Allergy and Clinical Immunology,

RGS4 promotes allergen- and aspirin-associated airway hyper-responsiveness by inhibiting PGE2 biosynthesis

RGS4 promotes allergen-associated airways hyper-responsiveness by inhibiting production of prostaglandin E2 in lungs and thus may represent a novel therapeutic target in severe asthma.

Allergy and Clinical Immunology

8h

Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multi-site cohort

This study demonstrates heterogeneity of type 2 immunity in eosinophilic esophagitis independent of esophageal eosinophil levels. These data substantiate the presence of clinical endotypes and suggest heterogeneity of responses to anti-type 2 therapy.

Allergy and Clinical Immunology

8h

IL-5Rα marks nasal polyp IgG4 and IgE-expressing cells in aspirin-exacerbated respiratory disease

Capsule Summary: Our study identified a plasma cell population enriched in the nasal polyps of patients with aspirin-exacerbated respiratory disease, defined by transcript enrichment of IL5RA, IGHG4 and IGHE, surface expression of IL-5Rα, and a functional IL-5 signaling pathway.

Allergy and Clinical Immunology

8h

CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow.

Interferon regulatory factor 8-dependent, bone-marrow resident macrophages are distinct from classical bone-marrow derived macrophages, show regulatory functions during sterile inflammation and exhibit anti-microbial effects during staphylococcal infections via expression of the scavenger receptor CD163.

Allergy and Clinical Immunology

8h

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