- SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferationThe transcription factor SNAIL1 is a master regulator of epithelial‐to‐mesenchymal transition, a process entailing massive gene expression changes. To better understand SNAIL1‐induced transcriptional reprogramming we performed time‐resolved transcriptome analysis upon conditional SNAIL1 expression in colorectal cancer cells. Gene set variation analyses indicated that SNAIL1 strongly affected features related to cell cycle and Wnt/β‐Catenin signal
- Cancers, Vol. 11, Pages 1268: Novel Human Bispecific Aptamer–Antibody Conjugates for Efficient Cancer Cell KillingCancers, Vol. 11, Pages 1268: Novel Human Bispecific Aptamer–Antibody Conjugates for Efficient Cancer Cell Killing Cancers doi: 10.3390/cancers11091268 Authors: Margherita Passariello Simona Camorani Cinzia Vetrei Laura Cerchia Claudia De Lorenzo Monoclonal antibodies have been approved by the Food and Drug Administration for the treatment of various human cancers. More recently, oligonucleotide aptamers have risen increa
- Risk‐adapted stereotactic body radiation therapy for central and ultra‐central early‐stage inoperable non‐small cell lung cancerAbstract To determine the therapeutic efficacy and safety of the risk‐adapted stereotactic body radiation therapy (SBRT) schedules for patients with early‐stage central and ultra‐central inoperable non‐small cell lung cancer (NSCLC). From 2006‐2015, 80 inoperable T1‐2N0M0 NSCLC patients were treated with two median dose levels: 60 Gy in 6 fractions (range, 48‐60 Gy in 4‐8 fractions) prescribed to the 74% isodose line (range, 58%‐79%) for central
- Tobacco Use, Attitudes, Knowledge, and Perception About Smoking Cessation Counseling Among Brazilian Dental Students: a Cross-Sectional StudyAbstract The aim of this study was to evaluate the prevalence of tobacco use, exposure to secondhand smoke, and knowledge and perception about smoking cessation counseling among dental students in Brazil. A cross-sectional study was performed at the School of Dentistry, Universidade Federal de Pernambuco, Brazil. The Global Health Professions Student Survey (GHPSS) research instrument was used. In the second half of 2017, stude
- Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort studyPurpose: To identify genetic risk factors associated with risk of stroke among survivors of childhood cancer treated with cranial radiation therapy (CRT). Experimental Design: We analyzed whole-genome sequencing (36.8-fold) data of 686 childhood cancer survivors of European ancestry [median (range): 40.4 (12.4-64.7) years old; 54% male] from the St. Jude Lifetime Cohort study treated with CRT, of whom 116 (17%) had clinically-diagnosed stroke. A
- Biophysical characterizations of the recognition of the AAUAAA polyadenylation signal [Article]Most eukaryotic messenger RNA precursors must undergo 3-end cleavage and polyadenylation for maturation. We and others recently reported the structure of the AAUAAA polyadenylation signal (PAS) in complex with the protein factors CPSF-30, WDR33 and CPSF-160, revealing the molecular mechanism for this recognition. Here we have characterized in detail the interactions between the PAS RNA and the protein factors using fluorescence polarization exper
- Novel single‐chain variant of antibody against mesothelin established by phage libraryMesothelin (MSLN) shows increased expression in various cancer cells. For clinical application of antibodies as a PET imaging reagent, a human shortened antibody is essential both for avoiding redundant immune responses and for providing rapid imaging. Therefore, we cloned a single‐chain fragment of variable regions (scFv) from a human‐derived gene sequences. This was achieved through the construction of a naïve phage library de
- Development and Usability Testing of a Decision Support App for Women Considering Breast Reconstruction SurgeryAbstract Women with breast cancer have difficulty deciding whether to undergo breast reconstruction when mastectomy is necessary. A computer-based decision aid that can be individualized to provide both surgery information and value clarification may be helpful for women considering breast reconstruction surgery. The objectives of this study are to program a prototype of an application (app) with a value clarification exercise
- Risk Estimation, Anxiety and Breast Cancer Worry in Women at Risk for Breast Cancer: A Single‐Arm Trial of Personalized Risk CommunicationAbstract Objective Elevated anxiety and breast cancer worry can impede mammographic screening and early breast cancer detection. Genetic advances and risk models make personalized breast cancer risk assessment and communication feasible, but it is unknown whether such communication of risk affects anxiety and disease‐specific worry. We studied the effect of a personalized breast cancer screening intervention on risk perception, anxiety and br
- Barriers to eliciting patient goals and values in shared‐decision making breast cancer surgery consultations: an ethnographic and interview studyAbstract Objective Previous research has demonstrated the importance of eliciting patients' goals and values during shared decision‐making (SDM), but this does not occur in most SDM conversations. Understanding challenges to eliciting patients' goals and values is crucial. This study assessed how clinicians balanced sharing medical information and considering patients' goals and values during breast cancer surgery consultation in an integrate
- Dacarbazine alone or associated with melanoma‐bearing cancer pain model induces painful hypersensitivity by TRPA1 activation in miceAntineoplastic therapy has been associated with pain syndrome development characterized by acute and chronic pain. The chemotherapeutic agent dacarbazine, used mainly to treat metastatic melanoma, is reported to cause painful symptoms, compromising patient quality of life. Evidence has proposed that transient receptor potential ankyrin 1 (TRPA1) plays a critical role in chemotherapy‐induced pain syndrome. Here, we investigated whether dacarbazine
- Plasma Circular RNA Panel to Diagnose Hepatitis B Virus‐Related Hepatocellular Carcinoma: A Large‐Scale, Multicenter StudyTo explore whether plasma circular RNAs (circRNAs) can diagnose hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC), microarray and qPCR were used to identify plasma circRNAs that were increased in HBV‐related HCC patients compared with controls (including healthy controls, chronic hepatitis B and HBV‐related liver cirrhosis). A logistic regression model was constructed using a training set (n=313) and then validated using another two
- Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulationTumor‐initiating cells are a subpopulation of cells that have self‐renewal capacity to regenerate a tumor. Here, we identify stem cell‐like chromatin features in human glioblastoma initiating cells (GICs) and link them to a loss of the repressive histone H3 lysine 9 trimethylation (H3K9me3) mark. Increasing H3K9me3 levels by histone demethylase inhibition led to cell death in GICs but not in their differentiated counterparts. The induction of apo
- Concurrent use of opioids with benzodiazepines or nonbenzodiazepine sedatives among patients with cancer referred to an outpatient palliative care clinicBackground The concurrent use of opioids with benzodiazepines (BZD) or nonbenzodiazepine sedatives (S) recently was found to be associated with an increased risk of overdose death compared with the use of opioids alone. In the current study, the authors examined the frequency and trend of concurrent opioid/BZD‐S use and its associated risk factors among patients with cancer. Methods Data regarding the frequency and trend of concurrent opio
- A Cancer Education-Plus-Navigation Intervention Implemented Within a Federally Qualified Health Center and Community-Based SettingsAbstract Despite the availability of effective cancer screening tests, Latinos are screened at lower rates than non-Hispanic Whites. We implemented and evaluated the effectiveness of an evidence-based community health worker (CHW) cancer education-plus-navigation intervention designed to increase cancer screening, knowledge of screening guidelines, and the benefit of early detection. The project included a community and clinic
- Temporal lobe sparing radiotherapy with photons or protons for cognitive function preservation in paediatric craniopharyngiomaCraniopharyngiomas are rare intracranial tumours arising in the suprasellar brain and more often diagnosed in the paediatric population. The treatment usually consists of a combination of surgery and radiotherapy, with current 10-year overall survival above 90% [1]. However, due to the midline location of the tumour, long-term effects are common in this population and include endocrine dysfunction, obesity, as well as cognitive impairment [1]. Im
- Is tumour sphericity an important prognostic factor in patients with lung cancer?Heterogeneity is present within tumours and across patients at a multitude of levels, including molecular, genetic, and phenotypic differences [1]. Despite differences, radiotherapy treatment for lung cancer is prescribed with a ‘one-size-fits-all’ approach. The goal of personalised radiotherapy is to exploit heterogeneity to prescribe the optimal treatment for each patient, aiming to improve patient outcome. For example, this could involve treat
- Impact of patient and treatment characteristics on heart and lung dose in adjuvant radiotherapy for left-sided breast cancerThe heart and lungs are routinely exposed to incidental irradiation during adjuvant radiotherapy (RT) of breast cancer. We analyzed the impact of patient and treatment characteristics on heart and lung dose in...
- Prevalence of metastases within the hypothalamic-pituitary area in patients with brain metastasesTo quantify the prevalence of brain metastases involving the hypothalamic-pituitary (HT-P) area.
- An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activationAbstract RIG-I is a cytosolic RNA sensor that recognizes short 5′ triphosphate RNA, commonly generated during virus infection. Upon activation, RIG-I initiates antiviral immunity, and in some circumstances, induces cell death. Because of this dual capacity, RIG-I has emerged as a promising target for cancer immunotherapy. Previously, a sequence-optimized RIG-I agonist (termed M8) was generated and shown to stimulate a robust im
- Nomograms for predicting the survival rate for cervical cancer patients who undergo radiation therapy: a SEER analysis.Related ArticlesNomograms for predicting the survival rate for cervical cancer patients who undergo radiation therapy: a SEER analysis. Future Oncol. 2019 Aug 27;: Authors: Yang J, Tian G, Pan Z, Zhao F, Feng X, Liu Q, Lyu J Abstract Aim: To integrate multiple independent risk factors to establish prognostic nomograms for better predicting overall survival and disease-specific survival in patients wi
- Optimizing outcomes and treatment sequences in EGFR mutation-positive non-small-cell lung cancer: recent updates.Related ArticlesOptimizing outcomes and treatment sequences in EGFR mutation-positive non-small-cell lung cancer: recent updates. Future Oncol. 2019 Aug 27;: Authors: Girard N Abstract The availability of several EGFR tyrosine kinase inhibitors (TKIs) for the treatment of EGFR mutation-positive NSCLC poses important questions regarding the optimum sequence of therapy. A key consideration is how best
- Jean Dutreix (1922–2019)Publication date: September 2019Source: Cancer/Radiothérapie, Volume 23, Issue 5Author(s): J.-M. Cosset, F. Eschwège
- Issue ContentsPublication date: September 2019Source: Cancer/Radiothérapie, Volume 23, Issue 5Author(s):
- Editorial BoardPublication date: September 2019Source: Cancer/Radiothérapie, Volume 23, Issue 5Author(s):
- Comités de retour d’expérience (CREX) dans les centres de radiothérapie français en 2019Publication date: Available online 28 August 2019Source: Cancer/RadiothérapieAuthor(s): S. Nardin, O. DupontRésuméDix ans après l’introduction des CREX (Comités de retour d’expérience) dans les centres de radiothérapie, nous avons interrogé 168 centres pour connaître leur ressenti. Au total, 100 nous ont répondu, et 95 % sont satisfaits de la dé
- Machines de radiothérapie hybrides : évolution ou révolution ?Publication date: Available online 27 August 2019Source: Cancer/RadiothérapieAuthor(s): L. Ferrer, S. Josset, A. Moignier, G. DelponRésuméL’arrivée de nouvelles machines hybrides de radiothérapie embarquant une IRM ou TEP est annoncée comme une étape marquante dans la prise en charge en radiothérapie. En appui avec une littérature récente, nous décrirons l’a
- Radiothérapie des oligométastases : principaux essais en cours et à venir en FrancePublication date: Available online 27 August 2019Source: Cancer/RadiothérapieAuthor(s): P. Giraud, H. Tournat, S. Kreps, J.-E. Bibault, A. Dautruche, E. Fabiano, T. Feutren, C. DurduxRésuméLa radiothérapie en conditions stéréotaxiques des oligométastases, non fractionnée ou hypofractionnée, représente un changement fondamental dans la pratique de la spécialité te
- Hypofractionnement modéré ou extrême et cancers prostatiques localisés : les temps sont en train de changerPublication date: Available online 27 August 2019Source: Cancer/RadiothérapieAuthor(s): S. Line Krhili, G. Créhange, H. Albert-Dufrois, V. Guimas, M. Minsat, S. SupiotRésuméIl existe de nombreuses options de traitement pour les cancers de prostate localisés, incluant la surveillance active, la curiethérapie, la radiothérapie externe et la prostatectomie radicale. La qualité de vie reste un
- Radiothérapie stéréotaxique du cancer bronchique non à petites cellules de stade I. État de l’art en 2019 et recommandations : la stéréotaxie comme alternative à la chirurgie ?Publication date: Available online 27 August 2019Source: Cancer/RadiothérapieAuthor(s): H. Kaiss, F. MornexRésuméLa radiothérapie en conditions stéréotaxiques (ou Stereotactic body radiation therapy [SBRT]) pulmonaire est une technique actuellement bien implantée dans l’arsenal thérapeutique de prise en charge des cancers bronchiques. C’est le traitement standard des patients in
- Radiothérapie stéréotaxique pulmonaire : quelle machine ?Publication date: Available online 27 August 2019Source: Cancer/RadiothérapieAuthor(s): P. Giraud, S. Kreps, H. Tournat, J.-E. Bibault, E. Fabiano, T. Feutren, A. Dautruche, C. DurduxRésuméLa radiothérapie en conditions stéréotaxiques représente un changement fondamental dans la pratique de la radiothérapie des cancers pulmonaires. Malgré la très grande hétérog&e
- Cancer du canal anal : personnalisation de la dose, du volume et du fractionnementPublication date: Available online 27 August 2019Source: Cancer/RadiothérapieAuthor(s): D. PeiffertRésuméLe traitement conservateur des cancers épidermoïdes du canal anal par irradiation est un standard en première intention. Malgré sa rareté, des progrès significatifs ont été accomplis au travers d’études cliniques historiques ou prospectives ces deux derni&
- Predictive value of preoperative serum squamous cell carcinoma antigen (SCC–Ag) level on tumor recurrence in cervical squamous cell carcinoma patients treated with radical surgery: A single-institution studyPublication date: Available online 27 August 2019Source: European Journal of Surgical OncologyAuthor(s): Qinhao Guo, Jun Zhu, Yong Wu, Hao Wen, Lingfang Xia, Xiaohua Wu, Xingzhu JuAbstractObjectiveWe seek to explore the clinical significance of serum squamous cell carcinoma antigen (SCC–Ag) and the optimal cut-off value for predicting tumor recurrence and survival in operable cervical squamous cell carcinoma patients.MethodsA total of 3471
- Cancers, Vol. 11, Pages 1267: Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma CellsCancers, Vol. 11, Pages 1267: Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma Cells Cancers doi: 10.3390/cancers11091267 Authors: Baeza-Kallee Bergès Soubéran Colin Denicolaï Appay Tchoghandjian Figarella-Branger A2B5+ cells isolated from human glioblastomas exhibit cancer stem cell properties. The A2B5 epitope belongs to the sialoganglioside fam
- Cancers, Vol. 11, Pages 1266: Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor VaccinationCancers, Vol. 11, Pages 1266: Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination Cancers doi: 10.3390/cancers11091266 Authors: Horrevorts Stolk Ven Hulst Hof Duinkerken Heineke Ma Dusoswa Nieuwland Garcia-Vallejo Loosdrecht de Gruijl Vliet van Kooyk Tumors that lack T cell infiltration are less likely to respond to imm
- Role of the Advanced Nurse Practitioner Within Teenage and Young Adult Oncology. What is the Impact on Patient and Staff Experience of a New Nurse Practitioner Role to a Teenage and Young Adult Service?Journal of Adolescent and Young Adult Oncology, Ahead of Print.
- Cancer invasion regulates vascular complexity in a three-dimensional biomimetic modelPublication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Judith Pape, Tarig Magdeldin, Morium Ali, Claire Walsh, Mark Lythgoe, Mark Emberton, Umber CheemaAbstractIntroductionThere is a growing appreciation for including a complex, vascularised stroma in three-dimensional (3D) tumour models to recapitulate the native tumour microenvironment in situ.MethodsUsing a compartmentalised, biomimetic, 3D cancer model, compr
- Incidence and mortality of myeloid malignancies in children, adolescents and Young adults in Brazil: A population-based studyPublication date: October 2019Source: Cancer Epidemiology, Volume 62Author(s): Suellen Valadares Moura Feliciano, Marceli de Oliveira Santos, Maria S. Pombo-de-Oliveira, Josefa Ângela Pontes de Aquino, Terezinha Almeida de Aquino, Miren Maite Uribe Arregi, Berenice Navarro Antoniazzif, Allini Mafra da Costa, Lucrecia Aline Cabral Formigosa, Cyntia Asturian Laporte, Carlos Anselmo Lima, Nayara Cabral Machado, José Carlo de Oliveira, Larissa Dell’A
- Cancers, Vol. 11, Pages 1265: Current Status of Gene Therapy in Hepatocellular CarcinomaCancers, Vol. 11, Pages 1265: Current Status of Gene Therapy in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11091265 Authors: Saranya Chidambaranathan Reghupaty Devanand Sarkar Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer related deaths world-wide. Liver transplantation, surgical resection, trans-arterial chemoembolization, and radio frequency ablation are effective
- Cancers, Vol. 11, Pages 1262: BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain TumorsCancers, Vol. 11, Pages 1262: BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors Cancers doi: 10.3390/cancers11091262 Authors: Karisa C. Schreck Stuart A. Grossman Christine A. Pratilas BRAF mutations have been identified as targetable, oncogenic mutations in many cancers. Given the paucity of treatments for primary brain tumors and the poor prognosis associated with high-grade gliomas, BRAF mutati
- Cancers, Vol. 11, Pages 1263: Health-Related Quality of Life during Chemoradiation in Locally Advanced Rectal Cancer: Impacts and Ethnic DisparitiesCancers, Vol. 11, Pages 1263: Health-Related Quality of Life during Chemoradiation in Locally Advanced Rectal Cancer: Impacts and Ethnic Disparities Cancers doi: 10.3390/cancers11091263 Authors: Stephanie Hui-Su Lim Emilia Ip Weng Ng Wei Chua Ray Asghari Aflah Roohullah Joseph Descallar Christopher Henderson Kevin Spring Paul de Souza Madeleine T. King Aims: There is limited data on health-related qualit
- Cancers, Vol. 11, Pages 1264: Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal MuscleCancers, Vol. 11, Pages 1264: Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle Cancers doi: 10.3390/cancers11091264 Authors: Gabriela S. de Castro Estefania Simoes Joanna D.C.C. Lima Milene Ortiz-Silva William T. Festuccia Flávio Tokeshi Paulo S. Alcântara José P. Otoch Dario Coletti Marilia Seelaender Cachexia is a wasting syndrome characterized by the continuo
- Cancers, Vol. 11, Pages 1261: Targeting of CD133+ Cancer Stem Cells by Mesenchymal Stem Cell Expressing TRAIL Reveals a Prospective Role of Apoptotic Gene Regulation in Non-Small Cell Lung CancerCancers, Vol. 11, Pages 1261: Targeting of CD133+ Cancer Stem Cells by Mesenchymal Stem Cell Expressing TRAIL Reveals a Prospective Role of Apoptotic Gene Regulation in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers11091261 Authors: Kamal Shaik Fakiruddin Moon Nian Lim Norshariza Nordin Rozita Rosli Zubaidah Zakaria Syahril Abdullah Mesenchymal stem cells (MSCs) are emerging as vehicles for anti-tumor cytother
- Identification of new OCT1‐target genes upregulated in castration‐resistant prostate cancerSummary Octamer transcription factor 1 (OCT1) is an androgen receptor (AR)‐interacting partner and regulates the expression of target genes in prostate cancer cells. However, the function of OCT1 in castration‐resistant prostate cancer (CRPC) has not been fully understood. In the present study, we used 22Rv1 cells as AR‐positive CRPC model cells to analyze the role of OCT1 in CRPC. We showed that OCT1 knockdown suppressed cell proliferation and
- Targeting Valosin‐Containing Protein Enhances the Efficacy of Radiation Therapy in Esophageal Squamous Cell CarcinomaSummary Overcoming resistance to radiation is a great challenge in cancer therapy. Here we highlight that targeting valosin‐containing protein (VCP) improves radiation sensitivity in esophageal squamous cell carcinoma (ESCC) cell lines and show the potential of using VCP as a prognosis marker in locally advanced ESCC treated with radiation therapy. ESCC cell lines with high VCP expression were treated with VCP inhibitor combined with radiotherap
- Second‐line chemotherapy in advanced biliary cancers: A retrospective, multicenter analysis of outcomesBackground Although gemcitabine plus platinum chemotherapy is the established first‐line regimen for advanced biliary cancer (ABC), there is no standard second‐line therapy. This study evaluated current practice and outcomes for second‐line chemotherapy in patients with ABC across 3 US academic medical centers. Methods Institutional registries were reviewed to identify patients who had received second‐line chemotherapy for ABC from April 2
- Stakeholder perspectives on addressing adverse events from adjuvant cancer therapy: A qualitative studyBackground With increasing survival rates, a growing population of patients with cancer have received or will receive adjuvant therapy to prevent cancer recurrences. Patients and caregivers will confront the complexities of balancing the preventative benefits of adjuvant therapy with possible near‐term or long‐term adverse events (AEs). Adjuvant treatment–related AEs (from minimal to severe) can impact therapeutic adherence, quality of life, emo
- Patient preferences for attributes of primary surgical debulking versus neoadjuvant chemotherapy for treatment of newly diagnosed ovarian cancerBackground Randomized trials have reported conflicting findings on survival for advanced‐stage ovarian cancer treated with primary debulking surgery (PDS) versus neoadjuvant chemotherapy with interval debulking; surgical complications and mortality are higher with PDS. We assessed women's preferences for tradeoffs related to this important clinical decision. Methods Ovarian cancer patients were recruited to complete a discrete‐choice exper
- Development and validation of an individualized risk prediction model for oropharynx cancer in the US populationBackground The incidence of oropharynx cancers has increased substantially in the United States. However, risk stratification tools for the identification of high‐risk individuals do not exist. In this study, an individualized risk prediction model was developed and validated for oropharynx cancers in the US population. Methods A synthetic, US population–based case‐control study was conducted. Oropharynx cancer cases diagnosed at Ohio Stat
- Long‐term risk of congestive heart failure in younger breast cancer survivors: A nationwide study by the SMARTSHIP groupBackground There is a controversy about late‐onset congestive heart failure (CHF) among breast cancer survivors. This study investigated the incidence rate and risk factors of late‐onset CHF more than 2 years after the breast cancer diagnosis. Methods A nationwide, retrospective study was conducted with the National Health Information Database. With 1:3 age‐ and sex‐matched noncancer controls, Cox proportional hazard regression models were
- Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort studyNeutrophil‐to‐lymphocyte ratio (NLR) is associated with poor prognosis in patients with lung cancer, but the predictive role of NLR on the risk of developing lung cancer is unknown. We investigated the association between NLR and lung cancer mortality in lung cancer‐free adults. A cohort study was performed with 527,124 Korean adults who were free of lung cancer and were followed for up to 16 years. Vital status and lung cancer–related deaths wer
- Cancers, Vol. 11, Pages 1260: CRISPR/Cas9 Editing of the Polyomavirus Tumor Antigens Inhibits Merkel Cell Carcinoma Growth In VitroCancers, Vol. 11, Pages 1260: CRISPR/Cas9 Editing of the Polyomavirus Tumor Antigens Inhibits Merkel Cell Carcinoma Growth In Vitro Cancers doi: 10.3390/cancers11091260 Authors: Arturo Temblador Dimitrios Topalis Graciela Andrei Robert Snoeck Merkel cell carcinoma (MCC) is an aggressive type of skin cancer whose main causative agent is Merkel cell polyomavirus (MCPyV). MCPyV is integrated into the genome of the tumor cells i
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου