- Chronic dengue virus encephalitis in a patient with progressive dementia with extrapyramidal featuresAbstract Objective To determine the underlying etiology in a patient with progressive dementia with extrapyramidal signs and chronic inflammation referred to the National Institutes of Health Undiagnosed Diseases Program. Methods Extensive investigations included metabolic profile, autoantibody panel, infectious etiologies, genetic screening, whole exome sequencing and the phage‐display assay, VirScan, for viral immune responses. An eti
- Cavernous Carotid Artery Aneurysms on a Single Institution: an Epidemiological Study with 201 PatientsPublication date: Available online 27 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Jefferson Rosi Junior, Louise Makarem Oliveira, Antonio Luiz Boechat, Manoel Jacobsen Teixeira, Eberval Gadelha FigueiredoAbstractObjectivesCavernous carotid aneurysms (CCA) represent 2-9% of all intracranial aneurysms. For long considered benign lesions, these entities are unique when it comes to clinical presentation and management. Usually a
- Conservative versus operative treatment in supratentorial intracerebral hemorrhage - a survey among neurosurgeons and neurologists in GermanyPublication date: Available online 27 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Christian Roth, Merdhad Salehi, Wolfgang Deinsberger, Stefanie Kaestner, Holger EngelAbstractObjectivesDecision making for surgical therapy in patients with intracerebral hemorrhage is still controversial among neurologists and neurosurgeons. Whereas neurologists may favor conservative treatments, surgeons may opt for operations. This might lea
- Risk Factors for Post-Discharge Complications and Readmissions in Home-Discharges after Elective Posterior Lumbar FusionsPublication date: Available online 27 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Azeem Tariq Malik, Jack Xie, Romi Xi, Elizabeth Yu, Jeffery Kim, Safdar N KhanAbstractObjectivesPrevious literature has studied overall post-operative outcomes following lumbar fusions. We examined the rates and risk factors for adverse outcomes in patients who are being discharged home.Patients and MethodsThe 2012-2016 ACS-NSQIP database was u
- Constraining computational models using electron microscopy wiring diagramsPublication date: October 2019Source: Current Opinion in Neurobiology, Volume 58Author(s): Ashok Litwin-Kumar, Srinivas C TuragaNumerous efforts to generate “connectomes,” or synaptic wiring diagrams, of large neural circuits or entire nervous systems are currently underway. These efforts promise an abundance of data to guide theoretical models of neural computation and test their predictions. However, there is not yet a standard set of tools for
- Editorial BoardPublication date: 1 October 2019Source: Journal of Neuroscience Methods, Volume 326Author(s):
- Reflex and habituation behavior of <em>Caenorhabditis elegans</em> assessed by a mechanical vibration system and image analysisPublication date: Available online 27 August 2019Source: Journal of Neuroscience MethodsAuthor(s): Wan-Hua Yang, Chia-Yi Chen, Kun-Liang Wang, Hong Luen Kwok, Arnold Stern, Szecheng J. Lo, Hung-Chi YangAbstractBackgroundThe nematodeCaenorhabditis elegans is an emerging invertebrate animal model for investigating neuronal functions in behavioral assays. C. elegans mechanosensation was characterized by the use of a constant mechanical stimulation
- Where Neurosurgery Meets Heart Failure: A Case Report of a Patient with Amyloid Transthyretin Wild Type in the Ligamentum Flavum and Cardiac Tissue with Bilateral Carpal Tunnel SyndromePublication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Richard S. Dowd, T. Jayde Nail, Knarik Arkun, James Kryzanski, Oscar Soto, Teresa Fogaren, Kelly Harrington, Ayan Patel, Raymond Comenzo, Ron I. RiesenburgerBackgroundTransthyretin wild-type (ATTRwt) amyloidosis is a systemic process resulting in deposition of misfolded transthyretin protein in several different tissues throughout the body. It is known to be a cause o
- Multiple Spinal Chronic Subdural Hematomas Associated with Thoracic Hematomyelia: A Case Report and Literature ReviewPublication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Yuki Oichi, Hiroki Toda, Koji Yamagishi, Yoshitaka TsujimotoBackgroundChronic subdural hematoma (CSDH) is uncommon in the spine. Most spinal CSDHs occur as solitary lesions in the lumbosacral region. We report a rare case of multiple spinal CSDHs associated with hematomyelia. The diagnostic and therapeutic management of these complex spinal CSDHs is reviewed as well a
- Infratentorial Glioblastoma Metastasis to BonePublication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Jocelyn A. Ricard, Samuel W. Cramer, River Charles, Carolina Gil Tommee, An Le, W. Robert Bell, Clark C. Chen, Margaret E. FlanaganBackgroundGlioblastoma multiforme (GBM) is a rapid-growing central nervous system neoplasm. We report a case of GBM with extensive intramedullary lumbar drop metastasis and highly unusual osseous spine metastasis from a primary infratentor
- Intraaxial and Extraaxial Cavernous Malformation with Venous Linkage: Immune Cellular Inflammation Associated with AggressivenessPublication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Jorge Marcondes de Souza, Camilo Abud Aiex, Nathalie Henriques Silva Canedo, Suelen Adriani Marques, Ana Maria Blanco MartinezBackgroundIntraorbital and intracerebral cavernous malformation (CM) lesions are considered independent entities. Purely cerebral CMs have variable biology with recent evidence depicting inflammation as an important player and a risk factor for
- Targeted Stereotactic Radiosurgery for Arteriovenous Malformation Downgrading Followed by Microsurgical Resection: A Case Report and Review of the LiteraturePublication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Elizabeth Wild, James Barry, Hai SunBackgroundAn unruptured brain arteriovenous malformation (bAVM) is a complex pathological entity with the potential to lead to disabling or fatal intracranial hemorrhage. The treatment approaches for these lesions have included microsurgical resection, endovascular embolization, stereotactic radiosurgery (SRS), and medical managemen
- Tentorial Angioleiomyoma: A Rare Neurosurgical Entity. Case Report and Review of the LiteraturePublication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Roberto Altieri, Antonio Morrone, Francesco Certo, Giuseppe Parisi, Giovanni Buscema, Giuseppe Broggi, Gaetano Magro, Giuseppe M. BarbagalloBackgroundAngioleiomyoma (ALM) is a soft tissue neoplasm rarely described in the intracranial site. Because of their uncommon presentation, atypical neuroradiologic and pathologic features, ALMs are often misdiagnosed.Case Descript
- Endoscopic Endonasal Approach for Urgent Decompression of Craniovertebral Junction in SyringobulbiaPublication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Paolo Pacca, Nicola Marengo, Giuseppe Di Perna, Federica Penner, Marco Ajello, Diego Garbossa, Francesco ZengaBackgroundSyringobulbia is an uncommon lesion that occurs in the central nervous system; it is often defined as a pathologic cavitation in the brainstem. The cases with partial blockage of the cerebrospinal fluid pathways at the level of the foramen magnum are
- Depression and Suicidality in Multiple Sclerosis: Red Flags, Management Strategies, and Ethical ConsiderationsAbstract Multiple sclerosis (MS) causes physical, emotional, and cognitive changes that impact function and quality of life (QoL). Risk factors for suicidality in MS patients include a high incidence of depression, increased isolation, and reduced function/independence. Purpose of Review To describe the epidemio
- Nasal respiration entrains neocortical long‐range gamma coherence during wakefulnessAbstract Recent studies have shown that slow cortical potentials in archi‐, paleo‐ and neocortex can phase‐lock with nasal respiration. In some of these areas’ gamma activity (γ: 30‐100 Hz) is also coupled to the animal's respiration. It has been hypothesized that these functional relationships play a role in coordinating distributed neural activity. In a similar way, inter‐cortical interactions at γ frequency have also been associated as a bind
- Microglia cytoarchitecture in the brain of adenosine A2A receptor knockout mice: brain region and sex specificitiesAbstract Microglia cells exert a critical role in brain development, mainly supported by their immune functions, which predicts an impact on the genesis of psychiatric disorders. In fact, microglia stress during gestation is, for instance, associated with chronic anxiety and cognitive deficits accompanied by long‐lasting, region‐ and sex‐specific changes in microglia morphology. We recently reported that the pattern of microglia morphologic plas
- Pathological responses to single pulse electrical stimuli in epilepsy: the role of feedforward inhibitionAbstract Delineation of epileptogenic cortex in focal epilepsy patients may profit from single pulse electrical stimulation during intracranial EEG recordings. Single pulse electrical stimulation evokes early and delayed responses. Early responses represent connectivity. Delayed responses are a biomarker for epileptogenic cortex, but up till now, the precise mechanism generating delayed responses remains elusive. We used a data‐driven modelling
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