IJMS, Vol. 21, Pages 2096: Identification and Characterization of the First Virulent Phages, Including a Novel Jumbo Virus, Infecting Ochrobactrum spp International Journal of Molecular Sciences doi: 10.3390/ijms21062096 Authors: Przemyslaw Decewicz Piotr Golec Mateusz Szymczak Monika Radlinska Lukasz Dziewit The Ochrobactrum genus consists of an extensive repertoire of biotechnologically valuable bacterial strains but also opportunistic pathogens. In our previous...
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IJMS, Vol. 21, Pages 2097: In Search for Genes Related to Atherosclerosis and Dyslipidemia Using Animal Models International Journal of Molecular Sciences doi: 10.3390/ijms21062097 Authors: Anastasia V. Poznyak Andrey V. Grechko Reinhard Wetzker Alexander N. Orekhov Atherosclerosis is a multifactorial chronic disease that affects large arteries and may lead to fatal consequences. According to current understanding, inflammation and lipid accumulation are the two key...
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IJMS, Vol. 21, Pages 2095: ECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS International Journal of Molecular Sciences doi: 10.3390/ijms21062095 Authors: Eva Nora Bukosza Christoph Kornauth Karin Hummel Helga Schachner Nicole Huttary Sigurd Krieger Katharina Nöbauer André Oszwald Ebrahim Razzazi Fazeli Klaus Kratochwill Christoph Aufricht Gabor Szénási Peter Hamar Christoph A. Gebeshuber The...
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IJMS, Vol. 21, Pages 2093: Does Melatonin Exert Its Effect on Ram Sperm Capacitation Through Nitric Oxide Synthase Regulation? International Journal of Molecular Sciences doi: 10.3390/ijms21062093 Authors: Sara Miguel-Jiménez Melissa Carvajal-Serna Silvia Calvo Adriana Casao José Álvaro Cebrián-Pérez Teresa Muiño-Blanco Rosaura Pérez-Pe Nitric oxide (NO·), synthesized from L-arginine by nitric oxide synthase (NOS), is involved in sperm functionality....
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IJMS, Vol. 21, Pages 2091: Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process International Journal of Molecular Sciences doi: 10.3390/ijms21062091 Authors: Colpitts Tsai Zeisel Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection....
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IJMS, Vol. 21, Pages 2092: The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21062092 Authors: Indrieri Carrella Carotenuto Banfi Franco MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling...
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IJMS, Vol. 21, Pages 2094: PDI-Mediated Reduction of Disulfide Bond on PSD95 Increases Spontaneous Seizure Activity by Regulating NR2A–PSD95 Interaction in Epileptic Rats Independent of S-Nitrosylation International Journal of Molecular Sciences doi: 10.3390/ijms21062094 Authors: Duk-Shin Lee Ji-Eun Kim Postsynaptic density-95 (PSD95), a major scaffolding protein, is critical in coupling N-methyl-D-aspartate receptor (NMDAR) to cellular signaling networks in the central nervous...
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IJMS, Vol. 21, Pages 2088: Molecular and Potential Regulatory Mechanisms of Melanin Synthesis in Harmonia axyridis International Journal of Molecular Sciences doi: 10.3390/ijms21062088 Authors: Da Xiao Xu Chen Renbin Tian Mengmeng Wu Fan Zhang Liansheng Zang James D. Harwood Su Wang Melanization is a common phenomenon in insects, and melanin synthesis is a conserved physiological process that occurs in epidermal cells. Moreover, a comprehensive understanding...
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IJMS, Vol. 21, Pages 2090: The Rice Basic Helix–Loop–Helix 79 (OsbHLH079) Determines Leaf Angle and Grain Shape International Journal of Molecular Sciences doi: 10.3390/ijms21062090 Authors: Hyoseob Seo Suk-Hwan Kim Byoung-Doo Lee Jung-Hyun Lim Sang-Ji Lee Gynheung An Nam-Chon Paek Changes in plant architecture, such as leaf size, leaf shape, leaf angle, plant height, and floral organs, have been major factors in improving the yield of cereal crops. Moreover,...
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IJMS, Vol. 21, Pages 2089: Current and New Predictors for Treatment Response in Metastatic Colorectal Cancer. The Role of Circulating miRNAs as Biomarkers International Journal of Molecular Sciences doi: 10.3390/ijms21062089 Authors: Alexandra Gherman Loredana Balacescu Sinziana Gheorghe-Cetean Catalin Vlad Ovidiu Balacescu Alexandru Irimie Cosmin Lisencu Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world. More than half of...
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IJMS, Vol. 21, Pages 2087: Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity International Journal of Molecular Sciences doi: 10.3390/ijms21062087 Authors: Irina B. Deryabina Viatcheslav V. Andrianov Lyudmila N. Muranova Tatiana K. Bogodvid Khalil L. Gainutdinov The processes of memory formation and its storage are extremely dynamic. Therefore, the determination of the nature...
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IJMS, Vol. 21, Pages 2086: Ellagic Acid and Urolithins A and B Differentially Regulate Fat Accumulation and Inflammation in 3T3-L1 Adipocytes While Not Affecting Adipogenesis and Insulin Sensitivity International Journal of Molecular Sciences doi: 10.3390/ijms21062086 Authors: Luis Cisneros-Zevallos Woo Young Bang Claudia Delgadillo-Puga Ellagic acid (EA) is a component of ellagitannins, present in crops such as pecans, walnuts, and many berries, which metabolized by the...
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IJMS, Vol. 21, Pages 2084: Potential Adverse Effects of Resveratrol: A Literature Review International Journal of Molecular Sciences doi: 10.3390/ijms21062084 Authors: Abdullah Shaito Anna Maria Posadino Nadin Younes Hiba Hasan Sarah Halabi Dalal Alhababi Anjud Al-Mohannadi Wael M Abdel-Rahman Ali H. Eid Gheyath K. Nasrallah Gianfranco Pintus Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s...
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IJMS, Vol. 21, Pages 2085: Adrenoceptor Expression during Intervertebral Disc Degeneration International Journal of Molecular Sciences doi: 10.3390/ijms21062085 Authors: Johannes Kupka Annika Kohler Karima El Bagdadi Richard Bostelmann Marco Brenneis Christoph Fleege Danny Chan Frank Zaucke Andrea Meurer Marcus Rickert Zsuzsa Jenei-Lanzl Healthy and degenerating intervertebral discs (IVDs) are innervated by sympathetic nerves, however, adrenoceptor...
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IJMS, Vol. 21, Pages 2083: LreEF1A4, a Translation Elongation Factor from Lilium regale, Is Pivotal for Cucumber Mosaic Virus and Tobacco Rattle Virus Infections and Tolerance to Salt and Drought International Journal of Molecular Sciences doi: 10.3390/ijms21062083 Authors: Daoyang Sun Xiaotong Ji Yong Jia Dan Huo Shiying Si Lingling Zeng Yanlong Zhang Lixin Niu Eukaryotic translation elongation factors are implicated in protein synthesis across different...
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IJMS, Vol. 21, Pages 2077: Proteomic and Ultrastructural Analysis of Cellulite—New Findings on an Old Topic International Journal of Molecular Sciences doi: 10.3390/ijms21062077 Authors: Conti Zingaretti Amuso Dai Prè Brandi Cecconi Manfredi Marengo Boschi Riccio Amore Iorio Busato Francesco Riccio Parodi Vaienti Sbarbati : Background: Cellulite is a condition in which the skin has a dimpled lumpy...
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IJMS, Vol. 21, Pages 2081: Drug Resistance in Non-Hodgkin Lymphomas International Journal of Molecular Sciences doi: 10.3390/ijms21062081 Authors: Pavel Klener Magdalena Klanova Non-Hodgkin lymphomas (NHL) are lymphoid tumors that arise by a complex process of malignant transformation of mature lymphocytes during various stages of differentiation. The WHO classification of NHL recognizes more than 90 nosological units with peculiar pathophysiology and prognosis. Since the end...
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IJMS, Vol. 21, Pages 2080: Resolution of Deep Venous Thrombosis: Proposed Immune Paradigms International Journal of Molecular Sciences doi: 10.3390/ijms21062080 Authors: J. Matthew Nicklas Aviva E. Gordon Peter K. Henke Venous thromboembolism (VTE) is a pathology encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE) associated with high morbidity and mortality. Because patients often present after a thrombus has already formed, the mechanisms that drive DVT...
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IJMS, Vol. 21, Pages 2079: Whole-Genome Uterine Artery Transcriptome Profiling and Alternative Splicing Analysis in Rat Pregnancy International Journal of Molecular Sciences doi: 10.3390/ijms21062079 Authors: Kathirvel Gopalakrishnan Sathish Kumar During pregnancy, the uterine artery (UA) undergoes extensive remodeling to permit a 20–40 fold increase in blood flow with associated changes in the expression of a multitude of genes. This study used next-gen RNA sequencing...
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IJMS, Vol. 21, Pages 2082: Mechanisms Responsible for the Anticoagulant Properties of Neurotoxic Dendroaspis Venoms: A Viscoelastic Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21062082 Authors: Vance G. Nielsen Michael T. Wagner Nathaniel Frank Using thrombelastography to gain mechanistic insights, recent investigations have identified enzymes and compounds in Naja and Crotalus species’ neurotoxic venoms that are anticoagulant in nature....
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Cancers, Vol. 12, Pages 718: Clinical Relevance of Circulating Tumor Cells in Esophageal Cancer Detected by a Combined MACS Enrichment Method Cancers doi: 10.3390/cancers12030718 Authors: Anna Woestemeier Katharina Harms-Effenberger Karl-F. Karstens Leonie Konczalla Tarik Ghadban Faik G. Uzunoglu Jakob R. Izbicki Maximilian Bockhorn Klaus Pantel Matthias Reeh Introduction. Current modalities to predict tumor recurrence and survival in esophageal...
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Cancers, Vol. 12, Pages 717: Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection Cancers doi: 10.3390/cancers12030717 Authors: Annarosaria De Vito Paola Orecchia Enrica Balza Daniele Reverberi Debora Scaldaferri Roberto Taramelli Douglas M. Noonan Francesco Acquati Lorenzo Mortara Human RNASET2 acts as a powerful...
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Cancers, Vol. 12, Pages 716: An Integrated Meta-Analysis of Secretome and Proteome Identify Potential Biomarkers of Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12030716 Authors: Grasieli de Oliveira Paula Paccielli Freire Sarah Santiloni Cury Diogo de Moraes Jakeline Santos Oliveira Maeli Dal-Pai-Silva Patrícia Pintor do Reis Robson Francisco Carvalho Pancreatic ductal adenocarcinoma (PDAC) is extremely aggressive, has an unfavorable...
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Cancers, Vol. 12, Pages 715: The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas Cancers doi: 10.3390/cancers12030715 Authors: Annarita Nappi Emery Di Cicco Caterina Miro Annunziata Gaetana Cicatiello Serena Sagliocchi Giuseppina Mancino Raffaele Ambrosio Cristina Luongo Daniela Di Girolamo Maria Angela De Stefano Tommaso Porcelli Mariano Stornaiuolo...
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Cancers, Vol. 12, Pages 711: Claudins: New Players in Human Fertility and Reproductive System Cancers Cancers doi: 10.3390/cancers12030711 Authors: Marta Justyna Kozieł Karolina Kowalska Agnieszka Wanda Piastowska-Ciesielska Claudins are major integral proteins of tight junctions (TJs), the apical cell–cell adhesions that enable maintaining polarity of epithelial cells, their differentiation, and cell signaling. A number of studies have indicated that claudins...
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Cancers, Vol. 12, Pages 714: Tumor Size Matters—Understanding Concomitant Tumor Immunity in the Context of Hypofractionated Radiotherapy with Immunotherapy Cancers doi: 10.3390/cancers12030714 Authors: Jean Philippe Nesseler Mi-Heon Lee Christine Nguyen Anusha Kalbasi James W. Sayre Tahmineh Romero Philippe Nickers William H. McBride Dörthe Schaue The purpose of this study was to determine the dynamic contributions of different immune cell subsets...
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IJMS, Vol. 21, Pages 2075: Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21062075 Authors: Tiago Gião Joana Saavedra Ellen Cotrina Jordi Quintana Jordi Llop Gemma Arsequell Isabel Cardoso Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the choroid plexus, and secreted into the blood and the...
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IJMS, Vol. 21, Pages 2078: Endocrine-Disrupting Chemicals and Their Effects during Female Puberty: A Review of Current Evidence International Journal of Molecular Sciences doi: 10.3390/ijms21062078 Authors: Laura Lucaccioni Viola Trevisani Lucia Marrozzini Natascia Bertoncelli Barbara Predieri Licia Lugli Alberto Berardi Lorenzo Iughetti Puberty is the process of physical changes between childhood and adulthood during which adolescents reach sexual maturity...
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IJMS, Vol. 21, Pages 2076: MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS) International Journal of Molecular Sciences doi: 10.3390/ijms21062076 Authors: Przemysław J. Kotyla Md Asiful Islam MicroRNAs (miRNAs) are single-stranded, endogenous RNA molecules that play a significant role in the regulation of gene expression as well as cell development, differentiation, and function. Recent data suggest that these small molecules are responsible...
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IJMS, Vol. 21, Pages 2074: Claudin-12 Knockout Mice Demonstrate Reduced Proximal Tubule Calcium Permeability International Journal of Molecular Sciences doi: 10.3390/ijms21062074 Authors: Allein Plain Wanling Pan Deborah O’Neill Megan Ure Megan R. Beggs Maikel Farhan Henrik Dimke Emmanuelle Cordat R. Todd Alexander The renal proximal tubule (PT) is responsible for the reabsorption of approximately 65% of filtered calcium, primarily via a paracellular...
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IJMS, Vol. 21, Pages 2072: RNAi-Based Biofungicides as a Promising Next-Generation Strategy for Controlling Devastating Gray Mold Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21062072 Authors: Md Tabibul Islam Sherif M. Sherif Botrytis cinerea is one of the most critical agro-economic phytopathogens and has been reported to cause gray mold disease in more than 1000 plant species. Meanwhile, small interfering RNA (siRNA), which induce RNA interference...
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Genes, Vol. 11, Pages 323: Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis Genes doi: 10.3390/genes11030323 Authors: Wang Li Zhang Abdalla Teng Li Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and present their antigens to prime the adaptive immune responses. As the progression of sepsis occurs, DCs are capable of orchestrating the aberrant innate immune response by sustaining the Th1/Th2 responses...
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Genes, Vol. 11, Pages 324: Genome-Wide Transcriptomic Analysis Reveals a Regulatory Network of Oxidative Stress-Induced Flowering Signals Produced in Litchi Leaves Genes doi: 10.3390/genes11030324 Authors: Lu Yu Lü Chen Zhong Zhou Litchi is an important subtropical fruit tree that requires an appropriately low temperature to trigger floral initiation. Our previous studies have shown that reactive oxygen species (ROS) are involved in litchi flowering. To identify...
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Genes, Vol. 11, Pages 325: A Novel Germline MLH1 In-Frame Deletion in a Slovenian Lynch Syndrome Family Associated with Uncommon Isolated PMS2 Loss in Tumor Tissue Genes doi: 10.3390/genes11030325 Authors: Klančar Blatnik Šetrajčič Dragoš Vogrič Stegel Blatnik Drev Gazič Krajc Novaković The diagnostics of Lynch syndrome (LS) is focused on the detection of DNA mismatch repair (MMR) system deficiency. MMR deficiency can be detected on tumor tissue by...
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Genes, Vol. 11, Pages 322: Identification of Genic SSRs Provide a Perspective for Studying Environmental Adaptation in the Endemic Shrub Tetraena mongolica Genes doi: 10.3390/genes11030322 Authors: Zhenhua Dang Lei Huang Yuanyuan Jia Peter J. Lockhart Yang Fong Yunyun Tian Tetraena mongolica is a xerophytic shrub endemic to desert regions in Inner Mongolia. This species has evolved distinct survival strategies that allow it to adapt to hyper-drought and heterogeneous habitats....
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Genes, Vol. 11, Pages 321: Comparative Transcriptomics Reveals Clues for Differences in Pathogenicity between Hysterothylacium aduncum, Anisakis simplex sensu stricto and Anisakis pegreffii Genes doi: 10.3390/genes11030321 Authors: Serena Cavallero Fabrizio Lombardo Marco Salvemini Antonella Pizzarelli Cinzia Cantacessi Stefano D’Amelio Ascaridoid nematodes are widespread in marine fishes. Despite their major socioeconomic importance, mechanisms associated to the fish-borne...
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Commentary on: Del Pozo Cruz B, Alfonso-Rosa RM, McGregor D, et al. Sedentary behaviour is associated with depression symptoms: compositional data analysis from a representative sample of 3233 US adults and older adults assessed with accelerometers. J Affect Disord 2020;265:59–62. doi: 10.1016/j.jad.2020.01.023.Implications for practice and researchNurses using a comprehensive 24-hour lifestyle management approach with their patients, rather than targeting individual sedentary behaviours, could contribute...
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Commentary on: Breen LJ, Aoun SM, O’Connor M, et al. Effect of caregiving at end of life on grief, quality of life and general health: a prospective, longitudinal, comparative study. Palliat Med 2020;34:145–54.Implications for practice and researchIndividualised bereavement support, pre-death and post-death, should be provided for all caregivers, not just those at risk of prolonged grief (PG).Further studies should ensure data collection takes place over a minimum of 12 months.ContextA terminal diagnosis...
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Publication date: Available online 18 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Saara Markkanen, Markus Rautiainen, Pekka Niemi, Mika Helminen, Timo Peltomäki
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