ObjectivesDermatitis is the most common occupational skin disease, and further evidence is needed regarding preventable risk factors. The Occupational Disease Surveillance System (ODSS) derived from administrative data was used to investigate dermatitis risk among industry and occupation groups in Ontario. MethodsODSS cohort members were identified from Workplace Safety and Insurance Board (WSIB) accepted lost time claims. A case was defined as having ≥2 dermatitis physician billing claims during...
ObjectivesThe causes of kidney cancer are not well understood though occupational exposures are thought to play a role. Crystalline silica is a known human carcinogen, and despite previous links with kidney disease, there have been few studies investigating its association with kidney cancer. We addressed this research gap using a population-based case-control study of Canadian men. MethodsQuestionnaire data were obtained from individuals with histologically confirmed kidney cancer, and population-based...
ObjectivesLower mortality rates compared with the general population have been reported for Agricultural Health Study (AHS) participants (enrolled 1993–1997) followed through 2007. We extended analysis of mortality among AHS participants (51 502 private pesticide applicators, their 31 867 spouses and 4677 commercial pesticide applicators from North Carolina and Iowa) through 2015 and compared results using several analytical approaches. MethodsWe calculated standardised mortality ratios (SMRs),...
ObjectivesThe validity of surrogate measures of retrospective occupational exposure in population-based epidemiological studies has rarely been evaluated. Using toenail samples as bioindicators of exposure, we assessed whether work tasks and expert assessments of occupational metal exposure obtained from personal interviews were associated with lead and manganese concentrations. MethodsWe selected 609 controls from a case–control study of bladder cancer in New England who had held a job for ≥1 year...
ObjectivesThe aim of this study is to determine if parental occupational exposure to 16 agents is associated with autism spectrum disorder (ASD). MethodsDemographic, health and parental occupational data were collected as part of the CHildhood Autism Risks from Genetics and Environment study. The workplace exposure assessment was conducted by two experienced industrial hygienists for the parents of 537 children with ASD and 414 typically developing (TD) children. For each job, frequency and intensity...
ObjectiveTo identify, appraise and synthesise studies that have examined the degree to which new workers are at an elevated risk of work-related acute injuries and musculoskeletal (MSK) injuries. MethodWe searched three relevant electronic databases for studies published between 1995 and early 2018. Fifty-one studies using multivariate analyses met our relevance and quality appraisal criteria. These studies examined two different work outcomes: acute injuries (eg, cuts, burns and falls) and MSK...
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Two new pieces of legislation were signed into law with the mission to improve education in New Jersey schools for children who are deaf, hard-of-hearing, or deaf-blind. The legislation was signed by Acting Governor Sheila Oliver and passed the full Assembly in June by a vote of 77-0. The first law created a Working Group on Deaf Education that will make recommendations for issues on early linguistic developments of children who are deaf or heard of hearing. This group within the Department of Education...
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Η κατανάλωση τροφίμων πλούσιων σε φλαβονοειδή όπως τα μήλα και το τσάι ασκούν προστατευτική δράση έναντι του καρκίνου και της καρδιαγγειακής νόσου, ιδιαίτερα σε ότι αφορά τους καπνιστές και τους βαρείς πότες σύμφωνα με τους ερευνητές με τους ερευνητές του Πανεπιστημίου Edith Cowan. Οι ερευνητές ανέλυσαν στοιχεία από την κοόρτη Διατροφής, Καρκίνου και Υγείας της Δανίας όπου αξιολογήθηκε η διατροφή 53.048 Δανών άνω των 23 ετών. Διαπίστωσαν ότι οι άνθρωποι που συνήθιζαν να καταναλώνουν μέτριες έως...
Νέα έρευνα συσχετίζει την υψηλή σε λιπαρά διατροφή με το μικροβίωμα του στομάχου και την αντίσταση στην ινσουλίνη. Στη νέα έρευνα που δημοσιεύθηκε στο Nature Communications ο Δρ. Dan Winer, Επιστημονικός Υπεύθυνος του Ερευνητικού Ινστιτούτου του Γενικού Νοσοκομείου του Τορόντο και του Τμήματος Παθολογίας του Πανεπιστημιακού Δικτύου Υγείας (UHN) και η ομάδα του, συμπεριλαμβανομένων των μεταπτυχιακών φοιτητών Helen Luck και Saad Khan, και o συν-συγγραφέας της μελέτης Δρ. Shawn Winer από το Νοσοκομείο...
Ιάπωνες επιστήμονες κατάφεραν για πρώτη φορά να διαχωρίσουν εύκολα τα σπερματοζωάρια σε «αρσενικά» και «θηλυκά», χάρη σε μια νέα τεχνική, η οποία -αν εφαρμοστεί ποτέ στους ανθρώπους- θα οδηγήσει στην εκ των προτέρων επιλογή του φύλου του μωρού στην εξωσωματική γονιμοποίηση. Ήδη άρχισαν να διατυπώνονται ανησυχίες ότι κάτι τέτοιο -εφόσον γίνει πραγματικότητα σε μεγάλη κλίμακα- μπορεί να έχει αρνητικές κοινωνικές επιπτώσεις, ιδίως σε ορισμένες κοινωνίες με παραδοσιακές προκαταλήψεις, οδηγώντας στη...
Επιστήμονες στη Βρετανία ανακάλυψαν ότι ένα κοινό βακτήριο (Clostridium difficile) που μολύνει το έντερο προκαλώντας έντονη διάρροια, εξελίσσεται πλέον σε δύο ξεχωριστά είδη, εκ των οποίων το ένα με το πέρασμα του χρόνου έχει ήδη αναπτύξει μεγάλη προσαρμοστικότητα, ώστε να εξαπλώνεται στα νοσοκομεία. Οι ερευνητές, με επικεφαλής τον Δρ. Νιτίν Κουμάρ του Ινστιτούτου Wellcome Sanger, που έκαναν τη σχετική δημοσίευση στο Nature Genetics, πραγματοποίησαν τη μεγαλύτερη μέχρι σήμερα διεθνώς γενετική ανάλυση...
Ένα αγαπημένο καλοκαιρινό φρούτο, το κεράσι, φαίνεται ότι μειώνει τις μυοσκελετικές επιπλοκές της θεραπείας με αναστολείς της αρωματάσης σε ασθενείς με μη μεταστατικό καρκίνο του μαστού, σύμφωνα με τα ευρήματα μιας νέας κλινικής δοκιμής που πραγματοποίησαν επιστήμονες από την Ιατρική Σχολή και το Αντικαρκινικό Κέντρο Joan C. Edwards του Πανεπιστημίου Marshall και παρουσιάστηκε στο Ετήσιο Συνέδριο Κλινικής Ογκολογίας στην Αμερική. Οι αναστολείς της αρωματάσης αποτελούν μια συμβατική θεραπεία για...
Λιγότερο αναπτυγμένες κοινωνικές δεξιότητες έχουν τα νήπια που ξοδεύουν πολλή ώρα μπροστά στην τηλεόραση ή χρησιμοποιούν ηλεκτρονικές συσκευές. Αυτό αναφέρει νέα έρευνα του Πανεπιστημίου της Αλμπέρτα που δημοσιεύθηκε στο BMC Public Health. Στη νέα μελέτη, η συμπεριφορική επιδημιολόγος Valerie Carson και η ερευνητική της ομάδα εξέτασαν τις σχέσεις μεταξύ της σωματικής δραστηριότητας και της καθιστικής συμπεριφοράς με τις κοινωνικές δεξιότητες, σε νήπια 1-2, 2-3 και 3-4 ετών σε 251 παιδιά. Οι ερευνητές...
Στα ίδια επίπεδα με τον τοκετό στο νοσοκομείο βρίσκεται ο κίνδυνος τοκετού στο σπίτι. Αυτό κατέδειξε νέα έρευνα του Πανεπιστημίου McMaster που δημοσιεύθηκε στο The Lancet’s EclinicalMedicine. Σύμφωνα με τους ερευνητές η επιλογή να γεννηθεί το παιδί στο σπίτι δεν αύξανε τις πιθανότητες περιγεννητικού ή νεογνικού θανάτου συγκριτικά με τη γέννηση του παιδιού στο προστατευμένο περιβάλλον του νοσοκομείου. «Σήμερα οι περισσότερες γυναίκες στις προηγμένες χώρες επιλέγουν να γεννήσουν στο σπίτι αλλά υπάρχουν...
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Publication date: Available online 14 August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Jiean Joseph Heifetz-Li, Samer Abdelsamie, Conor B. Campbell, Stephanie Roth, Allen F. Fielding, Joseph P. MulliganObjectiveMedication-related osteonecrosis of the jaw (MRONJ) is a pathologic process resulting in progressive jawbone destruction. There are no established guidelines for the medical management of MRONJ. Interest in pentoxifylline and tocopherol is growing...
Publication date: Available online 14 August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Khrystyna Zhurakivska, Giorgio Toni, Gregorio Laino, Renato Franco, Giuseppe Troiano, Luigi Laino, Andrea RonchiAbstractObjectivesthe occurrence of hairs in the oral cavity is an exceeding rare event, with unknown etiology. A literature review found only five cases, most of which describing a single hair localized in various sites of the oral cavity. The aim of the present...
Is the digital radiographic detection of approximal caries lesions influenced by viewing conditions?
Publication date: Available online 13 August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Carlos Augusto Souza Lima, Eduarda Helena Leandro do Nascimento, Hugo Gaêta-Araujo, Christiano Oliveira-Santos, Deborah Queiroz Freitas, Francisco Haiter-Neto, Matheus Lima OliveiraAbstractObjectivesTo assess the influence of different viewing conditions (combinations of computer display, horizontal viewing angle, and ambient lighting) on the digital radiographic detection...
Publication date: Available online 13 August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Paolo J. Fantozzi, Nathaniel Treister, Revathi Shekar, Sook-Bin Woo, Alessandro VillaAbstractObjectivesTo report on the clinical indications and treatment outcomes of intralesional steroid therapy (IST) for oral ulcerative conditions in an oral medicine practice.Study DesignA retrospective single-center study of patients with oral ulcerative conditions who were treated...
Publication date: Available online 13 August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Dong Hoon Lee, Tae Mi Yoon, Joon Kyoo Lee, Sang Chul LimABSTRACTOBJECTIVEWe investigated the computed tomography (CT) features of the maxillary sinus fungus ball and compared them with those of other maxillary sinus diseases.PATIENTS and METHODSThe CT findings of 98 fungus ball lesions in 96 patients, 35 cases of sinusitis confined to the maxillary sinus, and 35 other...
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Spinal epidural abscess is a neurologic emergency with a potential complication to the spinal cord such as paralysis. Frequently, it has a nonspecific initial presentation such as neck or back pain, and hence there is a delay in diagnosis. We present the case of a 60-year-old Caucasian male who presented to emergency room with one week of numbness and weakness of all four extremities. Neurological examination showed variable quadriparesis. Urgent MRI of spine with contrast revealed epidural abscess...
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Vincristine-induced Polyneuropathy at FDG PET/CT. Radiology. 2019 Aug 13;:190861 Authors: Ng KS, Leung JMS PMID: 31407973 [PubMed - as supplied by publisher]
Error Disclosure and Apology in Radiology: The Case for Further Dialogue. Radiology. 2019 Aug 13;:190126 Authors: Brown SD, Bruno MA, Shyu JY, Eisenberg R, Abujudeh H, Norbash A, Gallagher TH PMID: 31407972 [PubMed - as supplied by publisher]
U.S. PET/CT and Gamma Camera Diagnostic Reference Levels and Achievable Administered Activities for Noncardiac Nuclear Medicine Studies. Radiology. 2019 Aug 13;:190623 Authors: Becker MD, Butler PF, Siam M, Gress DA, Ghesani M, Harkness BA, Yoo DC, Oates ME Abstract Existing surveys of radiopharmaceutical doses for U.S. nuclear medicine laboratories are of limited scope and size. Dose data are important because they can be used to benchmark individual...
White Matter by Diffusion MRI Following Methylphenidate Treatment: A Randomized Control Trial in Males with Attention-Deficit/Hyperactivity Disorder. Radiology. 2019 Aug 13;:182528 Authors: Bouziane C, Filatova OG, Schrantee A, Caan MWA, Vos FM, Reneman L Abstract BackgroundMethylphenidate (MPH) is highly effective in treating attention-deficit/hyperactivity disorder (ADHD). However, not much is known about its effect on the development of human brain...
Delayed 18F FDG PET/CT Imaging in the Assessment of Residual Tumors after Transurethral Resection of Bladder Cancer. Radiology. 2019 Aug 13;:190032 Authors: Yan H, Zhou X, Wang X, Li R, Shi Y, Xia Q, Wan L, Huang G, Liu J Abstract Background Delayed fluorine 18 (18F) fluorodeoxyglucose (FDG) PET/CT is used to diagnose bladder cancer. However, it remains difficult to determine whether a lesion with abnormal 18F FDG uptake is tumor residue or recurrence...
Digital Mammography versus Breast Tomosynthesis: Impact of Breast Density on Diagnostic Performance in Population-based Screening. Radiology. 2019 Aug 13;:190425 Authors: Østerås BH, Martinsen ACT, Gullien R, Skaane P Abstract BackgroundPrevious studies comparing digital breast tomosynthesis (DBT) to digital mammography (DM) have shown conflicting results regarding breast density and diagnostic performance.PurposeTo compare true-positive and false-positive...
Predicting Axillary Response to Neoadjuvant Chemotherapy: Breast MRI and US in Patients with Node-Positive Breast Cancer. Radiology. 2019 Aug 13;:190014 Authors: Kim R, Chang JM, Lee HB, Lee SH, Kim SY, Kim ES, Cho N, Moon WK Abstract Background In patients who are expected to achieve axillary pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC), omission of axillary lymph node (LN) dissection could prevent morbidity and complications....
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Related ArticlesThe CFTR Corrector, VX-809 (Lumacaftor), Rescues ABCA4 Trafficking Mutants: a Potential Treatment for Stargardt Disease. Cell Physiol Biochem. 2019;53(2):400-412 Authors: Liu Q, Sabirzhanova I, Bergbower EAS, Yanda M, Guggino WG, Cebotaru L Abstract BACKGROUND/AIMS: Mutations in ABCA4 cause Stargardt macular degeneration, which invariably ends in legal blindness. We studied two common mutants, A1038V (in NBD1) and G1961E (in NBD2), with...
Related ArticlesEuterpe oleracea Mart. (Açai) Supplementation Attenuates Acute Doxorubicin-Induced Cardiotoxicity in Rats. Cell Physiol Biochem. 2019;53(2):388-399 Authors: Mathias LMBS, Alegre PHC, Dos Santos IOF, Bachiega T, Figueiredo AM, Chiuso-Minicucci F, Fernandes AA, Bazan SGZ, Minicucci MF, Azevedo PS, Okoshi MP, Zornoff LAM, Paiva SAR, Polegato BF Abstract BACKGROUND/AIMS: Doxorubicin, a chemotherapy drug used successfully for years, could...
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Publication date: Available online 14 August 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Montey Garg, Ben Tudor-Green, Brian BisaseAbstractAdenoid cystic carcinoma (ACC) is an aggressive, rare, malignant tumour that accounts for about 1% of all head and neck neoplasms and 10% of all salivary gland tumours. It is characterised by frequent local recurrences and distant metastases. Growth is slow but relentless, and progression poses a challenge to head and neck clinicians....
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Related ArticlesSedative/Tranquilizer Misuse is Associated with Alcohol and Illicit Drug Problems, Mental Health Issues, and Impulsivity and Compulsivity in University Students. J Addict Med. 2019 Aug 08;: Authors: Grant JE, Lust K, Chamberlain SR Abstract BACKGROUND: This study examined the prevalence of sedative/tranquilizer misuse among university students and its associations with psychosocial correlates. METHODS: Nine thousand four hundred...
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Dietary Meat Categories and Descriptions in Chronic Disease Research Are Substantively Different within and between Experimental and Observational Studies: A Systematic Review and Landscape Analysis. Adv Nutr. 2019 Aug 13;: Authors: O'Connor LE, Gifford CL, Woerner DR, Sharp JL, Belk KE, Campbell WW Abstract This systematic review and landscape analysis describes patterns in dietary meat (skeletal muscle and associated tissues from mammalian, avian,...
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Examining the effects of different teaching strategies on metacognition and academic performance. Adv Physiol Educ. 2019 Sep 01;43(3):414-422 Authors: Langdon J, Botnaru DT, Wittenberg M, Riggs AJ, Mutchler J, Syno M, Caciula MC Abstract The purpose of this study was to evaluate the effect of different metacognitive interventions on knowledge and regulation of cognition, as well as academic performance (i.e., exam and final grades) in three sections...
Understanding basic vein physiology and venous blood pressure through simple physical assessments. Adv Physiol Educ. 2019 Sep 01;43(3):423-429 Authors: Tansey EA, Montgomery LEA, Quinn JG, Roe SM, Johnson CD Abstract An understanding of the complexity of the cardiovascular system is incomplete without a knowledge of the venous system. It is important for students to understand that, in a closed system, like the circulatory system, changes to the venous...
Answering Huxley: "now" students take a "then" exam. Adv Physiol Educ. 2019 Sep 01;43(3):397-400 Authors: Rangachari PK Abstract Twenty-eight undergraduate students in a health sciences program volunteered for an exercise in the history of examinations. They had completed a second-year course in anatomy and physiology in which they studied modern texts and took standard contemporary exams. For this historical "experiment," students studied selected chapters...
Teaching physiology within a system dynamics framework. Adv Physiol Educ. 2019 Sep 01;43(3):435-440 Authors: Rubin DM, Letts RFR, Richards XL PMID: 31408384 [PubMed - in process]
Effect of in-class group clicker-quiz competition on student final exam performance. Adv Physiol Educ. 2019 Sep 01;43(3):430-434 Authors: Priego-Quesada JI, Jimenez-Perez I, Cibrián Ortiz de Anda RM, González-Peña R, Salvador Palmer R PMID: 31408383 [PubMed - in process]
Design of a student-led organizational partnership to host an annual statewide Science Olympiad K-12 outreach tournament. Adv Physiol Educ. 2019 Sep 01;43(3):401-407 Authors: Tavakol DN, Emmons K Abstract Since fall 2015, the University of Virginia's (UVA) Engineering Student Council (ESC) has partnered with the nonprofit Virginia Science Olympiad (VASO) organization to host a Science Olympiad (SciOly) state tournament in Charlottesville, Virginia, each...
Using technology to increase student (and faculty satisfaction with) engagement in medical education. Adv Physiol Educ. 2019 Sep 01;43(3):408-413 Authors: Kay D, Pasarica M Abstract Faculty dissatisfaction with diminishing levels of student engagement in lifestyle medicine sessions prompted this exploratory project that compared differences in students' substantive engagement in medical preclinical and clinical level lifestyle medicine sessions. The...
2nd Pan American Congress of Physiological Sciences, Havana, Cuba, May 27-31, 2019. Adv Physiol Educ. 2019 Sep 01;43(3):441-442 Authors: Carroll RG, Halpin PA, Silverthorn DU Abstract Physiology education was well represented at the 2nd Pan American Congress of Physiological Sciences in Havana, Cuba, with two symposia, a workshop, and a poster session.PMID: 31408380 [PubMed - in process]
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Dedicator of cytokinesis protein 2 couples with lymphoid enhancer-binding factor 1 to regulate expression of CD21 and B-cell differentiation. J Allergy Clin Immunol. 2019 Jul 29;: Authors: Jing Y, Kang D, Liu L, Huang H, Chen A, Yang L, Jiang P, Li N, Miller H, Liu Z, Zhu X, Yang J, Wang X, Sun J, Liu Z, Liu W, Zhou X, Liu C Abstract BACKGROUND: B-cell receptor (BCR) signaling, combined with CD19 and CD21 signals, imparts specific control of B-cell responses....
Related ArticlesBroncho-vaxom alleviates persistent allergic rhinitis in patients by improving Th1/Th2 cytokine balance of nasal mucosa. Rhinology. 2019 Aug 12;: Authors: Meng Q, Li P, Li Y, Chen J, Wang L, He L, Xie J, Gao X Abstract BACKGROUND: Probiotics are mainly distributed in the mucosal system and have the ability to enhance mucosal barrier function and regulate immune responses. Broncho-Vaxom (BV), as a probiotic, has been applied to patients...
Related ArticlesAcacetin-induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor. Phytother Res. 2019 May;33(5):1551-1561 Authors: Sun F, Li D, Wang C, Peng C, Zheng H, Wang X Abstract Aacacetin, a plant flavone has shown antitumor efficacy recently. However, its associated mechanisms are poorly known. We hypothesized that the muscarinic M3 receptor (M3 R), which is highly expressed in some...
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Related ArticlesImplications of structural heterogeneity for the electronic structure of the final oxygen-evolving intermediate in photosystem II. J Inorg Biochem. 2019 Aug 01;199:110797 Authors: Krewald V, Neese F, Pantazis DA Abstract Heterogeneity in intermediate catalytic states of the oxygen-evolving complex (OEC) of Photosystem II is known from a wide range of experimental and theoretical data, but its potential implications for the mechanism of...
Related ArticlesMedicinal bio-inorganic chemistry: papers from the Third International Summer School of Bioinorganic Medicinal Chemistry, Cagliari, Italy. J Inorg Biochem. 2019 Aug 06;199:110798 Authors: Nurchi VM PMID: 31404887 [PubMed - as supplied by publisher]
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Abstract Purpose To evaluate several clinical and functional parameters by administration of specific questionnaires to an elderly patient's cohort wearing three different types of removable partial denture (RPD): VALPLAST‐RPD (Polyamide VALPLAST), CoCr‐RPD (cobalt‐chromium alloy), and PMMA‐RPD (heat polymerized polymethyl methacrylate). Materials and Methods One hundred twenty patients (mean age 73 years) were included in this study. All patients were treated with a removable partial denture...
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Background. Renal fibrosis is a common outcome of all pathological types of chronic kidney disease (CKD). However, the noninvasive detection of renal fibrosis remains a challenge. Methods. We collected urine samples from 154 biopsy-proven IgA nephropathy (IgAN) patients and 61 healthy controls. The expression of mTOR was measured and the correlation with renal function parameter and pathological indicators. The receiver operating characteristic (ROC) curve for the diagnosis of IgAN and renal fibrosis...
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Publication date: Available online 13 August 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Jamma Li, Aryan Shahabi-Sirjani, Nikhita Ange, Melanie Figtree, Philip Hoyle, Suran L. Fernando
Publication date: Available online 13 August 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Lisa J. Kobrynski
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Related ArticlesPrevalence and Predictors of Vitamin D Deficiency among African Immigrants Living in Australia. Int J Environ Res Public Health. 2019 Aug 10;16(16): Authors: Horton-French K, Dunlop E, Lucas RM, Pereira G, Black LJ Abstract Vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) concentrations <50 nmol/L) is a public health issue in Australia and internationally. Those with darker skin require a greater dose of ultraviolet B radiation...
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Publication date: Available online 13 August 2019Source: Journal of the American College of SurgeonsAuthor(s): James R. Barrett, Melissa K. Drezdzon, Arezu H. Monawer, Ann P. O’Rourke, John E. ScarboroughAbstractBackgroundIn an era of competency-based education and concern about graduating resident readiness for practice, early resident autonomy and the ability to safely teach junior residents is becoming increasingly important. In this study we aimed to understand the effect of “Teaching Resident”...
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Abstract The 22q11.2 deletion syndrome (22q11.2DS) is a multisystem condition and the most prevalent microdeletion syndrome in humans. Approximately 25% of individuals with 22q11.2DS receive antipsychotic treatment. To assess whether patients with 22q11.2DS are vulnerable to adverse effects of antipsychotic medication, we carried out a literature review. A systematic search strategy was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Publications...
Abstract Co‐occurrence of primordial dwarfism and microcephaly together with particular skeletal findings are seen in a wide range of Mendelian syndromes including microcephaly micromelia syndrome (MMS, OMIM 251230), microcephaly, short stature, and limb abnormalities (MISSLA, OMIM 617604), and microcephalic primordial dwarfisms (MPDs). Genes associated with these syndromes encode proteins that have crucial roles in DNA replication or in other critical steps of the cell cycle that link DNA replication...
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Publication date: Available online 14 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Vera Mahler, Robert E. Esch, Jörg Kleine-Tebbe, William J. Lavery, Greg Plunkett, Stefan Vieths, David I. Bernstein
Publication date: Available online 14 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Ronald L. Rabin, Jennifer Bridgewater, Jay E. Slater
Publication date: Available online 13 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Benjamin Volkmer, Raquel Planas, Emanuel Gossweiler, Anna Lünemann, Lennart Opitz, Andrea Mauracher, Ursina Nüesch, Tenzin Gayden, Daniela Kaiser, Barbara Drexel, Claudia Dumrese, Nada Jabado, Stefano Vavassori, Jana Pachlopnik Schmid
Publication date: Available online 13 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Robert Bissonnette, Ana B. Pavel, Aisleen Diaz, John L. Werth, Chuanbo Zang, Ivana Vranic, Vivek S. Purohit, Michael A. Zielinski, Bonnie Vlahos, Yeriel D. Estrada, Etienne Saint-Cyr Proulx, William C. Ports, Emma Guttman-YasskyAbstractBackgroundCrisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild-to-moderate atopic dermatitis (AD). The...
Publication date: Available online 13 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Juan Carlos Bustamante Ogando, Armando Partida Gaytán, Juan Carlos Aldave Becerra, Aristóteles Álvarez Cardona, Liliana Bezrodnik, Arturo Borzutzky, Lizbeth Blancas Galicia, Diana Cabanillas, Antonio Condino-Neto, Ranero Agustín De Colsa, Sara Espinosa Padilla, Folloni Fernandes Juliana, Jorge Alberto García Campos, Héctor Gómez Tello, María Edith González Serrano, Alonso Gutiérrez Hernández,...
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Publication date: Available online 13 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Fahad Alkhudhairy, Fahim Vohra, Mustafa Naseem, Zeeshan H AhmadAbstractAimThe aim of this in-vitro study is to investigate the shear bond strength (SBS) of Bioactive bulk fill restorative material (BARM) (Activa) by surface pre-treatment using Er,Cr:YSGG (ECL) on dentin in comparison to conventional dentin conditioning techniques.Material and MethodsSixty extracted non-carious, non-fractured,...
Publication date: Available online 13 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Ibrahim AlShahrani, Muhammad Abdullah Kamran, Salem Almoammar, Ali AlhaizaeyAbstractAimTo evaluate the shear bond strength (SBS) and modes of lithium disilicate ceramics (LDC) photosensitized by Er,Cr:YSGG (ECL) and fractional carbon dioxide (CO2) laser bonded to metallic bracket compared to traditional conditioning methods.Material and MethodFifty LDC discs were polished and randomly allocated...
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Publication date: October 2019Source: Journal of Human Evolution, Volume 135Author(s): Megan Petersdorf, Anna H. Weyher, Jason M. Kamilar, Constance Dubuc, James P. HighamAbstractDue to wide variation in the presence and degree of expression of a diverse suite of sexually-selected traits, the tribe Papionini represents an outstanding model for understanding how variation in sexual selection pressures and mechanisms leads to trait evolution. Here, we discuss the particular value of Papio as a model...
Publication date: October 2019Source: Journal of Human Evolution, Volume 135Author(s): Clément Zanolli, Fereidoun Biglari, Marjan Mashkour, Kamyar Abdi, Hervé Monchot, Karyne Debue, Arnaud Mazurier, Priscilla Bayle, Mona Le Luyer, Hélène Rougier, Erik Trinkaus, Roberto MacchiarelliAbstractWezmeh Cave, in the Kermanshah region of Central Western Zagros, Iran, produced a Late Pleistocene faunal assemblage rich in carnivorans along with a human right maxillary premolar, Wezmeh 1, an unerupted tooth...
Publication date: October 2019Source: Journal of Human Evolution, Volume 135Author(s): Louise Humphrey, Alison Freyne, Marieke van de Loosdrecht, Joshua T. Hogue, Elaine Turner, Nick Barton, Abdeljalil BouzouggarAbstractInfant remains are relatively uncommon in the late Pleistocene (Upper Palaeolithic) archaeological record. Funerary treatment is considered indicative of social status and mirrors cultural attitudes toward the deceased or the group they represent. Here we report on the burials of...
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Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Edilberto Amorim, Michelle van der Stoel, Sunil B. Nagaraj, Mohammad M. Ghassemi, Jin Jing, Una-May O'Reilly, Benjamin M. Scirica, Jong Woo Lee, Sydney S. Cash, M. Brandon WestoverAbstractObjectiveElectroencephalogram (EEG) reactivity is a robust predictor of neurological recovery after cardiac arrest, however interrater-agreement among electroencephalographers is limited. We sought to evaluate the performance...
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Abstract The prevalence of shift work disorder (SWD) has been studied using self‐reported data and the International Classification of Sleep Disorders, Second Edition (ICSD‐2) criteria. We examined the prevalence in relation to ICSD‐2 and ICSD‐3 criteria, work schedules and the number of non‐day shifts (work outside 06:00–18:00 hours) using objective working‐hours data. Secondly, we explored a minimum cut‐off for the occurrence of SWD symptoms. Hospital shift workers without (n = 1,813) and with...
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Suneetha Viswanathaiah, Manohar Babu, M ManjunathaJournal of The Academy of Clinical Microbiologists 2019 21(1):34-37 There are very few reports of Aspergillus flavus causing endogenous Aspergillus endophthalmitis (EAE) in immunocompetent individuals although it is well recognized in the immunocompromised. Treatment can be with intravitreal, intravenous and oral antifungal agents. We present a case of EAE in a 23-year-old female with no predisposing risk factors. A detailed systemic evaluation...
Chand WattalJournal of The Academy of Clinical Microbiologists 2019 21(1):2-3
Deepa Pandey, Meenakshi Agarwal, Seema Chadha, Divya AggarwalJournal of The Academy of Clinical Microbiologists 2019 21(1):47-49 Mucormycosis is a life-threatening invasive fungal infection usually occurring in immunocompromised patients or in patients with uncontrolled diabetes mellitus. It carries a high mortality rate. Aspergillosis which is caused by Aspergillus species may cause an invasive disease in immunosuppressed patients. A 63-year-old female patient with type 2 diabetes mellitus presented...
Sanjay Bhattacharya, Vinitha Mary Joy, Gaurav Goel, Swapna R Nath, Shabina Santosh, Kalpana George, Ranganathan Iyer, Kavita Raja, A Uma, Aarti Gupta, Anitha Madhavan, Arindam Chakraborty, Barsha Sen, Beena Philomina, Dhruv K Mamtora, KP Dinoop, J Lancy, Mahua Dasgupta, Mannu R Jain, Mohd Tajuddin, Neethu Kishor, Prithi Nair, K Rejitha, Rekha N Nair, Sarada Devi, TS Shailaja, A Shilpa, Shoba Kurian, KV Suseela, SG Sagila, Syed Mustaq Ahmed, Yogesh Kumar GuptaJournal of The Academy of Clinical Microbiologists...
Sheeja T M Rajan, Sindhu Bhaskaran, Mamta George, Sapna Helen GeorgeJournal of The Academy of Clinical Microbiologists 2019 21(1):40-43 Phaeohyphomycosis is a group of rare opportunistic infections caused by dematiaceous fungi. Their significance in the newly emerging and rare fungal infections of solid organ transplant recipients is being increasingly recognised. We present a case of fungal infection of both hands in a post-renal transplant patient on immunosuppressive drugs, by Phaeoacremonium...
Syed Mustaq Ahmed, Ramakrishna Pai Jakribettu, Sumita Rajeevan, Ann George, Muhsina A K Mariyam, S Vidya RaoJournal of The Academy of Clinical Microbiologists 2019 21(1):10-15 INTRODUCTION: Blood stream infections (BSI) accounts for the most serious infection encountered in hospital. It has high rate of morbidity and mortality with high cost of treatment including high end antibiotics. Therefore, early detection, identification of the pathogens with their antibiogram is very important. With the...
Manjusree ShanmughamJournal of The Academy of Clinical Microbiologists 2019 21(1):1-1
Monica Selvan, R Deepashree, Prasanna Bhat, R Akshatha, Sunil Jayakar, Apurba Sankar SastryJournal of The Academy of Clinical Microbiologists 2019 21(1):16-23 INTRODUCTION: Blood stream infections (BSIs) are responsible for significant morbidity and mortality. Numerous studies have pointed to the importance of early and prompt institution of empirical antimicrobial therapy in reducing morbidity and mortality in BSI. The antibiotic spectrum must be narrowed as soon as possible, considering the clinical...
KM Rafeeda, M Geethanjali, BL Umapathy, Mary MathewJournal of The Academy of Clinical Microbiologists 2019 21(1):38-39 Fungal prosthetic valve endocarditis is a rare but serious complication of valve replacement surgery. We describe a case report of prosthetic valve endocarditis caused by Candida parapsilosis resistant to Amphotericin B, and the patient was completely recovered due to prompt redo surgery and with Caspofungin and Fluconazole therapy.
Bhavna T Jishnu, Ananya Thupakki Sriparna, K Vichitra, Anupma Jyoti KindoJournal of The Academy of Clinical Microbiologists 2019 21(1):24-28 CONTEXT: Aspergillus is present ubiquitously in the environment in the form of spores. Infection due to Aspergilli is uncommon in immunocompetent individuals, unless they possess any abnormalities or have undergone any treatment with corticosteroids in which pulmonary aspergillosis is the most common. In immunocompromised individuals, the infection by this...
Sumana Mahadevaaiah Neelambike, Sowmya Govindanahalli Shivappa, Chetak Kadbasal BasavarajJournal of The Academy of Clinical Microbiologists 2019 21(1):44-46 Gram's stain is an invaluable, simple and inexpensive staining technique which gives a clue to the aetiological bacterial agent, thus helping in choosing the appropriate antibiotic. The significance of Gram's stain in bone marrow aspirate has not been described in previous literature. This is the case report of a child who presented with fever...
Sushma Krishna, Kavitha R Dinesh, Tintu Abraham, Dilip Panikar, Sanjeev Singh, Shamsul KarimJournal of The Academy of Clinical Microbiologists 2019 21(1):29-33 BACKGROUND: Ventriculoperitoneal shunt insertions are one of the important neurosurgical procedures done to enhance the neurological functions and improve the survival of patients with hydrocephalus. However, shunt infections are associated with an increased risk of morbidity and the mortality of 30%–40%. The study objective was to evaluate...
Jonathan Lister, Saswati Rakshit, Srabanti Bose, Kingshuk Dhar, Maitrayee Sarkar De, Sanjay Bhattacharya, Venkata Raman Ramanan, Aseem Yogishwar Mahajan, Mammen ChandyJournal of The Academy of Clinical Microbiologists 2019 21(1):50-53 CONTEXT: Assessment of cleaning cost of hospitals is important for hospital administrators, infection control experts and housekeeping managers. Such data are lacking in the medical literature. AIMS: The aim of this study was to determine the cleaning cost of a...
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Abstract Background Allergic asthma causes substantial morbidity and constitutes a public health burden, which increases with asthma severity. There is evidence that allergy immunotherapy (AIT) prevents the progression from allergic rhinitis (AR) to asthma. However, evidence is missing on the potential of AIT to prevent progression from milder to more severe asthma. Methods This population‐based cohort study utilized healthcare data (2005 to 2014) from a statutory health insurance in Germany....
Abstract Background Recent studies pointed to a crucial role for apolipoproteins in the pathogenesis of inflammatory diseases. However, the role of apolipoprotein‐IV (ApoA‐IV) in allergic inflammation has not been addressed thoroughly thus far. Objective Here we explored the anti‐inflammatory effects and underlying signaling pathways of ApoA‐IV on eosinophil effector function in vitro and in vivo. Methods Migratory responsiveness, Ca2+‐flux and respiratory burst of human peripheral...
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New Findings The central question of this study was to evaluate the degree to which increases in haematocrit alter cerebral blood flow and cerebral oxygen delivery during acclimatization to high‐altitude. Through haemodilution, we determined that, following one‐week of acclimatization, the primary mechanism contributing to the cerebral blood flow response during acclimatization is increases in haemoglobin and haematocrit, while the remaining contribution to the cerebral blood flow response during...
New Findings The red nucleus contributes importantly to modulation of respiratory output. Stimulation of red nucleus mediates respiratory phase transitions and inhibitory or excitatory responses of medullary inspiratory and expiratory units. Rubromedullary and rubrospinal projections to zones mediating respiratory output have been well demonstrated. Red nucleus is critically required in mediating hypoxic ventilatory depression and may represent a zone mediating integration of respiratory output...
New Findings What is the central question of this study? We sought to determine the effect of age and sex on the resistive and viscoelastic components of work of breathing (Wb) during exercise. What is the main finding and its importance? We modelled the Wb‐minute ventilation relationship during exercise in healthy males and females. We found that the resistive and viscoelastic components of Wb were higher in older adults, regardless of sex. We also confirmed our previous findings that the...
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Abstract A recent study claims that participants wearing a bike helmet behave riskier in a computer‐based risk task compared to control participants without a bike helmet. We hypothesized that wearing a bike helmet reduces cognitive control over risky behavior. To test our hypothesis, we recorded participants' EEG brain responses while they played a risk game developed in our laboratory. Previously, we found that, in this risk game, anxious participants showed greater levels of cognitive control...
Abstract We utilized a data‐driven, unsupervised machine learning approach to examine patterns of peripheral physiological responses during a motivated performance context across two large, independent data sets, each with multiple peripheral physiological measures. Results revealed that patterns of cardiovascular response commonly associated with challenge and threat states emerged as two of the predominant patterns of peripheral physiological responding within both samples, with these two patterns...
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Chronic Respiratory Disease, Volume 16, Issue , January-December 2019. Acute exacerbations of chronic airway disease are common occurrences that cause a major burden of illness. Acute exacerbations are associated with impaired health status, increased lung function decline, hospitalization and increased risk of death. Exacerbation avoidance is a major priority. Despite this goal, exacerbations continue to occur and the need for effective models of care that optimize patient outcomes are urgently...
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Journal of International Medical Research, Ahead of Print.
Journal of International Medical Research, Ahead of Print.
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