• Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single‐blinded, placebo‐controlled trial

  Background Manuka honey (MH) has significant antibiofilm activity in vitro and in vivo against Staphylococcus aureus, methicillin‐resistant S aureus (MRSA), and Pseudomonas aeruginosa. This is the first randomized, single‐blinded, placebo‐controlled phase 1 clinical trial investigating the safety and preliminary efficacy of MH with augmented methylglyoxal (MGO) rinses in recalcitrant chronic rhinosinusitis (CRS). Methods Patients were incl

  International Forum of Allergy & Rhinology

  Wed Aug 28, 2019 11:02
• Practical Approach to Genetic Testing for Primary Immunodeficiencies

  Since the early identification of specific pathogenic variants in genes encoding Bruton’s tyrosine kinase (BTK), Wiskott Aldrich syndrome protein (WASp) and the gamma chain of the interlukin-2 receptor (IL2RG), the evolution of DNA sequencing technologies has led to the identification of variants in over 350 genes causing Primary Immune Deficiency Disorders (PIDD), with new discoveries being reported each year.1 Prior to the widespread availabili

  Annals of Allergy, Asthma & Immunology

  Tue Aug 27, 2019 17:00
• Advanced age adversely affects chronic rhinosinusitis surgical outcomes

  Background Patient‐specific and disease‐specific factors shape the course of chronic rhinosinusitis (CRS) and its response to treatment, with optimal management involving interventions tailored to these factors. Recent evidence suggests CRS inflammatory signatures depend on age. The objective of this study was to determine whether age also influences quality‐of‐life (QOL) and postoperative outcomes. Methods Retrospective analysis of prospe

  International Forum of Allergy & Rhinology

  Tue Aug 27, 2019 07:09
• Psychological Services for food allergy: the unmet need for patients and families in the UK

  Abstract Research over the past twenty years has demonstrated the significant impact food allergy can have on quality of life and mental health of patients and their families, yet there is a paucity of psychological services to support families in coping with this condition. This paper provides a short overview of the psychological impact of food allergy, followed by a discussion of the use of paediatric psychological services for long‐term cond

  Clinical & Experimental Allergy

  Tue Aug 27, 2019 12:29