Breslow thickness and Clark level are still important factors for cutaneous melanoma, but do not provide a precise prognosis in all cases. It is necessary to find new factors capable of a more accurate prediction of the tumor course. Angiogenesis is essential for tumor development and progression and is regulated by vascular endothelial growth factor A (VEGF-A) and semaphorins (SEMA), in particular, SEMA3A inhibits angiogenesis by affecting VEGF signaling. However, the prognostic role of angiogenetic...
Tue Sep 08, 2020 22:34
Immune checkpoint blockade therapy can induce immune-related toxicity, but cutaneous lymphoma development has not been reported. A 56-year-old woman presented with two well-demarcated erythematous macules on the right sole and vitiligo on her extremities. Her facial melanoma had been treated with combination therapy (ipilimumab and pembrolizumab), followed by pembrolizumab monotherapy, a year prior. Microscopy revealed small-to-medium-sized lymphocytes permeating along with the basal epidermal layer....
Tue Sep 08, 2020 22:34
Introduction of targeted therapy in the treatment of metastatic cutaneous malignant melanoma (CMM) has improved clinical outcome during the last years. However, only in a subset of the CMM patients, this will lead to long-term effects. CEBPB is a transcription factor that has been implicated in various physiological and pathological processes, including cancer development. We have investigated its prognostic impact on CMM and unexpectedly found that higher CEBPB mRNA levels correlated with a longer...
Tue Sep 08, 2020 22:34
Little is known on whether melanocortin 1 receptor (MC1R) associated cutaneous melanoma (CM) risk varies depending on histological subtype and body site, and whether tumour thickness at diagnosis (the most important prognostic factor for CM patients) differs between MC1R variant carriers and wild-type individuals. We studied the association between MC1R variants and CM risk by histological subtype, body site, and Breslow thickness, using the database of the M-SKIP project. We pooled individual data...
Tue Sep 08, 2020 22:34
Malignant melanoma has a propensity for the development of hepatic and pulmonary metastases. MicroRNAs (miRs) are small, noncoding RNA molecules containing about 22 nucleotides that mediate protein expression and can contribute to cancer progression. We aim to identify clinically useful differences in miR expression in metastatic melanoma tissue. RNA was extracted from formalin-fixed, paraffin-embedded samples of hepatic and pulmonary metastatic melanoma, benign, nevi, and primary cutaneous melanoma....
Tue Sep 08, 2020 22:34
We report a case of anti-protein death 1-induced sarcoid-like reaction in a 63-year-old Caucasian male who was diagnosed with stage IV-M1a melanoma. He was initially treated with pembrolizumab monotherapy (Q3W) and had a complete response after 14 cycles. However, relapse was suspected 3 months later with appearance of hilar, mediastinal and hepatic hilar lymph nodes as well as a skin lesion. Biopsy of both the hilar lymph nodes and the skin lesion demonstrated sarcomatoid granulomatosis. Pembrolizumab...
Tue Sep 08, 2020 22:34
Despite considerable progress made in the treatment of patients with advanced melanoma, the majority of the patients treated with BRAF and mitogen-activated protein inhibitors (BRAFi and MEKi) experience a disease progression due to acquired resistance. Currently, ongoing studies explore the possibility to overcome or reverse this process. Our multicenter retrospective analysis included 51 patients with metastatic BRAF-mutated melanoma who had previously progressed on BRAFi/MEKi than had progressed...
Tue Sep 08, 2020 22:34
Desmoplastic melanoma (DM) is a rare and histopathologically as well as prognostically distinct subset of melanoma that arises in chronically sun-damaged skin. DM is typically and relatively indolent in nature with most cases not progressing to metastatic disease. DM has been managed with both radiation and surgical approaches. Medical options for the treatment of metastatic DM have traditionally been limited. Recent advances in immunotherapies have shown promising responses in DM ushering in a new...
Tue Sep 08, 2020 22:34
While immunotherapies and targeted therapies such as BRAF inhibitors have improved the prognosis, BM is still associated with poor outcome and a short survival. Metastatic melanoma patients are a heterogeneous subgroup with variable prognosis. As several prospective clinical trials have addressed the question of optimal therapy for these patients, an accurate validated selection tool is needed. Melanoma molecular graded prognostic assessment (Melanoma-molGPA) is a new prognostic score for BM melanoma...
Tue Sep 08, 2020 22:34
Variants in the Melanocortin 1 Receptor (MC1R) gene have been associated with an increased risk of melanoma, but the role in nevus count is unclear. We investigated if specific MC1R gene variants or the number of MC1R gene variants and phenotypical features were associated with nevus count. A total of 494 participants of the ‘Leiden skin cancer study’ were included and the MC1R gene coding sequence was analysed by single-strand conformation polymorphism analysis followed by sequencing of unknown...
Tue Sep 08, 2020 22:34
This study aimed to assess whether dabrafenib/trametinib and vemurafenib/cobimetinib treatments are associated with a change in skeletal muscle area (SMA) and total fat-free mass (FFM) assessed by computed tomography (CT), and to compare the efficacy and safety profile of these treatments in patients with metastatic melanoma. Thirty-one patients treated with B-Raf proto-oncogene, serine/threonine kinase/MAPK extracellular receptor kinase inhibitors were included between 2016 and 2019. Eighteen patients...
Tue Sep 08, 2020 22:34
Hemophagocytic lymphohistiocytosis (HLH) has been only rarely reported in patients with BRAF-mutated advanced melanoma treated with targeted therapies and never with first-line dabrafenib/trametinib combination thus far. Two patients treated with first-line dabrafenib and trametinib combination therapy for metastatic melanoma presented with sudden occurrence of fever, cytopenia, rhabdomyolysis, hepatic cytolysis, hypertriglyceridemia and very high ferritin levels after few weeks of treatment, associated...
Tue Sep 08, 2020 22:34
Immune checkpoint inhibitors (ICI) have altered the prognosis of patients with melanoma over the past few years, with immune-related adverse effects (irAEs) being the only factor limiting their use. Neurologic and cardiac irAEs are rare, but usually severe. We reviewed the files of patients with melanoma treated with ICIs in one center to retrieve data from patients with neurologic irAEs. Patients with a combination of neurologic and cardiac manifestations were further analyzed. We also reviewed...
Tue Sep 08, 2020 22:34
No abstract available
Tue Sep 08, 2020 22:34
Melanoma disseminates to the skeletal system where it is then difficult to treat. Yet, there remains limited research investigating metastatic bone disease (MBD) in melanoma. Here, we evaluate whether there are distinct clinicopathologic variables at the time of primary melanoma diagnosis that predispose metastases to engraft bone, and we test the hypothesis that patients with MBD have different responses to treatment. Cutaneous melanoma patients enrolled in a prospective database were studied. Individuals...
Tue Sep 08, 2020 22:34
Abstract Background Diffusion-weighted imaging (DWI) has been shown to be helpful in providing information about cellular density and also predicting the histological features of aggressive tumors. Several studies have evaluated this technique for orbital tumors. However, very few articles have focused exclusively on evaluating pediatric orbital masses and, within those, only a small number of patients were included in the study. ...
Tue Sep 08, 2020 03:00
Related Articles Flow-Mediated Vasodilation and Reactive Hyperemia Index in Heart Failure with Reduced or Preserved Ejection Fraction. Tohoku J Exp Med. 2020 09;252(1):85-93 Authors: Waku R, Tokoi S, Toyoda S, Kitahara K, Naganuma J, Yazawa H, Sakuma M, Abe S, Nakajima T, Inoue T Abstract Vascular endothelial dysfunction is part of the underlying pathophysiology of heart failure. However, there are no reports in which vascular endothelial function...
Tue Sep 08, 2020 22:16
Related Articles Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. Allergy. 2020 Sep 07;: Authors: Breiteneder H, Peng YQ, Agache I, Diamant Z, Eiwegger T, Fokkens WJ, Traidl-Hoffmann C, Nadeau K, O'Hehir RE, O'Mahony L, Pfaar O, Torres MJ, Wang DY, Zhang L, Akdis CA Abstract Modern healthcare requires a proactive and individualized response to diseases, combining precision diagnosis and personalized...
Tue Sep 08, 2020 21:47
Related Articles Investigation on chronic tinnitus efficacy of combination of non-repetitive preferred music and educational counseling: a preliminary study. Eur Arch Otorhinolaryngol. 2020 Sep 05;: Authors: Chen J, Zhong P, Meng Z, Pan F, Qi L, He T, Lu J, He P, Zheng Y Abstract PURPOSE: To improve the efficacy of music therapy on tinnitus relief, specific music that was not repetitively played and satisfies individualized preference was developed....
Tue Sep 08, 2020 21:47
Related Articles Endoscopic anatomy of the sellar barrier: From the anatomical model to the operating room. Clin Anat. 2020 Apr;33(3):468-474 Authors: Villalonga JF, Fuchssteiner C, Solari D, Campero A, Cavallo LM, Cappabianca P, Hirtler L Abstract BACKGROUND: The sellar barrier concept reflects the association between the components of the roof of the pituitary fossa and the risk of intraoperative cerebrospinal fluid (CSF) leak in the surgery...
Tue Sep 08, 2020 21:47
Abstract Background The alteration of individual sets during resistance training (RT) is often used to allow for greater velocity and power outputs, reduce metabolite accumulation such as lactate and also reduce perceived exertion which can ultimately affect the resultant training adaptations. However, there are inconsistencies in the current body of evidence regarding the magnitude of the effects of alternative set structures (i.e.,...
Tue Sep 08, 2020 03:00
A new study reports the oldest mitochondrial genome of a Neanderthal from Central-Eastern Europe. The mitochondrial genome of the tooth, discovered at the site of Stajnia Cave in Poland, is closer to a Neanderthal specimen from the Caucasus than to the contemporaneous Neanderthals of Western Europe. Stone tools found at the site are also analogous to the southern regions suggesting that Neanderthals living in the steppe/taiga environment had a broader foraging radius than previously envisaged.
Tue Sep 08, 2020 18:33
Publication date: September 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 9Author(s):
Tue Sep 08, 2020 20:48
Publication date: September 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 9Author(s):
Tue Sep 08, 2020 20:48
Publication date: September 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 9Author(s):
Tue Sep 08, 2020 20:48
Contrast-induced sialadenitis (CIS) is a rare, delayed pseudoallergic reaction from iodine containing contrast. Previously reported cases of CIS demonstrated that the two major salivary glands (parotid and submandibular) can be affected. The initial encounter of this entity can raise alarms to physicians as the differential diagnoses include serious infectious and inflammatory conditions such as Ludwig’s angina and angioedema. Subsequently, it may lead to unnecessary testing and increased healthcare...
Tue Sep 08, 2020 15:50
Collision tumors are two independent, distinct tumors occupying the same anatomical space. This case presents a pituitary adenoma-craniopharyngioma collision tumor presenting with hemianopsia. A 60-year-old with a past history of a nonsecretory pituitary adenoma presented with progressive headaches, bitemporal hemianopsia, and nausea. Previously, in 2008, his adenoma was effectively treated with nasal septal flap and transsphenoidal pituitary resection. A magnetic resonance imaging (MRI) was ordered...
Tue Sep 08, 2020 10:05
Abstract Purpose To present the extent and site of lesion of auditory dysfunction in a large cohort of individuals with type 2 Stickler Syndrome. Type 2 Stickler Syndrome results from a mutation in the gene coding for α-1 type XI pro-collagen, which has been identified in the human vitreous, cartilage and the cochlea of the mouse. The condition is characterised by classic ocular abnormalities, auditory dysfunction, osteoarthropathy and...
Tue Sep 08, 2020 03:00
Related Articles [Finite element analysis of evaluating the change of the hip joint biomechanics following femoral neck shortening after cannulated screw fixation for osteoporotic femoral neck fracture]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2628-2632 Authors: Yu X, Zhang DF, Song MS, Chen ZM, Yang K, Pang QJ Abstract Objective: To evaluate the stress status of femoral head and neck, screws and acetabulum caused by femoral neck shortening...
Tue Sep 08, 2020 20:11
Related Articles [Prevalence and predictors of intraplaque hemorrhage in stroke patients with intracranial atherosclerosis]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2622-2627 Authors: Song XW, Wei CM, Xu WD, Wang LX, Zhao HL, Xu YL, Zhao XH, Zheng ZZ, Wu J Abstract Objective: To investigate the prevalence and predictors of intraplaque hemorrhage (IPH) in ischemic stroke patients with intracranial atherosclerosis. Methods: Ischemic stroke...
Tue Sep 08, 2020 20:11
Related Articles [Assessment of computed tomographic angiographysinus development combined with occipitalbone marks for the location of transverse sigmoid sinus junction]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2618-2621 Authors: Wu H, Li YL, Maimaitili M, Chen LX, Mamutijiang M, Bate G, Shen YS, Lyu MY, Zhu GH Abstract Objective: To introduce and evaluate a technique to precisely localize the transverse-sigmoid sinus junction (TSSJ) in...
Tue Sep 08, 2020 20:11
Related Articles [Analysis of factors related to recanalization of intramural hematoma-type carotid artery dissection]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2612-2617 Authors: Huang Y, Hui PJ, Ding YF, Yan YY, Liu M, Kong LJ, Hu CH, Fang Q Abstract Objective: To investigate the factors related to recanalization of intramural hematoma-type carotid artery dissection (CAD). Methods: Retrospective analysis was performed on 56 patients (61...
Tue Sep 08, 2020 20:11
Related Articles [Correlation between spatial navigation disorder and white matter hyperintensity in patients with mild cognitive impairment]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2607-2611 Authors: Li WP, Sun Y, Yan X, Chen Q, Liu JN, Wu WB, Zhang X, Qing Z, Yin ZY, Zhao H, Xu Y, Zhang B Abstract Objective: To investigate the relationship between white matter lesions and spatial navigation ability in patients with mild cognitive impairment...
Tue Sep 08, 2020 20:11
Related Articles [Blood loss in total knee arthroplasty using computer-assisted navigation or 3D-printed patient-specific instruments]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2601-2606 Authors: Li Y, Geng X, Tian H, Tao LY Abstract Objective: To compare the perioperative blood loss in patients undergoing a total knee arthroplasty (TKA) across three different techniques: computer-assisted navigation surgery (CAS), patient specific instrumentation...
Tue Sep 08, 2020 20:11
Related Articles [Application of thoracoscopy-guided thoracic paravertebral block for analgesia after single-port video-assisted pulmonary lobectomy]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2596-2600 Authors: Hu LH, Xu X, Shen WY, Qi Y, Tian H, He JX Abstract Objective: To investigate the effects of thoracoscopy-guided thoracic paravertebral block for analgesia after single-port video-assisted pulmonary lobectomy. Methods: From December...
Tue Sep 08, 2020 20:11
Related Articles [Efficacy of stellate ganglion block in perioperative period of patients with chronic sinusitis and hypertension]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2591-2595 Authors: Hu XQ, Zheng XY, Ma WX, Jiang X Abstract Objective: To observe the perioperative efficacy of stellate ganglion block (SGB) in functional endoscopic sinus surgery (FESS) in chronic sinusitis patients with hypertension. Methods: A total of 60 patients...
Tue Sep 08, 2020 20:11
Related Articles [Observation on the efficacy of CT-guided lumbar sympathetic chemical destructive block in the treatment of cold sensation of limbs]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2586-2590 Authors: Tao JC, Huang B, Wang TT, Xie KY, He QL, Ni HD, Zhu JJ, Lu YP, Zhang L, Yao M Abstract Objective: To observe the clinical effects of CT-guided chemical destructive block of lumbar sympathetic nerve in the treatment of cold sensation...
Tue Sep 08, 2020 20:11
Related Articles [Attention should be paid to the neuromodulation therapy of autonomic nervous dysfunction]. Zhonghua Yi Xue Za Zhi. 2020 Sep 08;100(33):2561-2564 Authors: Ni HD, Huang B, Yao M, Zhu JJ, Tao JC PMID: 32892602 [PubMed - in process]
Tue Sep 08, 2020 20:11
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