Abstract Mesenchymal stem cells are a highly promising source of cells for regeneration therapy because of their multilineage differentiation potential. However, distinct markers for mesenchymal stem cells are not well-established. To identify new candidate marker genes for multipotent human dental pulp stem cells, we analyzed the characteristics and gene expression profiles of cell clones obtained from a single dental pulp specimen derived from an 11-year-old female patient. Fifty...
9h
Abstract Dysfunctional variants of ATP-binding cassette transporter subfamily G member 2 (ABCG2), a urate transporter in the kidney and intestine, are the major causes of hyperuricemia and gout. A recent study found that ABCG2 is a major transporter of uremic toxins; however, few studies have investigated the relationship between ABCG2 gene polymorphisms and mortality. This prospective cohort study of 1214 hemodialysis patients investigated the association between serum uric acid...
14h
Abstract Kasumi-1 has played an important role in an experimental model with t(8;21) translocation, which is a representative example of leukemia cell lines. However, previous studies using Kasumi-1 show discrepancies in the genome profile. The wide use of leukemia cell lines is limited to lines that are well-characterized. The use of additional cell lines extends research to various types of leukemia, and to further explore leukemia pathogenesis, which can be achieved by uncovering...
18h
Journal of Interferon &Cytokine Research, Ahead of Print.
10h
Journal of Interferon &Cytokine Research, Ahead of Print.
10h
Abstract Background The CD-TK double suicide gene has become an effective therapy for bladder cancer. A novel molecular-targeted ultrasound (US) method has been developed to precisely guide nanobubbles loaded with this gene to regions within bladder tumor cells and is widely used due to its efficiency in delivering drugs to the target tumor. Methods Uniform...
11h
To evaluate the sensitivity and specificity of the Allplex™ Entero-DR, a quantitative PCR-based method, for the detection of β-lactamase-encoding genes and vancomycin-resistance determinants in 156 previously ...
11h
The aim of our research was to evaluate the relationship involving left ventricular ejection fraction, low density lipoprotein, B-type natriuretic peptide, Troponin I and coronary flow reserve, and to determin...
11h
After the large-scale earthquake in 2011, the disaster medical assistance team (DMAT) was made responsible for medical activities during the hyperacute phase of a disaster or accident in Japan. The medicines t...
11h
To evaluate the expression of a set of miRNAs to identify differentially expressed miRNAs that might be considered reliable biomarkers on Diabetic Retinopathy (DR) blood samples.
11h
According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the developmen...
11h
Abstract Introduction This study aimed to evaluate the effect of treatment with eye drops containing citicoline and vitamin B12 on changes in function of the inner retina, morphology of the inner and outer retina, and microvascular condition in patients with type 1 diabetes (DM1) with mild signs of non-proliferative diabetic retinopathy (NPDR) during 3 years of follow-up. ...
11h
by Daniel C. Wu, David Zamorano-Sánchez, Fernando A. Pagliai, Jin Hwan Park, Kyle A. Floyd, Calvin K. Lee, Giordan Kitts, Christopher B. Rose, Eric M. Bilotta, Gerard C. L. Wong, Fitnat H. Yildiz The assembly status of the V. cholerae flagellum regulates biofilm formation, suggesting that the bacterium senses a lack of movement to commit to a sessile lifestyle. Motility and biofilm formation are inversely regulated by the second messenger molecule cyclic dimeric guanosine monophosphate (c-di-GMP)....
12h
by Pierre Coste de Bagneaux, Leonie von Elsner, Tatjana Bierhals, Marta Campiglio, Jessika Johannsen, Gerald J. Obermair, Maja Hempel, Bernhard E. Flucher, Kerstin Kutsche P/Q-type channels are the principal presynaptic calcium channels in brain functioning in neurotransmitter release. They are composed of the pore-forming CaV2.1 α1 subunit and the auxiliary α2δ-2 and β4 subunits. β4 is encoded by CACNB4, and its multiple splice variants serve isoform-specific functions as channel subunits and...
12h
by Alberto Pérez-Posada, Omaya Dudin, Eduard Ocaña-Pallarès, Iñaki Ruiz-Trillo, Andrej Ondracka Progression through the cell cycle in eukaryotes is regulated on multiple levels. The main driver of the cell cycle progression is the periodic activity of cyclin-dependent kinase (CDK) complexes. In parallel, transcription during the cell cycle is regulated by a transcriptional program that ensures the just-in-time gene expression. Many core cell cycle regulators are widely conserved in eukaryotes,...
12h
by Heinrich Schäfer, Bertrand Beckert, Christian K. Frese, Wieland Steinchen, Aaron M. Nuss, Michael Beckstette, Ingo Hantke, Kristina Driller, Petra Sudzinová, Libor Krásný, Volkhard Kaever, Petra Dersch, Gert Bange, Daniel N. Wilson, Kürşad Turgay Bacillus subtilis cells are well suited to study how bacteria sense and adapt to proteotoxic stress such as heat, since temperature fluctuations are a major challenge to soil-dwelling bacteria. Here, we show that the alarmones (p)ppGpp, well known...
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A junior doctor has called on her colleagues to gather supplies that will help healthcare professionals working long hours during the covid-19 outbreak.Josie Cheetham, chair of the BMA’s Junior...
12h
“Patient 1” can breathe on his own after more than two weeks in intensive care for severe pneumonia. The 38 year old marathon runner, admitted to hospital on 21 February 2020, is believed to be the...
12h
A junior doctor has called on her colleagues to gather supplies that will help healthcare professionals working long hours during the covid-19 outbreak.Josie Cheetham, chair of the BMA’s Junior...
13h
“Patient 1” can breathe on his own after more than two weeks in intensive care for severe pneumonia. The 38 year old marathon runner, admitted to hospital on 21 February 2020, is believed to be the...
13h
The covid-19 outbreak is expected to last around one year (until spring 2021), with around 80% of the population infected and up to 15% of people (7.9 million) requiring hospitalisation in the UK, a...
14h
GP leaders have rejected the primary care networks directed enhanced service (DES) that was agreed as part of the 2020-21 GP contract in England.Delegates at a special conference of local medical...
14h
The covid-19 outbreak is expected to last around one year (until spring 2021), with around 80% of the population infected and up to 15% of people (7.9 million) requiring hospitalisation in the UK, a...
15h
GP leaders have rejected the primary care networks directed enhanced service (DES) that was agreed as part of the 2020-21 GP contract in England.Delegates at a special conference of local medical...
16h
Doctors are more uncertain when it comes to diagnosing emotional problems and depression in ethnic minority patients, a new report has suggested.Although the Race Equality Foundation found no...
18h
What you need to knowMobile messaging has the potential to support clinical practice and should be offered as an optional serviceBefore engaging in mobile messaging with your patients, develop a...
18h
“Get all the facts”Gabrielle Pendlebury, medicolegal consultant at Medical Protection, says, “To err is human. This can be uncomfortable to acknowledge within healthcare as errors, whether individual...
18h
Healthcare relies on a variety of regulatory activities to manage risks to the public and to drive improvement. But the regulation of patient safety in healthcare, and in the NHS in particular, is...
18h
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