related Articles Minimally invasive lateral paraorbital approach for repairing lateral recess of the sphenoid sinus spinal fluid leak. World Neurosurg. 2020 Sep 03;: Authors: Wong AK, Wong RH Abstract BACKGROUND: Cerebrospinal fluid (CSF) leaks in the lateral recess of the sphenoid sinus (LRSS) are typically spontaneous in nature and require surgical repair. Endoscopic endonasal approaches have become the mainstay of CSF leak repair in the LRSS...
Tue Sep 08, 2020 13:16
Related Articles Full-Endoscopic Posterior Lumbar Interbody Fusion Via an Interlaminar Approach Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Preliminary Retrospective Study. World Neurosurg. 2020 Sep 03;: Authors: Li Y, Dai Y, Wang B, Li L, Li P, Xu J, Jiang B, Lü G Abstract OBJECTIVES: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has been performed as a minimally invasive surgery for lumbar degenerative...
Tue Sep 08, 2020 13:16
Related Articles Calvarial Melanotic Neuroectodermal Tumor of Infancy with Rhabdomyosarcomatous differentiation - A rare case. World Neurosurg. 2020 Sep 03;: Authors: Nadarajah J, Garg A, Bohara S, Garg K, Devaranjan Sebastian LJ, Suri V, Bakhshi S, Singh M Abstract BACKGROUND: Malignant neuroectodermal tumor of infancy is a rare neural crest cell derived neoplasm of infants. Histologically MNTI usually consists of 2 types of cells: neuroblast...
Tue Sep 08, 2020 13:16
Related Articles Dural arteriovenous fistula formation as Eagle jugular syndrome: A case report and literature review. World Neurosurg. 2020 Sep 03;: Authors: Suzuki Y, Toma N, Kuroda Y, Miura Y, Shiba M, Yasuda R, Suzuki H Abstract BACKGROUND: An elongated styloid process can less frequently lead to symptomatic compression of the internal jugular vein (IJV). We present the first case of dural arteriovenous fistula (DAVF) in association with...
Tue Sep 08, 2020 13:16
Related Articles Spontaneous Spinal Subarachnoid Hemorrhage from a Ruptured Radiculopial Artery Aneurysm: A Case Report. World Neurosurg. 2020 Sep 03;: Authors: Cadieux M, Tso M, Fox S, Jacobs WB Abstract BACKGROUND: CSpontaneous spinal subarachnoid hemorrhage is an uncommon entity and occurs even rarer secondary to intraspinal ruptured aneurysm. While the clinical presentation of these cases usually includes backpain and headache, we report...
Tue Sep 08, 2020 13:16
Related Articles Novel Endoscopic Technique for Inserting a Sheath into a Slit Ventricle: the "Water-Slide" technique. World Neurosurg. 2020 Sep 03;: Authors: Yamamoto T, Takeuchi K, Nagata Y, Mizuno A, Wakabayashi T Abstract BACKGROUND: The efficacy and safety of endoscopic procedures for slit ventricle syndrome (SVS) have been presented in recent studies. However, inserting a sheath into a target ventricle is essential in the beginning of...
Tue Sep 08, 2020 13:16
Related Articles Slow-growing pituitary metastasis from renal cell carcinoma: literature review. World Neurosurg. 2020 Sep 03;: Authors: Moon RDC, Singleton W, Smith P, Urankar K, Evans A, Williams AP Abstract BACKGROUND: Tumour metastasis to the pituitary is rare, most commonly reported with either breast or lung cancer metastasising to the neurohypophysis. Pituitary metastases of renal cell carcinoma (RCC) are by contrast infrequently described...
Tue Sep 08, 2020 13:16
Related Articles Comparison between seven osteoporotic vertebral compression fractures treatments: A Systematic Review and Network Meta-Analysis. World Neurosurg. 2020 Sep 03;: Authors: Chang M, Zhang C, Shi J, Liang J, Yuan X, Huang H, Li D, Yang B, Tang S Abstract Vertebroplasty (VP), Kyphoplasty (KP), Spinejack system (SJ), Radiofrequency Kyphoplasty (RFK), Kiva system (Kiva), Sky kyphoplasty system (SK) and conservative treatment are widely...
Tue Sep 08, 2020 13:16
Related Articles Long-term outcome of endovascular therapy for large or giant thrombosed intracranial aneurysms. World Neurosurg. 2020 Sep 03;: Authors: Enomoto Y, Egashira Y, Matsubara H, Yoshimura S, Iwama T Abstract OBJECTIVE: Large or giant thrombosed intracranial aneurysms (LGTIAs) are highly associated with poor prognosis and remain a challenging disease to treat by both surgical and endovascular treatment (EVT). EVT has been progressively...
Tue Sep 08, 2020 13:16
Related Articles Comparison of First Pass Efficacy among Four Mechanical Thrombectomy Techniques| A Single Center experience. World Neurosurg. 2020 Sep 03;: Authors: Hafeez MU, Kan P, Srivatsan A, Moore S, Jafari M, Garza CD, Hafeez K, Nascimento FA, Srinivasan VM, Burkhardt JK, Chen S, Johnson J, Saleem Y Abstract INTRODUCTION: First Pass Efficacy (FPE) is an established marker of technical and clinical efficacy among Mechanical Thrombectomy...
Tue Sep 08, 2020 13:16
Related Articles Biomechanical Analysis of an Interspinous Process Fixation Device with In Situ Shortening Capabilities: Does Spinous Process Compression Improve Segmental Stability? World Neurosurg. 2020 Sep 03;: Authors: Wagener C, Gandhi A, Ferry C, Farmer S, DenHaese R Abstract STUDY DESIGN: In-vitro cadaveric biomechanical study STUDY OBJECTIVE: The objective of this study was to characterize the biomechanical implications of spinous process...
Tue Sep 08, 2020 13:16
Related Articles Keyhole superior interhemispheric transfalcine approach for tuberculum sellae meningioma: Technical nuances and visual outcomes. World Neurosurg. 2020 Sep 03;: Authors: Wong AK, Kramer DE, Wong RH Abstract BACKGROUND: Tuberculum sellae meningioma are challenging tumors often compressing the optic apparatus and involving the optic canals. Traditional approaches provide wide exposure, but optic canal access can remain difficult....
Tue Sep 08, 2020 13:16
Related Articles Microvascular decompression for oculomotor nerve palsy due to nonaneurysmal vascular compression: a case report. World Neurosurg. 2020 Sep 03;: Authors: Onuma K, Yanaka K, Akimoto Y, Yamano A, Nakamura K, Ishikawa E Abstract BACKGROUND: Oculomotor nerve palsy (ONP) is well known as being caused by diabetes mellitus or aneurysmal compression, but nonaneurysmal vascular compression of the oculomotor nerve has rarely been reported....
Tue Sep 08, 2020 13:16
Related Articles Static magnetic fields within spinal interbody cages for the promotion of spinal arthrodesis: a pilot study. World Neurosurg. 2020 Sep 03;: Authors: Hirschl RA, Biedrzycki AH, Sidhu HS, Wagner AS, Matheus V, Meiner ST, Foreman PM Abstract INTRODUCTION: Spinal arthrodesis is a commonly performed spinal operation. Spinal arthrodesis can be complicated by pseudoarthrosis and resultant hardware failure. Static magnetic fields (SMF)...
Tue Sep 08, 2020 13:16
Related Articles Certificate-of-Need State Laws and Elective Posterior Lumbar Fusions: Is it Time to Repeal the Mandate? World Neurosurg. 2020 Sep 03;: Authors: Sridharan M, Malik AT, Phillips FM, Retchin S, Xu W, Yu E, Khan SN Abstract OBJECTIVES: Our study aimed to assess whether elective posterior lumbar fusions (PLFs) performed in states with Certificate-of-Need (CON) laws verse states without CON laws had lower utilization rates, lower...
Tue Sep 08, 2020 13:16
Related Articles Endoscopic Spine Surgery in Athletes: Cases series and review of literature. World Neurosurg. 2020 Sep 03;: Authors: Sivakanthan S, Williams JR, Feroze AH, Eaton J, Pan ZJ, Boop S, McGrath LB, Harmon K, Hofstetter CP Abstract OBJECTIVE: Degenerative spine disease is common in athletes and can progress to requiring surgical intervention. Traditional open surgical techniques necessitate prolonged recovery time and time away from...
Tue Sep 08, 2020 13:16
Related Articles Outcomes and Complications of Endovascular Mechanical Thrombectomy in the Treatment of Acute Posterior Circulation Occlusions: A Systematic Review. World Neurosurg. 2020 Sep 03;: Authors: Watson CCL, Feria A, Chen CJ, Camacho A Abstract INTRODUCTION: The use of thrombectomy in the treatment for acute ischemic strokes (AIS) affecting the anterior circulation is well established. Comparatively, less data exists on the effectiveness...
Tue Sep 08, 2020 13:16
Related Articles Radio surgical Corpus Callosotomy: A Review of Literature. World Neurosurg. 2020 Sep 03;: Authors: Tripathi M, Maskara P, Rangan VS, Mohindra S, De Salles AAF, Kumar N Abstract BACKGROUND: Microsurgical callosotomy is a procedure still under debate and to best a palliative treatment for drug-resistant epilepsy. Unlike microsurgery, radiosurgical callosotomy is an under practiced treatment option with no definite account on its...
Tue Sep 08, 2020 13:16
Related Articles Personalized 3D Printing Pedicle Screw Guide Innovation for the Surgical Management of Adolescent Idiopathic Scoliosis Patients. World Neurosurg. 2020 Sep 03;: Authors: Senkoylu A, Cetinkaya M, Daldal I, Necefov E, Eren A, Samartzis D Abstract STUDY DESIGN: Prospective study. OBJECTIVES: To assess the safety and efficacy of patient-specific 3D rapid-prototype printing technology for pedicle screw insertion in adolescent...
Tue Sep 08, 2020 13:16
Related Articles Investigation on chronic tinnitus efficacy of combination of non-repetitive preferred music and educational counseling: a preliminary study. Eur Arch Otorhinolaryngol. 2020 Sep 05;: Authors: Chen J, Zhong P, Meng Z, Pan F, Qi L, He T, Lu J, He P, Zheng Y Abstract PURPOSE: To improve the efficacy of music therapy on tinnitus relief, specific music that was not repetitively played and satisfies individualized preference was developed....
Tue Sep 08, 2020 13:14
The tendency of biomolecular droplets to fuse is key to cellular functions and diseases. Using optical tweezers, fluorescence microscopy, and theoretical modeling, we have begun to unravel the molecular origin for disparate fusion speeds among different biomolecular droplets. Fusion speed is dictated by macromolecular packing density inside droplets, which can be reported by thioflavin T fluorescence. Abstract Biomolecular droplets formed through phase separation have a tendency to fuse....
Tue Sep 08, 2020 13:11
Caged crRNA was readily developed through a terminus modification with a photolabile linker and vitamin E for construction of a caged CRISPR/Cas9 system. The system was successfully used for photomodulation of VEGFA gene editing and control of EGFP gene silencing through the temporary inhibition of the interaction between the target DNA and Cas9/crRNA/tracrRNA complex. Abstract Currently CRISPR/Cas9 is a widely used efficient tool for gene editing. Precise control over the CRISPR/Cas9 system...
Tue Sep 08, 2020 13:11
A solid‐state PCN/LaOCl composite has been shown to feature fast inter‐particle charge separation properties by a one‐photon excitation pathway. It thus shows high photocatalytic activities toward overall water splitting to produce hydrogen and oxygen. Abstract It is a challenge to explore photocatalytic materials for sunlight‐driven water splitting owing to the limited choice of a single semiconductor with suitable band energy levels but with a minimized band gap for light harvesting....
Tue Sep 08, 2020 13:11
Three MOFs with high crystallinity were synthesized from the conjugated ligand tetrahydroxybenzoquinone (THBQ) and Fe, Co, Mn metal ions. Fe‐THBQ has a negative Seebeck coefficient and the highest electrical conductivity in THBQ‐based MOFs, which could be due to the FeII/FeIII mixed valence. Strong absorptions in the visible light region provide the possibility of application in the light‐harvesting devices. Abstract 3D well‐crystallized metal–organic frameworks (MOFs), M‐THBQ (M=Fe, Co,...
Tue Sep 08, 2020 13:11
Fluorination of semiconducting polymers resulted in highly bright polymer dots (QY=3.2 %) in the NIR‐II region. By performing through‐skull and through‐scalp imaging of the mouse brain, the vascular morphology of transgenic brain tumors was quantitatively analyzed. Abstract Here, we describe a fluorination strategy for semiconducting polymers for the development of highly bright second near‐infrared region (NIR‐II) probes. Tetrafluorination yielded a fluorescence QY of 3.2 % for the polymer...
Tue Sep 08, 2020 13:11
We describe a DNA‐based nanodevice that acts as a sulfur switch and can be temporally controlled through redox cycles of a disulfide‐linked allosteric modulator. The system has an unprecedented high tolerance to waste products and displays transient behavior for over 40 cycles without significant loss of efficiency. The approach is reversible and allows the transient loading and release of a ligand upon successive reduction and oxidation of the modulator. Abstract Nature employs sulfur...
Tue Sep 08, 2020 13:11
A PtIV prodrug with axial oleate and cinnamate ligands was synthesized. It is active against HER2‐positive breast cancer, which is an aggressive breast‐cancer subtype that typically responds poorly to standard chemotherapy. Moreover, the new PtIV prodrug is capable of overcoming the resistance of cancer stem cells (CSCs), inducing death in both CSCs and differentiated cancer cells. Abstract HER2‐positive breast cancer is an aggressive subtype that typically responds poorly to standard chemotherapy....
Tue Sep 08, 2020 13:11
A pH‐activatable fluorescent probe (pHocas‐RIS) with moderate bone‐binding affinity was synthesized by conjugating a BODIPY fluorophore to bisphosphonate‐targeting risedronate ligands. The probe enabled the imaging of acidic osteocytic lacunae that contain bone resorbing osteocytes in deep bone tissues in living animals. Abstract A rationally designed pH‐activatable fluorescent probe (pHocas‐RIS) has been used to measure localised pH levels in osteocytic lacunae in bone tissue. Conjugation...
Tue Sep 08, 2020 13:11
The King of Bitters. An enantioselective total synthesis of the labdane diterpenoid andrographolide, the bitter principle of the herb Andrographis paniculata (known as “King of Bitters”), is accomplished in 14 steps (LLS) ‐ 10 steps shorter than the prior total synthesis. Key transformations include iridium‐catalyzed carbonyl reductive coupling to form the quaternary carbon stereocenter at C4, diastereoselective alkene reduction to establish the trans ‐decalin ring, and carbonylative lactonization...
Tue Sep 08, 2020 13:11
Earth‐abundant/biocompatible metal catalysts for the asymmetric cis‐dihydroxylation (AD) of trisubstituted alkenes, in which OsO4‐based catalysts have been widely used, are highly appealing. In their Research Article on https://doi.org/10.1002/anie.202002866page 16561, C.‐M. Che and co‐workers describe a cis‐FeII(chiral N4 ligand)/H2O2 method that is an alternative/complement to the OsO4‐based method and converts various trisubstituted alkenes into cis‐diols in synthetically useful yields with...
Tue Sep 08, 2020 12:26
Metal‐organic frameworks (MOFs) have been proven to be an excellent platform in photocatalysis. However, to suppress the electron‐hole recombination, the Pt cocatalyst is usually inevitable, especially in photocatalytic H 2 production, which greatly limits the practical application. Herein, for the first time, the monodisperse, small‐size and noble‐metal‐free transitional metal phosphides (TMPs, e.g., Ni 2 P, Ni 12 P 5 ), are incorporated into a representative MOF, UiO‐66‐NH 2 , for photocatalytic...
Tue Sep 08, 2020 12:05
Breast cancer (BC) is one of the most common malignancies in women and often accompanied by inflammatory processes. Cyclooxygenase‐2 (COX‐2) plays a vital role in the progression of BC, correlating with the expression of programmed death‐ligand 1 (PD‐L1). Overexpression of PD‐L1 contributes to the immune escape of cancer cells, and its blockade would stimulate anticancer immunity. Two multispecific platinum(IV) complexes DNP and NP were prepared using non‐steroidal antiinflammatory drug naproxen...
Tue Sep 08, 2020 12:03
A general protocol for the Pd‐catalyzed coupling of aryl chlorides with alkyllithium reagents is reported. The use of the ylide‐substituted phosphines joYPhos allowed for high selectivities at room temperature, thus minimizing side reaction typical for these highly reactive reagents. This was demonstrated for a large substrate scope including the gram‐scale synthesis of building blocks for pharmaceutical industry. Abstract Organolithium compounds are amongst the most important organometallic...
Tue Sep 08, 2020 11:10
Pyridine‐substituted alkylidenecyclopropanes (Py‐ACPs) react with Au(III) salts through an unprecedented, proximal ring‐opening path, to generate catalytically active pyridine alkenyl [C^N]‐gold(III) species. Mechanistic studies reveal that the activation of the C−C bond of the ACP takes place via a concerted, σ‐bond metathesis type‐process under very mild conditions, aided by coordination of the pyridine ligand to the Au(III) center. Abstract Pyridine‐substituted alkylidenecyclopropanes...
Tue Sep 08, 2020 11:10
A homochiral molecular ferroelectric was incorporated into a perovskite film to enlarge the built‐in electric field of the perovskite solar cell (PSC), thereby facilitating charge separation and transportation. The molecular ferroelectric component of the PSC passivates the defects in the perovskite active layers to induce an approximately eightfold enhancement in photoluminescence intensity and a reduction in electron trap‐state density. Abstract The nonradiative recombination of electrons...
Tue Sep 08, 2020 11:09
A nickel‐catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochemical outcome. Markovnikov hydrofunctionalization products are obtained under mild ligand‐free conditions, with up to 99% yield and >20:1 selectivity. Alternatively, anti‐Markovnikov products can be accessed with a novel 4,4‐disubstituted Pyrox ligand in excellent yield and >20:1 selectivity. Both...
Mon Sep 07, 2020 22:29
Hemiasterlin is an anti‐mitotic marine natural product with reported sub‐nanomolar potency against several cancer cell lines. Herein, we describe an expeditious total synthesis of hemiasterlin featuring a four‐component Ugi reaction (Ugi‐4CR) as the key step. The convergent synthetic strategy enabled rapid access to taltobulin (HTI‐286), a similarly potent synthetic analogue. This short synthetic sequence enabled investigation of both hemiasterlin and taltobulin as cytotoxic payloads in antibody‐drug...
Mon Sep 07, 2020 22:00
We established a highly convergent 10‐step route for total synthesis of (–)‐deoxoapodine, which is a hexacyclic aspidosperma alkaloid. The quaternary carbon center at C5 on the characteristic tetrahydrofuran ring was constructed via a chiral phosphoric acid‐catalyzed enantioselective bromocycloetherification in a 5‐ endo fashion and subsequent allylation by using Keck’s protocol. The aspidosperma skeleton was constructed featuring the formation of 9‐membered lactam by catalytic C–H palladation/alkylation...
Mon Sep 07, 2020 21:28
A single‐step method for isolation of specific cells based on multiple surface markers will have unique advantages because of its scalability, efficacy, and mildness. Herein, we developed multi‐aptamer‐mediated proximity ligation method on live cell membranes that leverages a multi‐receptor co‐recognition design for enhanced specificity, as well as a robust in‐situ signal amplification design for improved sensitivity of cell isolation. We demonstrated the promising efficacy of our method on differentiating...
Mon Sep 07, 2020 20:41
Publication date: September–October 2020Source: Journal of Surgical Education, Volume 77, Issue 5Author(s):
Tue Sep 08, 2020 13:11
Publication date: September–October 2020Source: Journal of Surgical Education, Volume 77, Issue 5Author(s):
Tue Sep 08, 2020 13:11
Related Articles Exploring Adipose Tissue Structure by Methylsalicylate Clearing and 3D Imaging. J Vis Exp. 2020 Aug 19;(162): Authors: Gilleron J, Meziat C, Sulen A, Ivanov S, Jager J, Estève D, Muller C, Tanti JF, Cormont M Abstract Obesity is a major worldwide public health issue that increases the risk to develop cardiovascular diseases, type-2 diabetes, and liver diseases. Obesity is characterized by an increase in adipose tissue (AT)...
Tue Sep 08, 2020 13:04
Related Articles Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis. J Vis Exp. 2020 Aug 21;(162): Authors: Rhea L, Dunnwald M Abstract The murine excisional wound model has been used extensively to study each of the sequentially overlapping phases of wound healing: inflammation, proliferation and remodeling. Murine wounds have a histologically well-defined and easily recognizable wound bed over which these...
Tue Sep 08, 2020 13:04
Related Articles High-throughput and Deep-proteome Profiling by 16-plex Tandem Mass Tag Labeling Coupled with Two-dimensional Chromatography and Mass Spectrometry. J Vis Exp. 2020 Aug 18;(162): Authors: Wang Z, Kavdia K, Dey KK, Pagala VR, Kodali K, Liu D, Lee DG, Sun H, Chepyala SR, Cho JH, Niu M, High AA, Peng J Abstract Isobaric tandem mass tag (TMT) labeling is widely used in proteomics because of its high multiplexing capacity and...
Tue Sep 08, 2020 13:04
Related Articles Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling. J Vis Exp. 2020 Aug 22;(162): Authors: Bakovic M, Thakkar D, DeBenedittis P, Chong DC, Thomas MC, Iversen ES, Karra R Abstract By replacing lost or dysfunctional myocardium, tissue regeneration is a promising approach to treat heart failure. However, the challenge of detecting bona fide heart regeneration limits the validation of potential regenerative...
Tue Sep 08, 2020 13:04
Related Articles In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity. J Vis Exp. 2020 Aug 18;(162): Authors: Fischl MJ, Weisz CJC Abstract In vitro slice electrophysiology techniques measure single-cell activity with precise electrical and temporal resolution. Brain slices must be relatively thin to properly visualize and access neurons for patch-clamping or imaging, and in vitro examination of brain circuitry...
Tue Sep 08, 2020 13:04
Related Articles Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry. J Vis Exp. 2020 Aug 21;(162): Authors: Liu WJ, Ernst L, Doorschodt B, Bednarsch J, Becker F, Nakatake R, Masano Y, Neumann UP, Lang SA, Boor P, Lurje I, Lurje G, Tolba R, Czigany Z Abstract In the present era of organ transplantation with critical organ shortage, various strategies are employed to expand...
Tue Sep 08, 2020 13:04
Related Articles How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children. J Vis Exp. 2020 Aug 19;(162): Authors: Bruns N, Moosmann J, Münch F, Dohna-Schwake C, Woelfle J, Cesnjevar R, Dittrich S, Felderhoff-Müser U, Müller H Abstract Near infrared spectroscopy (NIRS) calculates regional tissue oxygenation (rSO2) using the different absorption spectra of oxygenated and deoxygenated hemoglobin molecules....
Tue Sep 08, 2020 13:04
Related Articles Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis. J Vis Exp. 2020 Aug 20;(162): Authors: Buenrostro-Jáuregui M, Rodríguez-Serrano LM, Chávez-Hernández ME, Tapia-de-Jesús A, Mata-Luevanos J, Mata F, Galicia-Castillo O, Tirado-Martínez D, Ortega-Martinez S, Bojorges-Valdez E Abstract Brainwaves amplitude obtained from electroencephalography (EEG)...
Tue Sep 08, 2020 13:04
Related Articles An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices. J Vis Exp. 2020 Aug 21;(162): Authors: Wacker M, Betke U, Borucki K, Hülsmann J, Awad G, Varghese S, Scherner M, Hansen M, Wippermann J, Veluswamy P Abstract In this study, the hemocompatibility of tubes with an inner diameter of 5 mm made of polyvinyl chloride (PVC) and coated with different...
Tue Sep 08, 2020 13:04
Related Articles Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination. J Vis Exp. 2020 Aug 18;(162): Authors: Peiris E, Hanauer S, Knapas K, Camargo PHC Abstract Localized surface plasmon resonance (LSPR) in plasmonic nanoparticles (NPs) can accelerate and control the selectivity of a variety of molecular transformations. This opens possibilities for the use of visible or near-IR...
Tue Sep 08, 2020 13:04
Related Articles Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study. J Vis Exp. 2020 Aug 18;(162): Authors: Delvecchio G, Oldani L, Mandolini GM, Pigoni A, Ciappolino V, Schiena G, Lazzaretti M, Caletti E, Barbieri V, Cinnante C, Triulzi F, Brambilla P Abstract Cannabis is the illicit drug most commonly used worldwide, and its consumption can both induce psychiatric symptoms in otherwise healthy subjects and...
Tue Sep 08, 2020 13:04
Related Articles Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation. J Vis Exp. 2020 Aug 19;(162): Authors: Eymael J, Miesen L, Mooren F, Jansen J, Wetzels J, van der Vlag J, Smeets B Abstract Parietal epithelial cell (PEC) activation is one of the key factors involved in the development and progression of glomerulosclerosis. Inhibition of pathways involved in parietal epithelial...
Tue Sep 08, 2020 13:04
The Ago2-miRNA-co-IP Assay to Study TGF- β1 Mediated Recruitment of miRNA to the RISC in CFBE Cells.
Related Articles The Ago2-miRNA-co-IP Assay to Study TGF- β1 Mediated Recruitment of miRNA to the RISC in CFBE Cells. J Vis Exp. 2020 Jul 31;(161): Authors: Mitash N, Donovan JE, Swiatecka-Urban A Abstract Micro(mi)RNAs are short, non-coding RNAs that mediate the RNA interference (RNAi) by post-transcriptional mechanisms. Specific miRNAs are recruited to the cytoplasmic RNA induced silencing complex (RISC). Argonaute2 (Ago2), an essential...
Tue Sep 08, 2020 13:04
Related Articles Fear Incubation Using an Extended Fear-Conditioning Protocol for Rats. J Vis Exp. 2020 Aug 22;(162): Authors: Acevedo-Triana C, Rico JL, Ortega LA, Cardenas MAN, Cardenas FP, Rojas MJ, Forigua-Vargas JC, Cifuentes J, Hurtado-Parrado C Abstract Emotional memory has been primarily studied with fear-conditioning paradigms. Fear conditioning is a form of learning through which individuals learn the relationships between aversive...
Tue Sep 08, 2020 13:04
Related Articles Immunohistochemical Analysis of Protective Effects of Maternal Fingolimod on the Placenta and Fetal Lung and Brain in Chorioamnionitis-Induced Preterm Birth Rat Model. Immunopharmacol Immunotoxicol. 2020 Sep 06;:1-21 Authors: Yavuz A, Sezik M, Eris Yalcin S, Asci H, Ozmen O Abstract Objectives: Fingolimod (FIN) is used for multiple sclerosis treatment and has potential antiapoptotic and anti-inflammatory effects. We aimed at...
Tue Sep 08, 2020 13:04
Abstract Despite advances in hearing technology, a growing body of research, as well as early intervention protocols, deaf children largely fail to meet age-based language milestones. This gap in language acquisition points to the inconsistencies that exist between research and practice. Current research suggests that bimodal bilingual early interventions at deaf identification provide children language foundations that can lead to more effective outcomes. Recommendations that...
Tue Sep 08, 2020 03:00
Abstract Background Quantitative assessment of swallowing function is necessary to prevent swallowing impairment due to aging. Though surface electromyography (EMG) has been widely used to measure swallowing activity, the relationship between EMG results and swallowing function is unclear. Objective This study examined the relationship between the temporal characteristics of muscle activity and laryngeal elevation (LE) during swallowing. Methods This study analyzed 60 healthy volunteers...
Mon Sep 07, 2020 21:54
ABSTRACT BackgroundThis systematic review sought to compare the urogenital functions after laparoscopic (LAP) and robotic (ROB) surgery for rectal cancer.MethodsThis study conformed to the PRISMA guidelines.Results26 studies (n=2,709 for ROB, n=2,720 for LAP) were included. There was a lower risk of 30‐day urinary retention in the ROB group (RR 0.78, 95%CI 0.61 to 0.99), but the long‐term risk was comparable (P=0.460). Meta‐regression showed a small, positive relationship between age and risk of...
Mon Sep 07, 2020 11:23
Background: Brain metastasis (BM) is the most common brain malignancy and a common cause of death in cancer patients. However, the relative outcome-related advantages and disadvantages of surgical resection (SR) and stereotactic radiosurgery (SRS) in the initial treatment of BM are controversial. Method: We systematically reviewed the English language literature up to March 2020 to compare the efficacy of SR and SRS in the initial treatment of BM. We identified cohort studies from the Cochrane Library,...
Tue Sep 08, 2020 12:14
Employees of the Loango Gorilla Project, Gabon. Abstract To determine the effectiveness of conservation strategies, not only should we monitor biological variables, such as population size and levels of illegal activity, but also we should examine changes in attitudes and behavior of local community members. Here, I use semistructured interviews of employees at two field sites, in Bwindi Impenetrable National Park, Uganda and Loango National Park, Gabon, to understand if their employment influenced...
Mon Sep 07, 2020 16:09
The mucopolysaccharidoses (MPS) are genetic, lysosomal storage disorders characterized by abnormal accumulation of glycosaminoglycans. Skeletal abnormalities are prevalent in several MPS subtypes. This study provides insights into how lysosomal storage differentially effects major skeletal cell types in MPS I and VII vertebrae at the onset of postnatal growth, and suggests a potential relationship between storage, ER stress, autophagy and cell death in the pathogenesis of MPS skeletal defects....
Mon Sep 07, 2020 18:45
Correspondence: What do we lose when we can't go into the anatomy lab?
Mon Sep 07, 2020 13:55
Front cover: Cover image: Microstructure of the patagium of Anomalurus beecrofti on a cross‐section. See A. Panyutina et al., ‘Morphological peculiarities in the integument of enigmatic anomalurid gliders (Anomaluridae, Rodentia)’, this issue.
Mon Sep 07, 2020 13:55
Epstein–Barr virus (EBV)‐associated enteritis is extremely rare and has not been well characterized. Herein, we present the first autopsy case of EBV‐associated enteritis with multiple ulcers in a 73‐year‐old Japanese male. The patient had abdominal pain and was clinically diagnosed with enteritis. An endoscopic examination revealed multiple ulcers at the terminal ileum. His condition worsened due to serosanguinous bowel discharge and the patient was then admitted to the hospital. Ileocecal and subtotal...
Mon Sep 07, 2020 21:23
Abstract Introduction The purpose of this study is to provide useful data by conducting a comprehensive study of the mylohyoid muscle and its related structures. Materials and Methods Fifty‐eight mandibles and 30 mylohyoid muscles from Korean adult cadavers were used. The shape and location of the mylohyoid line were analyzed by using digital calipers. The mylohyoid muscle and its herniation were observed using ultrasonography. After dissection, morphometric measurements of the muscle and...
Mon Sep 07, 2020 13:47
Abstract Objective To better understand the unexpected spread of contrast medium observed by conventional fluoroscopic X‐ray images during standard neuraxial techniques used in the treatment of pain. The support of 3D reconstruction of MRI images of structures within the lumbar spine was used to better understand the space of Okada. Methods Lumbar facet joint and epidural corticosteroid injections in five patients under fluoroscopic guidance with loss of resistance to air or saline to identify...
Mon Sep 07, 2020 13:47
ABSTRACT The teaching of anatomy is challenging due to the constraints of material and personnel resources. Research has established that the learning preferences of students are malleable and determined by the requirements of the course. Further, drawing has been reported to aid learning in anatomy by facilitating problem solving and reducing the cognitive overload in students. Considering these issues, the aims of the study were to investigate (i) if positive changes occur in the learning styles...
Mon Sep 07, 2020 11:13
Abstract We propose a theoretical model of insomnia symptoms and non‐suicidal self‐injury (NSSI) that posits bidirectional linkages. We hypothesised that heightened depressive symptoms and impulsivity that result from insomnia increase NSSI. We also posit that the shame associated with NSSI triggers repetitive negative thinking, in turn increasing insomnia. Using three longitudinal waves of questionnaire data collected annually from a sample of Swedish adolescents (n = 1,457; M age = 13.2, SD = 0.43;...
Mon Sep 07, 2020 22:24
Considerations for healthcare professionals in effectively managing patients during the COVID-19 pandemic.
Tue Sep 08, 2020 07:00
Abstract Background Endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) is a minimally invasive technique for cytological and histological diagnosis. The objective of this study was to explore the role of cytological diagnosis in EBUS‐TBNAs. Methods Eight hundred and thirteen consecutive cases performed EBUS‐TBNA with both cytological and histological diagnoses were retrospectively reviewed. All patients were followed up for clinical data. Results Before immunohistochemical...
Mon Sep 07, 2020 17:37
ABSTRACT Epigenetic gene silencing by aberrant DNA methylation is one of the important mechanisms leading to loss of key cellular pathways in tumorigenesis. Methyl‐CpG targeted transcriptional activation (MeTA) reactivates hypermethylation‐mediated silenced genes in a different way from DNA demethylating agents. Microarray coupled with MeTA (MeTA‐array) identified seven commonly hypermethylation‐mediated silenced genes in 12 pancreatic ductal adenocarcinoma (PDAC) cell lines. Among these, we focused...
Mon Sep 07, 2020 22:09
Circulating circERBB2 as a potential prognostic biomarker for gastric cancer: An investigative study
Abstract Circular RNA is a novel endogenous non‐coding RNA that can serve as a biomarker because of its stable loop structure. We investigated and examined the utility of plasma circERBB2 as a prognostic biomarker in 70 gastric cancer patients who underwent gastrectomy. We investigated the circERBB2 concentrations in the preoperative and postoperative plasma and the circERBB2 expression in the resected tumors by real‐time quantitative PCR. The relationships between circERBB2 concentration in plasma...
Mon Sep 07, 2020 20:32
Abstract Phenotypic variation plays an important role in how species cope with environmental challenges. Pinpointing which genes and genomic regions are underlying phenotypic variability thus helps to understand the processes of acclimation and adaptation. We used Daphnia as a system to identify candidates playing a role in phenotypic variation related to a predation risk environment with a genome‐wide association approach. Furthermore, a gene co‐expression network analysis allowed identifying clusters...
Mon Sep 07, 2020 22:00
Abstract Maternally transmitted bacterial symbionts can be important mediators of the interactions between insect herbivores and their foodplants. These symbionts are often facultative (present in some host individuals but not others) and can have large effects on their host’s phenotype, thus giving rise to heritable variation upon which selection can act. In the cowpea aphid (Aphis craccivora) it has been established that the facultative endosymbiont Arsenophonus improves aphid performance on black...
Mon Sep 07, 2020 19:24
Abstract Background Vitamin A regulates the adaptive immune response and a modulatory impact on type I allergy is discussed. The cellular mechanisms are largely unknown. Objective To determine the vitamin A‐responding specific lymphocyte reaction in vivo. Methods Antigen‐specific B and T lymphocytes were analyzed in an adoptive transfer airway inflammation mouse model in response to 9‐cis retinoic acid (9cRA) and after lymphocyte‐specific genetic targeting of the receptor RARα. Flow...
Mon Sep 07, 2020 17:19
ABSTRACT Background EAACI guidelines emphasise the importance of patient history in diagnosing food allergy (FA), and the need for studies investigating its value, using standardised allergy‐focused questionnaires. Objective To determine the contribution of reaction characteristics, allergic comorbidities, and demographics, in predicting FA in individuals experiencing food‐related adverse reactions. Methods Adult and school‐age participants in the standardised EuroPrevall population...
Mon Sep 07, 2020 16:30
Abstract Modern healthcare requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens...
Mon Sep 07, 2020 14:26
Background Although racial disparities in prostate cancer survival are well documented, the relative importance of contributing factors remains unclear. Few studies have examined the disparity between Whites and Hispanics or between Whites and Asian Americans and Pacific Islanders (AAPIs). Methods Using data from the National Cancer Database for 526,690 patients with prostate cancer who underwent radical prostatectomy between 2004 and 2014, this study systematically evaluated the impact of...
Tue Sep 08, 2020 11:21
Related Articles Spontaneous Regression of Recurrent Respiratory Papillomatosis with HPV Vaccination: A Case Study. J Voice. 2020 Sep 02;: Authors: Nyirjesy S, Osmundson P, Matrka L Abstract OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is characterized by recurrent laryngeal papillomas and treated with repeated surgical excision. The human papillomavirus (HPV) vaccine prevents infection with strains of HPV unrelated to RRP, and has...
Tue Sep 08, 2020 11:11
Abstract Mutations in adaptor protein complex‐4 (AP‐4) genes have first been identified in 2009, causing a phenotype termed as AP‐4 deficiency syndrome. Since then several patients with overlapping phenotypes, comprised of intellectual disability (ID) and spastic tetraplegia have been reported. To delineate the genotype‐phenotype correlation of the AP‐4 deficiency syndrome, we add the data from 30 affected individuals from 12 out of 640 Iranian families with ID in whom we detected disease‐causing...
Mon Sep 07, 2020 21:48
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