- Large Animal Models for the Clinical Application of Human Induced Pluripotent Stem CellsStem Cells and Development, Ahead of Print.
- The tumor suppressor NDRG2 cooperates with an mTORC1 inhibitor to suppress the Warburg effect in renal cell carcinomaSummary Renal cell carcinoma (RCC) is one of the most common malignancies worldwide, and metabolic reprogramming has a profound effect on RCC tumorigenesis. mTORC1 inhibitors are widely used in RCC treatment, yet some types of RCC cells are resistant to these compounds. Thus, clarification of the metabolic mechanism of mTORC1 inhibitors and exploration of new therapeutic approaches are urgently needed. In this study, we found t
- Mining featured biomarkers associated with vascular invasion in HCC by bioinformatics analysis with TCGA RNA sequencing dataPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Ruoyan Zhang, Junfeng Ye, Heyu Huang, Xiaohong DuAbstractThis study aims to identify the feature genes associated with vascular invasion in hepatocellular carcinoma (HCC). Here, the RNA sequencing data related to vascular invasion in The Cancer Genome Atlas (TCGA) database, including 292 HCC patients with complete clinical data were included in our study
- LncRNA NONHSAT113026 represses renal cell carcinoma tumorigenesis through interacting with NF-κB/p50 and SLUGPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Yan Pu, Zhihong Dong, Yu Xia, Mengmeng Zhang, Jianzhong Song, Jing Han, Huibin LiuAbstractRenal cell carcinoma (RCC) is one of the most lethal urological malignancies, yet its pathogenesis remains unclear. Here, we reported a long non-coding RNA (lncRNA), NONHSAT 113026 (NOAT113026), which may play an important role in the pathogenesis of RCC. The expres
- Effects of hypoxia on cardiomyocyte proliferation and association with stage of developmentPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Yanjun Sun, Chuan Jiang, Haifa Hong, Jinfen Liu, Lisheng Qiu, Yanhui Huang, Lincai YeAbstractBackgroundHypoxia has been suggested to be both beneficial and harmful to the proliferation of cardiomyocytes. This controversy remains unresolved, and the underlying mechanism by which hypoxia exerts its effects remains unclear. We here hypothesize that cardiomy
- Assessment of a new arbidol derivative against herpes simplex virus II in human cervical epithelial cells and in BALB/c micePublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Nian Ma, Mengxin Shen, Tian Chen, Yuanyuan Liu, Yidong Mao, Liangjun Chen, Hairong Xiong, Wei Hou, Dongying Liu, Zhanqiu YangAbstractAs one of the highly contagious forms, herpes simplex virus type 2 (HSV-2) commonly caused severe genital diseases and closely referred to the HIV infection. The lack of effective vaccines and drug-resistance proclaimed the
- Investigating the regulation mechanism of baicalin on triple negative breast cancer’s biological network by a systematic biological strategyPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Kailin Yang, Liuting Zeng, Anqi Ge, Zhouhua Chen, Tingting Bao, Zhiyong Long, Jinwen Ge, Lizhong HuangAbstractObjectiveTo investigate the regulation mechanism of baicalin on triple negative breast cancer (TNBC)’s biological network by a systematic biological strategy and cytology experiment.MethodsA systematic biological methodology is utilized to
- A <em>Malva parviflora</em>´s fraction prevents the deleterious effects resulting from neuroinflammationPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Cristina E. Ramírez-Serrano, Enrique Jiménez-Ferrer, Maribel Herrera-Ruiz, Alejandro Zamilpa, Gabriela Vargas-Villa, Ricardo Jair Ramírez-Carreto, Anahí Chavarría, Jaime Tortoriello, Gustavo Pedraza-Alva, Leonor Pérez-MartínezAbstractNeuroinflammation, a centralized immune response, is a physiological pro
- Evaluation of the Effect of Intravenous Immunoglobulin Dosing on Mortality in Patients with Sepsis: A Network Meta-analysisPublication date: Available online 27 August 2019Source: Clinical TherapeuticsAuthor(s): Yi Yang, Xian Yu, Fan Zhang, Yifan XiaAbstractPurposeIntravenous immunoglobulin (IVIG) has been proposed as an adjunctive therapy for sepsis. Related systematic reviews and meta-analyses of IVIG in sepsis indicate that IVIG can reduce the mortality of sepsis in adults. However, the effective dose of IVIG has not been clearly determined to date. We aimed to c
- Sorafenib attenuated the function of natural killer cells infiltrated in HCC through inhibiting ERK1/2Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Chunxiao Li, Shuhua Wei, Xiaofei Xu, Yuliang Jiang, Lixiang Xue, Ping Jiang, Junjie WangAbstractSorafenib has been systemically utilized to therapy the advanced hepatocellular carcinoma (HCC). Natural killer cells (NKs) are important cytotoxic innate lymphocytes, which can exert effector functions especially in liver and tumor. However, how Sorafenib affe
- Antibacterial effect of S-Porphin sodium photodynamic therapy on <em>Staphylococcus aureus</em> and multiple drug resistance <em>Staphylococcus aureus</em>Publication date: Available online 27 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Mengqi Jia, Bingjie Mai, Shupei Liu, Zhaozhao Li, Quanhong Liu, Pan WangAbstractBackgroundAntibacterial photodynamic therapy (aPDT) has been proposed as an alternative strategy to inactivate bacteria. This study was designed to investigate the antibacterial effect of a novel photosensitizer S-Porphin sodium (S-PS) on plankton and biofilm cu
- Feasibility of transgingival laser irradiation for antimicrobial photodynamic therapyPublication date: Available online 27 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Johannes-Simon Wenzler, Sarah Böcher, Roland Frankenberger, Andreas BraunAbstractAimDiode lasers are commonly used for antimicrobial photodynamic therapy (aPDT). This study aimed to assess the feasibility of transgingival laser irradiation during aPDT and evaluate whether the photosensitizer can be activated.Materials and MethodsFour d
- Using optical coherence tomography angiography to guide the treatment of pathological myopic patients with submacular hemorrhagePublication date: Available online 27 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Rui Hua, Hong NingAbstractThe present study aimed to investigate whether optical coherence tomography angiography (OCTA) could be used to guide the treatment of pathological myopic patients with submacular hemorrhage. Two pathological myopia patients with submacular hemorrhage were examined. Initially, choroidal neovascularization (CNV) was
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