Cells, Vol. 9, Pages 735: Indirect Role of AQP4b and AQP4d Isoforms in Dynamics of Astrocyte Volume and Orthogonal Arrays of Particles Cells doi: 10.3390/cells9030735 Authors: Marjeta Lisjak Maja Potokar Robert Zorec Jernej Jorgačevski Water channel aquaporin 4 (AQP4) plays a key role in the regulation of water homeostasis in the central nervous system (CNS). It is predominantly expressed in astrocytes lining blood–brain and blood–liquor boundaries. AQP4a...
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Cells, Vol. 9, Pages 734: Innate Cytokine Induced Early Release of IFNγ and CC Chemokines from Hypoxic Human NK Cells Is Independent of Glucose Cells doi: 10.3390/cells9030734 Authors: Sonia Y. Velásquez Bianca S. Himmelhan Nina Kassner Anna Coulibaly Jutta Schulte Kathrin Brohm Holger A. Lindner Natural killer (NK) cells are among the first innate immune cells to arrive at sites of tissue inflammation and regulate the immune response to infection and tumors by the...
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Cells, Vol. 9, Pages 733: Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development Cells doi: 10.3390/cells9030733 Authors: Martin G. Frasch Dino A. Giussani Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly...
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Publication date: Available online 16 March 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Kihyun Park, Jung-Ae Kim, Jaehoon Kim
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Publication date: Available online 16 March 2020Source: International Journal of Biological MacromoleculesAuthor(s): Yu-jie Meng, Shu-ya Wang, Zong-wei Guo, Mei-mei Cheng, Jun Li, De-qiang Li
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Publication date: Available online 16 March 2020Source: International Journal of Biological MacromoleculesAuthor(s): Ran Meng, Zhengzong Wu, He-Qiang Xie, Gao-Xin Xu, Jie-Shun Cheng, Bao Zhang
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Publication date: Available online 16 March 2020Source: International Journal of Biological MacromoleculesAuthor(s): Lulu Zhang, Xiaoxi Li, Srinivas Janaswamy, Ling Chen, Chengdeng Chi
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Abstract Autoimmune blistering disease management can be challenging as treatment modalities vary greatly and no single standard of care exists. We consolidated the recommendations of international management guidelines in order to provide optimal management suggestions to physicians. A comprehensive literature search in PubMed/MEDLINE for published blistering disease management guidelines and consensus statements was conducted in November 2019. Search terms included “guideline...
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Abstract Primary brain tumors are notoriously hard to resect surgically. Due to their infiltrative nature, finding the optimal resection boundary without damaging healthy tissue can be challenging. One potential tool to help make this decision is diffusion-weighted magnetic resonance imaging (dMRI) tractography. dMRI exploits the diffusion of water molecule along axons to generate a 3D modelization of the white matter bundles in the brain. This feature is particularly useful to...
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Abstract Benign alveolar ridge keratosis (BARK), the intraoral counterpart of cutaneous lichen simplex chronicus, is a reactive hyperkeratosis caused by trauma or friction that presents as a poorly demarcated white papule or plaque on the keratinized mucosa of the retromolar pad or alveolar ridge mucosa (often edentulous). This is a clinical and histopathologic analysis of BARK including evaluation of p53 expression in selected cases. One hundred and sixty-seven cases of BARK were...
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Biosensors, Vol. 10, Pages 25: Recyclable SERS-Based Immunoassay Guided by Photocatalytic Performance of Fe3O4@TiO2@Au Nanocomposites Biosensors doi: 10.3390/bios10030025 Authors: Yuanyuan Du Hongmei Liu Yiran Tian Chenjie Gu Ziqi Zhao Shuwen Zeng Tao Jiang A novel recyclable surface-enhanced Raman scattering (SERS)-based immunoassay was demonstrated and exhibited extremely high sensitivity toward prostate specific antigen (PSA). The immunoassay, which possessed...
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Typical ischemic damage to neurons were detected in the focus of experimental photothrombosis and in the transition zone. They were associated with symptoms of impaired motor functions and dysfunction of pelvic organs. The applied method of focal photothrombosis can be used for simulation of spinal cord ischemia for the development of methods for pharmacological correction and restoration of impaired sensorimotor functions.
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Abstract Glucose is utilized by fish as one of the sources of energy. It is a physiological parameter useful in the determination of the general health condition of cultured fish. The aim of this study was to determine the stability of plasma and blood glucose concentration, stored at different temperatures (4 °C and 30 °C) for 72 h. Two (2) milliliters of blood was collected via the caudal abdominal venipuncture of 10 female catfishes purchased. The fish were 8 months of age...
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Abstract Selenium (Se) is an antioxidant element that prevents the oxidative stress. Se incorporates into proteins such as selenocysteine and prevents oxidative damage to body tissues. In neonatal period, the different types of stress such as hypoglycemia and hypothermia may predispose them to many types of infectious diseases and also reduce growth rate at postnatal period. For these reasons, the present study was conducted on 12 newborn lambs to evaluate the effects of oral...
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Abstract We have investigated the effect of high-intensity interval exercise (HIIT) on DOX-induced cardiotoxicity and the expression of mitochondrial biogenesis genes SIRT-1, PGC-1α, and NRF-2 as well as microRNA-149-5p in a rat model. Twenty-four male Wistar rats (250–270 g) were randomly divided in four groups (n = 6/each): control, HIIT, DOX, and HIIT+DOX. HIIT was performed on a treadmill as seven alternative intervals of high and low intensity trainings for 1 h a day for...
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Abstract Background To augment orthodox anti-inflammatory drugs, which are scarce in some areas, local dwellers in some parts of Nigeria and Asia rely on herbal products such as Combretum zenkeri Engl. & Diels leaves for the treatment of inflammatory diseases. Aim This study investigated the anti-inflammatory activities of crude ethanol...
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Abstract Inflammatory mediators like pro-inflammatory cytokines have been linked with the pathogenesis of type 2 diabetes mellitus (T2DM). Neutrophil-lymphocyte ratio (NLR) has also recently emerged as a possible reliable and cost-effective marker of diabetes. This study was designed to evaluate pro-inflammatory cytokine levels (IL-6 and IL-1β) and NLR in T2DM subjects in Nigerian population. This was a case-control study involving 75 physician diagnosed T2DM subjects attending...
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Abstract Safety of natural products is a priority before they are acceptable for consumption. Alstonia boonei De Wild (Apocynaceae) stem-bark and Picralima nitida (Stapf) T. & H. Dur. (Apocynaceae) seed are combined into a powder dosage form for the treatment of malaria fever. This study evaluated the central nervous system effects and the toxicity of the remedy on acute and repeated doses with a view to providing information on its safety. The powder mixture (ratio 1:2)...
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Abstract To evaluate the nutritional impacts of powdered Aloe vera and nettle plants on growth performance and some parameters of immune response in rainbow trout, a total of 462 fish with an average weight of 10.80 ± 0.59 g were obtained from authentic fish farms. The fish were fed in seven groups with diets containing 0.5, 1, and 1.5% of Aloe vera powder and 0.5, 1, and 1.5% of nettle powder, and also a control with a basal diet without herbal supplementation for 4 weeks. The...
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Abstract Toxoplasma gondii (T. gondii) is an obligate intracellular parasitic protozoan, infecting a wide range of warm-blooded vertebrates. It is important for T. gondii to balance the response between cellular and humoral immune system for various aspects of its own survival. The aim of this study was to determine the level of IFN-γ and IL-4 production by murine peritoneal leukocytes stimulated with T. gondii lysate antigens (TLAs), excretory/secretory antigens (ESAs), and...
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Abstract One of the narrow-clawed crayfish of the freshwater is named Astacus leptodactylus. As the only crayfish species native to Iranian waters, Astacus leptodactylus is commonly distributed in Iranian water resources. Crayfish is considered a suitable biological indicator of the quality of water, a measure for the assessment of ecology and toxicology (ecotoxicology), and a model organism for the determination of the impact of pollutants. Blood biochemical parameters are useful...
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SUMMARY Background Limited options are available for treatment of pediatric psoriasis. Objectives To evaluate the efficacy and safety of ustekinumab in pediatric psoriasis patients (≥6 to <12 years of age). Methods CADMUS Junior (Jr), a phase 3, open‐label, single‐arm, multicenter study, evaluated ustekinumab in pediatric patients with moderate‐to‐severe plaque psoriasis. Patients received weight‐based dosing of ustekinumab (<60kg: 0.75mg/kg; ≥60to≤100kg: 45mg; >100kg:...
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Iron overload is commonly seen in the context of hematological diseases in patients who require frequent transfusions. On the other hand, an association between autoimmune hemolytic anemia complicating chronic lymphocytic leukemia and iron overload is unusual. Here, we report 2 cases of iron overload in patients with a background of chronic lymphocytic leukemia complicated by autoimmune hemolytic anemia. Both patients were found to have a high liver iron concentration on liver MRI (FerriScan). This...
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Abstract Objectives This study aimed to investigate the relationship between aging and tooth loss on masseter muscle quantity and quality. Materials and methods This cross-sectional study was conducted among 112 participants (in their 20s to 90s) who were independent in activities of daily living and were able to follow verbal commands. Exclusion criteria...
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Abstract Botryomycosis is a rare chronic suppurative granulomatous infection caused by several genera of non‐filamentous bacteria. The clinical and histopathological findings are similar to those of mycetoma caused by true fungi or aerobic actinomycetes. Botryomycosis is divided into cutaneous and visceral disease, with the cutaneous form being more common. Histopathology shows granules of etiologic bacteria called “sulfur granules”. Botryomycosis occurs more commonly among immunocompromised patients,...
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Abstract The term “acute diffuse and total alopecia” (ADTA) has been often used as a synonym for self‐regressing severe alopecia areata (AA). However, ADTA is originally defined as a rapidly‐progressive subtype of AA (RP‐AA) with short recovery time and favorable prognosis irrespective of interventions. Indeed, a subpopulation of ADTA recovers spontaneously. We focused on this unique subset of AA, which we coined as “self‐healing ADTA” (sADTA). Prompt and accurate differentiation of sADTA from...
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Abstract The molecular basis of interleukin (IL)‐17A in driving psoriasis pathogenesis is not fully elucidated yet. To investigate the underlying mechanisms and biomarkers associated with IL‐17A and the role in psoriasis pathogenesis, over 30 serum proteins were evaluated in a study assessing the effectiveness and safety of secukinumab, where treatment was directly switched from cyclosporin A to secukinumab. Serum β‐defensin 2 (BD‐2) levels rapidly and robustly reduced following secukinumab treatment....
21h
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