Metabolic perceptrons for neural computing in biological systemsNature Communications, Published online: 28 August 2019; doi:10.1038/s41467-019-11889-0So far, synthetic genetic circuits have relied on digital logic for information processing. Here the authors present metabolic perceptrons that use analog weighted adders to vary the contributions of multiple inputs, resulting in different classification functions.- Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapyNature Communications, Published online: 28 August 2019; doi:10.1038/s41467-019-11719-3Glioma therapy with checkpoint inhibitors has limited blood–brain barrier (BBB) penetration and therapeutic effects. Here, the authors develop nanopolymer-conjugated checkpoint inhibitors and show their trans-BBB delivery and anti-glioma efficacy.
- Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasmNature Communications, Published online: 28 August 2019; doi:10.1038/s41467-019-11919-xAuthor Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
- A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8<sup>+</sup> T-cell response and effective tumor controlNature Communications, Published online: 28 August 2019; doi:10.1038/s41467-019-11782-wInterleukin-2 (IL-2) based cancer therapy is limited by severe toxicity and strong Treg amplification at the therapeutic dosage. Here, the authors develop a recombinant IL-2 immunocytokine which is comprised of a tumor-targeting antibody fused to a super mutant IL-2 and show in mouse models that this next-generation IL2 has reduced toxicity and enhanced antitu
- Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challengeNature Communications, Published online: 28 August 2019; doi:10.1038/s41467-019-11926-yThe small molecule Nobiletin enhances circadian rhythms and protects against obesity-associated metabolic dysfunction in mice. Here the authors test its effect on health and lifespan, reporting that circadian enhancement promotes fitness and healthy aging in metabolically challenged mice.
- Author Correction: Isolated detection of elastic waves driven by the momentum of lightNature Communications, Published online: 28 August 2019; doi:10.1038/s41467-019-11969-1Author Correction: Isolated detection of elastic waves driven by the momentum of light
- Author Correction: Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanismsNature Communications, Published online: 28 August 2019; doi:10.1038/s41467-019-11810-9Author Correction: Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms
- Moving beyond the glial scar for spinal cord repairNature Communications, Published online: 28 August 2019; doi:10.1038/s41467-019-11707-7The scar formation that occurs following spinal cord injury has properties that are distinct to scars seen in other areas of the CNS, and in other tissues. Here the authors discuss the components of the spinal cord injury scar and how it can have both detrimental and positive roles in relation to recovery.
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου