Biomolecules, Vol. 10, Pages 468: The Role of Torsin AAA+ Proteins in Preserving Nuclear Envelope Integrity and Safeguarding Against Disease Biomolecules doi: 10.3390/biom10030468 Authors: Anthony J. Rampello Sarah M. Prophet Christian Schlieker Torsin ATPases are members of the AAA+ (ATPases associated with various cellular activities) superfamily of proteins, which participate in essential cellular processes. While AAA+ proteins are ubiquitously expressed and demonstrate distinct...
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Cells, Vol. 9, Pages 749: The Solo Play of TERT Promoter Mutations Cells doi: 10.3390/cells9030749 Authors: François Hafezi Danielle Perez Bercoff The reactivation of telomerase reverse transcriptase (TERT) protein is the principal mechanism of telomere maintenance in cancer cells. Mutations in the TERT promoter (TERTp) are a common mechanism of TERT reactivation in many solid cancers, particularly those originating from slow-replicating tissues. They are associated with increased...
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IJMS, Vol. 21, Pages 2099: Hormesis in Plants: The Role of Oxidative Stress, Auxins and Photosynthesis in Corn Treated with Cd or Pb International Journal of Molecular Sciences doi: 10.3390/ijms21062099 Authors: Eugeniusz Małkowski Krzysztof Sitko Michał Szopiński Żaneta Gieroń Marta Pogrzeba Hazem M. Kalaji Paulina Zieleźnik-Rusinowska Hormesis, which describes the stimulatory effect of low doses of toxic substances on growth, is a well-known phenomenon in the plant...
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Medicina, Vol. 56, Pages 137: Traumatic Brain Injury and Stem Cells: An Overview of Clinical Trials, the Current Treatments and Future Therapeutic Approaches Medicina doi: 10.3390/medicina56030137 Authors: Giovanni Schepici Serena Silvestro Placido Bramanti Emanuela Mazzon Traumatic brain injury represents physical damage to the brain tissue that induces transitory or permanent neurological disabilities. The traumatic injury activates an important inflammatory response, followed...
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Nutrients, Vol. 12, Pages 808: Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats Nutrients doi: 10.3390/nu12030808 Authors: Jeong-Hyun Yoo Eun-Jung Park So Hyeun Kim Hae-Jeung Lee Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against...
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Religions, Vol. 11, Pages 139: Item Response Theory Applied to the Spiritual Needs Questionnaire (SpNQ) in Portuguese Religions doi: 10.3390/rel11030139 Authors: Cassiano Augusto Oliveira da Silva Ana Paula Rodrigues Cavalcanti Kaline da Silva Lima Carlos André Macêdo Cavalcanti Tânia Cristina de Oliveira Valente Arndt Büssing The item response theory (IRT), or latent trace theory, is based on a set of mathematical models to complement the qualitative analysis of the items...
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Vaccines, Vol. 8, Pages 135: Intratumoral Gene Electrotransfer of Plasmid DNA Encoding shRNA against Melanoma Cell Adhesion Molecule Radiosensitizes Tumors by Antivascular Effects and Activation of an Immune Response Vaccines doi: 10.3390/vaccines8010135 Authors: Simona Kranjc Brezar Valter Mrak Masa Bosnjak Monika Savarin Gregor Sersa Maja Cemazar In this study, radiotherapy was combined with the gene electrotransfer (GET) of plasmid encoding shRNA against melanoma cell...
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