Antibiotics, Vol. 8, Pages 119: The Oral Pheneticillin Absorption Test: An Accurate Method to Identify Patients with Inadequate Oral Pheneticillin Absorption Antibiotics doi: 10.3390/antibiotics8030119 Authors: Dijkmans Kweekel Dissel Esdonk Kamerling Burggraaf Severe streptococcal infections are commonly treated with intravenous followed by oral penicillin (pheneticillin) therapy. However, switching from iv to oral therapy is complicated by the variability in oral...
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Antioxidants, Vol. 8, Pages 310: Myrciaria tenella (DC.) O. Berg (Myrtaceae) Leaves as a Source of Antioxidant Compounds Antioxidants doi: 10.3390/antiox8080310 Authors: Ana Raquel Carneiro Ribeiro Maria Lúcia da Silva Cordeiro Larissa Marina Pereira Silva Cesar Orlando Munoz Cadavid Ricardo Basílio de Oliveira Caland Marília Medeiros Fernandes-Negreiros Moacir Fernandes Queiroz Jefferson da Silva Barbosa Cicero Flavio Soares Aragão Silvana Maria Zucolotto Riva...
Antioxidants, Vol. 8, Pages 311: Bioactive Amines Screening in Four Genotypes of Thermally Processed Cauliflower Antioxidants doi: 10.3390/antiox8080311 Authors: Diamante Borges Silva Minatel Corrêa Gomez Lima Biogenic amines are important indicators of food quality with recognized antioxidant capacity. Diets that are rich in these compounds promote several benefits for human health, although the consumption in excess may result in food poisoning. This study...
Antioxidants, Vol. 8, Pages 309: In Vitro and In Vivo Antioxidant Properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-Induced Hypertensive Rats Antioxidants doi: 10.3390/antiox8080309 Authors: Olukayode O. Aremu Adebola O. Oyedeji Opeoluwa O. Oyedeji Benedicta N. Nkeh-Chungag Constance R. Sewani Rusike Oxidative stress has gained attention as one of the fundamental mechanisms responsible for the development of hypertension. The present study investigated...
Antioxidants, Vol. 8, Pages 308: Anti-Hyperglycemic and Anticholinergic Effects of Natural Antioxidant Contents in Edible Flowers Antioxidants doi: 10.3390/antiox8080308 Authors: Paulina Nowicka Aneta Wojdyło In this study, 16 selected edible flowers were evaluated for their content of bioactive compounds (polyphenols, carotenoids, triterpenoids) and for their anti-diabetic (ability to inhibit α-amylase and α-glucosidases) and anti-aging (ability to inhibit acetylcholinesterase...
Antioxidants, Vol. 8, Pages 307: Caffeoylquinic Acids and Flavonoids of Fringed Sagewort (Artemisia frigida Willd.): HPLC-DAD-ESI-QQQ-MS Profile, HPLC-DAD Quantification, in Vitro Digestion Stability, and Antioxidant Capacity Antioxidants doi: 10.3390/antiox8080307 Authors: Daniil N. Olennikov Nina I. Kashchenko Nadezhda K. Chirikova Aina G. Vasil’eva Aydan I. Gadimli Javanshir I. Isaev Cecile Vennos Fringed sagewort (Artemisia frigida Willd., Compositae family) is...
Antioxidants, Vol. 8, Pages 305: Effect of Neem (Azadirachta indica L.) on Lipid Oxidation in Raw Chilled Beef Patties Antioxidants doi: 10.3390/antiox8080305 Authors: Manel Ouerfelli Juliana Villasante Leila Bettaieb Ben Kaâb MaríaPilar Almajano The aim of this study was to determine the total polyphenol content, radical scavenging and antimicrobial activities of Azadirachta indica (A. indica) and to evaluate their effect on shelf-life stability of raw beef patties during refrigerated...
Antioxidants, Vol. 8, Pages 306: Protective Effects of Melon Extracts on Bone Strength, Mineralization, and Metabolism in Rats with Ovariectomy-Induced Osteoporosis Antioxidants doi: 10.3390/antiox8080306 Authors: Bongju Kim Sung-Ho Lee Su-Jin Song Won Hyeon Kim Eun-Sung Song Jae-Chang Lee Sung-Jae Lee Dong-Wook Han Jong-Ho Lee A polyphenolic extract from melon (Cucumis melo L.), as a potential source of natural antioxidants, has been reported to have a positive...
Antioxidants, Vol. 8, Pages 304: A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn. Fruits for Cosmetic Applications Antioxidants doi: 10.3390/antiox8080304 Authors: Samantha Drouet Emilie A. Leclerc Laurine Garros Duangjai Tungmunnithum Atul Kabra Bilal Haider Abbasi Éric Lainé Christophe Hano Silybum marianum (L.) Gaertn. (aka milk thistle) constitutes the...
Antioxidants, Vol. 8, Pages 303: Antioxidant, Anti-Inflammatory, and Multidrug Resistance Modulation Activity of Silychristin Derivatives Antioxidants doi: 10.3390/antiox8080303 Authors: Jitka Viktorová Simona Dobiasová Kateřina Řehořová David Biedermann Kristýna Káňová Karolína Šeborová Radka Václavíková Kateřina Valentová Tomáš Ruml Vladimír Křen Tomáš Macek Silychristin A is the second most abundant compound of silymarin. Silymarin complex was previously...
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Atmosphere, Vol. 10, Pages 469: The Collective Contribution of Atmospheric and Oceanic Components to ENSO Asymmetry Atmosphere doi: 10.3390/atmos10080469 Authors: Yanli Tang Lijuan Li Bin Wang Pengfei Lin Wenjie Dong Kun Xia Four cross-coupled models were used to investigate the relative contributions of atmospheric and oceanic components to the asymmetry of the El Niño–Southern Oscillation (ENSO). Strong El Niño and La Niña events...
Atmosphere, Vol. 10, Pages 468: Evidence for Rayleigh-Taylor Plasma Instability at the Front of Solar Coronal Mass Ejections Atmosphere doi: 10.3390/atmos10080468 Authors: Daniele Telloni Francesco Carbone Alessandro Bemporad Ester Antonucci This work focuses on the interaction of a Coronal Mass Ejection (CME) with the ambient solar corona, by studying the spatial and temporal evolution of the density fluctuations observed by the SOHO/UV Coronagraph Spectrometer (UVCS) during...
Atmosphere, Vol. 10, Pages 467: Expanding the Theory of Planned Behaviour to Reveal Urban Residents’ Pro-Environment Travel Behaviour Atmosphere doi: 10.3390/atmos10080467 Authors: Weiya Chen Chao Cao Xiaoping Fang Zixuan Kang Exploring the mechanism that influences the choice of urban public travel mode is an important policy research topic that can promote urban residents’ pro-environment travel (PET) behaviour and relieve the pressure on urban traffic and environmental...
Atmosphere, Vol. 10, Pages 466: Modeling Streamflow Enhanced by Precipitation from Atmospheric River Using the NOAA National Water Model: A Case Study of the Russian River Basin for February 2004 Atmosphere doi: 10.3390/atmos10080466 Authors: Heechan Han Jungho Kim V. Chandrasekar Jeongho Choi Sanghun Lim This study aims to address hydrological processes and impacts of an atmospheric river (AR) event that occurred during 15–18 February 2004 in the Russian River...
Atmosphere, Vol. 10, Pages 465: Characteristics of Oceanic Warm Cloud Layers within Multilevel Cloud Systems Derived by Satellite Measurements Atmosphere doi: 10.3390/atmos10080465 Authors: Yuhao Ding Qi Liu Ping Lao Low-level warm clouds are a major component in multilayered cloud systems and they are generally hidden from the top-down view of satellites with passive measurements. This study conducts an investigation on oceanic warm clouds embedded in multilayered structures by...
Atmosphere, Vol. 10, Pages 464: Volatile Organic Compound Emissions from Prescribed Burning in Tallgrass Prairie Ecosystems Atmosphere doi: 10.3390/atmos10080464 Authors: Andrew R. Whitehill Ingrid George Russell Long Kirk R. Baker Matthew Landis Prescribed pasture burning plays a critical role in ecosystem maintenance in tallgrass prairie ecosystems and may contribute to agricultural productivity but can also have negative impacts on air quality. Volatile organic compound...
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Behavioral Sciences, Vol. 9, Pages 88: An EEG Study on Emotional Intelligence and Advertising Message Effectiveness Behavioral Sciences doi: 10.3390/bs9080088 Authors: Joseph Ciorciari Jeffrey Pfeifer John Gountas Some electroencephalography (EEG) studies have investigated emotional intelligence (EI), but none have examined the relationships between EI and commercial advertising messages and related consumer behaviors. This study combines brain (EEG) techniques with an EI psychometric...
Behavioral Sciences, Vol. 9, Pages 87: Mindfulness Meditation and Fantasy Relaxation in a Group Setting Leads to a Diminished Sense of Self and an Increased Present Orientation Behavioral Sciences doi: 10.3390/bs9080087 Authors: Niko Kohls Tobias Esch Lea Gerber Lucas Adrian Marc Wittmann (1) Background: Mind-body interventions (MBI), such as meditation or other relaxation techniques, have become the focus of attention in the clinical and health sciences. Differences in the...
Behavioral Sciences, Vol. 9, Pages 86: Shifting Gear in the Study of the Bilingual Advantage: Language Switching Examined as a Possible Moderator Behavioral Sciences doi: 10.3390/bs9080086 Authors: Evy Woumans Shauni Van Herck Esli Struys The bilingual advantage is a heavily debated topic in research on bilingualism. The current study further investigated one specific aspect of bilingualism proposed to be a determining factor for the bilingual advantage, namely language switching...
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Bioengineering, Vol. 6, Pages 71: Multifactorial Modeling Reveals a Dominant Role of Wnt Signaling in Lineage Commitment of Human Pluripotent Stem Cells Bioengineering doi: 10.3390/bioengineering6030071 Authors: Tiago P. Dias Tiago G. Fernandes Maria Margarida Diogo Joaquim M. S. Cabral The human primed pluripotent state is maintained by a complex balance of several signaling pathways governing pluripotency maintenance and commitment. Here, we explore a multiparameter approach...
Bioengineering, Vol. 6, Pages 70: Mechanical Response Changes in Porcine Tricuspid Valve Anterior Leaflet Under Osmotic-Induced Swelling Bioengineering doi: 10.3390/bioengineering6030070 Authors: Samuel D. Salinas Margaret M. Clark Rouzbeh Amini Since many soft tissues function in an isotonic in-vivo environment, it is expected that physiological osmolarity will be maintained when conducting experiments on these tissues ex-vivo. In this study, we aimed to examine how not adhering...
Bioengineering, Vol. 6, Pages 69: Thermal and Physico-Mechanical Characterizations of Thromboresistant Polyurethane Films Bioengineering doi: 10.3390/bioengineering6030069 Authors: Aaron C. Wilson Shih-Feng Chou Roberto Lozano Jonathan Y. Chen Pierre F. Neuenschwander Hemocompatibility remains a challenge for injectable and/or implantable medical devices, and thromboresistant coatings appear to be one of the most attractive methods to down-regulate the unwanted enzymatic...
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Biomolecules, Vol. 9, Pages 373: Human FcRn Tissue Expression Profile and Half-Life in PBMCs Biomolecules doi: 10.3390/biom9080373 Authors: Yao-Yun Fan Vahid Farrokhi Teresa Caiazzo Mengmeng Wang Denise M. O’Hara Hendrik Neubert System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically-based...
Biomolecules, Vol. 9, Pages 371: Structural Changes in the Acceptor Site of Photosystem II upon Ca2+/Sr2+ Exchange in the Mn4CaO5 Cluster Site and the Possible Long-Range Interactions Biomolecules doi: 10.3390/biom9080371 Authors: Koua The Mn4CaO5 cluster site in the oxygen-evolving complex (OEC) of photosystem II (PSII) undergoes structural perturbations, such as those induced by Ca2+/Sr2+ exchanges or Ca/Mn removal. These changes have been known to induce long-range positive shifts...
Biomolecules, Vol. 9, Pages 372: Gold Nanoparticle Size-Dependent Enhanced Chemiluminescence for Ultra-Sensitive Haptoglobin Biomarker Detection Biomolecules doi: 10.3390/biom9080372 Authors: Nirala Shtenberg Bovine mastitis (BM) is a frequent disease in the dairy industry that causes staggering economical losses due to decreased milk production and increased health care costs. Traditionally, BM detection depends on the efficacy and reliability of analytical techniques that measure...
Biomolecules, Vol. 9, Pages 370: Integrative Approaches in Structural Biology: A More Complete Picture from the Combination of Individual Techniques Biomolecules doi: 10.3390/biom9080370 Authors: Linda Cerofolini Marco Fragai Enrico Ravera Christoph A. Diebolder Ludovic Renault Vito Calderone With the recent technological and computational advancements, structural biology has begun to tackle more and more difficult questions, including complex biochemical pathways and...
Biomolecules, Vol. 9, Pages 368: Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor Biomolecules doi: 10.3390/biom9080368 Authors: Vasudevan Borroto-Escuela Huysentruyt Fuxe Saini Stove The interplay between the dopamine (DA) and opioid systems in the brain is known to modulate the additive effects of substances of abuse. On one hand, opioids serve mankind by their analgesic...
Biomolecules, Vol. 9, Pages 369: Post-Translational Modifications in NETosis and NETs-Mediated Diseases Biomolecules doi: 10.3390/biom9080369 Authors: Hamam Palaniyar : Neutrophils undergo a unique form of cell death that generates neutrophil extracellular traps (NETs) that may help to neutralize invading pathogens and restore homeostasis. However, uncontrolled NET formation (NETosis) can result in numerous diseases that adversely affect health. Recent studies further elucidate...
Biomolecules, Vol. 9, Pages 367: Ziziphora taurica subsp. taurica: Analytical Characterization and Biological Activities Biomolecules doi: 10.3390/biom9080367 Authors: Michał Tomczyk Olcay Ceylan Marcello Locatelli Angela Tartaglia Vincenzo Ferrone Cengiz Sarikurkcu The Lamiaceae family comprises many flowering plants classified into about 236 genera. The genus Ziziphora is one of the well-known genera of this family and its species are important in different fields of...
Biomolecules, Vol. 9, Pages 365: Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology Biomolecules doi: 10.3390/biom9080365 Authors: Mithunan Ravindran Meraj A. Khan Nades Palaniyar Neutrophil extracellular traps (NETs), a unique DNA framework decorated with antimicrobial peptides, have been in the scientific limelight for their role in a variety of pathologies ranging from cystic fibrosis to cancer. The formation of NETs, as well as relevant regulatory...
Biomolecules, Vol. 9, Pages 366: The Early Phase of β2m Aggregation: An Integrative Computational Study Framed on the D76N Mutant and the ΔN6 Variant Biomolecules doi: 10.3390/biom9080366 Authors: Rui J. S. Loureiro Diogo Vila-Viçosa Miguel Machuqueiro Eugene I. Shakhnovich Patrícia F. N. Faísca Human β2-microglobulin (b2m) protein is classically associated with dialysis-related amyloidosis (DRA). Recently, the single point mutant D76N was identified as the causative...
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Biosensors, Vol. 9, Pages 100: Gold Nanostar Colorimetric Detection of Fructosyl Valine as a Potential Future Point of Care Biosensor Candidate for Glycated Haemoglobin Detection Biosensors doi: 10.3390/bios9030100 Authors: Mulder Phiri Vorster Diabetes Mellitus is a growing global concern. The current methods used to detect glycated haemoglobin are precise, however, utilise expensive equipment, reagents and consumables. These are luxuries which rural communities cannot access....
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Brain Sciences, Vol. 9, Pages 201: EEG Signals Feature Extraction Based on DWT and EMD Combined with Approximate Entropy Brain Sciences doi: 10.3390/brainsci9080201 Authors: Ji Ma Dong Zhang The classification recognition rate of motor imagery is a key factor to improve the performance of brain–computer interface (BCI). Thus, we propose a feature extraction method based on discrete wavelet transform (DWT), empirical mode decomposition (EMD), and approximate entropy....
Brain Sciences, Vol. 9, Pages 200: Adjunct Diagnostic Value of Transcranial Magnetic Stimulation in Mucopolysaccharidosis-Related Cervical Myelopathy: A Pilot Study Brain Sciences doi: 10.3390/brainsci9080200 Authors: Mariagiovanna Cantone Giuseppe Lanza Alice Le Pira Rita Barone Giovanni Pennisi Rita Bella Manuela Pennisi Agata Fiumara Background: Cervical myelopathy (CM) is a common cause of morbidity and disability in patients with mucopolysaccharidosis (MPS)...
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Cancers, Vol. 11, Pages 1190: FDG-PET/CT for Response Monitoring in Metastatic Breast Cancer: Today, Tomorrow, and Beyond Cancers doi: 10.3390/cancers11081190 Authors: Hildebrandt Lauridsen Vogsen Holm Vilstrup Braad Gerke Thomassen Ewertz Høilund-Carlsen (PREMIO) While current international guidelines include imaging of the target lesion for response monitoring in metastatic breast cancer, they do not provide specific recommendations for choice...
Cancers, Vol. 11, Pages 1189: How to Deal with Second Line Dilemma in Metastatic Colorectal Cancer? A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers11081189 Authors: Galvano Incorvaia Badalamenti Rizzo Guarini Cusenza Castellana Barraco Calò Cutaia Currò Silvestris Beretta Bazan Russo Monoclonal antibodies targeting epidermal growth factor receptor (EGFR) or vascular endothelial growth factor (VEGF) have demonstrated...
Cancers, Vol. 11, Pages 1187: 4-Methylumbelliferone Inhibits Cancer Stem Cell Activation and Overcomes Chemoresistance in Ovarian Cancer Cancers doi: 10.3390/cancers11081187 Authors: Noor A. Lokman Zoe K. Price Emily K. Hawkins Anne M. Macpherson Martin K. Oehler Carmela Ricciardelli We have recently shown that the extracellular matrix molecule hyaluronan (HA) plays a role in the development of ovarian cancer chemoresistance. This present study determined if HA production...
Cancers, Vol. 11, Pages 1188: Anaplastic Thyroid Cancer: Clinical Picture of the Last Two Decades at a Single Oncology Referral Centre and Novel Therapeutic Options Cancers doi: 10.3390/cancers11081188 Authors: Joana Simões-Pereira Ricardo Capitão Edward Limbert Valeriano Leite Anaplastic thyroid cancer (ATC) is a rare tumour but also one of the most lethal malignancies. Therapeutic modalities have usually been limited, but clinical trials with new drugs are now being implemented....
Cancers, Vol. 11, Pages 1180: Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015 Cancers doi: 10.3390/cancers11081180 Authors: Masafumi Kanno Norihiko Narita Yasushi Fujimoto Naohiro Wakisaka Tomokazu Yoshizaki Takeshi Kodaira Chiyoko Makita Yuichiro Sato Keisuke Yamazaki Takanori Wakaoka Yuzo Shimode Hiroyuki Tsuji Ryosuke Kito Hajime Ishinaga Seiji Hosokawa Hiromasa Takakura Kunihiro...
Cancers, Vol. 11, Pages 1182: NF-κB Signaling in Ovarian Cancer Cancers doi: 10.3390/cancers11081182 Authors: Brittney S. Harrington Christina M. Annunziata The NF-κB signaling pathway is a master and commander in ovarian cancer (OC) that promotes chemoresistance, cancer stem cell maintenance, metastasis and immune evasion. Many signaling pathways are dysregulated in OC and can activate NF-κB signaling through canonical or non-canonical pathways which have both...
Cancers, Vol. 11, Pages 1185: Targeted Treatment Options of Recurrent Radioactive Iodine Refractory Hürthle Cell Cancer Cancers doi: 10.3390/cancers11081185 Authors: Mehtap Derya Aydemirli Willem Corver Ruben Beuk Paul Roepman Nienke Solleveld-Westerink Tom van Wezel Ellen Kapiteijn Hans Morreau Objective: To evaluate the efficacy and treatment rationale of Hürthle cell carcinoma (HCC) following a patient with progressive and metastatic HCC. HCC was recently...
Cancers, Vol. 11, Pages 1184: TIMP-1-Mediated Chemoresistance via Induction of IL-6 in NSCLC Cancers doi: 10.3390/cancers11081184 Authors: Wei Xiao Lan Wang John Howard Ravindra Kolhe Amyn M. Rojiani Mumtaz V. Rojiani Elevated tissue inhibitor of metalloproteinase-1 (TIMP-1) is a negative prognosticator in non-small cell lung carcinoma NSCLC patients. This study sought to identify mechanisms whereby TIMP-1 impacts anticancer therapy. Using NSCLC cells and their TIMP-1...
Cancers, Vol. 11, Pages 1183: Hyperthermia Treatment Planning Including Convective Flow in Cerebrospinal Fluid for Brain Tumour Hyperthermia Treatment Using a Novel Dedicated Paediatric Brain Applicator Cancers doi: 10.3390/cancers11081183 Authors: Gerben Schooneveldt Hana Dobšíček Trefná Mikael Persson Theo de Reijke Klas Blomgren Petra Kok Hans Crezee Hyperthermia therapy (40–44 °C) is a promising option to increase efficacy of radiotherapy/chemotherapy...
Cancers, Vol. 11, Pages 1181: Unravelling the Diagnostic Dilemma: A MicroRNA Panel of Circulating MiR-16 and MiR-877 as A Diagnostic Classifier for Distal Bile Duct Tumors Cancers doi: 10.3390/cancers11081181 Authors: Laura L. Meijer Jisce R. Puik Tessa Y.S. Le Large Michal Heger Frederike Dijk Niccola Funel Thomas Wurdinger Ingrid Garajová Nicole C.T. van Grieken Mark A. van de Wiel Elisa Giovannetti Geert Kazemier Accurate diagnosis of pancreatic head...
Cancers, Vol. 11, Pages 1186: Clinical Relevance of Collagen Protein Degradation Markers C3M and C4M in the Serum of Breast Cancer Patients Treated with Neoadjuvant Therapy in the GeparQuinto Trial Cancers doi: 10.3390/cancers11081186 Authors: Malgorzata Banys-Paluchowski Sibylle Loibl Isabell Witzel Christoph Mundhenke Bianca Lederer Christine Solbach Thomas Karn Frederik Marmé Valentina Nekljudova Christian Schem Elmar Stickeler Nicholas Willumsen Morten...
Cancers, Vol. 11, Pages 1179: Papillary Thyroid Carcinoma Variants are Characterized by Co-dysregulation of Immune and Cancer Associated Genes Cancers doi: 10.3390/cancers11081179 Authors: Jaideep Chakladar Wei Tse Li Michael Bouvet Eric Y. Chang Jessica Wang-Rodriguez Weg M. Ongkeko Papillary thyroid carcinoma (PTC) variants exhibit different prognosis, but critical characteristics of PTC variants that contribute to differences in pathogenesis are not well-known. This...
Cancers, Vol. 11, Pages 1177: Electrochemotherapy Causes Caspase-Independent Necrotic-Like Death in Pancreatic Cancer Cells Cancers doi: 10.3390/cancers11081177 Authors: Philana Fernandes Tracey R. O’Donovan Sharon L. McKenna Patrick F. Forde Pancreatic cancer represents a major challenge in oncology. Poor permeability of the pancreas and resistance to currently available therapies are impediments to improved patient survival. By transiently increasing cell membrane porosity...
Cancers, Vol. 11, Pages 1176: Adaptive Responses as Mechanisms of Resistance to BRAF Inhibitors in Melanoma Cancers doi: 10.3390/cancers11081176 Authors: Saei Eichhorn : The introduction of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors in melanoma patients with BRAF (V600E) mutations has demonstrated significant clinical benefits. However, rarely do tumours regress completely. Frequently, the reason for this is that therapies targeting specific oncogenic mutations...
Cancers, Vol. 11, Pages 1178: p21 in Cancer Research Cancers doi: 10.3390/cancers11081178 Authors: Shamloo Usluer p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models emphasized the role of this protein in cell cycle arrest under the p53 transcription factor activity. Although tumor-suppressor function of p21 is the most studied aspect of this protein in cancer,...
Cancers, Vol. 11, Pages 1175: Multi-Drug/Gene NASH Therapy Delivery and Selective Hyperspectral NIR Imaging Using Chirality-Sorted Single-Walled Carbon Nanotubes Cancers doi: 10.3390/cancers11081175 Authors: Md. Tanvir Hasan Elizabeth Campbell Olga Sizova Veronica Lyle Giridhar Akkaraju D. Lynn Kirkpatrick Anton V. Naumov Single-walled carbon nanotubes (SWCNTs) can serve as drug delivery/biological imaging agents, as they exhibit intrinsic fluorescence in the near-infrared,...
Cancers, Vol. 11, Pages 1168: Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody–DM1 Drug Conjugates Cancers doi: 10.3390/cancers11081168 Authors: Haozhong Ding Mohamed Altai Sara S. Rinne Anzhelika Vorobyeva Vladimir Tolmachev Torbjörn Gräslund Anna Orlova Affibody molecules are small affinity-engineered scaffold proteins which can be engineered to bind to desired targets. The therapeutic potential of using an affibody molecule...
Cancers, Vol. 11, Pages 1169: The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma Cancers doi: 10.3390/cancers11081169 Authors: Sioletic Stefano Scambia Giovanni Soft tissue sarcoma (STS) is a rare malignancy of mesenchymal origin classified into more than 50 different subtypes with distinct clinical and pathologic features. Despite the poor prognosis in the majority of patients, only modest improvements in treatment strategies have been achieved, largely due to the rarity and heterogeneity...
Cancers, Vol. 11, Pages 1174: Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies Cancers doi: 10.3390/cancers11081174 Authors: Fausto Petrelli Michele Ghidini Antonio Ghidini Gianluca Perego Mary Cabiddu Shelize Khakoo Emanuela Oggionni Chiara Abeni Jens Claus Hahne Gianluca Tomasello Alberto Zaniboni The association between antibiotic use and risk of cancer development is unclear, and clinical trials are...
Cancers, Vol. 11, Pages 1172: The Tumor Microenvironment in Colorectal Cancer Therapy Cancers doi: 10.3390/cancers11081172 Authors: Leire Pedrosa Francis Esposito Timothy M. Thomson Joan Maurel The current standard-of-care for metastatic colorectal cancer (mCRC) includes chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, even though the addition of anti-angiogenic agents to backbone chemotherapy provides little benefit for...
Cancers, Vol. 11, Pages 1171: Untargeted Assessment of Tumor Fractions in Plasma for Monitoring and Prognostication from Metastatic Breast Cancer Patients Undergoing Systemic Treatment Cancers doi: 10.3390/cancers11081171 Authors: Christoph Suppan Iva Brcic Verena Tiran Hannah D Mueller Florian Posch Martina Auer Erkan Ercan Peter Ulz Richard J Cote Ram H Datar Nadia Dandachi Ellen Heitzer Marija Balic The aim of this study was to assess the prognostic...
Cancers, Vol. 11, Pages 1170: Noncoding RNAs in Extracellular Fluids as Cancer Biomarkers: The New Frontier of Liquid Biopsies Cancers doi: 10.3390/cancers11081170 Authors: Barbara Pardini Alexandru Anton Sabo Giovanni Birolo George Adrian Calin The last two decades of cancer research have been devoted in two directions: (1) understanding the mechanism of carcinogenesis for an effective treatment, and (2) improving cancer prevention and screening for early detection of the disease....
Cancers, Vol. 11, Pages 1173: Comparative Cytogenetic Abnormalities in Paired Choroidal Melanoma Samples Obtained Before and After Proton Beam Irradiation by Transscleral Fine-Needle Aspiration Biopsy and Endoresection Cancers doi: 10.3390/cancers11081173 Authors: Alexandre Matet Khadija Aït Raïs Denis Malaise Martina Angi Rémi Dendale Sarah Tick Livia Lumbroso-Le Rouic Christine Lévy-Gabriel Manuel Rodrigues Gaëlle Pierron Nathalie Cassoux This study compared...
Cancers, Vol. 11, Pages 1167: TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors Cancers doi: 10.3390/cancers11081167 Authors: Ufuk Mert Alshaimaa Adawy Elisabeth Scharff Pierre Teichmann Anna Willms Verena Haselmann Cynthia Colmorgen Johannes Lemke Silvia von Karstedt Jürgen Fritsch Anna Trauzold Binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to the plasma membrane TRAIL-R1/-R2 selectively...
Cancers, Vol. 11, Pages 1166: Cisplatin-Resistance in Oral Squamous Cell Carcinoma: Regulation by Tumor Cell-Derived Extracellular Vesicles Cancers doi: 10.3390/cancers11081166 Authors: Xin-Hui Khoo Ian C. Paterson Bey-Hing Goh Wai-Leng Lee Drug resistance remains a severe problem in most chemotherapy regimes. Recently, it has been suggested that cancer cell-derived extracellular vesicles (EVs) could mediate drug resistance. In this study, the role of EVs in mediating the response...
Cancers, Vol. 11, Pages 1165: Long-Term Dynamics of Three Dimensional Telomere Profiles in Circulating Tumor Cells in High-Risk Prostate Cancer Patients Undergoing Androgen-Deprivation and Radiation Therapy Cancers doi: 10.3390/cancers11081165 Authors: Landon Wark Harvey Quon Aldrich Ong Darrel Drachenberg Aline Rangel-Pozzo Sabine Mai Patient-specific assessment, disease monitoring, and the development of an accurate early surrogate of the therapeutic efficacy of locally...
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Cells, Vol. 8, Pages 904: Genome-Wide Identification and Characterization of Long Noncoding RNAs of Brown to White Adipose Tissue Transformation in Goats Cells doi: 10.3390/cells8080904 Authors: Linjie Wang Xin Yang Yuehua Zhu Siyuan Zhan Zhe Chao Tao Zhong Jiazhong Guo Yan Wang Li Li Hongping Zhang Long noncoding RNAs (lncRNAs) play an important role in the thermogenesis and energy storage of brown adipose tissue (BAT). However, knowledge of the cellular transition...
Cells, Vol. 8, Pages 905: The Autophagy-Cilia Axis: An Intricate Relationship Cells doi: 10.3390/cells8080905 Authors: Morleo Franco Primary cilia are microtubule-based organelles protruding from the surface of almost all vertebrate cells. This organelle represents the cell’s antenna which acts as a communication hub to transfer extracellular signals into intracellular responses during development and in tissue homeostasis. Recently, it has been shown that loss of cilia...
Cells, Vol. 8, Pages 900: Clinical and Genetic Analysis of Children with Kartagener Syndrome Cells doi: 10.3390/cells8080900 Authors: Rute Pereira Telma Barbosa Luís Gales Elsa Oliveira Rosário Santos Jorge Oliveira Mário Sousa Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder characterized by dysfunction of motile cilia causing ineffective mucus clearance and organ laterality defects. In this study, two unrelated Portuguese children with strong...
Cells, Vol. 8, Pages 902: Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection Cells doi: 10.3390/cells8080902 Authors: Sodsai Tovanabutra Rujipas Sirijatuphat Phuc Pham Lydia Bonar Elizabeth Harbolick Meera Bose Hongshuo Song David Chang Celina Oropeza Anne O’Sullivan Joyce Balinang Eugene Kroon Donn Colby Carlo Sacdalan Joanna Hellmuth Phillip Chan Peeriya Prueksakaew...
Cells, Vol. 8, Pages 903: Antioxidant and Pro-Oxidant Activities of Melatonin in the Presence of Copper and Polyphenols In Vitro and In Vivo Cells doi: 10.3390/cells8080903 Authors: Jiajia Wang Xiaoxiao Wang Yufeng He Lijie Jia Chung S. Yang Russel J. Reiter Jinsong Zhang Melatonin is a well-documented antioxidant. Physicochemical analysis using the density functional theory suggests that melatonin is a copper chelating agent; however, experimental evidence is still...
Cells, Vol. 8, Pages 901: Zebrafish in Inflammasome Research Cells doi: 10.3390/cells8080901 Authors: Gabriel Forn-Cuní Annemarie H. Meijer Monica Varela Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function in vivo have started to emerge....
Cells, Vol. 8, Pages 899: Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity Cells doi: 10.3390/cells8080899 Authors: Anna Szlachcic Martyna Sochacka Aleksandra Czyrek Lukasz Opalinski Daniel Krowarsch Jacek Otlewski Malgorzata Zakrzewska Fibroblast growth factor 1 (FGF1) has been shown to interact with integrin αvβ3 through a specific binding site, involving Arg35 residue. The FGF1 mutant (R35E) with impaired...
Cells, Vol. 8, Pages 898: Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent Cells doi: 10.3390/cells8080898 Authors: Alessia Alunno Ivan Padjen Antonis Fanouriakis Dimitrios T. Boumpas Four Janus kinases (JAKs) (JAK1, JAK2, JAK3, TYK2) and seven signal transducers and activators of transcription (STATs) (STAT1, STAT2, STAT3, STAT4, STAT5A,...
Cells, Vol. 8, Pages 897: Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats Cells doi: 10.3390/cells8080897 Authors: He Li Meng Wu Zhao Zhao Background: Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial contributor in the inflammatory process during cerebral ischemia/reperfusion (I/R) injury. ATF4 plays a pivotal role in the pathogenesis of cerebral I/R injury,...
Cells, Vol. 8, Pages 896: Gap Junction Intercellular Communication in the Carcinogenesis Hallmarks: Is This a Phenomenon or Epiphenomenon? Cells doi: 10.3390/cells8080896 Authors: Zefferino Piccoli Gioia Capitanio Conese If occupational tumors are excluded, cancer causes are largely unknown. Therefore, it appeared useful to work out a theory explaining the complexity of this disease. More than fifty years ago the first demonstration that cells communicate with each other...
Cells, Vol. 8, Pages 895: Therapeutic Targeting of the IGF Axis Cells doi: 10.3390/cells8080895 Authors: Eliot Osher Valentine M. Macaulay The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease. Here, we review the functions mediated by ligand-induced IGF axis activation, and discuss the evidence for the involvement of IGF signaling in the pathogenesis of cancer, endocrine...
Cells, Vol. 8, Pages 894: Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux Cells doi: 10.3390/cells8080894 Authors: David P. Dannheisig Eileen Beck Enrico Calzia Paul Walther Christian Behrends Astrid S. Pfister Nucleolar stress is a cellular response to inhibition of ribosome biogenesis or nucleolar disruption leading to cell cycle arrest and/or apoptosis. Emerging evidence points to a tight connection between nucleolar stress and autophagy...
Cells, Vol. 8, Pages 893: PML Bodies in Mitosis Cells doi: 10.3390/cells8080893 Authors: Anna Lång Emma Lång Stig Ove Bøe Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm each time a cell divides, due to breakdown...
Cells, Vol. 8, Pages 892: Low Dose of Paclitaxel Combined with XAV939 Attenuates Metastasis, Angiogenesis and Growth in Breast Cancer by Suppressing Wnt Signaling Cells doi: 10.3390/cells8080892 Authors: Dattatrya Shetti Bao Zhang Conghui Fan Canlong Mo Bae Hoon Lee Kun Wei Triple-negative breast cancer (TNBC) accounts for 15% of overall breast cancer. A lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2 receptor)...
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Chemosensors, Vol. 7, Pages 38: A Naphthalimide-Benzothiazole Conjugate as Colorimetric and Fluorescent Sensor for Selective Trinitrophenol Detection Chemosensors doi: 10.3390/chemosensors7030038 Authors: Pramod D. Jawale Patil Rajita D. Ingle Sopan M. Wagalgave Rajesh S. Bhosale Sidhanath V. Bhosale Rajendra P. Pawar Sheshanath V. Bhosale Although chemical structural modification of naphthalimides is widely employed for the purpose of sensing explosives, the effects...
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Climate, Vol. 7, Pages 99: Land-Use/Land-Cover Changes and Their Impact on Surface Urban Heat Islands: Case Study of Kandy City, Sri Lanka Climate doi: 10.3390/cli7080099 Authors: Dissanayake Morimoto Ranagalage Murayama An urban heat island (UHI) is a phenomenon that shows a higher temperature in urban areas compared to surrounding rural areas due to the impact of impervious surface (IS) density, and other anthropogenic activities including changes of land use/land cover...
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Diagnostics, Vol. 9, Pages 97: Triple Test Plus Rapid Cognitive Screening Test: A Combination of Clinical Signs and A Tool for Cognitive Assessment in Older Adults Diagnostics doi: 10.3390/diagnostics9030097 Authors: Saadet Koc Okudur Ozge Dokuzlar Derya Kaya Pinar Soysal Ahmet Turan Isik Less time-consuming, easy-to-apply and more reliable cognitive screening tests are essential for use in primary care. The aim of this study was to investigate the diagnostic value of the...
Diagnostics, Vol. 9, Pages 96: Development of a Highly Sensitive Technique for Capturing Renal Cell Cancer Circulating Tumor Cells Diagnostics doi: 10.3390/diagnostics9030096 Authors: Naoe Kusaka Ohta Hasebe Unoki Shimoyama Nakasato Oshinomi Morita Fuji Ogawa Tsukada Sunagawa Ishii purpose: Liquid biopsy is becoming increasingly important as a guide for selecting new drugs and determining their efficacy. In urological cancer, serum...
Diagnostics, Vol. 9, Pages 95: Who Is Classified as Untestable on Brief Cognitive Screens in an Acute Stroke Setting? Diagnostics doi: 10.3390/diagnostics9030095 Authors: Emma Elliott Bogna A. Drozdowska Martin Taylor-Rowan Robert C. Shaw Gillian Cuthbertson Terence J. Quinn Full completion of cognitive screening tests can be problematic in the context of a stroke. Our aim was to examine the completion of various brief cognitive screens and explore reasons for untestability....
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Diversity, Vol. 11, Pages 137: Biotic and Abiotic Factors Affecting the Population Dynamics of Ceratium hirundinella, Peridinium cinctum, and Peridiniopsis elpatiewskyi Diversity doi: 10.3390/d11080137 Authors: Behrouz Zarei Darki Alexandr F. Krakhmalnyi The present research was conducted to assess the impact of abiotic and biotic factors on the growth of freshwater dinoflagellates such as Ceratium hirundinella, Peridinium cinctum, and Peridiniopsis elpatiewskyi, which reduce the...
Diversity, Vol. 11, Pages 136: Phytoplankton Blooms, Red Tides and Mucilaginous Aggregates in the Urban Thessaloniki Bay, Eastern Mediterranean Diversity doi: 10.3390/d11080136 Authors: Genitsaris Stefanidou Sommer Moustaka-Gouni We investigated the plankton community composition and abundance in the urban marine environment of Thessaloniki Bay. We collected water samples weekly from March 2017 to February 2018 at the coastal front of Thessaloniki city center and monthly...
Diversity, Vol. 11, Pages 135: Genetic Diversity and Population Structure of Bermudagrass [Cynodon dactylon (L.) Pers.] along Latitudinal Gradients and the Relationship with Polyploidy Level Diversity doi: 10.3390/d11080135 Authors: Jingxue Zhang Miaoli Wang Zhipeng Guo Yongzhuo Guan Jianyu Liu Xuebing Yan Yuxia Guo Understanding the population genetic pattern and process of gene flow requires a detailed knowledge of how landscape characteristics structure populations....
Diversity, Vol. 11, Pages 134: Invasive Goldenrod (Solidago gigantea) Influences Soil Microbial Activities in Forest and Grassland Ecosystems in Central Europe Diversity doi: 10.3390/d11080134 Authors: Lenka Bobuľská Lenka Demková Andrea Čerevková Marek Renčo A giant goldenrod plant, Solidago gigantea, native to North America is rapidly spreading in Europe and may have serious impact on ecosystems that inhabit. There is a lack of information about the effects of this species...
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Environments, Vol. 6, Pages 96: Nitrogen Mineralization in a Sandy Soil Amended with Treated Low-Phosphorus Broiler Litter Environments doi: 10.3390/environments6080096 Authors: Ariel A. Szogi Paul D. Shumaker Kyoung S. Ro Gilbert C. Sigua Low-phosphorus (P) litter, a manure treatment byproduct, can be used as an organic soil amendment and nitrogen (N) source but its effect on N mineralization is unknown. A laboratory incubation study was conducted to compare the effect of adding...
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Foods, Vol. 8, Pages 348: Occurence of Ochratoxin A and Biogenic Amines in Croatian Commercial Red Wines Foods doi: 10.3390/foods8080348 Authors: Paula Žurga Nada Vahčić Igor Pasković Mara Banović Mladenka Malenica Staver Food safety is one of the main concerns in the world and in wine it depends mostly on metabolites of microbial origin. The aim of this study was to investigate the occurrence of natural contaminants, ochratoxin A and biogenic amines (cadaverine, histamine,...
Foods, Vol. 8, Pages 347: Cheese Whey Processing: Integrated Biorefinery Concepts and Emerging Food Applications Foods doi: 10.3390/foods8080347 Authors: Iliada K. Lappa Aikaterini Papadaki Vasiliki Kachrimanidou Antonia Terpou Dionysios Koulougliotis Effimia Eriotou Nikolaos Kopsahelis Cheese whey constitutes one of the most polluting by-products of the food industry, due to its high organic load. Thus, in order to mitigate the environmental concerns, a large number...
Foods, Vol. 8, Pages 346: The Stability and Activity Changes of Apigenin and Luteolin in Human Cervical Cancer Hela Cells in Response to Heat Treatment and Fe2+/Cu2+ Addition Foods doi: 10.3390/foods8080346 Authors: Wan-Ning Liu Jia Shi Yu Fu Xin-Huai Zhao Flavonoids are natural polyphenolic compounds with desired bio-functions but with chemical instability and sensitivity to temperature, oxygen, and other factors. Apigenin and luteolin, two flavones of the flavonoid family...
Foods, Vol. 8, Pages 345: Mineral Elements in the Raw Milk of Several Dairy Farms in the Province of Alberta Foods doi: 10.3390/foods8080345 Authors: Zwierzchowski Ametaj The objective of this study was to determine the concentrations of 20 minerals in the whole raw milk from Holstein dairy cows in the province of Alberta, Canada. A total of 156 milk samples were collected from 26 dairy farms (n = 6 per farm) and analyzed with inductively coupled plasma mass spectrometry (ICP-MS)...
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Geriatrics, Vol. 4, Pages 48: The Development of a Digital Dysphagia Guide with Care Homes: Co-Production and Evaluation of a Nutrition Support Tool Geriatrics doi: 10.3390/geriatrics4030048 Authors: Susan Pownall Elizabeth Barnett Julie Skilbeck Angel Jimenez-Aranda Sally Fowler-Davis Good nutrition is a recognised outcome in the health and well-being of older care home residents and dysphagia is a known risk factor associated with under nutrition and poor outcomes. The...
Geriatrics, Vol. 4, Pages 47: Population Ageing: The Need for a Care Revolution in a World 2.0 Geriatrics doi: 10.3390/geriatrics4030047 Authors: Virginia Boccardi In recent years, we have seen a substantial improvement in social and health conditions, with a significant increase in the human survival rate as never seen before [...]
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Humanities, Vol. 8, Pages 140: Response to Yarbakhsh Elisabeth. Reading Derrida in Tehran: Between an Open Door and an Empty Sofreh. Humanities, 2018, 7, 21 Humanities doi: 10.3390/h8030140 Authors: Demetra Kasimis This critical engagement with Elisabeth Yarbaksh’s essay asks what Iran might be gaining from sustaining its particular form of (un-)hospitality. It considers whether Iranian dynamics of hospitality might be working to meet the specific political interests of the...
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