Abstract Bleeding canker of horse chestnut trees is a bacterial disease, caused by the bacterium Pseudomonas syringae pv. aesculi, estimated to be present in ~ 50% of UK horse chestnut trees. Currently, the disease has no cure and tree removal can be a common method of reducing inoculum and preventing spread. One potential method of control could be achieved using naturally occurring bacteriophages infective to the causative bacterium. Bacteriophages were isolated from symptomatic...
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Abstract The positive effects of mild stress on ageing, lifespan and resistance to stress have been studied mainly in Drosophila melanogaster flies and in the nematode Caenorhabditis elegans. These studies now allow to know the effects of the strength of the mild stress and of the number of exposures, the duration of the positive effects, if mild stress is effective when applied at any age, and whether combining two or three mild stresses is more efficient than a single one. This...
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Abstract Human HSP27 is a small heat shock protein that modulates the ability of cells to respond to heat shock and oxidative stress, and also functions as a chaperone independent of ATP, participating in the proteasomal degradation of proteins. The expression of HSP27 is associated with survival in mammalian cells. In cancer cells, it confers resistance to chemotherapy; in neurons, HSP27 has a positive effect on neuronal viability in models of Alzheimerʼs and Parkinsonʼs diseases....
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As many of you may know, a unique four-society collaborative group was founded in 2018 to discuss the perspectives of the various specialists involved in treating patients with thyroid cancer. The societies engaging in this collaboration are the European Thyroid Association (ETA), the European Association for Nuclear Medicine (EANM), the Society of Nuclear and Molecular Imaging (SNMMI) and the American Thyroid Association (ATA), with moderator Laszlo Hegedüs at the helm. The inception of this group...
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Transitional B cells (TrB cells) represent a crucial link between immature B cells in the bone marrow and mature peripheral B cells. Although TrB cells represent one of the regulatory B cell subpopulations in ...
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Kidney stone disease (KSD) is more common in individuals with hypertension (HTN) than in individuals with normotension (NTN). Urinary dysbiosis is associated with urinary tract disease and systemic diseases. H...
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What it’s like in New Rochelle, New York, the site of the state’s biggest coronavirus outbreak -- Read more on ScientificAmerican.com
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Scientists, engineers and health professionals can bring our collective knowledge to bear on this challenge and change the trajectory of the response -- Read more on ScientificAmerican.com
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In the 20th century’s middle decades, the first recipient of phalloplasty surgery fought to be recognized as a man -- Read more on ScientificAmerican.com
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by Marcel Hohl, Aditya Mojumdar, Sarem Hailemariam, Vitaly Kuryavyi, Fiorella Ghisays, Kyle Sorenson, Matthew Chang, Barry S. Taylor, Dinshaw J. Patel, Peter M. Burgers, Jennifer A. Cobb, John H. J. Petrini The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor suppression. Components of the Mre11 complex...
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by Jose F. Victorino, Melanie J. Fox, Whitney R. Smith-Kinnaman, Sarah A. Peck Justice, Katlyn H. Burriss, Asha K. Boyd, Megan A. Zimmerly, Rachel R. Chan, Gerald O. Hunter, Yunlong Liu, Amber L. Mosley RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate serine 5 phosphorylation on the CTD; however, its role in the regulation of RNAPII termination has not been explored....
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by Nino A. Espinas, Le Ngoc Tu, Leonardo Furci, Yasuka Shimajiri, Yoshiko Harukawa, Saori Miura, Shohei Takuno, Hidetoshi Saze Intronic regions of eukaryotic genomes accumulate many Transposable Elements (TEs). Intronic TEs often trigger the formation of transcriptionally repressive heterochromatin, even within transcription-permissive chromatin environments. Although TE-bearing introns are widely observed in eukaryotic genomes, their epigenetic states, impacts on gene regulation and function,...
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In the Abstracts of the 2019 Critical Care Canada Forum, listed under the March 2020 contents of the Canadian Journal of Anesthesia, published online only, DOI: 10.1007/s12630-019-01552-z.
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Abstract Unveiling the key pathways underlying postnatal beta-cell proliferation can be instrumental to decipher the mechanisms of beta-cell mass plasticity to increased physiological demand of insulin during weight gain and pregnancy. Using transcriptome and global Serine Threonine Kinase activity (STK) analyses of islets from newborn (10 days old) and adult rats, we found that highly proliferative neonatal rat islet cells display a substantially elevated activity of the mitogen...
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To translate, culturally adapt and conduct a psychometric evaluation of the Yoruba version of the Back Beliefs Questionnaire (BBQ) among patients with chronic low-back pain.
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Literature has paid little attention in describing the specific contribution of each modifiable and non-modifiable characteristics on health-related quality of life (HRQoL) in physician-managed anticoagulated ...
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Cancer of the cervix is the most frequent cancer among women in Ethiopia. The disease burden and its treatment adversely affects patients’ health-related quality of life (HRQoL). We aimed to investigate the HR...
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by Kyousuke Kobayashi, Katsumi Mizuta, Satoshi Koike Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease (HFMD). However, this infection is sometimes associated with severe neurological complications. Identification of neurovirulence determinants is important to understand the pathogenesis of EV71. One of the problems in evaluating EV71 virulence is that its genome sequence changes rapidly during replication in cultured cells. The factors that induce rapid mutations in...
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Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems
by Juanjuan Wang, Jing-Wen Li, Jing Li, Yijia Huang, Shaomeng Wang, Jing-Ren Zhang Streptococcus pneumoniae is well known for phase variation between opaque (O) and transparent (T) colonies within clonal populations. While the O variant is specialized in invasive infection (with a thicker capsule and higher resistance to host clearance), the T counterpart possesses a relatively thinner capsule and thereby higher airway adherence and colonization. Our previous study found that phase variation...
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by Xin Wu, Amelia R. I. Lindsey, Paramita Chatterjee, John H. Werren, Richard Stouthamer, Soojin V. Yi Wolbachia are maternally transmitted intracellular bacteria that induce a range of pathogenic and fitness-altering effects on insect and nematode hosts. In parasitoid wasps of the genus Trichogramma, Wolbachia infection induces asexual production of females, thus increasing transmission of Wolbachia. It has been hypothesized that Wolbachia infection accompanies a modification of the host epigenome....
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by Wenbiao Wang, Dingwen Hu, Caifeng Wu, Yuqian Feng, Aixin Li, Weiyong Liu, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Muhammad Adnan Shereen, Weijie Chen, Pan Pan, Pin Wan, Kailang Wu, Jianguo Wu One of the fundamental reactions of the innate immune responses to pathogen infection is the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 inflammasome. The stimulator of interferon genes (STING) has the essential roles in innate immune response against...
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Information for our customers, suppliers and contractors
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Extranodal natural killer/T cell lymphoma, nasal type, is one of the more common subtypes of mature T cell lymphoma, especially in the Far East Asian population. This aggressive histologic subtype of periphera...
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In the publication of this article [1], there is an error in the name of one of the contributing authors.
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Abstract Background Competition has been shown to improve motivation and physical performance in young people. This method has been rarely studied in older people. Aims To evaluate the feasibility of senior physical activity (PA) contests between two nursing homes and to assess changes in the motivational level and physical performance of the residents over...
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Oral immunotherapy (OIT) is an emerging approach to the treatment of patients with IgE-mediated food allergy and is in the process of transitioning to clinical practice.
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Zusammenfassung Hintergrund Die Echinokokkosen sind in Deutschland seltene Parasitosen, für die die Weltgesundheitsorganisation stadiengerechte Behandlungsstrategien empfiehlt. Ziel der Arbeit Das Ziel der Arbeit war die Analyse der Behandlungsergebnisse von Patienten mit hepatischer Echinokokkose an einem Exzellenzzentrum für Leberchirurgie. ...
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Publication date: Available online 18 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Pucci, A. Weyh, C. Smotherman, V. Valentini, A. Bunnell, R. Fernandes
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The Miami Cancer Institute is one of the leading organizations in diversity amongst its clinical trials, and chief research officer Scott Lipkin, DPM, CIP, spoke on the present and future of diversity within the organization. (Source: CancerNetwork)
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The peer-reviewed article provides insights and advice on how to continue providing proper cancer care during the novel coronavirus pandemic. (Source: CancerNetwork)
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The study authors found that not only did some professionals view racial and ethnic minorities as less promising study participants, some respondents also reported withholding trial opportunities from minorities based on these perceptions. (Source: CancerNetwork)
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Though the combination of bevacizumab and trebananib was found to be well tolerated, it did not significantly improve survival outcomes for patients with recurrent glioblastoma over bevacizumab alone. (Source: CancerNetwork)
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This study assessed whether the accumulative, static, or dynamic method was best suited for determining the familial risk of breast cancer. (Source: CancerNetwork)
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