- Metabolic landscape of the tumor microenvironment at single cell resolutionNature Communications, Published online: 21 August 2019; doi:10.1038/s41467-019-11738-0Each cell type in the tumour microenvironment has unique metabolic demands enabling specific functions. Here the authors use published single-cell RNA-seq data and develop a computational framework to better understand the heterogeneity of tumour metabolism, highlighting the discordance between results obtained from single cells and bulk tumours.
- Ballistic superconductivity and tunable <i>π</i>–junctions in InSb quantum wellsNature Communications, Published online: 21 August 2019; doi:10.1038/s41467-019-11742-4Hybrid superconductor-semiconductor devices offer a promising platform for topological superconductivity. Here, Ke and Moehle et al. create ballistic Josephson junctions in InSb quantum wells and use magnetic and electric fields to control their free energy landscape.
- Three-dimensional solitary waves with electrically tunable direction of propagation in nematicsNature Communications, Published online: 21 August 2019; doi:10.1038/s41467-019-11768-8In a previous work, the authors have demonstrated the formation of localized waves in nematic liquid crystals driven by an electric field. Here they demonstrate the realization of solitary waves of (3+2)D type which can be steered along longitudinal and transverse directions by the electric field.
- Significant contribution of metastable particulate organic matter to natural formation of silver nanoparticles in soilsNature Communications, Published online: 21 August 2019; doi:10.1038/s41467-019-11643-6Silver nanoparticles are known environmental contaminants, however it is unclear whether they arise in soils through natural processes, anthropogenic processes, or both. Here Huang and colleagues offer fresh insight into the natural formation of these contaminants by soil particulate organic matter exposed to solar irradiation.
- Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopyNature Communications, Published online: 21 August 2019; doi:10.1038/s41467-019-11320-8The Src-homology 3 domain of phosphatidyl-inositol-3-kinase (PI3K-SH3) is a model system for studying amyloid fibril formation. Here the authors present the 3.4 Å cryo-EM structure of the PI3K-SH3 amyloid fibril, which allows them to rationalize the effects of mutations on the kinetics of fibril formation.
- Measurement of the variation of electron-to-proton mass ratio using ultracold molecules produced from laser-cooled atomsNature Communications, Published online: 21 August 2019; doi:10.1038/s41467-019-11761-1Ultracold molecules are suitable platforms for precision measurements due to their internal degrees of freedom. Here the authors derive a limit on the variation of the electron-to-proton mass ratio by using the spectroscopy of ultracold KRb molecules.
- Using X-ray tomoscopy to explore the dynamics of foaming metalNature Communications, Published online: 21 August 2019; doi:10.1038/s41467-019-11521-1Understanding fast phenomena that happen in hot and opaque environments, such as during metal foaming, remains a challenge. Here, the authors use ultra-fast imaging of more than 200 three-dimensional volumes per second to explore bubble coalescence in an aluminium alloy.
- Memoriam - Dr. James J. Baldwin: A Scientific Beacon in Orthodontics.Related ArticlesMemoriam - Dr. James J. Baldwin: A Scientific Beacon in Orthodontics. Angle Orthod. 2019 Sep;89(5):827-829 Authors: Roberts WE PMID: 31430198 [PubMed - in process]
- Academic Opportunities.Related ArticlesAcademic Opportunities. Angle Orthod. 2019 Sep;89(5):836 Authors: PMID: 31430197 [PubMed - in process]
- Response to the Letter.Related ArticlesResponse to the Letter. Angle Orthod. 2019 Sep;89(5):831 Authors: Sivarajan S, Doss JG, Papageorgiou SN, Cobourne MT, Wey MC PMID: 31430196 [PubMed - in process]
- Letter to the Editor.Related ArticlesLetter to the Editor. Angle Orthod. 2019 Sep;89(5):830 Authors: Al Jawad FA PMID: 31430195 [PubMed - in process]
- Response to the Letter.Related ArticlesResponse to the Letter. Angle Orthod. 2019 Sep;89(5):835 Authors: Lee SK, Abbas NH, Bayome M, Baik UB, Kook YA, Hong M, Park JH PMID: 31430194 [PubMed - in process]
- Letter to the Editor.Related ArticlesLetter to the Editor. Angle Orthod. 2019 Sep;89(5):834 Authors: Yılmaz B, Seker ED, Kurt G PMID: 31430193 [PubMed - in process]
- Response to the Letter.Related ArticlesResponse to the Letter. Angle Orthod. 2019 Sep;89(5):833 Authors: Gandini LG PMID: 31430192 [PubMed - in process]
- Letter to the Editor.Related ArticlesLetter to the Editor. Angle Orthod. 2019 Sep;89(5):832 Authors: Xavier HR, Yashwant AV, Rajasekaran UB PMID: 31430191 [PubMed - in process]
- A review of fluid-structure interaction simulation for patients with sleep related breathing disorders with obstructive sleep.Related ArticlesA review of fluid-structure interaction simulation for patients with sleep related breathing disorders with obstructive sleep. Comput Methods Programs Biomed. 2019 Aug 12;180:105036 Authors: Faizal WM, Ghazali NNN, Badruddin IA, Zainon MZ, Yazid AA, Ali MAB, Khor CY, Ibrahim NB, Razi RM Abstract Obstructive sleep apnea is one of the most common breathing disorders. Undiagnosed sleep a
- Circulating ESM-1 levels are correlated with the presence of coronary artery disease in patients with obstructive sleep apnea.Related ArticlesCirculating ESM-1 levels are correlated with the presence of coronary artery disease in patients with obstructive sleep apnea. Respir Res. 2019 Aug 20;20(1):188 Authors: Sun H, Fang F, Li K, Zhang H, Zhang M, Zhang L, Li J, Qin Y, Wei Y Abstract BACKGROUND: Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patient
- Factors Influencing Adherence to Auto-CPAP: An Observational Monocentric Study Comparing Patients With and Without Cardiovascular Diseases.Related ArticlesFactors Influencing Adherence to Auto-CPAP: An Observational Monocentric Study Comparing Patients With and Without Cardiovascular Diseases. Front Neurol. 2019;10:801 Authors: Nsair A, Hupin D, Chomette S, Barthélémy JC, Roche F Abstract Introduction: Obstructive sleep apnea/hypopnea (OSAH) affects more than 15% of the general population and increases the occurrence of cardiovascular (
- Effects of adenotonsillectomy on the growth of children with obstructive sleep apnoea-hypopnea syndrome (OSAHS): protocol for a systematic review.Related ArticlesEffects of adenotonsillectomy on the growth of children with obstructive sleep apnoea-hypopnea syndrome (OSAHS): protocol for a systematic review. BMJ Open. 2019 Aug 18;9(8):e030866 Authors: Hua F, Zhao T, Walsh T, Sun Q, Chen X, Worthington H, Jiang F, He H Abstract INTRODUCTION: Obstructive sleep apnoea-hypopnea syndrome (OSAHS) is characterised by recurring episodes of complete or
- Postoperative high flow nasal insufflation for obstructive sleep apnea: potential therapeutic alternative or prudence needed?Related ArticlesPostoperative high flow nasal insufflation for obstructive sleep apnea: potential therapeutic alternative or prudence needed? Korean J Anesthesiol. 2019 Aug 20;: Authors: Diaz-Abad M, Steiropoulos P, Esquinas AM PMID: 31426624 [PubMed - as supplied by publisher]
- MinimallyInvasive Radiofrequency Surgery in Sleep-Disordered Breathing.Related ArticlesMinimallyInvasive Radiofrequency Surgery in Sleep-Disordered Breathing. Healthcare (Basel). 2019 Aug 18;7(3): Authors: Patel A, Kotecha B Abstract Sleep-disordered breathing encompasses a spectrum of conditions ranging from simple snoring to obstructive sleep apnoea (OSA). Radiofrequency surgery represents a relatively new technique available to surgeons involved in managing this cond
- Two novel mutations in exon 3 of PHOX2B gene: think about congenital central hypoventilation syndrome in patients with Hirschsprung disease.Related ArticlesTwo novel mutations in exon 3 of PHOX2B gene: think about congenital central hypoventilation syndrome in patients with Hirschsprung disease. Ital J Pediatr. 2019 Apr 18;45(1):49 Authors: Paglietti MG, Cherchi C, Porcaro F, Agolini E, Schiavino A, Petreschi F, Novelli A, Cutrera R Abstract BACKGROUND: Congenital central hypoventilation syndrome (CCHS) is characterized by alveolar hyp
- ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-P27 axis.Related ArticlesARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-P27 axis. Carcinogenesis. 2019 Aug 20;: Authors: Wang L, Shen S, Xiao H, Ding F, Wang M, Li G, Hu F Abstract Rho GTPase-activating proteins (RhoGAPs) have been reported to be of great importance in the initiation and development of many different cancers. However, thei
- lncRNA GAS5 regulates myocardial infarction by targeting the miR-525-5p/CALM2 axis.Related ArticleslncRNA GAS5 regulates myocardial infarction by targeting the miR-525-5p/CALM2 axis. J Cell Biochem. 2019 Aug 19;: Authors: Zhang Y, Hou YM, Gao F, Xiao JW, Li CC, Tang Y Abstract Long noncoding RNAs (lncRNAs) play critical roles in the pathogenesis of cardiovascular diseases, especially in myocardial infarction (MI). However, the underlying molecular mechanism of how lncRNA involves a
- SQSTM1/p62 is involved in docosahexaenoic acid-induced cellular autophagy in glioblastoma cell lines.Related ArticlesSQSTM1/p62 is involved in docosahexaenoic acid-induced cellular autophagy in glioblastoma cell lines. In Vitro Cell Dev Biol Anim. 2019 Aug 19;: Authors: Tan X, Zou L, Qin J, Xia D, Zhou Y, Jin G, Jiang Z, Li H Abstract Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the human brain and works as an anticancer agent to induce cell cycle arrest and apop
- REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression.Related ArticlesREG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. J Cancer Res Clin Oncol. 2019 Aug 19;: Authors: Sun S, Hu Z, Huang S, Ye X, Wang J, Chang J, Wu X, Wang Q, Zhang L, Hu X, Yu H Abstract OBJECTIVES: Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), ST
- Lobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer.Related ArticlesLobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer. Front Oncol. 2019;9:538 Authors: Zhang H, Chen R, Wang X, Zhang H, Zhu X, Chen J Abstract Platinum-based chemotherapy is recommended as the first-line treatment regimen for patients with advanced non-small-cell lung cancer (NSCLC). Lobaplatin (LBP), a third-gener
- Redox Balance-DDR-miRNA Triangle: Relevance in Genome Stability and Stress Responses in Plants.Related ArticlesRedox Balance-DDR-miRNA Triangle: Relevance in Genome Stability and Stress Responses in Plants. Front Plant Sci. 2019;10:989 Authors: Cimini S, Gualtieri C, Macovei A, Balestrazzi A, De Gara L, Locato V Abstract Plants are continuously faced with complex environmental conditions which can affect the oxidative metabolism and photosynthetic efficiency, thus leading to the over-productio
- The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis.Related ArticlesThe p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis. Sci Rep. 2019 Aug 19;9(1):12059 Authors: Koyano T, Namba M, Kobayashi T, Nakakuni K, Nakano D, Fukushima M, Nishiyama A, Matsuyama M Abstract Renal fibrosis is accompanied by the progression of chronic kidney disease. Despite a number of past and ongoing studies, our u
- The Drosophila Trpm channel mediates calcium influx during egg activation.Related ArticlesThe Drosophila Trpm channel mediates calcium influx during egg activation. Proc Natl Acad Sci U S A. 2019 Aug 19;: Authors: Hu Q, Wolfner MF Abstract Egg activation is the process in which mature oocytes are released from developmental arrest and gain competency for embryonic development. In Drosophila and other arthropods, eggs are activated by mechanical pressure in the female repro
- Machine Learning Diagnosis of Peritonsillar Abscess.Related ArticlesMachine Learning Diagnosis of Peritonsillar Abscess. Otolaryngol Head Neck Surg. 2019 Aug 20;:194599819868178 Authors: Wilson MB, Ali SA, Kovatch KJ, Smith JD, Hoff PT Abstract Peritonsillar abscess (PTA) is a difficult diagnosis to make clinically, with clinical examination of even otolaryngologists showing poor sensitivity and specificity. Machine learning is a form of artificial in
- Sensory processing and categorization in cortical and deep neural networksPublication date: Available online 21 August 2019Source: NeuroImageAuthor(s): Dimitris A. Pinotsis, Markus Siegel, Earl K. MillerAbstractMany recent advances in artificial intelligence (AI) are rooted in visual neuroscience. However, ideas from more complicated paradigms like decision-making are less used. Although automated decision-making systems are ubiquitous (driverless cars, pilot support systems, medical diagnosis algorithms etc.), achievi
- Rapid sensory gain with emotional distracters precedes attentional deployment from a foreground taskPublication date: Available online 20 August 2019Source: NeuroImageAuthor(s): Valeria Bekhtereva, Matt Craddock, Christopher Gundlach, Matthias M. MüllerAbstractThe steady-state visual evoked potential (SSVEP), an electrophysiological marker of attentional resource allocation, has recently been demonstrated to serve as a neural signature of emotional content extraction from a rapid serial visual presentation (RSVP). SSVEP amplitude was reduced fo
- Joint and separate exposure to alcohol and ∆9-tetrahydrocannabinol produced distinct effects on glucose and insulin homeostasis in male rats.Related ArticlesJoint and separate exposure to alcohol and ∆9-tetrahydrocannabinol produced distinct effects on glucose and insulin homeostasis in male rats. Sci Rep. 2019 Aug 19;9(1):12025 Authors: Nelson NG, Weingarten MJ, Law WX, Sangiamo DT, Liang NC Abstract Cannabis and alcohol co-use is common, and the trend may increase further given the current popularity of cannabis legalization. However, t
- Root Adaptation to H2O2-Induced Oxidative Stress by ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking.Related ArticlesRoot Adaptation to H2O2-Induced Oxidative Stress by ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking. Plant Cell Physiol. 2019 Feb 01;60(2):255-273 Authors: Zwiewka M, Bielach A, Tamizhselvan P, Madhavan S, Ryad EE, Tan S, Hrtyan MN, Dobrev P, Vankovï R, Friml J, Tognetti VB Abstract Abiotic stress poses constant challenges for plant survival and is a serious problem for glob
- Vitamin D Protects Against Alcohol-Induced Liver Cell Injury Within an NRF2-ALDH2 Feedback Loop.Related ArticlesVitamin D Protects Against Alcohol-Induced Liver Cell Injury Within an NRF2-ALDH2 Feedback Loop. Mol Nutr Food Res. 2019 03;63(6):e1801014 Authors: Zhang H, Xue L, Li B, Zhang Z, Tao S Abstract SCOPE: Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Oxidative stress induced during the alcohol metabolism plays a crucial role in ALD, and clinical evi
- Congratulations to the 2019 Editorial Fellows.Related ArticlesCongratulations to the 2019 Editorial Fellows. Radiology. 2019 Aug 20;:194014 Authors: Klein JS PMID: 31429683 [PubMed - as supplied by publisher]
- First-Trimester Exposure to Gadolinium-based Contrast Agents: A Utilization Study of 4.6 Million U.S. Pregnancies.Related ArticlesFirst-Trimester Exposure to Gadolinium-based Contrast Agents: A Utilization Study of 4.6 Million U.S. Pregnancies. Radiology. 2019 Aug 20;:190563 Authors: Bird ST, Gelperin K, Sahin L, Bleich KB, Fazio-Eynullayeva E, Woods C, Radden E, Greene P, McCloskey C, Johnson T, Shinde M, Krefting I Abstract BackgroundThe safety of gadolinium-based contrast agent (GBCA) exposure during pregnanc
- City Patterns of Screening Mammography Uptake and Disparity across the United States.Related ArticlesCity Patterns of Screening Mammography Uptake and Disparity across the United States. Radiology. 2019 Aug 20;:190647 Authors: Kim E, Moy L, Gao Y, Hartwell CA, Babb JS, Heller SL Abstract Background Although previous studies have focused on rural disparities in the use of screening mammography, city-level use throughout the United States has not been well evaluated even though more th
- MRI for Detecting Root Avulsions in Traumatic Adult Brachial Plexus Injuries: A Systematic Review and Meta-Analysis of Diagnostic Accuracy.Related ArticlesMRI for Detecting Root Avulsions in Traumatic Adult Brachial Plexus Injuries: A Systematic Review and Meta-Analysis of Diagnostic Accuracy. Radiology. 2019 Aug 20;:190218 Authors: Wade RG, Takwoingi Y, Wormald JCR, Ridgway JP, Tanner S, Rankine JJ, Bourke G Abstract Background Traumatic brachial plexus injuries affect 1% of patients involved in major trauma. MRI is the best test for t
- Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function Detected at Quantitative MRI.Related ArticlesAcute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function Detected at Quantitative MRI. Radiology. 2019 Aug 20;:190562 Authors: Caporale A, Langham MC, Guo W, Johncola A, Chatterjee S, Wehrli FW Abstract Background Previous studies showed that nicotinized electronic cigarettes (hereafter, e-cigarettes) elicit systemic oxidative stress and inflammation. However, the
- Benign Breast Papilloma without Atypia: Outcomes of Surgical Excision versus US-guided Directional Vacuum-assisted Removal or US Follow-up.Related ArticlesBenign Breast Papilloma without Atypia: Outcomes of Surgical Excision versus US-guided Directional Vacuum-assisted Removal or US Follow-up. Radiology. 2019 Aug 20;:190096 Authors: Choi HY, Kim SM, Jang M, Yun B, Kang E, Kim EK, Park SY, Kim B, Cho N, Moon WK Abstract Background Recent studies suggest that US-guided directional vacuum-assisted removal (DVAR) is a satisfactory alternati
- Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes.Related ArticlesPhenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes. Oncoimmunology. 2019;8(9):e1638211 Authors: Klampatsa A, O'Brien SM, Thompson JC, Rao AS, Stadanlick JE, Martinez MC, Liousia M, Cantu E, Cengel K, Moon EK, Singhal S, Eruslanov EB, Albelda SM Abstract Given the growing interest and promising preliminary results of immunotherapy in malignant p
- Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line.Related ArticlesImmunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line. Oncoimmunology. 2019;8(9):e1638210 Authors: Kreutzman A, Yadav B, Brummendorf TH, Gjertsen BT, Hee Lee M, Janssen J, Kasanen T, Koskenvesa P, Lotfi K, Markevärn B, Olsson-Strömberg U, Stentoft J, Stenke L, Söderlund S, Udby L, Richter J, Hjorth-Hansen H, Mustjoki S Abstract Changes
- Targeted transcriptional profiling of the tumor microenvironment reveals lymphocyte exclusion and vascular dysfunction in metastatic osteosarcoma.Related ArticlesTargeted transcriptional profiling of the tumor microenvironment reveals lymphocyte exclusion and vascular dysfunction in metastatic osteosarcoma. Oncoimmunology. 2019;8(9):e1629779 Authors: Sorenson L, Fu Y, Hood T, Warren S, McEachron TA Abstract Osteosarcoma (OS) is the most common bone tumor in pediatric and adolescent/young adult patients yet little is known about the microenviro
- HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory.Related ArticlesHPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory. Oncoimmunology. 2019;8(9):e1629259 Authors: Grunwitz C, Salomon N, Vascotto F, Selmi A, Bukur T, Diken M, Kreiter S, Türeci Ö, Sahin U Abstract HPV16 infections are associated with a variety of cancers and there is compelling evidence that the
- High tumor mutation burden predicts better efficacy of immunotherapy: a pooled analysis of 103078 cancer patients.Related ArticlesHigh tumor mutation burden predicts better efficacy of immunotherapy: a pooled analysis of 103078 cancer patients. Oncoimmunology. 2019;8(9):e1629258 Authors: Cao D, Xu H, Xu X, Guo T, Ge W Abstract The relation between tumor mutation burden (TMB) and outcome of cancer patients receiving immunotherapy has been reported. This study aimed to evaluate the prognostic role of TMB in cancer
- Aberrant fucosylation enables breast cancer clusterin to interact with dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN).Related ArticlesAberrant fucosylation enables breast cancer clusterin to interact with dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN). Oncoimmunology. 2019;8(9):e1629257 Authors: Merlotti A, Malizia AL, Michea P, Bonte PE, Goudot C, Carregal MS, Nuñez N, Sedlik C, Ceballos A, Soumelis V, Amigorena S, Geffner J, Piaggio E, Sabatte J Abstract Clusterin is a glycoprotein able to mediate di
- High tumoral PD-L1 expression and low PD-1+ or CD8+ tumor-infiltrating lymphocytes are predictive of a poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system.Related ArticlesHigh tumoral PD-L1 expression and low PD-1+ or CD8+ tumor-infiltrating lymphocytes are predictive of a poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system. Oncoimmunology. 2019;8(9):e1626653 Authors: Kim S, Nam SJ, Park C, Kwon D, Yim J, Song SG, Ock CY, Kim YA, Park SH, Kim TM, Jeon YK Abstract We investigated the clinicopathological role of the PD-1
- CCR5 status and metastatic progression in colorectal cancer.Related ArticlesCCR5 status and metastatic progression in colorectal cancer. Oncoimmunology. 2019;8(9):e1626193 Authors: Suarez-Carmona M, Chaorentong P, Kather JN, Rothenheber R, Ahmed A, Berthel A, Heinzelmann A, Moraleda R, Valous NA, Kosaloglu Z, Eurich R, Wolf J, Grauling-Halama S, Hundemer M, Lasitschka F, Klupp F, Kahlert C, Ulrich A, Schneider M, Falk C, Jäger D, Zoernig I, Halama N Abstract
- NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma.Related ArticlesNPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma. Oncoimmunology. 2019;8(9):e1625688 Authors: Singh VK, Werner S, Schwalm S, Lennerz V, Ruf S, Stadler S, Hackstein H, Reiter A, Wölfel T, Damm-Welk C, Woessmann W Abstract The oncoantigen nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces cellular and humoral immu
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