Objectives. Flufenamic acid (FFA) is a representative of the fenamic acids, an important group of NSAIDs. In the present study, we study the effects of FFA on adipogenesis of human mesenchymal stem cells (MSCs) and we explore the potential mechanism. Methods. To investigate the effects of FFA on adipogenic differentiation of hMSCs, human adipose-derived stem cells (hASCs) and human bone marrow mesenchymal stem cells (hBMMSCs), representative of hMSCs, were treated with FFA during adipogenic differentiation...
17h
Avulsion fracture of the tibial tuberosity is an infrequent injury in adolescents and an extremely rare occurrence in adults. We describe the case of an 86-year-old gentleman presenting after a fall, sustaining injury to the left knee. Radiographs of the left knee showed avulsion fracture of the tibial tuberosity. The purpose of this study was to present a rare case of tibial tuberosity avulsion fracture in an adult, the treatment performed, and the challenges faced. The case is discussed with the...
17h
Dose-dependent cardiotoxicity of doxorubicin may lead to irreversible congestive heart failure. Although multiple mechanisms are involved, generation of free radicals is the most commonly postulated mechanism. Therefore, free radical scavengers are considered as potential therapeutic agents. As Murraya koenigii leaves are a rich source of flavonoids and phenols, they have the ability to scavenge free radicals effectively. Therefore, the objective of this study was to investigate the cardioprotective...
17h
SSD (Single Shot MultiBox Detector) is one of the best object detection algorithms and is able to provide high accurate object detection performance in real time. However, SSD shows relatively poor performance on small object detection because its shallow prediction layer, which is responsible for detecting small objects, lacks enough semantic information. To overcome this problem, SKIPSSD, an improved SSD with a novel skip connection of multiscale feature maps, is proposed in this paper to enhance...
17h
N-doped graphene (NG)/TiO2 composites were prepared by a two-step hydrothermal method using HF as the surface etchant and urea as the nitrogen source. The morphology, structure, and bonding conditions of the NG/TiO2 composites were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, UV-visible diffuse reflectance spectroscopy (UV-Vis DRS), and photoluminescence (PL) spectroscopy. The effects of...
17h
With the growing demand of cloud services, cloud data centers (CDCs) can provide flexible resource provisioning in order to accommodate the workload demand. In CDCs, the virtual machine (VM) resource allocation problem is an important and challenging issue to provide efficient infrastructure services. In this paper, we propose a unified resource allocation scheme for VMs in the CDC system. To provide a fair-efficient solution, we concentrate on the basic concept of Shapley value and adopt its variations...
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Natural antioxidants present in several medicinal plants are responsible for inhibiting the harmful effects of oxidative stress. These plants contain polyphenols and flavonoids that act as free radical scavengers and reduce oxidative stress and may be an alternative remedy to cure various harmful human diseases. This study aims to quantify the total phenolic and flavonoid contents (TPC and TFC) and antioxidant properties of methanol extracts of fruits, seeds, and bark of an important medicinal and...
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This article introduces voltage feedback controlling using the PI controller tuned gains by metaheuristic optimizations for a four-phase interleaved boost converter. The metaheuristic optimizations, particle swarm optimization (PSO), genetic algorithm (GA), and Tabu search (TS) are applied to find the optimal gains for the proposed control system. In experiment, the designed control system is implemented on the DSP board TMS320F28335 with MATLAB/Simulink. In this paper, there are two conditions of...
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Housing is closely related to population. The world’s demographics have been changing greatly, like ageing, urbanization, and shrinking household. This paper takes China as the research object to study the effects of demographics on housing consumption. Demographics were considered from three aspects: natural structure, regional structure, and social structure. Based on Life Cycle Theory and Permanent Income Hypothesis, the models on housing consumption were constructed. Results show that demographic...
17h
Vendor managed inventory (VMI) is an improved sustainable inventory management system, but it is difficult to establish and solve an integrated Stackelberg game model under the complicated practical environment. In this paper, a bilevel programming model is proposed to formulate the VMI system by taking into account the uncertainty of demand, the competition among retailers, the cooperative advertising, the shortage and holding costs, and the practical constraints. For the established stochastic...
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Background. Pure red cell aplasia (PRCA) is less common blood disorder; the causes and the treatments of PRCA are varied. Methods. We conducted a retrospective study during January 2010–December 2017, to explore the etiologies and to evaluate the response and treatment burden in adult patients with PRCA. Results. Of 32 PRCA patients, median age was 57 years (18–90 years). Median hemoglobin level and reticulocyte count at the time of diagnosis were 5.6 g/dL (3.3–7.3 g/dL) and 0.3% (0.1–0.7%), respectively....
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Climate change has caused uneven changes in hydrological processes (precipitation and evapotranspiration) on a space-temporal scale, which would influence climate types, eventually impact agricultural production. Based on data from 61 meteorological stations from 1961 to 2014 in the North China Plain (NCP), the spatiotemporal characteristics of climate variables, such as humidity index, precipitation, and potential evapotranspiration (ET0), were analyzed. The sensitivity coefficients and contribution...
17h
Gastrobronchial fistulas are a rare occurrence in the literature. We report a case of a gastrobronchial fistula after robotic repair of a chronic traumatic diaphragmatic hernia. The patient had severe respiratory symptoms with multiple studies that were inconclusive. The fistula was ultimately discovered after an esophagogastroduodenoscopy (EGD). The patient underwent a left thoracotomy for takedown of his fistula and eventually recovered. Earlier EGD and a lower threshold for differential that included...
17h
Unlike conventional pneumatic tires, the nonpneumatic tires (NPT) are explosion proof and simple to maintain and provide low rolling resistance. At high vehicle speeds, however, the complex airflow produced by the open flexible-spoke structure of NPT yields high aerodynamic noise, which contributes to sound pollution in the vehicular traffic environment. Inspired by the idea that a nonsmooth riblet structure can affect fluid flow and offer noise reduction, the analyses of the effect of the nonsmooth...
17h
Planetary gears are widely used in automobiles, helicopters, heavy machinery, etc., due to the high speed reductions in compact spaces; however, the gear fault and early damage induced by the vibration of planetary gears remains a key concern. The time-varying parameters have a vital influence on dynamic performance and reliability of the gearbox. An analytical model is proposed to investigate the effect of gear tooth crack on the gear mesh stiffness, and then the dynamical model of the planetary...
17h
Direction of arrival (DOA) estimation is an essential problem in the radar systems. In this paper, the problem of DOA estimation is addressed in the multiple-input and multiple-output (MIMO) radar system for the fast-moving targets. A virtual aperture is provided by orthogonal waveforms in the MIMO radar to improve the DOA estimation performance. Different from the existing methods, we consider the DOA estimation method with only one snapshot for the fast-moving targets and achieve the super-resolution...
17h
Facing serious environmental degradation and its resulting of climate warming, how to conserve energy and reduce emissions becomes a serious issue for government supervisors and modern vehicle enterprises. Reducing the mass of a vehicle is one of the most effective ways to reduce emissions and improve fuel utilization, essential to persist the low-carbon and sustainable-development bases in industrial production processes. When it comes to the selection of lightweight material for a car body in the...
17h
Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia (PCP) in an infant with acquired combined immunodeficiency secondary to maternal chemotherapy exposure during the second and third trimesters of pregnancy. The infant required cardiorespiratory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. This case highlights the potential for severe acquired immunodeficiency...
17h
The damage to a concrete wall caused by a strong earthquake is generally concentrated at the bottom of the concrete wall, which seriously threatens the safety of the steel-concrete hybrid structure and is very difficult to repair after an earthquake. In this paper, a steel-concrete hybrid structure with buckling restrained braces at a scale of 1/10 is constructed and tested on a shaking table. First, the mechanical properties of the BRBs are obtained through a static reciprocating loading test. Then,...
17h
An intelligent rolling contact fatigue test equipment is developed, and the control methods are presented. For obtaining the slip accurately, the control method based on master-slave synchronization is proposed. For controlling the loads in high precision, the control method took into consideration the influence by two factors, displacement and the load. The nonlinear interference and excess torque in load control are effectively suppressed. Based on the SIMOTION D425 which is the Siemens integrated...
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Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological...
17h
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