- Infliximab induction regimens in steroid‐refractory acute severe colitis: a multicentre retrospective cohort study with propensity score analysisSummary Background Accelerated induction regimens of infliximab have been proposed to improve response rates in patients with steroid‐refractory acute severe colitis. Aim To determine the differences in outcome for acute severe ulcerative colitis between accelerated and standard‐dose infliximab Methods We collected data on hospitalised patients receiving differing regimens of rescue therapy for steroid‐refractory acute severe ulce
- Targeting Valosin-Containing Protein Enhances the Efficacy of Radiation Therapy in Esophageal Squamous Cell Carcinoma.Related ArticlesTargeting Valosin-Containing Protein Enhances the Efficacy of Radiation Therapy in Esophageal Squamous Cell Carcinoma. Cancer Sci. 2019 Aug 27;: Authors: Luo H, Song H, Mao R, Gao Q, Feng Z, Wang N, Song S, Jiao R, Ni P, Ge H Abstract Overcoming resistance to radiation is a great challenge in cancer therapy. Here we highlight that targeting valosin-containing protein (VCP) improves ra
- Shikonin potentiates paclitaxel antitumor efficacy in esophageal cancer cells via the apoptotic pathway.Related ArticlesShikonin potentiates paclitaxel antitumor efficacy in esophageal cancer cells via the apoptotic pathway. Oncol Lett. 2019 Sep;18(3):3195-3201 Authors: Du W, Hao X, Yuan Z, Wang Y, Zhang X, Liu J Abstract Shikonin is a natural naphthoquinone pigment that can suppress the growth of a number of cancer cell types. Paclitaxel is an antineoplastic chemotherapy drug, which is used for the tr
- MicroRNA-490-3p inhibits proliferation and stimulates apoptosis of ESCC cells via MAPK1 downregulation.Related ArticlesMicroRNA-490-3p inhibits proliferation and stimulates apoptosis of ESCC cells via MAPK1 downregulation. Oncol Lett. 2019 Sep;18(3):3170-3176 Authors: Zabihula B, Yiliyasi M, Lu Y, Salai A Abstract The present study aimed to investigate whether microRNA (miR)-490-3p can regulate MAPK1 expression, increase proliferation of esophageal squamous cell carcinoma (ESCC) and reduce ESCC cell a
- Ramucirumab for the treatment of gastric or gastro-esophageal junction cancer.Related ArticlesRamucirumab for the treatment of gastric or gastro-esophageal junction cancer. Expert Opin Biol Ther. 2019 Aug 27;:1-7 Authors: Khan U, Shah MA Abstract Introduction: Gastric cancer remains one of the most lethal malignancy, accounting for an estimated 783,000 deaths worldwide in 2018. Although there are several approved drugs for the treatment of gastric cancer, the survival of patie
- Dysphagia Score as a Predictor of Adverse Events Due to Triplet Chemotherapy and Oncological Outcomes in 434 Consecutive Patients with Esophageal Cancer.Related ArticlesDysphagia Score as a Predictor of Adverse Events Due to Triplet Chemotherapy and Oncological Outcomes in 434 Consecutive Patients with Esophageal Cancer. Ann Surg Oncol. 2019 Aug 26;: Authors: Hagi T, Makino T, Yamasaki M, Tanaka K, Nishida N, Sakai D, Motoori M, Kimura Y, Satoh T, Mori M, Doki Y Abstract BACKGROUND: Dysphagia is a major symptom of esophageal cancer (EC) that signific
- Prognostic Significance of Cyclin D1 Over-expression in Colorectal Cancer: An Experience from Madinah, Saudi Arabia.Related ArticlesPrognostic Significance of Cyclin D1 Over-expression in Colorectal Cancer: An Experience from Madinah, Saudi Arabia. Asian Pac J Cancer Prev. 2019 08 01;20(8):2471-2476 Authors: Albasri AM, Elkablawy MA, Ansari IA, Alhujaily AS Abstract Background and study aim: Cyclin D1 is a key regulatory protein in the cell cycle and is over-expressed in many tumors, including endometrial, thyroi
- Oesophageal hepatoid carcinoma with liver metastasis, a diagnostic dilemma.Related ArticlesOesophageal hepatoid carcinoma with liver metastasis, a diagnostic dilemma. Malays J Pathol. 2019 Apr;41(1):59-63 Authors: Yahaya A, Wa Kammal WS, Abd Shukor N, Osman SS Abstract Alpha-fetoprotein (AFP)-producing carcinoma which microscopically mimics hepatocellular carcinoma (HCC) is a rare entity known as hepatoid adenocarcinoma (HC). They usually arise in the stomach, while oesopha
- Centralization of Esophagectomy in the United States: Might It Benefit Underserved Populations?Related ArticlesCentralization of Esophagectomy in the United States: Might It Benefit Underserved Populations? Ann Surg Oncol. 2018 06;25(6):1463-1464 Authors: Cooke DT PMID: 29556845 [PubMed - indexed for MEDLINE]
- [Microvascular reconstruction of the larynx following total laryngectomy].Related Articles[Microvascular reconstruction of the larynx following total laryngectomy]. Laryngorhinootologie. 2018 02;97(2):100-109 Authors: Hackenberg S, Kleinsasser N, Scherzad A, Kraus F, Hagen R Abstract Total laryngectomy still is a standard procedure for the treatment of advanced laryngeal or hypopharyngeal carcinoma. The unavoidable loss of voice may lead to serious impairments in quality
- Impact of Extracapsular Lymph Node Involvement After Neoadjuvant Chemoradiation Therapy Followed by Surgery in Carcinoma of the Esophagus: A Multicenter Study.Related ArticlesImpact of Extracapsular Lymph Node Involvement After Neoadjuvant Chemoradiation Therapy Followed by Surgery in Carcinoma of the Esophagus: A Multicenter Study. Ann Surg. 2018 12;268(6):1000-1007 Authors: Depypere LP, Moons J, Mariette C, D'Journo XB, Thomas PA, Hölscher AH, Bollschweiler E, van Berge-Henegouwen MI, Van Lanschot JJB, Lerut TEMR, Nafteux PR Abstract OBJECTIVES: T
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