Cancers, Vol. 12, Pages 719: Wee1 Inhibition Enhances the Anti-Tumor Effects of Capecitabine in Preclinical Models of Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers12030719 Authors: Todd M. Pitts Dennis M. Simmons Stacey M. Bagby Sarah J. Hartman Betelehem W. Yacob Brian Gittleman John J. Tentler Diana Cittelly D. Ryan Ormond Wells A. Messersmith S. Gail Eckhardt Jennifer R. Diamond Triple-negative breast cancer (TNBC) is an...
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Abstract Introduction PET/CT using 68Ga-labeled somatostatin analogs (SSA) targeting somatostatin receptors (SSR) on the cell surface of well-differentiated neuroendocrine tumors (NET) represents the clinical reference standard for imaging. However, economic and logistic challenges of the 68Ge/68Ga generator-based approach have disadvantages over 18F-labeled compounds. Here, we present the first in-human data of 18F-SiFAlin-TATE,...
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Abstract Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of healthy humans and subjects with pulmonary fibrosis using the αvβ6-selective [18F]FB-A20FMDV2 PET ligand. Methods ...
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Abstract The incidence of neuroendocrine tumours (NETs) is increasing, but curative therapeutic options are limited because diagnosis is often delayed until the tumour has metastasized. Peptide receptor radionuclide therapy (PRRT) is among the most effective therapeutic options for metastatic NETs because of targeted delivery of radioactivity to the tumour via the somatostatin receptor (SSTR) and relatively low systemic toxicity. However, current PRRT regimes result in palliation...
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Abstract Background Hyaluronic acid (HA) injections involve a risk of vascular complications. Transillumination (TL) is a noninvasive technique that appears to allow preliminary detection of superficial vascular structures of the face to avoid intravascular HA injection. The purpose of our study was to test the efficacy of TL in terms of its sensitivity to locate vessels in the areas undergoing treatment and to reduce post-injection...
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JCM, Vol. 9, Pages 830: Intraoperative Autofluorescence and Indocyanine Green Angiography for the Detection and Preservation of Parathyroid Glands Journal of Clinical Medicine doi: 10.3390/jcm9030830 Authors: Demarchi Karenovics Bédat Triponez Fluorescence imaging is a well-known method for both the in vivo and in vitro identification of specific cells or tissues. This imaging tool is gaining importance in the intraoperative detection and preservation of parathyroid glands...
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JCM, Vol. 9, Pages 831: Right Ventricular Dysfunction Staging System for Mortality Risk Stratification in Heart Failure With Preserved Ejection Fraction Journal of Clinical Medicine doi: 10.3390/jcm9030831 Authors: Santas De la Espriella Chorro Palau Miñana Heredia Amiguet Merenciano Sanchis Lupón Bayés-Genís Núñez Right ventricular dysfunction (RVD) parameters are increasingly important features in heart failure with preserved ejection fraction...
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JCM, Vol. 9, Pages 828: Network Mapping of Connectivity Alterations in Disorder of Consciousness: Towards Targeted Neuromodulation Journal of Clinical Medicine doi: 10.3390/jcm9030828 Authors: Lucia Mencarelli Maria Chiara Biagi Ricardo Salvador Sara Romanella Giulio Ruffini Simone Rossi Emiliano Santarnecchi Disorder of consciousness (DoC) refers to a group of clinical conditions that may emerge after brain injury, characterized by a varying decrease in the level of...
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JCM, Vol. 9, Pages 829: The Influence of Vaginal Native Tissues Pelvic Floor Reconstructive Surgery in Patients with Symptomatic Pelvic Organ Prolapse on Preexisting Storage Lower Urinary Tract Symptoms (LUTS) Journal of Clinical Medicine doi: 10.3390/jcm9030829 Authors: Rechberger Skorupska Rechberger Wojtaś Miotła Kulik-Rechberger Wróbel The aim of this study was to assess the effectiveness of vaginal native tissue repair (VNTR) on preexisting Lower Urinary...
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JCM, Vol. 9, Pages 827: Improved Isolation and Culture of Urine-Derived Stem Cells (USCs) and Enhanced Production of Immune Cells from the USC-Derived Induced Pluripotent Stem Cells Journal of Clinical Medicine doi: 10.3390/jcm9030827 Authors: Kim Gil Dayem Choi Kang Yang Cho Jeong Kim Seok Kwak Saha Kim Cho The availability of autologous adult stem cells is one of the essential prerequisites for human stem cell therapy. Urine-derived...
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JCM, Vol. 9, Pages 824: Endothelin Receptor Antagonists: Status Quo and Future Perspectives for Targeted Therapy Journal of Clinical Medicine doi: 10.3390/jcm9030824 Authors: Frederik C. Enevoldsen Jayashree Sahana Markus Wehland Daniela Grimm Manfred Infanger Marcus Krüger The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin receptor antagonists...
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JCM, Vol. 9, Pages 825: Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting Journal of Clinical Medicine doi: 10.3390/jcm9030825 Authors: Young Suk Kwon Jun Woo Choi Ho Seok Lee Jong Ho Kim Youngmi Kim Jae Jun Lee Postoperative nausea and vomiting (PONV) are common complications after anesthesia, but no study has considered the effects of a proton pump inhibitor (PPI) and gastroesophageal reflux disease...
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JCM, Vol. 9, Pages 826: Vertebral Bone Marrow and Endplate Assessment on MR Imaging for the Differentiation of Modic Type 1 Endplate Changes and Infectious Spondylodiscitis Journal of Clinical Medicine doi: 10.3390/jcm9030826 Authors: Schwarz-Nemec Friedrich Stihsen Schwarz Trattnig Weber Grohs Nemec On magnetic resonance (MR) imaging, Modic type 1 (MT1) endplate changes and infectious spondylodiscitis share similar findings. Therefore, this study investigated...
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JCM, Vol. 9, Pages 821: Added-Value of Endometrial Biopsy in the Diagnostic and Therapeutic Strategy for Pelvic Actinomycosis Journal of Clinical Medicine doi: 10.3390/jcm9030821 Authors: Julie Carrara Blandine Hervy Yohann Dabi Claire Illac Bassam Haddad Dounia Skalli Gregoire Miailhe Fabien Vidal Cyril Touboul Charlotte Vaysse The particularity of pelvic actinomycosis lies in the difficulty of establishing the diagnosis prior to treatment. The objective of...
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JCM, Vol. 9, Pages 823: Updating the Definition of the Alcohol Hangover Journal of Clinical Medicine doi: 10.3390/jcm9030823 Authors: Joris C. Verster Andrew Scholey Aurora J.A.E. van de Loo Sarah Benson Ann-Kathrin Stock In 2016, the Alcohol Hangover Research Group defined the alcohol hangover as “the combination of mental and physical symptoms experienced the day after a single episode of heavy drinking, starting when blood alcohol concentration (BAC) approaches...
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JCM, Vol. 9, Pages 822: Health in Preconception, Pregnancy and Postpartum Global Alliance: International Network Pregnancy Priorities for the Prevention of Maternal Obesity and Related Pregnancy and Long-Term Complications Journal of Clinical Medicine doi: 10.3390/jcm9030822 Authors: Briony Hill Helen Skouteris Jacqueline A. Boyle Cate Bailey Ruth Walker Shakila Thangaratinam Hildrun Sundseth Judith Stephenson Eric Steegers Leanne M. Redman Cynthia Montanaro Siew...
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JCM, Vol. 9, Pages 820: Ponatinib Induces Vascular Toxicity through the Notch-1 Signaling Pathway Journal of Clinical Medicine doi: 10.3390/jcm9030820 Authors: Rosalinda Madonna Damiana Pieragostino Maria Concetta Cufaro Vanessa Doria Piero Del Boccio Martino Deidda Sante Donato Pierdomenico Christian Cadeddu Dessalvi Raffaele De Caterina Giuseppe Mercuro Ponatinib, a third-generation tyrosine kinase inhibitor (TKI), is the only approved TKI that is effective...
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JCM, Vol. 9, Pages 819: Real-Life Patterns of Exacerbations While on Inhaled Corticosteroids and Long-Acting Beta Agonists for Asthma over 15 Years Journal of Clinical Medicine doi: 10.3390/jcm9030819 Authors: Michael J. McGeachie Alberta L. Wang Sharon M. Lutz Joanne E. Sordillo Scott T. Weiss Kelan G. Tantisira Carlos Iribarren Meng X. Lu Ann Chen Wu Asthma affects more than 300 million people in the world, costs over $80 billion annually in the United States,...
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Publication date: Available online 18 March 2020Source: European Journal of CancerAuthor(s): Daniel M. Berney, Jonathan Shamash, Sara Stoneham, Michelle Lockley
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This Medical News series offers an occasional roundup of developments in cardiovascular medicine.
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This Viewpoint reviews legal powers the US president and state governors have to implement travel and other restrictions to control the spread of coronavirus, and discusses the need to balance rights to privacy and liberty with public health in ways that do not disadvantage already vulnerable populations.
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This Medical News story examines the status of Makena, the only drug approved for the indication of preventing preterm birth.
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Michela Bartoccetti, Bernard K. van der Veer, Xinlong Luo, Rita Khoueiry, Pinyi She, Manmohan Bajaj, Jiayi Xu, Adrian Janiszewski, Bernard Thienpont, Vincent Pasque, Kian Peng Koh
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Daniel Haensel, Suoqin Jin, Peng Sun, Rachel Cinco, Morgan Dragan, Quy Nguyen, Zixuan Cang, Yanwen Gong, Remy Vu, Adam L. MacLean, Kai Kessenbrock, Enrico Gratton, Qing Nie, Xing Dai
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Yan Bi, Zhifen Tu, Yanping Zhang, Peng Yang, Mingyue Guo, Xuehao Zhu, Chengchen Zhao, Jianfeng Zhou, Hong Wang, Yixuan Wang, Shaorong Gao
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Xie Dang, Binqing Chen, Fenglian Liu, Huibo Ren, Xin Liu, Jie Zhou, Yuan Qin, Deshu Lin
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Naofumi Kawahira, Daisuke Ohtsuka, Naoki Kida, Ken-ichi Hironaka, Yoshihiro Morishita
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Noriyuki Kinoshita, Yutaka Hashimoto, Naoko Yasue, Makoto Suzuki, Ileana M. Cristea, Naoto Ueno
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Devon L. Moose, Benjamin L. Krog, Tae-Hyung Kim, Lei Zhao, Sophia Williams-Perez, Gretchen Burke, Lillian Rhodes, Marion Vanneste, Patrick Breheny, Mohammed Milhem, Christopher S. Stipp, Amy C. Rowat, Michael D. Henry
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Giorgio Ramadori, Rafael M. Ioris, Zoltan Villanyi, Raquel Firnkes, Olesya O. Panasenko, George Allen, Georgia Konstantinidou, Ebru Aras, Xavier Brenachot, Tommasina Biscotti, Anne Charollais, Michele Luchetti, Fedor Bezrukov, Alfredo Santinelli, Muntaha Samad, Pierre Baldi, Martine A. Collart, Roberto Coppari
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Giustina Ferone, Ji-Ying Song, Oscar Krijgsman, Jan van der Vliet, Miranda Cozijnsen, Ekaterina A. Semenova, David J. Adams, Daniel Peeper, Anton Berns
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Sophie Uzureau, Laurence Lecordier, Pierrick Uzureau, Dorle Hennig, Jonas H. Graversen, Fabrice Homblé, Pepe Ekulu Mfutu, Fanny Oliveira Arcolino, Ana Raquel Ramos, Rita M. La Rovere, Tomas Luyten, Marjorie Vermeersch, Patricia Tebabi, Marc Dieu, Bart Cuypers, Stijn Deborggraeve, Marion Rabant, Christophe Legendre, Søren K. Moestrup, Elena Levtchenko
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Jung Hwa Ko, Hyeon Ji Kim, Hyun Jeong Jeong, Hyun Ju Lee, Joo Youn Oh
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Clarice X. Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A. Flavell, Jorge Henao-Mejia, Herbert Strobl
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Souad Amiar, Nicholas J. Katris, Laurence Berry, Sheena Dass, Samuel Duley, Christophe-Sebastien Arnold, Melanie J. Shears, Camille Brunet, Bastien Touquet, Geoffrey I. McFadden, Yoshiki Yamaryo-Botté, Cyrille Y. Botté
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Anastasia Selyutina, Mirjana Persaud, Lacy M. Simons, Angel Bulnes-Ramos, Cindy Buffone, Alicia Martinez-Lopez, Viviana Scoca, Francesca Di Nunzio, Joseph Hiatt, Alexander Marson, Nevan J. Krogan, Judd F. Hultquist, Felipe Diaz-Griffero
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Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Bartek Nogal, Matteo Bianchi, Christopher A. Cottrell, Robert N. Kirchdoerfer, Leigh M. Sewall, Hannah L. Turner, Fangzhu Zhao, Devin Sok, Dennis R. Burton, Lars Hangartner, Andrew B. Ward
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