IL-8 and IFN-γ as Preoperative Predictors of the Outcome of Tonsillectomy.

IL-8 and IFN-γ as Preoperative Predictors of the Outcome of Tonsillectomy.:

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IL-8 and IFN-γ as Preoperative Predictors of the Outcome of Tonsillectomy.

Ear Nose Throat J. 2020 Mar 17;:145561320910682

Authors: Seethaler A, Stenner M, McNally A, Rudack C, Roth J, Vogl T, Spiekermann C

Abstract

OBJECTIVES: Tonsillectomy (TE) and tonsillotomy (TO) due to recurrent episodes of acute tonsillitis (RAT) belong to the most frequent surgical procedures. However, an adequate objective marker predicting the outcome of TE/TO preoperatively is missing.

METHODS: Patients with RAT who underwent TE/TO (n = 31) were included in this pilot study. A panel of cytokines and chemokines in serum and saliva were determined preoperatively. Health-related quality of life was assessed pre- and postoperatively by the Tonsillectomy Outcome Inventory-14.

RESULTS: Health-related quality of life improved significantly after surgery. Increased serum levels of interleukin-8 (IL-8) and interferon gamma (IFN-γ) are associated with a less successful outcome. No correlation between the number of acute tonsillitis episodes and the health-related quality of life after TE or TO could be observed.

CONCLUSIONS: Tonsillectomy and TO improve health-related quality of life independently from the number of past acute tonsillitis episodes. Interleukin-8 and IFN-γ in serum may serve as promising markers, predicting the benefit of TE or TO for patients preoperatively.

PMID: 32182134 [PubMed - as supplied by publisher]