Stem Cells and Development, Volume 28, Issue 16, Page 1059-1077, August 15, 2019.
Publication date: Available online 6 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Shengjing Xu, LingLi Zhang, Min ZhangAbstractBackgroundBasal cell carcinoma (BCC) that occurs in the external auditory canal (EAC) is very rare. Currently reported cases were mainly treated with surgical resection. Here, we described an early-detected BCC of the EAC, which achieved good results with photodynamic therapy (PDT).Methods5-aminolevulinic acid (5-ALA) solution was applied on the tumor...
Publication date: Available online 6 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Minglan Shi, Sijin He, Pingjiao Chen, Qian Li, Menghua Zhu, Jia Guo, Lifen Jiang, Qi Wang, Xiaoming Peng, Songshan Li, Changxing Li, Kang ZengAbstractThe facial angiofbromas due to tuberous sclerosis complex produced significant social and emotional distress for affected individuals, but there is no specific therapeutic strategy up to now. Herein, we report a case of facial angiofibromas successfully...
Publication date: Available online 5 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Surjendu Bikash Dutta, Hemant Krishna, Sharad Gupta, Shovan K. MajumderAbstractPhoto-stability of urine is of crucial importance for the applicability of fluorescence spectroscopy of urine samples for diagnosis of cancer. We report the results of a detailed study on fluorescence photo-bleaching of human urine samples. We also present the results of a preliminary investigation on evaluation of...
Publication date: Available online 5 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Kit Man Chan, Krasimir Vasilev, Hanieh Safizadeh Shirazi, KYM Mcnicholas, Jordan Li, Jonathan Gleadle, Melanie MacgregorAbstractExogenous administration of the photodynamic agent hexaminolevulinate induces Protoporphyrin IX (PpIX) accumulation in malignant tissue which enables its differentiation from healthy tissues by emission of a distinctive red fluorescence. It provides the photo-specific...
Publication date: Available online 5 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Xin Jin, Hao Xu, Jing Deng, Hongxia Dan, Ping Ji, Qianming Chen, Xin ZengAbstractTo assess the impact of photodynamic therapy (PDT) parameters in the management of oral potentially malignant disorders (OPMDs). We conducted a systematic review and meta-analysis of studies that assessed the curative effect of PDT published in PubMed and Embase until Dec 2018. Random or fixed effects models for...
Publication date: Available online 5 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Sana Mirza, Aftab Ahmed Khan, Abdulaziz Abdullah Al-Kheraif, Sultan Zeb Khan, Syed Saad ShafqatAbstractAimsTo evaluate the clinical periodontal, serum glycated haemoglobin (HbA1c) and levels of advanced glycation end-products (AGEs) in the gingival crevicular fluid (GCF) among patients with periodontitis and type 2 diabetes mellitus (DM) after photodynamic therapy (PDT) as an adjunct to full-mouth...
Publication date: Available online 5 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Luiz G.P. Soares, Pedro J.L. Crugeira, Iago P.F. Nunes, Amanda S. Santos, Maria C.T. Cangussú, Paulo F. de Almeida, Antônio L.B. Pinheiro, Fernando A.L. HabibAbstractBackgroundOrthodontics involves diagnosis and treatment of dental and skeletal malocclusions. Orthodontic apparatuses besides being used by technical reasons they also impair oral hygiene making patients prone to develop both periodontal...
Publication date: Available online 5 August 2019Source: Clinical TherapeuticsAuthor(s): Emilie Jouanjus, Maryse Lapeyre-Mestre, Matthieu Nodot, Anne Roussin, Nicolas Franchitto, Jean-Paul Boyes, Nathalie Nasr, Stéphane Oustric, Julie DupouyAbstractPurposeRecent evolution toward a medical perspective on patients with substance use disorders (SUDs) has led to a lack of medical training in substance abuse. To increase this knowledge, a distance learning course (“e-learning”) was implemented to teach...
Summary Background AT-101 is a BH3 mimetic that inhibits the heterodimerization of Bcl-2, Bcl-xL, Bcl-W, and Mcl-1 with pro-apoptotic proteins, thereby lowering the threshold for apoptosis. This phase I trial investigated the MTD of AT-101 in combination with paclitaxel and carboplatin in patients with advanced solid tumors. Methods Patients were treated with AT-101 (40 mg) every 12 h on days 1, 2 and 3 of each cycle combined with varying dose levels (DL) of paclitaxel and carboplatin...
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