- Multi‐institutional analysis of outcomes following transoral surgery for HPV‐positive oropharyngeal squamous cell carcinoma in elderly patientsAbstract Background The incidence of human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) is rising, even in elderly patients. The outcomes of transoral surgery (TOS) in this population are not entirely known. Methods A retrospective review was performed at two institutions from October 2003 to September 2016 on patients 70 years or older with HPV‐related OPSCC treated with TOS. Results A total of 75 pa
- Impact of adenotonsillectomy on the evolution of inflammatory markersAbstract Lymphoid organs of Waldeyer's ring, mainly the palatal and pharyngeal (adenoid) tonsils, are the first immunocompetent tissues contacting exogenous microorganisms because of their strategic location at the entry of the respiratory and digestive systems.1 Tonsils are secondary lymphoid organs included in the mucosa‐associated lymphoid tissue. They are organized in a manner closely related to their function in the immune system. In the ex
- Analyse von Gesichtsasymmetrien bei Patienten mit SchiefnasenLaryngo-Rhino-OtolDOI: 10.1055/a-0987-9945 Hintergrund Das chirurgische Management der Schiefnase stellt selbst für erfahrene Rhinochirurgen eine Herausforderung dar, obwohl zahlreiche Techniken zur Korrektur beschrieben sind. Nicht selten besteht zusätzlich zur Schiefnase eine Asymmetrie des Gesichtes, die das ästhetische Ergebnis der Operation beeinflusst. In dieser Studie sollte festgestellt werden, wie hä
- Swallowing Characteristics in Zenker's‐like Diverticulum After Anterior Cervical Spine SurgeryObjectives A Zenker's diverticulum (ZD) is a hypopharyngeal pulsion diverticula caused by dysfunction of the cricopharyngeus muscle with herniation of hypopharyngeal mucosa through Killian's dehiscence. Anterior cervical spine surgery (ACSS) can cause a Zenker's‐like traction diverticulum (ZTD) with a similar presentation but different pathophysiology. The purpose of this investigation was to compare the fluoroscopic parameters and surgical outc
- Defect repair with fibrin glue/polyglycolic acid after endoscopic laryngopharyngeal cancer resectionObjectives/Hypothesis In 2013, we introduced a modified technique for mucosal/muscle layer defect coverage with fibrin glue and polyglycolic acid (PGA) sheets (mMCFP technique) in patients undergoing endoscopic transoral surgeries for laryngopharyngeal cancers. This technique allows easy and convenient coverage of the wound surface, even when it involves the laryngopharyngeal lumen. To our knowledge, use of the MCFP technique for coverage of pos
- Saliva pepsin level of laryngopharyngeal reflux patients is not correlated with reflux episodesObjective To investigate the relationship between the laryngopharyngeal reflux (LPR) episodes at the multichannel intraluminal impedance‐pH monitoring (MII‐pH) and the concentration of pepsin in the saliva of LPR patients. Methods Patients with LPR were enrolled from the polyclinic of Poitiers, France. Patients benefited from 24‐hour MII‐pH that allowed a correlation study between reflux episodes and symptoms. Patients reported the occurre
- Early glottic cancer in a veteran population: Impact of race on management and outcomesObjectives Multiple population studies have shown racial discrepancies in head and neck cancer treatment and outcomes. We sought to characterize the impact of race on clinical outcomes for patients with early glottic squamous cell carcinoma (SCC) in a tertiary institution which provides equivalent access to care. Methods We retrospectively reviewed all early glottic (T1–T2) squamous cell carcinoma at a single institution, the Michael E. De
- Ectopic cervical thymus in children: Clinical and radiographic featuresObjectives Ectopic thymus is rare and can be a diagnostic challenge. This study evaluated the management of children radiographically diagnosed with ectopic cervical thymus. Methods A retrospective review of 100 patients was performed. Data related to clinical presentation, radiological imaging, pathology, and management were collected. Changes in lesion volume were tracked over time. Clinical characteristics were compared based on lesion
- Does new sensitization correlate with nasal symptoms in children with allergic rhinitis?Objectives To evaluate the correlation between the increased number of sensitized allergens and nasal symptoms in patients with allergic rhinitis who were sensitized to house dust mites (HDMs). Methods Among the patients who were enrolled in the Allergic Rhinitis Cohort Study for Kids, 174 children with rhinitis symptoms who were sensitized to HDMs were included in the analysis. Skin prick tests, serum total immunoglobulin E, eosinophil co
- Inclusion of the first cervical nerve does not influence outcomes in upper airway stimulation for treatment of obstructive sleep apneaObjectives/Hypothesis Upper airway stimulation (UAS) has demonstrated efficacy in the management of obstructive sleep apnea (OSA). Branches of the hypoglossal nerve that selectively activate tongue protrusor and stiffener muscles are included within the stimulation cuff electrode. The first cervical nerve (C1) is often also included to stimulate additional muscles contributing to tongue protrusion and stabilization. The purpose of this study was
- The natural phytochemical trans‐communic acid inhibits cellular senescence and pigmentation through FoxO3a activationAbstract Aging is characterized by the accumulation of chronic and irreversible oxidative damage, chronic inflammation, and organ dysfunction. To attenuate these aging‐related changes, various natural phytochemicals are often applied. Trans‐communic acid (TCA), an active component of brown pine leaf extract, has antimicrobial and cancer chemopreventive activity and inhibits ultraviolet B (UVB)‐induced MMP‐1 expression. To determine if the phytoc
- SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF‐κB pathway in Mycosis FungoidesAbstract Mycosis Fungoides (MF) is the most common subtype of cutaneous T‐cell lymphomas (CTCL). Shank‐associated RH domain‐interacting protein (SHARPIN) participates in the initiation and development of multiple tumors. However, the clinical significance of SHARPIN in MF hasn't been investigated. The c‐Jun N‐terminal kinases (JNKs) pathway is a member of mitogen‐activated protein kinases (MAPKs). Its dysregulation is observed in various tumors
- Comparative outcome of surgical and nonsurgical therapy for T4bN0M0 sinonasal squamous cell carcinomas.Related ArticlesComparative outcome of surgical and nonsurgical therapy for T4bN0M0 sinonasal squamous cell carcinomas. Eur Arch Otorhinolaryngol. 2019 Aug 26;: Authors: Li R, Tian S, Lin L, Liu Q, Wang S Abstract PURPOSE: Definitive radiotherapy (RT) is recommended by NCCN guidelines for T4b tumors of sinonasal squamous cell carcinomas (SNSCC). However, no multi-institutional clinical studies have p
- Long-term soft tissue outcomes for hydroxyapatite-coated bone-anchored hearing implant surgery.Related ArticlesLong-term soft tissue outcomes for hydroxyapatite-coated bone-anchored hearing implant surgery. Eur Arch Otorhinolaryngol. 2019 Aug 26;: Authors: Kanzara T, Walijee H, Badar Sheikh R, Lau A, Temple R Abstract PURPOSE: To investigate skin-related postoperative outcomes following a tissue preservation technique in percutaneous hydroxyapatite-coated bone-anchored hearing aid (BAHA) abutm
- Cardiac Rehabilitation for Patients With Lung or Esophageal Cancer Receiving Definitive Radiation TherapyConditions: Lung Cancer; Esophageal CancerIntervention: Procedure: Cardiac rehabilitationSponsor: Washington University School of MedicineNot yet recruiting
- Epstein-Barr Virus DNA to Systemic Therapy for Treatment Adaptation in Nasopharyngeal CarcinomaCondition: Nasopharyngeal CarcinomaInterventions: Drug: sintilimab; Drug: CapecitabineSponsors: Sun Yat-sen University; National Cancer Centre, Singapore; Wuzhou Red Cross HospitalNot yet recruiting
- A Study to Evaluate the Amount of Drug That Becomes Available to the Blood Circulation When Inhaled by a Nebulizer and Dry Powder Inhaler in Healthy Subjects.Condition: AsthmaIntervention: Drug: AZD7594Sponsors: AstraZeneca; ParexelNot yet recruiting
- Study of NGM120 in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination TherapyConditions: Pancreatic Cancer; Metastatic Castration-resistant Prostate Cancer; Bladder Cancer; Melanoma; Non-small Cell Lung Cancer; Colorectal Cancer; Gastric Cancer; Esophageal Cancer; Ovarian Cancer; Head Neck Squamous Cell CarcinomaInterventions: Biological: NGM120; Other: PlaceboSponsor: NGM Biopharmaceuticals, IncNot yet recruiting
- Sentinel Node in Larynx and Pharynx CancersConditions: Head and Neck Cancer; Lymph Node MetastasesIntervention: Procedure: Radioactive tracer injection via flexible endoscopy and SPECT scan for visualization of lymph nodes.Sponsor: Radboud UniversityNot yet recruiting
- Study to Find the Highest Dose of BAY2416964 That Participants Could Take Without Having Too Many Side Effects, How the Drug it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug and How Well the Drug Works in Patients With Advanced Solid Tumors.Condition: Advanced Solid TumorsIntervention: Drug: BAY2416964Sponsor: BayerNot yet recruiting
- Persistency of Thyroid Dysfunction from Early to Late PregnancyThyroid, Ahead of Print.
- Outcomes with non-sedated MRI for infants with sensorineural hearing lossPublication date: Available online 28 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Evette Ronner, Rochelle Reid, Razan A. Basonbul, Christen Caloway, Julie Arruda, Amy Fan-Yee Juliano, Michael S. Cohen
- Pediatric obstructive sleep apnea screening questionnaire and post-operative outcomes: A prospective observational studyPublication date: Available online 28 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Vidya T. Raman, Emily Geyer, Rebecca Miller, Dmitry Tumin, Mark Splaingard, Kris R. Jatana, Joseph D. TobiasAbstractIntroductionObstructive Sleep Apnea (OSA) and Sleep Disordered Breathing (SDB) in children tend to be a more complex and multifactorial disease than in adults. Although adult screening tools, such as the STOP-BA
- Lateral pharyngeal flap with a double pedicle for repair of unilateral velopharyngeal insufficiencyPublication date: Available online 28 August 2019Source: Auris Nasus LarynxAuthor(s): Shun-ichi Chitose, Kiminori Sato, Mioko Fukahori, Takashi Kurita, Kiminobu Sato, Fumihiko Sato, Hirohito UmenoAbstractObjectivesConventional pharyngeal flap surgery, which closes the median portion of the velopharynx, has been performed for dysarthria patients with velopharyngeal insufficiency (VPI). However, for VPI due to unilateral pharyngeal paralysis, medi
- 2019 European Thyroid Association Guidelines for the Treatment and Follow-Up of Advanced Radioiodine-Refractory Thyroid CancerThe vast majority of thyroid cancers of follicular origin (TC) have a very favourable outcome, but 5–10% of cases will develop metastatic disease. Around 60–70% of this subset, hence less than 5% of all patients with TC, will become radioiodine refractory (RAI-R), with a significant negative impact on prognosis and a mean life expectancy of 3–5 years. Since no European expert consensus or guidance for this challenging condition is currently avail
- Recurrent laryngeal nerve monitoring with surface electrodes in pediatric thyroid surgeryObjective To prospectively evaluate 1) use of endotracheal tube (ETT) surface electrodes for recurrent laryngeal nerve (RLN) monitoring in thyroid surgery in children, and 2) effects of thyroid surgery on the RLN in children. Methods Patients <18 years old undergoing thyroidectomy were included. Vocal cord mobility was assessed pre‐ and postoperatively. RLNs were monitored using adhesive or integrated electrodes. Recordings were made be
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