| Photochemistry and Photobiology Early View
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Research Articles
Relation of Photochemical Internalization to Heat, pH and Ca2+ Ions
Version of Record online: 24 August 2019
Photochemical internalization (PCI) is a strategy to utilize light and photosensitizers for the endosomal membrane destabilization to release endocytosed macromolecules entrapped in endosomes. We studied the contributions of several factors, including heat, pH and calcium ions, on the PCI mechanism.
Research Articles
Optical Spectroscopy as a Method for Skin Cancer Risk Assessment
Version of Record online: 24 August 2019
This study reports the application of elastic scattering spectroscopy coupled with machine learning to assist in the discrimination of skin lesions that are concerning for malignancy. The method requires no special skin preparation, is non‐invasive, requires minimal training, and allows rapid lesion classification. The classification algorithm was developed on a 950‐lesion training dataset, and diagnostic performance was evaluated against a 357‐lesion testing dataset. The observed sensitivity was 100% (14/14) for melanoma and 94% (105/112) for nonmelanoma skin cancer. The overall specificity was 36% (84/231). ESS has potential to assist physicians in evaluating common benign and malignant skin lesions.
Research Articles
Significant Associations Between Sun Exposure and Adiposity Were Not Observed in Breast and Prostate Cancer Patients in a Cross‐sectional Analysis
Version of Record online: 24 August 2019
We examined the cross‐sectional relationship between sun exposure and adiposity in a convenience cohort of female breast and male prostate cancer patients. Participants were enrolled in a 3‐month exercise program. Self‐reported questionnaires were used to measure time spent outdoors (previous week, winter, and summer), sex, age, treatment received and physical activity levels. Adiposity measures included body mass index, waist‐hip ratio, and body fat percentage (via DXA). There were no statistically significant associations between time spent outdoors and adiposity after adjusting for sex, age, treatments received, and physical activity.
Letters To The Editor
Impact of Long‐Wavelength Ultraviolet A1 and Visible Light on Light‐Skinned Individuals
Version of Record online: 23 August 2019
Solar radiation is known to be a major contributor to the development of skin cancer. Most sunscreen formulations, including those with broad spectrum, offer minimal protection in long wavelength ultraviolet A1 (UVA1; 370–400 nm) and visible light (VL; 400–700 nm) domain. There is limited information regarding the impact of this broad waveband (VL + UVA1, 370‐700 nm) on those with light skin. This study demonstrates that VL + UVA1 induces clinically perceptible erythema. This is a novel finding since the erythemogenic spectrum of sunlight has primarily been attributed to ultraviolet B and short wavelength ultraviolet A (320–340 nm).
Research Articles
The Growth‐promoting Mechanism of Unusual Spectroscopic Form of LH2 (LH4) from Rhodopseudomonas palustris CGA009 in Low Light
Version of Record online: 22 August 2019
A pucBAd deletion mutant of Rhodopseudomonas palustris CGA009 was constructed and presents lower growth rate under low light intensity. The deletion of pucBAd of CGA009 contains no LH4 and only LH2 complexes under low light conditions. LH4 has higher energy transfer activity than that of LH2, and it can provide more photons with higher energetic state for photosynthesis.
Research Articles
Protective Effects of Ginseng Proteins on Photoaging of Mouse Fibroblasts Induced by UVA
First Published: 23 August 2019
Research Articles
Adrenocorticotropic Hormone and Cyclic Adenosine Monophosphate are Involved in the Control of Shark Bioluminescence
First Published: 23 August 2019
Special Issue Research Article
Predictors and Limitations of the Penetration Depth of Photodynamic Effects in the Rodent Brain
First Published: 23 August 2019
Research Articles
Photobiomodulation Enhances Cisplatin Cytotoxicity in a Culture Model with Oral Cell Lineages
First Published: 19 August 2019
Special Issue Research Article
Cancer Cell‐targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Co‐culture Model
First Published: 19 August 2019
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