- Niche stiffness underlies the ageing of central nervous system progenitor cellsNature, Published online: 29 August 2019; doi:10.1038/s41586-019-1552-1Author Correction: Niche stiffness underlies the ageing of central nervous system progenitor cells
- Make science PhDs more than just a training path for academiaNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02586-5Science PhD programmes cater almost exclusively to students bound for academia, but they don’t have to, says Sarah Anderson.
- Metastatic-niche labelling reveals parenchymal cells with stem featuresNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1487-6A cell-penetrating fluorescent marker is used to label cells in the metastatic tumour microenvironment, revealing a variety of cell types including parenchymal cells with lung stem-cell characteristics.
- Carbon-nanotube computer scaled upNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02519-2Electronic devices that are based on carbon nanotubes have the potential to be more energy efficient than their silicon counterparts, but have been restricted in functionality. This limitation has now been overcome.
- Structural basis of assembly of the human TCR–CD3 complexNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1537-0Structural basis of assembly of the human TCR–CD3 complex
- Elusive cranium of early hominin foundNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02520-9A 3.8-million-year-old hominin fossil reveals what the cranium of the oldest known Australopithecus species looked like, casting doubt on assumptions about how these ancient relatives of humans evolved.
- Structure and mechanism of mitochondrial proton-translocating transhydrogenaseNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1519-2The structure of a mammalian proton-translocating transhydrogenase in various conformations is solved by cryo-electron microscopy, and a mechanism for the coupling process within the enzyme is proposed.
- Daily briefing: “Exceptionally rare” skull puts new face to human originsNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02582-9Look into the face of an exceptional Australopithecus, a secret space plane has broken records and all the ways we’ve tried (and failed) to quash hurricanes.
- Age and context of mid-Pliocene hominin cranium from Woranso-Mille, EthiopiaNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1514-7Two related studies describe a newly discovered cranium of Australopithecus anamensis, the environment in which this hominin would have lived approximately 3.8 million years ago and how it is related to Australopithecus afarensis.
- Superconductivity seen in a non-magnetic nickel oxideNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02518-3Magnetism alone was thought to be responsible for superconductivity in copper oxides. The finding of superconductivity in a non-magnetic compound that is structurally similar to these copper oxides challenges this view.
- Modern microprocessor built from complementary carbon nanotube transistorsNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1493-8A 16-bit microprocessor built from over 14,000 carbon nanotube transistors may enable energy efficiency advances in electronics technologies beyond silicon.
- Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through <i>S</i>-palmitoylationNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1511-xThe palmitoylation of STAT3 is mediated by fatty acids and/or the palmitoyl acyltransferase ZDHHC19, and deregulation of this palmitoylation has a role in inflammation and tumorigenesis.
- Rare 3.8-million-year-old skull recasts origins of iconic ‘Lucy’ fossilNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02573-wAncient cranium discovered in Ethiopia suggests early hominin evolutionary tree is messier than we thought.
- Changing climate both increases and decreases European river floodsNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1495-6Analysis of a comprehensive European flood dataset reveals regional changes in river flood discharges in the past five decades that are consistent with models suggesting that climate-driven changes are already happening.
- A 3.8-million-year-old hominin cranium from Woranso-Mille, EthiopiaNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1513-8Two related studies describe a newly discovered cranium of Australopithecus anamensis, the environment in which this hominin would have lived approximately 3.8 million years ago and how it is related to Australopithecus afarensis.
- Biggest carbon-nanotube chip yet says ‘Hello, World!’Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02576-7Researchers have built a 16-bit computer processor from the material.
- Cells tagged near an early spread of cancerNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02399-6Cancer cells that travel to a distant site can prompt the normal neighbouring cells at that location to create a tumour-promoting microenvironment. A tool that identifies these normal cells offers a way to study this process.
- An actin-based viscoplastic lock ensures progressive body-axis elongationNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1509-4Molecular analysis and mathematical modelling are combined to identify a network of factors that account for viscoplastic deformation in elongation of Caenorhabditis elegans during embryonic development.
- Ancient skull, Amazon fires and giraffe protectionsNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02515-6The week in science: 23–29 August 2019.
- Natural selection on the <i>Arabidopsis thaliana</i> genome in present and future climatesNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1520-9The predicted increase in frequency of droughts and rising temperatures in Europe will lead core populations of a temperate plant to an evolutionary dead-end unless they acquire genetic alleles that are present only in extreme edge Mediterranean, Scandinavian, or Siberian populations.
- Organization and regulation of gene transcriptionNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1517-4Structural and microscopy studies of gene transcription underpin a model in which phosphorylation controls the shuttling of RNA polymerase II between promoter and gene-body condensates to regulate transcription initiation and elongation.
- The flight response impairs cytoprotective mechanisms by activating the insulin pathwayNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1524-5The release of tyramine during the flight response in nematodes activates the DAF-2/insulin–IGF pathway to downregulate cytoprotective mechanisms and shorten lifespan.
- Superconductivity in an infinite-layer nickelateNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1496-5Superconductivity is demonstrated in an infinite-layer nickelate similar to infinite-layer copper oxides, which is synthesized using soft- chemistry topotactic reduction of the perovskite precursor phase.
- Podcast: Carbon-based computing, and depleting ancient-human genomesNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02577-6Listen to the latest from the world of science, with Shamini Bundell and Benjamin Thompson.
- Emergence of tissue-like mechanics from fibrous networks confined by close-packed cellsNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1516-5Tissue rheology emerges from the interplay between fibrous networks and cell inclusions, and the mechanical properties of tissues are modulated by restricting the relaxation modes of fibres close to volume-conserving cells.
- Efficient molecular doping of polymeric semiconductors driven by anion exchangeNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1504-9The limitations of conventional chemical doping of polymeric semiconductors can be overcome by adding a second ionic species into the system, leading to enhanced doping, electrical conductivity and stability.
- Temporal plasticity of apical progenitors in the developing mouse neocortexNature, Published online: 28 August 2019; doi:10.1038/s41586-019-1515-6In the brains of embryonic mice, some types of progenitor (apical progenitors) can revert to earlier molecular, electrophysiological and neurogenic states when transplanted into younger hosts, whereas others cannot, highlighting progenitor-type-specific differences in fate plasticity.
- The reality behind cannabidiol’s medical hypeNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02524-5The cannabis compound known as CBD is being touted as a treatment for a variety of conditions. But the substance’s uncertain legal status is stalling serious investigation.
- The bioengineering of cannabisNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02525-4Genetic modification could enable industrial-scale production of cannabinoids that have pharmaceutical potential.
- Younger scientists need better supportNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02561-0Universities must accept that there will be consequences if early-career researchers are not properly supported.
- The professionalization of cannabis growingNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02527-2As the wave of legalization advances, a budding industry is adopting the high standards of consumer-product makers to meet regulatory requirements.
- Weighing the dangers of cannabisNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02530-7As interest builds in the potential health benefits from the plant, accumulating evidence confirms that taking the drug also carries risks.
- Working out with weedNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02529-0Scientists investigate the counter-intuitive connections between exercise and cannabis.
- Can cannabis go green?Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02526-3With its demand for water, land and artificial lighting, cannabis growing can leave a large environmental footprint. But heightened awareness could make cultivation more benign.
- Regulators need to rethink restrictions on cannabis researchNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02531-6Policy changes are needed to support crucial work in the United States, says Jahan Marcu.
- What makes a dictator, a guide to the apocalypse, and demythologizing language: Books in briefNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02481-zBarbara Kiser reviews five of the week’s best science picks.
- Seeds travelNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02522-7Plotting a route.
- Cannabis research round-upNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02532-5Highlights from laboratory studies and clinical trials.
- Cannabis’s chemical synergiesNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02528-1The notion of an ‘entourage effect’ that magnifies the drug’s effects is intriguing but lacks solid evidence.
- Use ancient remains more wiselyNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02516-5Researchers rushing to apply powerful sequencing techniques to ancient-human remains must think harder about safeguarding, urge Keolu Fox and John Hawks.
- CannabisNature, Published online: 28 August 2019; doi:10.1038/d41586-019-02523-6A field in flux.
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου