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Esophageal acid sensitivity is similar in GERD patients with and without IEM. The study shows thatreflux patients with higher body mass index appear to have diminished esophageal acid sensitivity, suggesting increasing body mass index can be a risk factor in GERD via the mechanism of mpaired esophageal acid perception. Abstract Background/Aim Esophageal acid sensitivity plays a role in symptomatic manifestation of gastroesophageal reflux disease (GERD). Esophageal hypomotility is common in patients...
Diverticulosis is the presence of small, bulging pouches in the lining of the intestinal colonic mucosal and submucosal layers. This condition is usually asymptomatic. The few patients (25%) that do develop abdominal symptoms are diagnosed with symptomatic uncomplicated diverticular disease (SUDD). Up to now it is not clear which pathophysiological events trigger the transition from asymptomatic diverticulosis to SUDD. However, data from Barbaro and colleagues published in the current issue of Neurogastroenterology...
The limited pediatric data available suggest marked differences between adult and pediatric gastroparesis (GP) in several aspects including: etiology, co‐morbidities, symptom presentation, diagnosis, therapy response, and outcomes. Further research in pediatric GP is needed. Abstract Background Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric...
The reflux burden within patients with EE is predominantly low in China and adjunctive HRM and MII‐pH profiles from Lyon criteria do not segregate PPI response. Abstract Background & aims The Lyon Consensus defines LA grades C&D erosive esophagitis (EE) or acid exposure time (AET) >6% as the conclusive evidence for gastro‐esophageal reflux disease (GERD). However, most of EE is LA grade A&B and the rate of AET exceeding 6% is low in China. We aimed to evaluate patients with EE...
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