Τρίτη 13 Αυγούστου 2019

Prevalence of humoral immunodeficiency in adult patients with recurrent tonsillitis
Author links open overlay panelOsama G.Abdel-Naby Awad
Otolaryngology, Head and Neck Department, Minia University Hospital, Minia, Egypt
Received 25 May 2019, Available online 13 August 2019.

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https://doi.org/10.1016/j.amjoto.2019.08.006Get rights and content
Abstract
Purpose
Recurrent tonsillitis in adults has a significant impact on patients' daily life and healthcare costs. Humoral immunodeficiency increases the susceptibility to recurrent infections. The purpose of this study was to investigate the prevalence and contribution of humoral immunodeficiency in adult patients with recurrent tonsillitis.

Material and methods
A prospective cross-sectional study conducted over 3 years duration with two groups of subjects. Group 1: included 50 normal adult subjects and group 2: included 50 adult patients with recurrent tonsillitis. Recruitment occurred in a tertiary care hospital in Egypt. Different immunoglobulins (Ig A, Ig M and Ig G isotypes) were quantitatively assessed and compared in 2 groups. Incidence of different infections was also compared in patients with humoral immunodeficiency versus patients with intact immunity.

Results
4 (8%) subjects in group 1 had selective humoral Immunodeficiency versus 13 (26%) patients in group 2. Patients with recurrent tonsillitis had significantly lower mean of most assessed immunoglobulins: IgA (P = 0.002), IgM (P = 0.003), IgG (P < 0.0001), IgG1 (P < 0.0001) and IgG3 (P < 0.0001) compared to normal subjects; with no significant difference in mean of IgG2 (P = 0.395) and IgG4 (P = 0.105). Patients with humoral immunodeficiency had significantly higher incidence of tonsillitis (P < 0.0001) and rhinosinusitis (P < 0.0001) attacks compared to patients with normal immunity.

Conclusion
Adult patients with recurrent tonsillitis may have higher prevalence of humoral immunodeficiency compared to normal subjects. These findings suggest that assessment of immune function should be undertaken routinely in these patients.

Keywords
Recurrent tonsillitisImmunoglobulinsHumoral immunodeficiencyPrimary immunodeficiencies
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© 2019 Elsevier Inc. All rights reserved.

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