Abstract Inflammation is a complex biological process which alters the normal physiological function of the immune system resulting in an abnormal microenvironment that leads to several clinical complications. The process of inflammation is mediated through various intracellular signaling factors inside the cells. Apoptosis signal–regulating kinase 1 (ASK1) is an inflammation-derived kinase that controls the activation of other family...
03:00
Abstract Sex differences in the immune response can also affect the febrile response, particularly the fever induced by lipopolysaccharide (LPS). However, other pathogen-associated molecular patterns, such as zymosan A (Zym) and polyinosinic-polycytidylic acid (Poly I:C), also induce fever in male rats with a different time course of cytokine release and different mediators such as endothelin-1 (ET-1). This study investigated whether female sex hormones affect Zym- and Poly I:C-induced...
Tue Sep 01, 2020 03:00
Abstract Purpose There is scarce data about the interpretation of high thyroid hormone levels in hospitalized patients. We wished to investigate the significance of high thyroxine (T4) in hospitalized patients with low TSH. Methods We conducted a retrospective study of data from patients in nonsurgical departments. Three groups of random patients with...
03:00
Abstract Purpose The length of time a critically ill coronavirus disease 2019 (COVID-19) patient remains infectious and should therefore be isolated remains unknown. This prospective study was undertaken in critically ill patients to evaluate the reliability of single negative real-time polymerase chain reaction (RT-PCR) in lower tracheal aspirates (LTA) in predicting a second negative test and to analyze clinical factors potentially...
Tue Sep 01, 2020 03:00
Abstract Purpose of Review This paper purports to review recent relevant publications on the efficacy of traditional Chinese medicine in treating allergic diseases, to illustrate the pertinent mechanisms of action of TCM, and to explore the possible role of TCM in the management of allergic diseases in the foreseeable future. As TCM embodies multiple treatment modalities, only the most popular two, namely CHM (Chinese herbal medicine)...
03:00
Abstract Numerous studies have reported the stimulation of plant growth following inoculation with an IAA-producing PGPB. However, the specific mode of IAA production by the PGPB is rarely elucidated. In part, this is due to the overwhelming complexity of IAA biosynthesis and regulation. The promiscuity of the enzymes implicated in IAA biosynthesis adds another element of complexity when attempting to decipher their role in IAA biosynthesis. To date, the...
03:00
Abstract Mannosylerythritol lipids (MEL) are glycolipids mainly produced by pseudo-yeasts. These molecules present remarkable biological activities widely explored in many fields, including medicine, pharmaceuticals, and cosmetics. This review presents the main biological activity of MEL on the HL60, K562, B16, PC12, and skin cells. There is strong evidence that MEL changes the levels of glycosphingolipids of HL-60 lineage, which induce differentiation...
03:00
Abstract The probiotic bacteria are helpful for nutritional and therapeutic purposes, and they are commercially available in various forms, such as capsules or powders. Increasing pieces of evidence indicate that different growth conditions and variability in manufacturing processes can determine the properties of probiotic products. In recent years, the lipidomic approach has become a useful tool to evaluate the impact that probiotics induce in host physiology....
03:00
Abstract Brewers’ spent grain (BSG) is the most abundant by-product of brewing. Due to its microbiological instability and high perishability, fresh BSG is currently disposed of as low-cost cattle feed. However, BSG is an appealing source of nutrients to obtain products with high added value through microbial-based transformation. As such, BSG could become a potential source of income for the brewery itself. While recent studies have covered the relevance of BSG chemical composition...
03:00
Abstract Leishmaniasis is one of the most important tropical neglected diseases according to the World Health Organization. Even after more than a century, we still have few drugs for the disease therapy and their great toxicity and side effects put in check the treatment control program around the world. Moreover, the emergence of strains resistant to conventional drugs, co-infections such as HIV/Leishmania spp., the small therapeutic arsenal (pentavalent antimonials, amphotericin...
03:00
Abstract Gluten is a cereal protein that is incompletely digested by human proteolytic enzymes that create immunogenic peptides that accumulate in the gastrointestinal tract (GIT). Although both environmental and human bacteria have been shown to expedite gluten hydrolysis, gluten intolerance is a growing concern. Here we hypothesize that together with food, we acquire environmental bacteria that could impact our GIT with gluten-degrading bacteria. Using...
03:00
Abstract Rationale Compulsive cocaine use, defined as the continued use despite the dire consequences, is a hallmark of cocaine addiction. Thus, understanding the brain mechanism regulating the compulsive cocaine-seeking and cocaine-taking behaviors is essential to understand cocaine addiction and the key to identification of the molecular targets for the development of medications against this condition. ...
Tue Sep 01, 2020 03:00
Abstract Rationale The nonmedical use of new psychoactive substances (NPS) is a worldwide public health concern. The so-called “benzofury” compounds, 5-(2-aminopropyl)benzofuran (5-APB) and 6-(2-aminopropyl)benzofuran (6-APB), are NPS with stimulant-like properties in human users. These substances are known to interact with monoamine transporters and 5-HT receptors in transfected cells, but less is known about their effects in animal models....
Tue Sep 01, 2020 03:00
Tue Sep 01, 2020 03:00
Abstract Involved with various bodily functions, including ingestion and swallowing, the tongue is an important organ. We measured resting tongue hardness using real-time tissue elastography (RTE) to establish a simple tongue evaluation for patients who may have limited capacities to follow commands. Relationships between tongue hardness, thickness, and pressure were investigated, using both intra- and extraoral probes. Assessments were performed for a total of 27 healthy adults...
Tue Sep 01, 2020 03:00
We studied with great interest a recent published article by Ab Rani et al1 entitled "Nonselective Laryngeal Reinnervation versus Type 1 Thyroplasty in Patients with Unilateral Vocal Fold Paralysis: A Single Tertiary Centre Experience" which has been published in Journal of Voice. The authors investigated some numerical variables at baseline, 6, and 12 months postoperative. They used one-way analysis of variance (ANOVA) to compare the numerical variables between three time-points of measurement.
Tue Sep 01, 2020 03:00
For decades, social scientists have, with notable exceptions, rued modernization’s seemingly inevitable transformation of rural lifeways. Statistics on rural to urban migration, along with visibly emptying communities, lent credence to this concern. Anthropologists long decried the inequity of this situation, citing how capitalist market forces (particularly the undervaluation of agricultural labor and products) pushed rural folk to urban areas which then benefited from their labor without investing...
Tue Sep 01, 2020 22:00
Osteoarthritis (OA) is a condition associated with severe inflammation, cartilage destruction and degeneration of joints. Rhein (Rh) is an effective anti-inflammatory drug with proven efficacy in in-vitro and ...
Mon Aug 31, 2020 03:00
In the era of increased antibiotic resistance and ever-stricter control on antibiotic use, it is urgent to develop green, safe, and non-residue alternatives to antibiotics applied to the poultry industry. To t...
Mon Aug 31, 2020 03:00
Publication date: Available online 31 August 2020Source: Clinical TherapeuticsAuthor(s): Tiffany Luong, Ann-Charlott Salabarria, Dwayne R. Roach
Tue Sep 01, 2020 22:07
The term orchid child is becoming more mainstream and hopefully this can help families better understand what it means.
Tue Sep 01, 2020 20:03
Eduardo López-CollazoEl cáncer, uno de los rompecabezas médicos aparentemente irresolubles, si no el que más, pone de manifiesto el frágil y difícil equilibrio que representa un organismo vivo complejo.En la investigación que se ha desarrollado en las últimas décadas se han hecho avances en el conocimiento de los procesos y mecanismos implicados, y también avances terapéuticos subsecuentes, atendiendo a cada tipo de cáncer con un enfoque más ajustado a sus características intrínsecas.Se puede decir...
Tue Sep 01, 2020 19:53
Abstract Head and neck ultrasound can be used as a non‐invasive image modality for the diagnosis of congenital pyriform sinus fistula (CPSF) in children. The pathognomonic ultrasonic images of CPSFs include a hypoechoic fistulous tract by the perithyroid or trans‐thyroid route, a hyperechoic gas‐line within an inflammatory mass or cystic lesion during the Valsalva maneuver or swallowing action, and thyroiditis with increasing vascular flow in the ipsilateral thyroid lobe. The diagnosis of CPSF...
Mon Aug 31, 2020 20:06
Abstract Introduction Litigation against the National Health Service (NHS) in England is rising, costing £2.4 billion in 2018/19. The aim of this study was to determine the incidence and characteristics of otorhinolaryngology clinical negligence claims in England. Methods A retrospective review was undertaken of all clinical negligence claims in England held by NHS Resolution relating to otorhinolaryngology between April 2013 and April 2018. Analysis was performed using information for...
Mon Aug 31, 2020 19:07
ABSTRACT Objectives This study aimed to compare the prognosis according to age, genotype or HPV variant in patients with recurrent respiratory papillomatosis (RRP). Design Non‐concurrent cohort. Participants 41 patients with RRP. Setting Tertiary referral hospital. Main outcome measures Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV‐6 variants were...
Mon Aug 31, 2020 18:50
Abstract Choosing the best approach for selected pathologies is always source of debates and controversies, whatever the surgical speciality. In endoscopic endonasal surgery (EES), most of surgical series have compared their outcomes with conventional procedures to assess their safety and efficacy.However, there are few objective ways to compare the technical advantages of one approach versus another.Nowadays, it is possible to generate surgical models of skull base anatomy in several identical...
Mon Aug 31, 2020 18:50
Abstract Background Endoscopic sinus surgery (ESS) is an important treatment modality for chronic rhinosinusitis (CRS). However, its effect on olfaction remains controversial. Objective of review To assess the olfactory impact of ESS in patients with CRS Type of review A meta‐analysis Search strategy A systematic literature search in the PubMed, EMBASE, and Cochrane Library databases was conducted to identify studies that assessed change in olfaction after ESS in patients with...
Mon Aug 31, 2020 13:20
Abstract Budd–Chiari syndrome is a vascular pathology of the liver, commonly seen in adults and uncommon in children. Most children with Budd–Chiari syndrome present with ascites, and an etiology is found in only about 50%. Ultrasonography (US) with color Doppler is the main modality used in the diagnosis. US imaging additionally guides radiologic interventions and follow-up after recanalization or shunt procedure. In this pictorial review, we illustrate the findings in pediatric...
Tue Sep 01, 2020 03:00
Abstract Background With the development of an artificial environment to support the extremely premature infant, advanced imaging techniques tested in this extrauterine system might be beneficial to evaluate the fetal brain. Objective We evaluated the feasibility of (a) performing contrast-enhanced ultrasound (CEUS) and (b) quantifying normal and decreased...
Tue Sep 01, 2020 03:00
Abstract Background Very preterm birth can disturb brain maturation and subject these high-risk children to neurocognitive difficulties later. Objective The aim of the study was to evaluate the impact of prematurity on microstructure of frontostriatal tracts in children with no severe neurologic impairment, and to study whether the diffusion tensor...
Tue Sep 01, 2020 03:00
Patients with advanced-stage mycosis fungoides (MF) and Sézary syndrome (SS) have a poor prognosis. Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment option; however, since most patients with MF/SS are elderly, they often have difficulty in finding HLA-matched donors. In recent years, HCT from HLA-haploidentical donors (haplo-HCT) using posttransplant cyclophosphamide (PTCy) as graft-versus-host disease prophylaxis has been conducted for patients without HLA-matched...
Tue Sep 01, 2020 16:38
Lactic acidosis is pathophysiologically classified into type A and type B. The latter is a rare but potentially life-threatening emergency, mainly described in hematological malignancies. The association between Type B lactic acidosis and malignancy is known as the Warburg effect. Patients with the Warburg effect have a very poor prognosis. Herein, we report a case of gastric diffuse large B-cell lymphoma (DLBCL) with severe lactic acidosis and hypoglycemia owing to the Warburg effect that were effectively...
Tue Sep 01, 2020 16:38
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