Publication date: Available online 15 March 2020Source: BiochimieAuthor(s): Varlamova Elena Gennadyevna
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On the first page, third paragraph of the introduction, the second sentence should have a typographical correction to state -.
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Abstract Purpose There is an increasing agreement that acromegaly caused by growth hormone (GH) cell adenoma has two distinct subtypes: densely granulated (DG) and sparsely granulated (SG). We hypothesized that differential molecular signatures may explain their behavior. Methods Total transcriptome sequencing was performed on ten DG and seven SG adenomas....
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Abstract Purpose Peroxisome proliferator-activated receptor γ (PPARγ) gene is strongly associated with type 2 diabetes mellitus, as well as postprandial lipemia, and plays an important role in Wnt dependent adipogenesis in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). We aimed to study the expression of PPARγ gene in SAT and VAT to find out its correlation with postprandial hypertriglyceredemia and glucose intolerance....
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Health care providers need a well-organized response grounded in science and ethics as the U.S. responds to the pandemic -- Read more on ScientificAmerican.com
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Blending philosophy and neuroscience in unraveling the mysteries of free will. -- Read more on ScientificAmerican.com
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Online harassment of scientists and health professionals is a serious and growing problem -- Read more on ScientificAmerican.com
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A narrow focus on the latest hot topic can be rewarding—but it’s not necessarily a good long-term strategy -- Read more on ScientificAmerican.com
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Abstract Novel duck reovirus (NDRV), the prototype strain of the species Avian orthoreovirus (ARV), is associated with high mortality in Pekin ducklings. σC is an outer capsid protein encoded by the S1 genome segment of NDRV which mediates attachment to host cells. Our previous studies using immunoprecipitation and mass spectrometry found that σC coprecipitated with some host proteins including Translocation-associated membrane protein 1 (TRAM1). However, the interaction between...
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by Yuyan Wang, Shujuan Du, Caixia Zhu, Chong Wang, Nuoya Yu, Ziqi Lin, Jin Gan, Yi Guo, Xinxin Huang, Yuping He, Erle Robertson, Di Qu, Fang Wei, Qiliang Cai Latent Epstein-Barr virus (EBV) infection is strongly associated with several malignancies, including B-cell lymphomas and epithelial tumors. EBNA1 is a key antigen expressed in all EBV-associated tumors during latency that is required for maintenance of the EBV episome DNA and the regulation of viral gene transcription. However, the mechanism...
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by Biao Zhou, Xiangkai Zhen, Huan Zhou, Feiyang Zhao, Chenpeng Fan, Vanja Perčulija, Yigang Tong, Zhiqiang Mi, Songying Ouyang Using bacteriophage-derived endolysins as an alternative strategy for fighting drug-resistant bacteria has recently been garnering renewed interest. However, their application is still hindered by their narrow spectra of activity. In our previous work, we demonstrated that the endolysin LysIME-EF1 possesses efficient bactericidal activity against multiple strains of...
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by Yuan-Bao Li, Rui Xu, Chengyu Liu, Ningning Shen, Li-Bo Han, Dingzhong Tang Magnaporthe oryzae causes rice blast disease, but little is known about the dynamic restructuring of the actin cytoskeleton during its polarized tip growth and pathogenesis. Here, we used super-resolution live-cell imaging to investigate the dynamic organization of the actin cytoskeleton in M. oryzae during hyphal tip growth and pathogenesis. We observed a dense actin network at the apical region of the hyphae and...
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by Françoise Myster, Mei-Jiao Gong, Justine Javaux, Nicolás M. Suárez, Gavin S. Wilkie, Tim Connelley, Alain Vanderplasschen, Andrew J. Davison, Benjamin G. Dewals Alcelaphine herpesvirus 1 (AlHV-1) is a gammaherpesvirus that is carried asymptomatically by wildebeest. Upon cross-species transmission to other ruminants, including domestic cattle, AlHV-1 induces malignant catarrhal fever (MCF), which is a fatal lymphoproliferative disease resulting from proliferation and uncontrolled activation...
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by Weili Kong, Ayan Biswas, Dawei Zhou, Guillaume Fiches, Koh Fujinaga, Netty Santoso, Jian Zhu Recent efforts have been paid to identify previously unrecognized HIV-1 latency-promoting genes (LPGs) that can potentially be targeted for eradication of HIV-1 latent reservoirs. From our earlier orthologous RNAi screens of host factors regulating HIV-1 replication, we identified that the nucleolar protein NOP2/NSUN1, a m5C RNA methyltransferase (MTase), is an HIV-1 restriction factor. Loss- and...
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by Fengming Huang, Cong Zhang, Qiang Liu, Yan Zhao, Yuqing Zhang, Yuhao Qin, Xiao Li, Chang Li, Congzhao Zhou, Ningyi Jin, Chengyu Jiang Infection with avian influenza A H5N1 virus results in acute lung injury (ALI) and has a high mortality rate (52.79%) because there are limited therapies available for treatment. Drug repositioning is an economical approach to drug discovery. We developed a method for drug repositioning based on high-throughput RNA sequencing and identified several drugs as...
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Genes, Vol. 11, Pages 317: Genes, Pathways, and Mechanisms Involved in the Virulence of Mucorales Genes doi: 10.3390/genes11030317 Authors: Lax Pérez-Arques Navarro-Mendoza Cánovas-Márquez Tahiri Pérez-Ruiz Osorio-Concepción Murcia-Flores Navarro Garre Nicolás The order Mucorales is a group of ancient fungi with limited tools for gene manipulation. The main consequence of this manipulation unwillingness is the limited knowledge about its biology...
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Genes, Vol. 11, Pages 316: A Gene-Set Enrichment and Protein–Protein Interaction Network-Based GWAS with Regulatory SNPs Identifies Candidate Genes and Pathways Associated with Carcass Traits in Hanwoo Cattle Genes doi: 10.3390/genes11030316 Authors: Krishnamoorthy Srikanth Seung-Hwan Lee Ki-Yong Chung Jong-Eun Park Gul-Won Jang Mi-Rim Park Na Yeon Kim Tae-Hun Kim Han-Ha Chai Won Cheoul Park Dajeong Lim Non-synonymous SNPs and protein coding SNPs within...
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Genes, Vol. 11, Pages 315: Grape-RNA: A Database for the Collection, Evaluation, Treatment, and Data Sharing of Grape RNA-Seq Datasets Genes doi: 10.3390/genes11030315 Authors: Yi Wang Rui Zhang Zhenchang Liang Shaohua Li Since its inception, RNA sequencing (RNA-seq) has become the most effective way to study gene expression. After more than a decade of development, numerous RNA-seq datasets have been created, and the full utilization of these datasets has emerged as a major...
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Am 21. September 2018 hat das Bundesgericht einen zweiten Leitentscheid zum neuen Kindesunterhaltsrecht gefällt und gleichzeitig weitere konkretisierende Entscheide in Aussicht gestellt. Der neue Entscheid zeigt auf, in welche Richtung das Bundesgericht zu gehen gedenkt, weshalb vorliegend eine kritische Auseinandersetzung mit den zentralen Erwägungen aus Sicht des Praktikers erfolgen soll.
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The publication of Nan Z. Da's study in Critical Inquiry has triggered a debate about the methodological and conceptual dimensions of digitally assisted inquiry in literary studies. Nan Z. Da's fundamental critique of what she calls "Computational Literary Studies" addresses the work of the international Special Interest Group "Digital Literary Stylistics" (SIG - DLS) of the Alliance of Digital Humanities Organizations (ADHO). Thus we — the five scholars forming the SIG's current steering committee...
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Aux xviie et xviiie siècles, les extraits constituent le type d’article privilégié de nombreux périodiques qui, sur le modèle du Journal des savants, rendent compte des livres parus dans les différents domaines des lettres. En étudiant la manière dont les journalistes francophones définissent l’extrait et ses principales fonctions dans l’espace médiatique, nous verrons que ce genre est au centre d’un faisceau de tensions qui mobilisent une éthique de la lecture et une déontologie journalistique en...
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The Oltener Aktionskomitee was elected in February 1918 by the committee of the Swiss Federation of Trade Unions (Schweizerischer Gewerkschaftsbund, SGB), the executive board of the Social Democratic Party of Switzerland (SPS), the social democratic faction of the national council, and representatives of the social democratic press. It made repeated demands in spring and summer 1918, mainly on food supply, and acted as national leadership during the general strike in November 1918.
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Anti-war socialists from ten countries met in Zimmerwald in September 1915. They adopted a manifesto and founded the International Socialist Commission (ISC), with its headquarters in Bern. A subsequent conference in Kiental in April 1916 criticised supporters of the war even more strongly. When the ISC was relocated to Stockholm in 1917 – closer to the revolutionary movement in the Russian Empire – it had already lost its importance.
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From 12 to 14 November 1918, a national general strike took place in Switzerland, in which around 250,000 strikers participated. The strike largely ran an orderly course and was terminated by the national strike leadership after three days, under the threat of a military operation.
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This paper introduces the terminology as well as key concepts relevant to the understanding of what is referred to as 'conflict prevention'. After an overview of the evolution of the concept on the international policy level, concrete examples illustrate some efforts that are used to prevent violent conflicts in different geographical contexts, stages of conflict and levels of society. The methods introduced are early warning and early response, local peace committees, women situation rooms and infrastructures...
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The boost of available digital media has led to asignificant increase in derivative work. With tools for manipulating objects becoming more and more mature, it can bevery difficult to determine whether one piece of media was derived from another one or tampered with. As derivations can be done with malicious intent, there is an urgent need for reliable and easily usable tampering detection methods. However, even media considered semantically untampered by humans might have already undergone compression...
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This paper presents an after-the-fact summary of the participation of the vitrivr system to the 2018 Video Browser Showdown. A particular focus is on additions made since the original publication and the systems performance during the competition.
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Im Vogelflug passiert der Zuschauer die geöffneten Newa-Brücken von St. Petersburg, den Dom von Kaliningrad, den Mamai-Hügel in Wolgograd und den Kaukasus bei Sotschi, ehe eine Dampflok durch die verschneiten russischen Weiten in die Hauptstadt Moskau fährt und dort von den Türmen des Kreml, der Christ-Erlöser-Kathedrale und dem ehrwürdigen Bolschoi-Theater empfangen wird. Auf diese Kurzreise zu den wichtigen symbolischen Orten des Gastgeberlandes wurden die Zuschauer der Fußball-WM 2018 vor jeder...
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Weimarer Verhältnisse? Die frühe Neuzeit ähnelt unserer viel eher. Wutprediger zogen umher und die Menschen entdeckten, dass ein "Volk" gegen die "Eliten" stehen könnte.
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"Game of Thrones" ist die beliebteste Serie des sogenannten postfaktischen Zeitalters. Kein Zufall, denn "GoT" greift Ressentiments auf, die auch AfD und Donald Trump gegenüber dem politischen System befeuern.
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Impact investing is increasingly becoming an omnipresent topic. Anglo-American practices are spilling over into continental Europe's foundation sector. However, there are still few studies focusing on foundations as impact investors. This study uses 16 semi-structured interviews with foundation representatives and intermediaries to examine their views on impact investing. A framework based on different understandings of impact investing is developed. Depending on the segment of impact investing,...
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Background: Place-based leadership plays a crucial role in local development. However, the role of nonprofit leaders is still an under-researched topic. Thus, we ask whether nonprofit leadership helps to develop rural areas and makes them attractive. Data and methodology: On a sample of 6,262 Czech municipalities, we tested whether membership of municipalities in local action groups (LAGs) and nonprofit leadership attributed to population growth. We have applied the propensity score method combined...
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The knowledge of atomic structures is essential to understand the mechanics and chemistry of proteins in fundamental research and is often the base for drug development. During the last decades, X-ray crystallography has been the primary method for determining atomic models providing an impressive number of molecular structures. Nevertheless, the technique is limited by the fact that the complexes of interest have to be crystallized. Nuclear magnetic resonance (NMR), which is used as an alternative...
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