Abstract Background Liquid‐based cytology (LBC) has improved exfoliative cytology by facilitating the extraction of more precise information from epithelial cells. The aim of this study was to optimize a protocol using a conventional cytobrush to perform LBC, obtaining oral keratinocytes for their further cellular and molecular analysis. Methods LBC was performed in 30 healthy donors from buccal mucosa. We evaluated the use of diethyl pyrocarbonate (DEPC)‐treated Dulbecco's Modified Eagle...
Wed Sep 02, 2020 22:00
Abstract NTRK1/3 rearrangements have been reported in 2.3–3.4% of papillary thyroid carcinoma (PTC) and are regarded as potential therapeutic targets. Recently, the application of immunohistochemistry (IHC) to detect NTRK rearrangements has been widely discussed. The current study aimed to characterize the clinicopathological features of PTC with NTRK1/3 fusions, to examine the utility of pan-TRK IHC, and to compare IHC with fluorescent in situ hybridization (FISH) and next-generation...
Thu Sep 03, 2020 03:00
Publication date: Available online 3 September 2020Source: Human PathologyAuthor(s): Nobuyoshi Hiraoka, Hiroaki Nitta, Akihiro Ohba, Hiroshi Yoshida, Chigusa Morizane, Takuji Okusaka, Satoshi Nara, Minoru Esaki, Yoji Kishi, Kazuaki Shimada
Thu Sep 03, 2020 19:13
Publication date: Available online 2 September 2020Source: Human PathologyAuthor(s): Juehua Gao, Yanming Zhang, Nabeel R. Yaseen, Yuqiang Fang, Xinyan Lu, Madina Sukhanova, Qing Chen, Yi-Hua Chen
Thu Sep 03, 2020 19:13
Abstract RAS family genes (HRAS, KRAS and NRAS) were frequently observed in several tumors. The expression of constitutively active RAS proteins mediated by RAS variations promote the development of tumors. KRAS is an important prognostic and drug resistance biomarker. It would also be a promising drug target. Several trials which evaluating the efficacy of RAS G12C inhibitor in solid tumors are initiated. Herein, we analyzed the alterations status of KRAS/NRAS/HRAS across diverse...
Thu Sep 03, 2020 19:16
Abstract Malignancies are still responsible for a large share of lethalities. Macroscopical evaluation of the surgical resection margins is uncertain. Big data based imaging approaches have emerged in the recent decade (mass spectrometry, two-photon microscopy, infrared and Raman spectroscopy). Indocianine green labelled MS is the most common approach, however, label free mid-infrared imaging is more promising for future practical application. We aimed to identify and separate...
Thu Sep 03, 2020 19:16
Abstract Squamous cell carcinoma (SCC) of the head and neck region is the sixth most frequent malignancy with high mortality rate. Due to its poor prognosis it is considered a growing public health problem worldwide inspite of existing treatment modalities. Thus, early diagnosis of new diseases and recurrences is emerging on one hand, but on the other hand troublesome in the lack of reliable tumor markers in this field. The rapid development of proteomics has opened new perspectives...
Thu Sep 03, 2020 19:16
Abstract Many pheochromocytoma and extra-adrenal paraganglioma are benign, but some are malignant. Pheochromocytoma of the Adrenal gland Scaled Score analyzed the histological characteristics of the tumor. Tumors with a Pheochromocytoma of the Adrenal gland Scaled Score of 4 or higher have a higher risk of recurrence. This pattern is thought to be applicable to paraganglioma as well, and to future patient follow-up efforts. We report a recurrent and metastatic paraganglioma...
Thu Sep 03, 2020 19:16
Publication date: Available online 3 September 2020Source: Pathology - Research and PracticeAuthor(s): Irene Sansano, Begoña Vieites, Magdalena Sancho de Salas, Carmen García, Isabel Amendoeira, Laia Bernet, José Manuel Pérez-García, Martín Espinosa-Bravo, Isabel T. Rubio, Santiago Ramón y Cajal, Vicente Peg
Thu Sep 03, 2020 18:22
Publication date: Available online 2 September 2020Source: Pathology - Research and PracticeAuthor(s): Montironi Rodolfo, Cimadamore Alessia, Scarpelli Marina, Cheng Liang, Lopez-Beltran Antonio, Mikuz Gregor
Thu Sep 03, 2020 18:22
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