Currently, multiple circular RNAs (circRNAs) have been verified to act as essential regulators in the progression of gastric cancer (GC). We aimed to investigate the role of circ_0008035 in GC progression.
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0789-7Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0797-7The prognostic significance of immune microenvironment in breast ductal carcinoma in situ
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0792-zA novel model of liver cancer stem cells developed from induced pluripotent stem cells
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0794-xSerine-dependent redox homeostasis regulates glioblastoma cell survival
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0793-yDifferential prognostic impact of CD8+ T cells based on human leucocyte antigen I and PD-L1 expression in microsatellite-unstable gastric cancer
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A nationwide study found that low-dose aspirin was associated with a significantly lower risk of hepatocellular carcinoma and lower liver-related mortality compared to no aspirin use, without a significantly higher risk of gastrointestinal bleeding. (Source: CancerNetwork)
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This study found that carboplatin-pemetrexed treatment followed by pemetrexed maintenance was a valid option for first-line treatment of elderly patients with advanced nonsquamous non-small cell lung cancer. (Source: CancerNetwork)
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A population-based analysis found that racial and ethnic disparities in childhood central nervous system tumor survival seem to have their roots at least partially in post-diagnosis factors, possibly due to the lack of access to high quality care, leading to poorer overall outcomes. (Source: CancerNetwork)
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Researchers found that regret following allogeneic HSCT was related to disease recurrence, suggesting that social connectedness may serve as a protective factor against later regret. (Source: CancerNetwork)
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ABSTRACT Advances in genome sequencing have led to a tremendous increase in the discovery of novel missense variants, but evidence for determining clinical significance can be limited or conflicting. Here, we present LEAP, a machine learning model that utilizes a variety of feature categories to classify variants, and achieves high performance in multiple genes and different health conditions. Feature categories include functional predictions, splice predictions, population frequencies, conservation...
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Abstract The X-ray effective energy differs for each computed tomography (CT) scanner even at the same tube voltage because of differences in the bow-tie filter and additional filter. Even when scanning with the same tube voltage and dose setting, these differences in effective energy result in different image noise levels. Although this qualitative change is known, the related quantitative changes have not been clarified. In this study, using two CT scanners with the same geometric...
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Abstract This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different. Despite some similarities, there are crucial differences separating these two technologies. Liqui-Pellet uses liqui-mass system (wet mass/paste admixture), and liquisolid pellet uses liquisolid system (flowable powder admixture). The understanding of the well-defined term ‘liquisolid system’ is crucial to understand what...
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Abstract Habitat heterogeneity in the Pantanal results from flood dynamics and vegetation characteristics. Considering that these impacts affect landbird nesting conditions and food resource availability, species turnover and richness should respond to them. We conducted this study in the northeastern Pantanal, in two dominant habitats, savanna and forest, covering two annual cycles. The objectives were: (1) evaluation of trophic structure, (2) analyses of species dissimilarity...
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Abstract Earth hummocks are widely distributed in arctic, sub-Arctic and alpine regions and have important roles in determining plant diversity and the nutrient content of soils. We investigated the impact of the spatial heterogeneity on soil properties and plant communities caused by the hummocks on the Tibetan Plateau. The results indicated alpine hummocks created higher plant diversity and soil fertile island patterns under Kobresia Genus communities. Vegetation height, cover,...
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Abstract Monocyte‐derived macrophages play a role in the repair of the injured brain. We previously reported that a deficiency of the Parkinson's disease (PD)‐associated gene DJ‐1 delays repair of brain injury produced by stereotaxic injection of ATP, a component of damage‐associated molecular patterns. Here, we show that a DJ‐1 deficiency attenuates monocyte infiltration into the damaged brain owing to a decrease in C‐C motif chemokine ligand 2 (CCL2) expression in astrocytes. Like DJ‐1‐knockout...
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Main points 1) Sox10 induces miR‐204 expression in oligodendroglial cells. 2) miR‐204 reduces proliferation and increases differentiation of primary oligodendroglia. 3) miR‐204 functions at least in part by inhibiting CyclinD2 and Sox4. Abstract Oligodendrocytes wrap and physically shield axons of the central nervous system with myelin sheaths, resulting in rapid signal transduction and accurate neuronal function. The complex oligodendroglial development from immature oligodendrocyte precursor...
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• Tanycyte ablation resulted in a modest increase of fat mass independent of weight gain and induced insulin resistance.• Tanycyte ablation did not significantly affect the blood‐hypothalamus barrier, leptin response in brain, or pituitary hormone levels. Abstract Tanycytes are radial glial cells located in the mediobasal hypothalamus. Recent studies have proposed that tanycytes play an important role in hypothalamic control of energy homeostasis, although this has not been directly tested....
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Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet del...
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Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types. However, how HOXB4 promotes ovarian cancer (OV) progression remains unclear.
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Following publication of the original article [1], the authors reported that they had misspelt the name of a cell line and supplied the incorrect Fig. 7 for publication.
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Background Clinical experience is limited for primary central nervous system (CNS) lymphoma that arises from the dura mater, which is denoted with the term primary dural lymphoma (PDL). This study was aimed at determining the relative incidence, presentation, and outcomes of PDL. Methods The institutional databases of the Divisions of Neuro‐Oncology at the Massachusetts General Hospital and the Yale School of Medicine were retrospectively searched for patients with primary CNS lymphoma....
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Limited evidence exists on the role of modifiable lifestyle factors on the risk of lymphoma. In this work, the associations between adherence to healthy lifestyles and risks of Hodgkin lymphoma (HL) and non‐Hodgkin lymphoma (NHL) were evaluated in a large‐scale European prospective cohort. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 2,999 incident lymphoma cases (132 HL and 2,746 NHL) were diagnosed among 453,808 participants after 15 years (median) of follow‐up....
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There is limited evidence regarding a possible association between exposure to ambient air pollutants and the risk of non‐Hodgkin lymphoma (NHL). Previous epidemiological studies have relied on crude estimations for air pollution exposure and/or small numbers of NHL cases. The objective of this study was to analyze this association based on air pollution modeled at the address level and NHL cases identified from the nation‐wide Danish Cancer Registry. We identified 20,874 incident NHL cases diagnosed...
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