Successful tri-modality treatment of atypical carcinoma ex-pleomorphic adenoma with more than 50 nodal metastases☆
Author links open overlay panelFederico L.AmpilaNestor de laCruzb
a
Department of Radiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA
b
Department of Pathology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA
Received 15 July 2019, Revised 23 July 2019, Accepted 25 July 2019, Available online 8 August 2019.

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https://doi.org/10.1016/j.oraloncology.2019.07.025Get rights and content
Abstract
Carcinoma ex-pleomorphic adenoma (CEPA), an extremely aggressive malignant tumor, bears a significant potential for locoregional recurrence and distant metastases. Management of the disease usually involves definitive surgery with postoperative radiotherapy administered for identified nodal metastases. Two cases of CEPA with many (>50) cervical lymph node metastases and other histopathological features were managed by tri-modality treatment scheme. No evidence of disease occurred during follow-up of at least 2 years. These cases may eventually establish the value of surgery with adjuvant radiochemotherapy in patients with CEPA and supernumerary nodal metastases.

Keywords
Carcinoma ex-pleomorphic adenomaNodal metastasesComposite resectionRadiotherapyChemotherapy
Abbreviations
CEPAcarcinoma ex-pleomorphic adenomaSGCsalivary gland cancerSNMsupernumerary nodal metastasesNMnodal metastasesPET-CTpositron emission tomography/computed tomographyPORTpostoperative radiotherapyHNChead and neck cancer
☆
This research did not receive any specific grant from funding agencies in the public, commercial, and not-for-profit sectors.

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