The American Cancer Society has estimated that in 2019 approximately 22,500 women would be diagnosed with epithelial ovarian, primary peritoneal, or fallopian-tube ("ovarian") cancer, and 14,000 would die. Despite the absence of randomized data showing a survival benefit conferred by primary…
Thu Nov 14, 2019 02:00
Acute upper airway obstruction is a life-threatening emergency and requires immediate assessment and intervention with little margin for error, making it a constant challenge for clinicians. Substantial advances have been made in preventive medicine, our understanding of the pathophysiology of…
Thu Nov 14, 2019 02:00
"You must sing for me," she said. "I’m dying, after all." Ms. N. was sitting on her vast white sofa, frail among the cushions, enveloped in a pink dressing gown that paled next to the fuchsia of her lipstick. She was partially silhouetted by the late November sun from the wall of windows behind…
Thu Nov 14, 2019 02:00
To the Editor: Recurrent aphthous stomatitis is a chronic, painful ulcerative disease of the oral mucosa that may be resistant to treatment. Its clinical heterogeneity has complicated classification of the disorder, but variants in cytokine genes, including tumor necrosis factor α (TNF-α), have…
Thu Nov 14, 2019 02:00
Presentation of Case. Dr. Joshua Salvi (Medicine): A 66-year-old man with a history of pancytopenia was transferred to this hospital in the winter for evaluation of pancytopenia and rash. The patient had been well until 1 year before admission, when episodic fevers began to occur. Approximately 3…
Thu Nov 14, 2019 02:00
Behçet’s syndrome is a multisystem vasculitis that causes oral and genital ulcers, papulopustular and nodular lesions, arthritis, uveitis, arterial aneurysms, and arterial and venous thrombosis and may involve the central nervous system and gastrointestinal tract. Recurrent relapsing and remitting…
Thu Nov 14, 2019 02:00
Wearable devices with optical sensors, such as smartwatches, are commonly used to measure wearers’ pulse rates. Algorithms that use pulse wave data to detect atrial fibrillation and atrial flutter have been developed. An Apple Watch application (app) can use intermittent, passively detected pulse…
Thu Nov 14, 2019 02:00
The eradication of smallpox through vaccination has not eliminated the risk of reintroduction of the infection by accidental or intentional release of the variola virus. Moreover, recent studies have shown the potential for de novo synthesis. Smallpox vaccination was highly successful, but it had…
Thu Nov 14, 2019 02:00
In September 2008, the National Library of Medicine (NLM) of the National Institutes of Health (NIH) expanded the database at ClinicalTrials.gov to include the results of registered clinical trials in response to the Food and Drug Administration Amendments Act (FDAAA). This database consists of…
Thu Nov 14, 2019 02:00
A striking trend in medical education and practice over the past half century has been the decline in the rate of autopsies conducted throughout much of the world. Older physicians recall regular visits to the autopsy room to have a pathologist reveal the diseased anatomy of their former patients.…
Thu Nov 14, 2019 02:00
Arguably the best biomarker in the world for vaccine efficacy is the "take." The take, the reaction observed after an inoculation of smallpox vaccine, is typically a small pustular lesion that occurs approximately 1 week after inoculation and often leaves a poxlike scar at the vaccination site.…
Thu Nov 14, 2019 02:00
New England Journal of Medicine, Volume 381, Issue 20, Page 1894-1895, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1979-1981, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1918-1928, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1951-1960, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1975-1977, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1964-1965, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1909-1917, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1962-1963, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1940-1949, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1977-1978, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1929-1939, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1978-1979, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1889-1891, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1950-1950, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1966-1974, November 2019.
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New England Journal of Medicine, Volume 381, Issue 20, Page 1897-1908, November 2019.
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