Orbital metastases are rare. Breast cancer represents the first etiology to be evoked in carcinomas. We report a rare case of a young 43-year-old patient who developed significant orbital metastasis 2 months after the end of adjuvant treatment for triple-negative breast cancer. Good partial response was shown with an improvement of symptoms under chemotherapy (docetaxel combined with carboplatin), zoledronic acid and palliative radiotherapy. The patient quickly progressed in the pulmonary, hepatic...
Tue Sep 01, 2020 16:37
Mucoepidermoid carcinoma (MEC) of the lung is an extremely rare tumor, and a standard chemotherapy has not been established. Furthermore, little work has been conducted on the genetic characteristics of MEC. We herein report the case of a 42-year-old nonsmoking male patient who was referred to our hospital due to cough. Chest computed tomography demonstrated infiltration and atelectasis in the right lower lobe. He was eventually diagnosed with non-small cell lung cancer (NSCLC) with MEC differentiation...
Tue Sep 01, 2020 16:36
Patients with neurofibromatosis type 1 (NF1) have an increased lifetime risk for the development of nervous system tumors, including high-grade gliomas (glioblastoma). NF1 is associated with the loss of expression of neurofibromin 1 (NF1 gene product). This hyperactivates the mitogen-activated protein kinase pathway, leading to cellular proliferation and survival. MEK-inhibitor monotherapy is a promising treatment strategy in this setting, but is associated with distinct adverse events, most prominently...
Tue Sep 01, 2020 16:36
Jumping translocations are uncommon cytogenetic abnormalities in which a segment of a donor chromosome, often 1q, is transferred to two or more receptor chromosomes. We describe the case of a 64-year-old man with a history of acute myeloid leukemia associated with myelodysplastic syndrome, who presented with a relapse of the leukemia and, concomitantly, with the appearance of a jumping translocation involving chromosome 1q. The patient had a poor clinical course without the possibility of performing...
Tue Sep 01, 2020 16:35
Publication date: 15 January 2021Source: Talanta, Volume 222Author(s): Qiuju Zhou, Yajun Fang, Jiayu Li, Dan Hong, Panpan Zhu, Shihong Chen, Kejun Tan
Tue Sep 01, 2020 17:54
Despite lifestyle changes and risk-factor reduction, patients with chronic coronary disease remain at high risk for acute cardiovascular events. The central role of inflammation in the progression of coronary disease is well recognized. The possibility that antiinflammatory therapy may improve…
Mon Aug 31, 2020 03:00
The prevalence of atrial fibrillation increases with age, and both atrial fibrillation and age are independent risk factors for stroke. Clinical guidelines for the prevention of stroke in patients with atrial fibrillation recommend the use of direct oral anticoagulants, including in elderly…
Sun Aug 30, 2020 03:00
Transcatheter aortic-valve implantation (TAVI) is an established treatment in patients with symptomatic severe aortic stenosis. Ischemic and bleeding complications that frequently occur after TAVI can be life-threatening. Practice guidelines recommend clopidogrel in addition to aspirin for the…
Sun Aug 30, 2020 03:00
Even with current guideline-based management, patients with atrial fibrillation have stroke, acute coronary syndrome, heart failure, and cardiovascular death at a rate of approximately 5% of patients per year, and 35 to 50% of patients with atrial fibrillation who receive adequate anticoagulation…
Sat Aug 29, 2020 03:00
In patients with type 2 diabetes, sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure and the risk of serious adverse renal events, benefits that are not seen with other antihyperglycemic drugs. In large-scale, randomized, placebo-controlled…
Sat Aug 29, 2020 03:00
Familial hypercholesterolemia is a genetic condition characterized by an elevated plasma concentration of low-density lipoprotein (LDL) cholesterol starting at birth and an increased risk of premature atherosclerotic cardiovascular disease. With an estimated prevalence of 1 in 250 in the general…
Sat Aug 29, 2020 03:00
Summary Background and objectives The aim of the present study was to establish and evaluate a new interprofessional teaching concept on the topic of wound management. Methods After determining the status quo using a survey among medical students, we developed a new teaching concept that included a 150‐minute course aimed at providing students with the opportunity to gain hands‐on wound management skills. This interprofessional course was offered at the existing ‘SkillsLab’ teaching facility....
Mon Aug 31, 2020 20:13
Publication date: 15 September 2020Source: Hearing Research, Volume 395Author(s):
Tue Sep 01, 2020 17:19
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01518K, PaperChae Eun Heo, Areum Hong, Minji Kim, Jong Wha Lee, Soo Yeon Chae, Ki Woong Sung, Ji Won Lee, Sung Woo Heo, Hugh I. KimHuman tumor cells in a 3-dimensional (3D) spheroid can reflect the characteristics of solid tumors by forming cell-cell interactions and microenvironments. This makes 3D cell culture useful for preclinical stability...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Sep 01, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00886A, Critical ReviewYuqing Li, Juewen LiuAdenine is a key nucleobase, adenosine is an endogenous regulator of the immune system, while adenosine triphosphate (ATP) is the energy source of many biological reactions. Selective detection of these...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Sep 01, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN01245A, PaperEdward D. Burgoyne, Andrés F. Molina-Osorio, Reza Moshrefi, Rachel Shanahan, Gerard P. McGlacken, Talia Jane Stockmann, Micheál D. ScanlonMiniaturization of electrochemical detection of Pseudomonas aeruginosa quorum sensing molecules at a liquid/liquid interface through facilitated proton transfer reactions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal...
Tue Sep 01, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01469A, PaperJingui Qian, Jifeng Ren, Yi Liu, Raymond H. W. Lam, Joshua LeeThis work describes a two-chip acoustofluidic platform for two-dimensional (2D) manipulation of microparticles in a closed microchamber on a reusable surface acoustic wave (SAW) device. This platform comprises two microfabricated...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Sep 01, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01609H, PaperSurasak Kasetsirikul, Muhammad Umer, Narshone Soda, Sreejith Kamalalayam Rajan, Muhammad J A Shiddiky, Nam-Trung NguyenThis paper reports the development of a rapid, simple and inexpensive colorimetric paper-based assay for the detection of Severe Acute Respiratory Symptom Coronavirus 2 (SARS-CoV-2) humanized antibody. The paper device...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Sep 01, 2020 02:00
Abstract EVEN‐PLUS syndrome is a rare condition characterized by its involvement of the Epiphyses, Vertebrae, Ears, and Nose, PLUS other associated findings. We report here the fifth case of EVEN‐PLUS syndrome with novel variants c.818 T > G (p.L273X) and c.955C > T (p.L319F) in the HSPA9 gene identified through whole‐exome sequencing. The patient is the first male known to be affected and presented with additional features not previously described with EVEN‐PLUS syndrome. These features include...
Tue Sep 01, 2020 16:44
Abstract Background Radiotherapy, applied to the head and neck region, can cause radiation side effects such as reduction of saliva and radiation caries. The aim of this study was to perform an in vitro assessment of the effects of radiation therapy on the morphological, mechanical, and chemical properties of primary and permanent teeth. Methods ...
Tue Sep 01, 2020 03:00
Abstract Background Our aim was to determine if azithromycin therapy, as an adjunct to scaling and root planing (SRP), decreases the number of pathobiontic subgingival plaque species and sites demonstrating pocket depth (PD) ≥ 5 mm and bleeding on probing (BOP) 6 months post-treatment. Methods In a double-blind randomized parallel-arm...
Tue Sep 01, 2020 03:00
Human epidermal growth factor receptor 2 (HER2) protein overexpression is associated with HER2 gene amplification, a critical driver oncogenetic change in gastric cancer. HER2 heterogeneity in advanced gastric cancer is associated with a poor prognosis and affects the clinical efficacy of trastuzumab. However, the mechanisms of HER2 heterogeneity are not fully understood. Here, we examined whether HER2 heterogeneous gastric cancer exhibited intratumoral genetic heterogeneity in other cancer‐related...
Tue Sep 01, 2020 14:55
Abstract Accumulating studies authenticate that circular RNAs (circRNAs) are involved in the progression of cancers. However, their role in breast cancer (BC) remains largely unknown. In this study, real‐time polymerase chain reaction was employed to detect the circ_0000291 and miR‐326 expressions in BC tissues and cells. The correlation between the expression level of circ_0000291 and clinicopathological parameters of BC patients was analyzed. Western blot was used to detect the expression of E26...
Tue Sep 01, 2020 14:55
Mon Aug 31, 2020 19:57
Patients that undergo surgical intervention for the management of malignant small bowel obstruction have an increased overall survival without significant difference in 30‐day mortality compared to conservatively managed patients. Patient selection is paramount as surgical intervention is associated with significant morbidity and its imperative that realistic goals and expectations are discussed with patients pre‐operatively. Abstract Background The management of patients presenting...
Mon Aug 31, 2020 18:37
A summary of published population‐based data on pancreatic cancer from Australia, highlighting areas of knowledge as well as issues that need to be addressed in the future. Abstract Pancreatic cancer is a disease associated with a poor overall survival. Advances in surgical techniques have helped improve outcomes of patients who are amenable to surgical resection. Sadly, surgery is amenable in only a small percentage of patients with the disease. Thus, there is a need to direct efforts...
Mon Aug 31, 2020 18:36
Ethnic and rural disparities in medical treatment are demonstrated across many medical conditions, including colorectal cancer. This study compares investigative and treatment delays in Māori and non‐Māori as well as urban and non‐urban patients diagnosed with colorectal cancer in Northland, New Zealand. No significant difference was found between investigative and treatment delays. Abstract Background Ethnic and rural disparities in medical treatment and outcomes have been demonstrated...
Mon Aug 31, 2020 18:34
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου