- Multi‐institutional analysis of outcomes following transoral surgery for HPV‐positive oropharyngeal squamous cell carcinoma in elderly patientsAbstract Background The incidence of human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) is rising, even in elderly patients. The outcomes of transoral surgery (TOS) in this population are not entirely known. Methods A retrospective review was performed at two institutions from October 2003 to September 2016 on patients 70 years or older with HPV‐related OPSCC treated with TOS. Results A total of 75 pa
- Prognostic biomarkers in oral leukoplakiaAbstract I would like to make some comments on the systematic review recently published in Oral Diseases (Villa et al., 2019) on prognostic biomarkers in oral leukoplakia. I consider this an important subject as oral medicine specialists are keen to understand the role of biomarkers in stratifying the risk of oral leukoplakia and to reinvigorate future research. This article is protected by copyright. All rights reserved.
- Cosmetic benefits of a novel biomimetic lamellar formulation containing niacinamide in healthy females with oily, blemish‐prone skin in a randomised proof‐of‐concept studyAbstract Objective A randomised study was designed to evaluate the potential cosmetic benefit of a biomimetic, niacinamide‐containing moisturising cream in oily, blemish‐prone skin. Methods Healthy adult women with oily, blemish‐prone skin were randomised to one of three treatment groups: test, control, or positive control. In the test group, subjects used the test product (containing 4% niacinamide), plus the standard cleanser (Simple®
- Impact of adenotonsillectomy on the evolution of inflammatory markersAbstract Lymphoid organs of Waldeyer's ring, mainly the palatal and pharyngeal (adenoid) tonsils, are the first immunocompetent tissues contacting exogenous microorganisms because of their strategic location at the entry of the respiratory and digestive systems.1 Tonsils are secondary lymphoid organs included in the mucosa‐associated lymphoid tissue. They are organized in a manner closely related to their function in the immune system. In the ex
- Analyse von Gesichtsasymmetrien bei Patienten mit SchiefnasenLaryngo-Rhino-OtolDOI: 10.1055/a-0987-9945 Hintergrund Das chirurgische Management der Schiefnase stellt selbst für erfahrene Rhinochirurgen eine Herausforderung dar, obwohl zahlreiche Techniken zur Korrektur beschrieben sind. Nicht selten besteht zusätzlich zur Schiefnase eine Asymmetrie des Gesichtes, die das ästhetische Ergebnis der Operation beeinflusst. In dieser Studie sollte festgestellt werden, wie hä
- Pectoralis major turnover flap based on thoracoacromial vessels for sternal dehiscenceAbstract Background Reconstruction of long and deep sternal defects has been challenging. The pectoralis major can be used in the conventional turnover method that requires the internal thoracic vessel. We developed a new turnover pectoralis major flap based on thoracoacromial vessels. The purpose of this report is to present results from 14 patients. Methods Fourteen patients with a mean age of 73.6 years (range, 53–83 years) who had s
- Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single‐blinded, placebo‐controlled trialBackground Manuka honey (MH) has significant antibiofilm activity in vitro and in vivo against Staphylococcus aureus, methicillin‐resistant S aureus (MRSA), and Pseudomonas aeruginosa. This is the first randomized, single‐blinded, placebo‐controlled phase 1 clinical trial investigating the safety and preliminary efficacy of MH with augmented methylglyoxal (MGO) rinses in recalcitrant chronic rhinosinusitis (CRS). Methods Patients were incl
- Swallowing Characteristics in Zenker's‐like Diverticulum After Anterior Cervical Spine SurgeryObjectives A Zenker's diverticulum (ZD) is a hypopharyngeal pulsion diverticula caused by dysfunction of the cricopharyngeus muscle with herniation of hypopharyngeal mucosa through Killian's dehiscence. Anterior cervical spine surgery (ACSS) can cause a Zenker's‐like traction diverticulum (ZTD) with a similar presentation but different pathophysiology. The purpose of this investigation was to compare the fluoroscopic parameters and surgical outc
- Defect repair with fibrin glue/polyglycolic acid after endoscopic laryngopharyngeal cancer resectionObjectives/Hypothesis In 2013, we introduced a modified technique for mucosal/muscle layer defect coverage with fibrin glue and polyglycolic acid (PGA) sheets (mMCFP technique) in patients undergoing endoscopic transoral surgeries for laryngopharyngeal cancers. This technique allows easy and convenient coverage of the wound surface, even when it involves the laryngopharyngeal lumen. To our knowledge, use of the MCFP technique for coverage of pos
- Saliva pepsin level of laryngopharyngeal reflux patients is not correlated with reflux episodesObjective To investigate the relationship between the laryngopharyngeal reflux (LPR) episodes at the multichannel intraluminal impedance‐pH monitoring (MII‐pH) and the concentration of pepsin in the saliva of LPR patients. Methods Patients with LPR were enrolled from the polyclinic of Poitiers, France. Patients benefited from 24‐hour MII‐pH that allowed a correlation study between reflux episodes and symptoms. Patients reported the occurre
- Early glottic cancer in a veteran population: Impact of race on management and outcomesObjectives Multiple population studies have shown racial discrepancies in head and neck cancer treatment and outcomes. We sought to characterize the impact of race on clinical outcomes for patients with early glottic squamous cell carcinoma (SCC) in a tertiary institution which provides equivalent access to care. Methods We retrospectively reviewed all early glottic (T1–T2) squamous cell carcinoma at a single institution, the Michael E. De
- Ectopic cervical thymus in children: Clinical and radiographic featuresObjectives Ectopic thymus is rare and can be a diagnostic challenge. This study evaluated the management of children radiographically diagnosed with ectopic cervical thymus. Methods A retrospective review of 100 patients was performed. Data related to clinical presentation, radiological imaging, pathology, and management were collected. Changes in lesion volume were tracked over time. Clinical characteristics were compared based on lesion
- Does new sensitization correlate with nasal symptoms in children with allergic rhinitis?Objectives To evaluate the correlation between the increased number of sensitized allergens and nasal symptoms in patients with allergic rhinitis who were sensitized to house dust mites (HDMs). Methods Among the patients who were enrolled in the Allergic Rhinitis Cohort Study for Kids, 174 children with rhinitis symptoms who were sensitized to HDMs were included in the analysis. Skin prick tests, serum total immunoglobulin E, eosinophil co
- Inclusion of the first cervical nerve does not influence outcomes in upper airway stimulation for treatment of obstructive sleep apneaObjectives/Hypothesis Upper airway stimulation (UAS) has demonstrated efficacy in the management of obstructive sleep apnea (OSA). Branches of the hypoglossal nerve that selectively activate tongue protrusor and stiffener muscles are included within the stimulation cuff electrode. The first cervical nerve (C1) is often also included to stimulate additional muscles contributing to tongue protrusion and stabilization. The purpose of this study was
- Maternal alcohol consumption and oral clefts: a meta-analysisOur aim was to evaluate the possible correlation between maternal alcohol consumption during the first trimester and the risk of having an offspring with non-syndromic oral cleft. We electronically searched all published papers from 1950 to 2019 about maternal alcohol consumption and oral clefts in PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Institute for Scientific Information (ISI) databases. Descriptive and qu
- Metastatic epithelioid haemangioendothelioma masquerading as periodontal pathosis: a case reportWe present a non-healing lesion on the gingivae attached to the mandible that mimicked periodontal disease, and was refractory to local debridement and oral hygiene measures. Biopsy examination showed a metastatic epithelioid haemangioendothelioma. This rare vascular tumour is considered to be malignant and management is controversial, owing to the paucity of published data. Treatment was provided in a multi-disciplinary setting as a result of es
- Use of a suction tube to prevent nasal pressure sores during nasotracheal intubationNasotracheal intubation is commonly used in head and neck surgery. While the most common complication is epistaxis, alar pressure sores from the prolonged compression of the tube on the alar rim can cause considerable discomfort.1 The risk increases with the duration of the anaesthesia, the patient being male, and other factors such as permissive hypotension during midface procedures.2
- Practical Approach to Genetic Testing for Primary ImmunodeficienciesSince the early identification of specific pathogenic variants in genes encoding Bruton’s tyrosine kinase (BTK), Wiskott Aldrich syndrome protein (WASp) and the gamma chain of the interlukin-2 receptor (IL2RG), the evolution of DNA sequencing technologies has led to the identification of variants in over 350 genes causing Primary Immune Deficiency Disorders (PIDD), with new discoveries being reported each year.1 Prior to the widespread availabili
- Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive ReviewAbstract Cholangiocarcinoma (CCA) is the most common malignancy in patients with primary sclerosing cholangitis (PSC) and carries a high rate of mortality. Although the pathogenesis of CCA in PSC is largely unknown, inflammation-driven carcinogenesis concomitant with various genetic and epigenetic abnormalities are underlying factors. The majority of CCA cases develop from a dominant stricture (DS), which is defined as a strict
- Lateral pharyngeal flap with a double pedicle for repair of unilateral velopharyngeal insufficiencyConventional pharyngeal flap surgery, which closes the median portion of the velopharynx, has been performed for dysarthria patients with velopharyngeal insufficiency (VPI). However, for VPI due to unilateral pharyngeal paralysis, median closing disrupts pharyngeal contraction of the unaffected side and allows pharyngeal pressure to escape through the nose at the lateral portion of the affected side during speech and swallowing. The purpose of th
- Huge toxic goiter extending to the posterior mediastinum; Case report with literature review.Related ArticlesHuge toxic goiter extending to the posterior mediastinum; Case report with literature review. Int J Surg Case Rep. 2019 Aug 20;62:69-72 Authors: Abdullah AS, Bahjat AS, Mohammed AA Abstract INTRODUCTION: Retrosternal goiter may occur in up to 7% of the cases, most of them extend to the anterior mediastinum, extension to the posterior mediastinum is very rare. It causes compression on
- Dysphagia and factors associated with malnutrition risk: A five-year multicentre study.Related ArticlesDysphagia and factors associated with malnutrition risk: A five-year multicentre study. J Adv Nurs. 2019 Aug 26;: Authors: Blanař V, Hödl M, Lohrmann C, Amir Y, Eglseer D Abstract AIMS: To describe the associations between dysphagia and malnutrition risk and to identify predictors for dysphagia in a group of persons at risk of malnutrition in hospitals and nursing homes. DESI
- Dysphagia Score as a Predictor of Adverse Events Due to Triplet Chemotherapy and Oncological Outcomes in 434 Consecutive Patients with Esophageal Cancer.Related ArticlesDysphagia Score as a Predictor of Adverse Events Due to Triplet Chemotherapy and Oncological Outcomes in 434 Consecutive Patients with Esophageal Cancer. Ann Surg Oncol. 2019 Aug 26;: Authors: Hagi T, Makino T, Yamasaki M, Tanaka K, Nishida N, Sakai D, Motoori M, Kimura Y, Satoh T, Mori M, Doki Y Abstract BACKGROUND: Dysphagia is a major symptom of esophageal cancer (EC) that signific
- Updated Systematic Review of Achalasia, with a Focus on POEM Therapy.Related ArticlesUpdated Systematic Review of Achalasia, with a Focus on POEM Therapy. Dig Dis Sci. 2019 Aug 27;: Authors: Cappell MS, Stavropoulos SN, Friedel D Abstract AIM: To systematically review clinical presentation, diagnosis, and therapy of achalasia, focusing on recent developments in high-resolution esophageal manometry (HREM) for diagnosis and peroral endoscopic myotomy (POEM) for therapy.
- Oral Feeding for Infants and Children Receiving Nasal Continuous Positive Airway Pressure and High-Flow Nasal Cannula Respiratory Supports: A Survey of Practice.Related ArticlesOral Feeding for Infants and Children Receiving Nasal Continuous Positive Airway Pressure and High-Flow Nasal Cannula Respiratory Supports: A Survey of Practice. Dysphagia. 2019 Aug 26;: Authors: Canning A, Fairhurst R, Chauhan M, Weir KA Abstract To investigate oral-feeding practices for infants and children receiving nasal continuous positive airway pressure (nCPAP) and high-flow na
- Plummer-Vinson Syndrome and Heart Failure: An Unusual Association in an African American Woman.Related ArticlesPlummer-Vinson Syndrome and Heart Failure: An Unusual Association in an African American Woman. Am J Case Rep. 2019 Aug 27;20:1264-1267 Authors: Field Z, Russin M, Kropf J, Olivier M, Ge L, Galili Y, Carlan SJ Abstract BACKGROUND Plummer-Vinson syndrome (PVS) is a rare disorder composed of the triad of dysphagia, iron-deficiency anemia (IDA), and esophageal webs. It is most prevalent
- Measurement of cerebrospinal fluid ACE level in aseptic meningitis: diagnostic?Related ArticlesMeasurement of cerebrospinal fluid ACE level in aseptic meningitis: diagnostic? BMJ Case Rep. 2019 Aug 26;12(8): Authors: Saha BK, Saha A, Beegle S Abstract Neurosarcoidosis (NS) is a rare disease, affecting only 3%-10% of patients with sarcoidosis. The clinical presentation can be protean and often represents a diagnostic challenge. Cerebrospinal fluid (CSF) ACE level has poor sensit
- Unusual cause of dysphagia.Related ArticlesUnusual cause of dysphagia. BMJ Case Rep. 2019 Aug 26;12(8): Authors: Koh D, Thakur U, Lim WM Abstract In this case, we describe a unique case of large renal hydronephrosis in a 79-year-old Indian male patient who had initially presented with 3 months of progressive dysphagia and loss of weight. His dysphagia was initially thought to be related to the atypical diagnosis of achalasia a
- Prevalence of dysphagia in a regional hospital setting: Acute care hospital and a geriatric sociosanitary care hospital: A cross-sectional study.Related ArticlesPrevalence of dysphagia in a regional hospital setting: Acute care hospital and a geriatric sociosanitary care hospital: A cross-sectional study. Clin Nutr ESPEN. 2019 Oct;33:86-90 Authors: Peñalva-Arigita A, Prats R, Lecha M, Sansano A, Vila L Abstract RATIONALE: Oropharyngeal Dysphagia (OD) is a symptom commonly found in hospitalized patients and related to a vast array of clinical
- Lesion location and other predictive factors of dysphagia and its complications in acute stroke.Related ArticlesLesion location and other predictive factors of dysphagia and its complications in acute stroke. Clin Nutr ESPEN. 2019 Oct;33:178-182 Authors: Fernández-Pombo A, Seijo-Raposo IM, López-Osorio N, Cantón-Blanco A, González-Rodríguez M, Arias-Rivas S, Rodríguez-Yáñez M, Santamaría-Nieto A, Díaz-Ortega C, Gómez-Vázquez E, Martínez-Olmos MÁ Abstract BACKGROUND AND AIMS: Early detection of
- Physical and Radiobiological Evaluation of Accelerated Intensity Modulated Radiotherapy for Locally Advanced Head and Neck Cancer and Comparison with Short-Term Clinical Outcomes.Related ArticlesPhysical and Radiobiological Evaluation of Accelerated Intensity Modulated Radiotherapy for Locally Advanced Head and Neck Cancer and Comparison with Short-Term Clinical Outcomes. Asian Pac J Cancer Prev. 2019 08 01;20(8):2463-2470 Authors: Buchapudi RR, Manickam R, M R AK, C R TP, Chandraraj V, Pyakuryal A, Narayanasamy G Abstract Objective: The present study aims to evaluate the acc
- Swallowing evaluation in patients without restriction of oral food three months after ischemic stroke.Related ArticlesSwallowing evaluation in patients without restriction of oral food three months after ischemic stroke. NeuroRehabilitation. 2019 Aug 19;: Authors: Montaldi MR, Dantas RO Abstract BACKGROUND: Our hypothesis was that even patients without complaints and without evident clinical signs of dysphagia three months after ischemic stroke, may have swallowing alterations. OBJECTIVE: To
- The consumption of snacks and soft drinks between meals may contribute to the development and to persistence of gastro-esophageal reflux disease.Related ArticlesThe consumption of snacks and soft drinks between meals may contribute to the development and to persistence of gastro-esophageal reflux disease. Med Hypotheses. 2019 Apr;125:84-88 Authors: Fiorentino E Abstract THE HYPOTHESIS: The habit of snacking and drinking soft beverages between breakfast, lunch and dinner, which is very widespread in the western world, could be a primum moven
- Prolactin and Prolactin-inducible protein (PIP) in the pathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).Related ArticlesProlactin and Prolactin-inducible protein (PIP) in the pathogenesis of primary acquired nasolacrimal duct obstruction (PANDO). Med Hypotheses. 2019 Apr;125:137-138 Authors: Ali MJ, Paulsen F Abstract Primary acquired nasolacrimal duct obstruction (PANDO) is a syndrome of unknown etiology, predominantly affecting post-menopausal females, characterized by progressive inflammation, fib
- Durchführung und Interpretation der FEES (Fiberoptic Endoscopic Evaluation of Swallowing).Related ArticlesDurchführung und Interpretation der FEES (Fiberoptic Endoscopic Evaluation of Swallowing). Laryngorhinootologie. 2018 02;97(2):86-88 Authors: Müller B, Bohne S, Geißler K, Guntinas-Lichius O PMID: 29401545 [PubMed - indexed for MEDLINE]
- Complications in children with percutaneous endoscopic gastrostomy (PEG) placement.Related ArticlesComplications in children with percutaneous endoscopic gastrostomy (PEG) placement. World J Pediatr. 2019 Feb;15(1):12-16 Authors: Balogh B, Kovács T, Saxena AK Abstract INTRODUCTION: The aim of this study was to analyze the complication rates and mortality in association with different operative techniques of percutaneous endoscopic gastrostomy (PEG), age, underlying disease
- The novel cytokine Metrnl/IL-41 is elevated in psoriatic arthritis synovium and induced at the enthesisPublication date: Available online 27 August 2019Source: Clinical ImmunologyAuthor(s): Charlie Bridgewood, Tobias Russell, Helen Weedon, Thomas Baboolal, Abdulla Watad, Kassem Sharif, Richard Cuthbert, Miriam Wittmann, Mihir Wechalekar, Dennis McGonagleAbstractMeteorin-like(IL-41), is a novel cytokine that is thought to be immunoregulatory and is highly expressed in psoriatic skin. We investigated IL-41 protein expression in synovial tissue in R
- Pregnancy-related immune suppression leads to altered influenza vaccine recall responsesPublication date: Available online 27 August 2019Source: Clinical ImmunologyAuthor(s): Nishel M. Shah, Nesrina Imami, Peter Kelleher, Wendy S. Barclay, Mark R. JohnsonAbstractPregnancy is a risk factor for severe influenza infection. Despite achieving seroprotective antibody titres post immunisation fewer pregnant women experience a reduction in influenza-like illness compared to non-pregnant cohorts. This may be due to the effects that immune-m
- Efficacy of photodynamic therapy versus local nystatin in the treatment of denture stomatitis: A randomized clinical study.Related ArticlesEfficacy of photodynamic therapy versus local nystatin in the treatment of denture stomatitis: A randomized clinical study. Photodiagnosis Photodyn Ther. 2019 Aug 24;: Authors: Alrabiah M, Alsahhaf A, Alofi RS, Al-Aali KA, Abduljabbar T, Vohra F Abstract AIM: The aim of the present randomized clinical study was to compare the efficacies of photodynamic inactivation (PDI) with nystatin
- Oral mucositis and microbial colonization in oral cancer patients undergoing radiotherapy and chemotherapy: A prospective analysis in a tertiary care dental hospital.Related ArticlesOral mucositis and microbial colonization in oral cancer patients undergoing radiotherapy and chemotherapy: A prospective analysis in a tertiary care dental hospital. J Investig Clin Dent. 2019 Aug 27;:e12454 Authors: Subramaniam N, Muthukrishnan A Abstract AIM: The ulcerative phase of oral mucositis following radiotherapy/chemotherapy for oral cancer colonizes bacteria, fungi and vir
- The Spirocyclic Imine from a Marine Benthic Dinoflagellate, Portimine, Is a Potent Anti-Human Immunodeficiency Virus Type 1 Therapeutic Lead Compound.Related ArticlesThe Spirocyclic Imine from a Marine Benthic Dinoflagellate, Portimine, Is a Potent Anti-Human Immunodeficiency Virus Type 1 Therapeutic Lead Compound. Mar Drugs. 2019 Aug 24;17(9): Authors: Izumida M, Suga K, Ishibashi F, Kubo Y Abstract In this study, we aimed to find chemicals from lower sea animals with defensive effects against human immunodeficiency virus type 1 (HIV-1). A librar
- Language nutrition for language health in children with disorders: a scoping review.Related ArticlesLanguage nutrition for language health in children with disorders: a scoping review. Pediatr Res. 2019 Aug 27;: Authors: Bang JY, Adiao AS, Marchman VA, Feldman HM Abstract The quantity and quality of child-directed speech-language nutrition-provided to typically-developing children is associated with language outcomes-language health. Limited information is available about child-dire
- Language Comprehension After Mild Traumatic Brain Injury: The Role of Speed.Related ArticlesLanguage Comprehension After Mild Traumatic Brain Injury: The Role of Speed. Am J Speech Lang Pathol. 2019 Aug 27;:1-12 Authors: Norman RS, Shah MN, Turkstra LS Abstract Purpose The aim of this study was to characterize language comprehension in mild traumatic brain injury (mTBI) by testing a speed-based hypothesis. We hypothesized that adults with mTBI would perform worse than a grou
- Developmental sociolinguistics: Children's acquisition of language variation.Related ArticlesDevelopmental sociolinguistics: Children's acquisition of language variation. Wiley Interdiscip Rev Cogn Sci. 2019 Aug 27;:e1515 Authors: Johnson EK, White KS Abstract Developmental sociolinguistics is a rapidly evolving interdisciplinary framework that builds upon theoretical and methodological contributions from multiple disciplines (i.e., sociolinguistics, language acquisition, the
- Speech polar plots for different directionality settings of SONNET cochlear implant processor.Related ArticlesSpeech polar plots for different directionality settings of SONNET cochlear implant processor. Cochlear Implants Int. 2019 Aug 27;:1-13 Authors: De Ceulaer G, Pascoal D, Nopp P, Péan V, Govaerts PJ Abstract Objectives: The newest CI processor from MED-EL company, the SONNET, has two new directional microphone settings. Besides the Omnidirectional microphone mode, it has the possibilit
- Acoustic context effects in speech perception.Related ArticlesAcoustic context effects in speech perception. Wiley Interdiscip Rev Cogn Sci. 2019 Aug 27;:e1517 Authors: Stilp C Abstract The extreme acoustic variability of speech is well established, which makes the proficiency of human speech perception all the more impressive. Speech perception, like perception in any modality, is relative to context, and this provides a means to normalize the
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