Cytomegalovirus-induced pathology in human temporal bones with congenital and acquired infection
Author links open overlay panelVladimirTsuprunaNevraKeskinab
R.SchleisscPatSchachernaSebahattinCureoglua
a
Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN, USA
b
Department of Veterinary Internal Medicine, Ankara University, Ankara, Turkey
c
Division of Pediatric Infectious Disease and Immunology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Received 17 May 2019, Available online 2 August 2019.
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Abstract
Objective
Publications on histopathology of human temporal bones with cytomegalovirus (CMV) infection are limited. We aim to determine histopathology of the inner ears and the middle ears in human temporal bones with congenital and acquired CMV infections.
Methods
Temporal bones from 2 infants with congenital and 2 adults with acquired CMV infection were evaluated by light microscopy.
Results
Two infants with congenital CMV infection showed striking pathological changes in the inner ear. There was a hypervascularization of the stria vascularis in the cochlea of the first infant, but no obvious loss of outer and inner hair cells was seen in the organ of Corti. However, cytomegalic cells and a loss of outer hair cells were found in the cochlea of the second infant. The vestibular organs of both infants showed cytomegalic cells, mostly located on dark cells. There was a loss of type I and type II hair cells in the macula of the saccule and utricle. Loss of hair cells and degeneration of nerve fibers was also seen in the semicircular canals. Both infants with congenital infection showed abundant inflammatory cells and fibrous structures in the middle ear cavity. No evidence of cytomegalic cells and hair cell loss was found in the cochlea or vestibular labyrinth in acquired CMV infection.
Conclusions
In two infants with congenital CMV infection, the cochlea, vestibule, and middle ear were highly affected. Temporal bones of adult donors with acquired viral infection showed histological findings similar to donors of the same age without ear disease.
CytomegalovirusHuman temporal bonesCochleaVestibular systemMiddle earHistopathology
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© 2019 Published by Elsevier Inc.
Author links open overlay panelVladimirTsuprunaNevraKeskinab
R.SchleisscPatSchachernaSebahattinCureoglua
a
Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN, USA
b
Department of Veterinary Internal Medicine, Ankara University, Ankara, Turkey
c
Division of Pediatric Infectious Disease and Immunology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Received 17 May 2019, Available online 2 August 2019.
Show less
https://doi.org/10.1016/j.amjoto.2019.08.001Get rights and content
Abstract
Objective
Publications on histopathology of human temporal bones with cytomegalovirus (CMV) infection are limited. We aim to determine histopathology of the inner ears and the middle ears in human temporal bones with congenital and acquired CMV infections.
Methods
Temporal bones from 2 infants with congenital and 2 adults with acquired CMV infection were evaluated by light microscopy.
Results
Two infants with congenital CMV infection showed striking pathological changes in the inner ear. There was a hypervascularization of the stria vascularis in the cochlea of the first infant, but no obvious loss of outer and inner hair cells was seen in the organ of Corti. However, cytomegalic cells and a loss of outer hair cells were found in the cochlea of the second infant. The vestibular organs of both infants showed cytomegalic cells, mostly located on dark cells. There was a loss of type I and type II hair cells in the macula of the saccule and utricle. Loss of hair cells and degeneration of nerve fibers was also seen in the semicircular canals. Both infants with congenital infection showed abundant inflammatory cells and fibrous structures in the middle ear cavity. No evidence of cytomegalic cells and hair cell loss was found in the cochlea or vestibular labyrinth in acquired CMV infection.
Conclusions
In two infants with congenital CMV infection, the cochlea, vestibule, and middle ear were highly affected. Temporal bones of adult donors with acquired viral infection showed histological findings similar to donors of the same age without ear disease.
Figures (4)
CytomegalovirusHuman temporal bonesCochleaVestibular systemMiddle earHistopathology
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© 2019 Published by Elsevier Inc.
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