With conventional antibiotic therapies being increasingly ineffective, bacterial infections with subsequent biofilm formation represent a global threat to human health. Here, an active and a passive strategy based on polymeric micelles were combined to fight bacterial growth. The passive strategy involved covalent immobilization of polymeric micelles through Michael addition between exposed maleimide and thiol functionalized surfaces. Compared to the bare surface, micelle-decorated surfaces showed...
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A new series of mono- and polytopic 4`-arylamino-2,2`:6`,2``-terpyridines has been prepared by the reaction of 4`-chloro-2,2`:6`,2``-terpyridine with arylamines. Representative coordination chemistry of these new ligands is preserted.
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Vesicle-templated nanocontainers prepared from ABA triblock copolymers possess great potential for applications in areas such as drug delivery or pharmacology. For example, PMOXA-PDMS-PMOXA copolymers self-aggregate in water to form vesicles in a size range from 50 nm up to 100 μm. Intravesicular crosslinking of polymerizable end groups transforms the vesicles into solid-like nanocontainers. The permeability of these nanocontainers can be controlled either by attachment of stimuli-responsive groups...
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Over the years, polymers have attracted a great deal of interest because they offer a unique platform for the development of materials in fields as diverse as biomedicine and packaging. Many of these purposes use polymers that had been developed for totally different applications. Recently, however, chemical tailoring and molecular and supramolecular control of the chemistry and, thus, the physical and biological response have become a key interest of many researchers. In particular, systems that...
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Asymmetric molecules and materials provide an important basis for the organization and function of biological systems. It is well known that, for example, the inner and outer leaflets of biological membranes are strictly asymmetric with respect to lipid composition and distribution. This plays a crucial role for many membrane-related processes like carrier-mediated transport or insertion and orientation of integral membrane proteins. Most artificial membrane systems are, however, symmetric with respect...
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Blockcopolymere können zu membranartigen Überstrukturen aggregieren und dabei ultradünne Filme und nanometergroße Micellen bilden. Chemisch auf vielfältige Weise modifizierbar, ermöglichen die Polymerbausteine Architekturen und Funktionen, die mit konventionellen Lipiden nicht zu erreichen sind. Die Polymermembranen nehmen Kanalproteine auf, und solche Hybridsysteme sind in der Lage, kontrolliert auf biologische Reize zu reagieren.
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Here we present three different types of mechanically stable nanometer-sized hollow capsules. The common point of the currently developed systems in our laboratory is that they are liposome based. Biomolecules can be used to functionalize lipid vesicles to create a new type of intelligent material. For example, insertion of membrane channels into the capsule wall can modify the permeability. Covalent binding of antibodies allows targeting of the capsule to specific sites. Liposomes loaded with enzymes...
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Triblock copolymeric nanoreactors are introduced as an alternative for liposomes as encapsulating carrier for prodrug activating enzymes. Inosine−adenosine−guanosine preferring nucleoside hydrolase of Trypanosoma vivax, a potential prodrug activating enzyme, was encapsulated in nanometer-sized vesicles constructed of poly(2-methyloxazoline)-block-poly(dimethylsiloxane)-block-(2-methyloxazoline) triblock copolymers. The nanoreactor is functionalized by incorporation of bacterial porins, OmpF or Tsx,...
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To develop an intelligent sensorâˆ'effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4âˆ'6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted...
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Nanotechnology promises new avenues to medical diagnosis and treatment. Of special interest are injectable nanovehicles that are programmable towards specific targets, are able to evade the immune defense, and are versatile enough to be suited as carriers of complex functionality. Biotin-functionalized (poly(2-methyloxazoline)–b-poly(dimethylsiloxane)–b-poly(2-methyloxazoline) triblock copolymers were self-assembled to form nanocontainers, and biotinylated targeting ligands were attached by using...
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A review dedicated to block copolymer self assembly. We discuss general progress in physicochemical interpretations and provide insight to recent developments in (hybrid) materials.
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We report the design and application of a prism-based detection system for fluorescence (cross) correlation spectroscopy. The system utilizes a single laser wavelength for the simultaneous excitation of several dyes of different emission spectra. Fluorescence light is spectrally separated with a prismatic setup, and wavelengths are selected by scanning a fiber-coupled avalanche photodiode across the image spots. Multicolor autocorrelations are demonstrated with standard and tandem dyes, and fluorescence...
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A nanocompartment system based on two deletion mutants of the large channel protein FhuA (FhuA Delta 1-129; FhuA Delta 1-160) and an ABA triblock copolymer (PMOXA-PDMS-PMOXA) has been developed for putative biotechnological applications. FhuA is ideally suited for applications in biotechnology due to its monomeric structure, large pore diameter (39-46 angstrom elliptical cross-section) that ensures rapid compound flux, and solved crystallographic structure. Two areas of application were targeted...
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Edición y publicación de la obra teatral La Estatua escrita por Raúl Ruiz en 1960
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Over the last decades, C(sp3)-H activation has emerged as a powerful tool for building structural complexity in a step-economical manner. In this context, our group developed diverse methodologies and applied them to the synthesis of natural products, bioactive molecules and valuable building blocks. More recently, our group was attracted, as others, by the development of asymmetric versions of such reactions. In this regard, the synthesis of enantioenriched indanes through asymmetric palladium-catalyzed...
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Dysregulation of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) form the basis of immune-mediated inflammatory diseases. Vitex trifolia L. is a medicinal plant growi...
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Parents often choose Complementary and Alternative Medicine (CAM) as a supportive agent with the aim to reduce cancer treatment-related symptoms in their children. Therefore, it is necessary to understand pare...
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Viruses, Vol. 12, Pages 331: Phylogenetic and Demographic Characterization of Directed HIV-1 Transmission Using Deep Sequences from High-Risk and General Population Cohorts/Groups in Uganda Viruses doi: 10.3390/v12030331 Authors: Nicholas Bbosa Deogratius Ssemwanga Alfred Ssekagiri Xiaoyue Xi Yunia Mayanja Ubaldo Bahemuka Janet Seeley Deenan Pillay Lucie Abeler-Dörner Tanya Golubchik Christophe Fraser Pontiano Kaleebu Oliver Ratmann ...
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Viruses, Vol. 12, Pages 330: CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA Viruses doi: 10.3390/v12030330 Authors: Caroline S. Binda Bep Klaver Ben Berkhout Atze T. Das Although several studies demonstrated that the HIV proviral DNA can be effectively targeted and inactivated by the CRISPR-Cas9 system, the precise inactivation mechanism has not yet been analyzed. Whereas some studies suggested efficient proviral DNA excision...
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Viruses, Vol. 12, Pages 329: Pervasive Differential Splicing in Marek’s Disease Virus can Discriminate CVI-988 Vaccine Strain from RB-1B Very Virulent Strain in Chicken Embryonic Fibroblasts Viruses doi: 10.3390/v12030329 Authors: Yashar Sadigh Abdessamad Tahiri-Alaoui Stephen Spatz Venugopal Nair Paolo Ribeca Marek’s disease is a major scourge challenging poultry health worldwide. It is caused by the highly contagious Marek’s disease virus (MDV),...
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Viruses, Vol. 12, Pages 328: PERK-Mediated Unfolded Protein Response Signaling Restricts Replication of the Tick-Borne Flavivirus Langat Virus Viruses doi: 10.3390/v12030328 Authors: Tyler G. Lewy Danielle K. Offerdahl Jeffrey M. Grabowski Eliza Kellman Luwanika Mlera Abhilash Chiramel Marshall E. Bloom The unfolded protein response (UPR) maintains protein-folding homeostasis in the endoplasmic reticulum (ER) and has been implicated as both beneficial and...
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Pathogens, Vol. 9, Pages 226: Recent Advances in Diagnostic Approaches for Epstein–Barr Virus Pathogens doi: 10.3390/pathogens9030226 Authors: AbuSalah Gan Al-Hatamleh Irekeola Shueb Yean Epstein–Barr virus (EBV) is the causative agent of many diseases including infectious mononucleosis (IM), and it is associated with different subtypes of lymphoma, sarcoma and carcinoma such as Hodgkin's lymphoma, non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and gastric...
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Pathogens, Vol. 9, Pages 225: Complex Cell Type-Specific Roles of Autophagy in Liver Fibrosis and Cirrhosis Pathogens doi: 10.3390/pathogens9030225 Authors: Hung Hsiao Lin Lee The lysosomal degradation pathway, or autophagy, plays a fundamental role in cellular, tissue, and organismal homeostasis. A correlation between dysregulated autophagy and liver fibrosis (including end-stage disease, cirrhosis) is well-established. However, both the up and downregulation of autophagy...
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Pathogens, Vol. 9, Pages 224: High Human Papillomavirus DNA loads in Inflammatory Middle Ear Diseases Pathogens doi: 10.3390/pathogens9030224 Authors: Nicola Malagutti John Charles Rotondo Luca Cerritelli Claudio Melchiorri Monica De Mattei Rita Selvatici Lucia Oton-Gonzalez Francesco Stomeo Manuela Mazzoli Michela Borin Beatrice Mores Andrea Ciorba Mauro Tognon Stefano Pelucchi Fernanda Martini Background. Previous studies reported human papillomaviruses...
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Pathogens, Vol. 9, Pages 223: Molecular Diagnostics and Pathogenesis of Fungal Pathogens on Bast Fiber Crops Pathogens doi: 10.3390/pathogens9030223 Authors: Yi Cheng Xiaoyu Tang Chunsheng Gao Zhimin Li Jia Chen Litao Guo Tuhong Wang Jianping Xu Bast fibers and products derived from them are undergoing a resurgence in demand in the global market. However, fungal diseases have become an important factor limiting their yield and quality, causing devastating consequences...
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ObjectivesPneumoconiosis remains a major global occupational health hazard and illness. Accurate data on the incidence of pneumoconiosis are critical for health resource planning and development of health policy.MethodsWe collected data for the period between 1990 and 2017 on the annual incident cases and the age-standardised incidence rates (ASIR) of pneumoconiosis aetiology from the Global Burden of Disease Study 2017. We calculated the average annual percentage changes of ASIR by sex, region and...
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ObjectivesTo determine the associations of lifestyle factors and cumulative physical workload exposures with sickness absence (SA) due to a shoulder lesion and to calculate their population attributable fractions (PAF).MethodsOur nationally representative cohort consisted of 4344 individuals aged 30–62 years who participated in the Finnish Health 2000 Survey. Education, smoking, chronic diseases and work exposures were assessed during interviews and leisure time physical activity with a questionnaire....
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BackgroundTo guide fall prevention efforts, United States organisations, such as the Joint Commission and the Agency for Healthcare Research and Quality, have recommended organisational-level implementation strategies: leadership support, interdisciplinary falls committees, electronic health record tools, and staff, family and patient education. It is unclear whether hospitals adhere to such strategies or how these strategies are operationalised.ObjectiveTo identify and describe the prevalence of...
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Patients who read their clinical notes via online patient portals (‘open notes’) report that doing so engages them actively in their care, improves their sense of control over their health and enhances safety.1–3 In several surveys, patients who are older, less educated, non-white or whose first language is not English report even greater benefits than do their counterparts.2–4 However, for many reasons, persons from these demographic groups are less likely to use health portals than other patient...
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