Τετάρτη, 28 Αυγούστου 2019


Receptor tyrosine kinase inhibitor Sunitinib and integrin antagonist peptide HM-3 show similar lipid raft dependent biphasic regulation of tumor angiogenesis and metastasis
Anti-angiogenesis remains an attractive strategy for cancer therapy. Some anti-angiogenic reagents have bell-shape dose-response curves with higher than the effective doses yielding lower anti-angiogenic effec...
Journal of Experimental & Clinical Cancer Research - Latest Articles
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Modulating lncRNA SNHG15/CDK6/miR-627 circuit by palbociclib, overcomes temozolomide resistance and reduces M2-polarization of glioma associated microglia in glioblastoma multiforme
Accumulating evidence demonstrates the oncogenic roles of lncRNA (long non-coding RNA) molecules in a wide variety of cancer types including glioma. Equally important, However, tumorigenic functions of lncRNA ...
Journal of Experimental & Clinical Cancer Research - Latest Articles
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The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study
PurposeThe Uppsala–Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county in Sweden. The study was initiated to (1) investigate possible changes in the epigenetic profile of infants inferred through the ART procedures and their consequence and (2) to assess the impact of lifestyle and health exposures on treatment outcome. ParticipantsRecruitment took place between September 2011...
BMJ Open Current Issue
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Modern contraceptive use among sexually active women aged 15-19 years in North-Western Tanzania: results from the Adolescent 360 (A360) baseline survey
ObjectivesTo describe differences in modern contraceptive use among adolescent women aged 15–19 years according to their marital status and to determine factors associated with modern contraceptive use among sexually active women in this population. DesignCross-sectional analysis of Adolescent 360 evaluation baseline survey. SettingThe 15 urban and semiurban wards of Ilemela district, Mwanza region, North-Western Tanzania. ParticipantsAdolescent women aged 15–19 years who were living in the study...
BMJ Open Current Issue
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Intervention development and treatment success in UK health technology assessment funded trials of physical rehabilitation: a mixed methods analysis
ObjectivesPhysical rehabilitation is a complex process, and trials of rehabilitation interventions are increasing in number but often report null results. This study aimed to establish treatment success rates in physical rehabilitation trials funded by the National Institute of Health Research Health Technology Assessment (NIHR HTA) programme and examine any relationship between treatment success and the quality of intervention development work undertaken. DesignThis is a mixed methods study. SettingThis...
BMJ Open Current Issue
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Using electronic health record data to establish a chronic kidney disease surveillance system in China: protocol for the China Kidney Disease Network (CK-NET)-Yinzhou Study
IntroductionChronic kidney disease (CKD) is an important public health problem worldwide. However, there are few active disease surveillance systems for it. The China Kidney Disease Network (CK-NET) was established as a comprehensive surveillance system for CKD using various data sources. As part of this, the proposed CK-NET-Yinzhou study aims to build a regional surveillance system in a developed coastal area in China to obtain detailed dynamic information about kidney disease and to improve the...
BMJ Open Current Issue
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Factors associated with maternity waiting home use among women in Jimma Zone, Ethiopia: a multilevel cross-sectional analysis
ObjectiveTo identify individual-, household- and community-level factors associated with maternity waiting home (MWH) use in Ethiopia. DesignCross-sectional analysis of baseline household survey data from an ongoing cluster-randomised controlled trial using multilevel analyses. SettingTwenty-four rural primary care facility catchment areas in Jimma Zone, Ethiopia. Participants3784 women who had a pregnancy outcome (live birth, stillbirth, spontaneous/induced abortion) 12 months prior to September...
BMJ Open Current Issue
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Semistructured interviews regarding patients perceptions of Choosing Wisely and shared decision-making: an Australian study
ObjectivesThis study aimed to examine how patients perceive shared decision-making regarding CT scan referral and use of the five Choosing Wisely questions with their general practitioner (GP). DesignThis is a qualitative exploratory study using semistructured interviews. SettingThis study was conducted in a large metropolitan public healthcare organisation in urban Australia. ParticipantsFollowing purposive sampling, 20 patients and 2 carers participated. Patient participants aged 18 years or...
BMJ Open Current Issue
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Association between maternal education and breast feeding practices in China: a population-based cross-sectional study
ObjectiveTo investigate the association between maternal education and breast feeding in the Chinese population, with a consideration of household income and health-seeking behaviours. DesignA nationally representative population-based cross-sectional study. Setting77 counties from 12 geographically distinct regions in China. Participants10 408 mothers with children from 0 to 12 months of age, aged 15–53 years old (mean: 29.15, SD: 5.11) were classified into primary school or below group (n=781),...
BMJ Open Current Issue
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Efficacy of adaptive e-learning for health professionals and students: a systematic review and meta-analysis
ObjectiveAlthough adaptive e-learning environments (AEEs) can provide personalised instruction to health professional and students, their efficacy remains unclear. Therefore, this review aimed to identify, appraise and synthesise the evidence regarding the efficacy of AEEs in improving knowledge, skills and clinical behaviour in health professionals and students. DesignSystematic review and meta-analysis. Data sourcesCINAHL, EMBASE, ERIC, PsycINFO, PubMed and Web of Science from the first year...
BMJ Open Current Issue
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Efficacy of Xuebijing Injection for Sepsis (EXIT-SEP): protocol for a randomised controlled trial
IntroductionSepsis is a major challenge with high incidence and is associated with high mortality worldwide. Current management of sepsis remains mainly supportive except for treatment with antibiotics. Both basic research and clinical investigation have shown that the Chinese herbal-derived therapeutic Xuebijing (XBJ) injection is beneficial for patients with sepsis. However, the quality of evidence supporting the therapeutic use of XBJ in sepsis is limited. The aim of this trial is to evaluate...
BMJ Open Current Issue
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Longitudinal study of use and cost of subacromial decompression surgery: the need for effective evaluation of surgical procedures to prevent overtreatment and wasted resources
ObjectivesTo illustrate the need for better evaluation of surgical procedures, we investigated the use and cost of subacromial decompression in England over the last decade compared with other countries and explored how this related to the conduct and outcomes of randomised, placebo-controlled clinical trials. DesignLongitudinal observational study using Hospital Episode Statistics linked to Payment by Results tariffs in England, 2007/2008 to 2016/2017. SettingHospital care in England; Finland;...
BMJ Open Current Issue
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Relationships between the clinical phenotypes and genetic variants associated with the immunological mechanism in childhood idiopathic nephrotic syndrome: protocol for a prospective observational single-centre cohort study
IntroductionIdiopathic nephrotic syndrome (INS) is the most common glomerulopathy that results in childhood chronic kidney disease in China, but the relationships between different clinical phenotypes and immunological genetic variants observed in patients with INS are ambiguous and have not been well studied. A cohort study combined with whole exome sequencing might further identify the effects of immunological genetic variants on clinical phenotypes and treatment outcomes. Methods and analysisWe...
BMJ Open Current Issue
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Evaluation of policies for free maternal healthcare in low/middle-income countries: a scoping review protocol
IntroductionImproving maternal health remains a health priority at the global and national levels. As part of the global strategy, many low/middle-income countries (LMICs) have implemented free primary healthcare policies for different service packages including maternal health. Free maternal healthcare policies aim to improve maternal health by removing the financial burden of accessing maternal healthcare services. The objective of this scoping review is to assess evaluations of free maternal healthcare...
BMJ Open Current Issue
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Complex intervention in augmentative and alternative communication (AAC) care in Germany: a study protocol of an evaluation study with a controlled mixed-methods design
IntroductionThe current practice of service delivery in Germany for people with complex communication needs (CCN) who are in need of augmentative and alternative communication (AAC) is characterised by diverse problems, including a lack of clarity in the responsibilities of the service providers involved. To address these issues a new service delivery model has been put in place, implemented in three AAC counselling centres for patients with a particular health insurance across Germany. The implementation...
BMJ Open Current Issue
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IJMS, Vol. 20, Pages 4227: The Reason for Growth Inhibition of Ulmus pumila ‘Jinye’: Lower Resistance and Abnormal Development of Chloroplasts Slow Down the Accumulation of Energy
IJMS, Vol. 20, Pages 4227: The Reason for Growth Inhibition of Ulmus pumila ‘Jinye’: Lower Resistance and Abnormal Development of Chloroplasts Slow Down the Accumulation of Energy International Journal of Molecular Sciences doi: 10.3390/ijms20174227 Authors: Lihui Zuo Shuang Zhang Yichao Liu Yinran Huang Minsheng Yang Jinmao Wang Ulmus pumila ‘Jinye’, the colorful leaf mutant of Ulmus pumila L., is widely used in landscaping. In common with most leaf...
International Journal of Molecular Sciences
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