Abstract After the ‘empirical turn’ in bioethics, few specific approaches have been developed for doing clinical ethics research in close connection with clinical decision‐making on a daily basis. In this paper we describe the ‘committed researcher’ approach to research in clinical ethics that we have developed over the years. After comparing it to two similar research methodological approaches, the ‘embedded researcher’ and ‘deliberative engagement’, we highlight its main features: it is patient‐oriented,...
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Abstract Rob Lovering has developed an interesting new critique of views that regard embryos as equally valuable as other human beings: the moral argument for frozen human embryo adoption. The argument is aimed at those who believe that the death of a frozen embryo is a very bad thing, and Lovering concludes that some who hold this view ought to prevent one of these deaths by adopting and gestating a frozen embryo. Contra Lovering, we show that there are far more effective strategies for preserving...
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Abstract Prognosis after severe brain injury is highly uncertain, and decisions to withhold or withdraw life‐sustaining treatment are often made prematurely. These decisions are often driven by a desire to avoid a situation where the patient becomes ‘trapped’ in a condition they would find unacceptable. However, this means that a proportion of patients who would have gone on to make a good recovery, are allowed to die. I propose a shift in practice towards the routine provision of aggressive care,...
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Biomedicines, Vol. 8, Pages 49: Three-Dimensional Model of Dorsal Root Ganglion Explant as a Method of Studying Neurotrophic Factors in Regenerative Medicine Biomedicines doi: 10.3390/biomedicines8030049 Authors: Klimovich Rubina Sysoeva Semina Neurotrophiс factors play a key role in the development, differentiation, and survival of neurons and nerve regeneration. In the present study, we evaluated the effect of certain neurotrophic factors (NGF, BDNF, and GDNF) on axon...
Tue Mar 03, 2020 02:00
Biomolecules, Vol. 10, Pages 392: Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation Biomolecules doi: 10.3390/biom10030392 Authors: Garufi Federici Gilardini Montani Crispini Cirone D’Orazi The unfolded protein response (UPR) is an adaptive response to intrinsic and external stressors, and it is mainly activated by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) lumen producing ER stress....
Tue Mar 03, 2020 02:00
Biomolecules, Vol. 10, Pages 393: Homocysteine Induces Inflammation in Retina and Brain Biomolecules doi: 10.3390/biom10030393 Authors: Elsherbiny Sharma Kira Alhusban Samra Jadeja Martin Al-Shabrawey Tawfik Homocysteine (Hcy) is an amino acid that requires vitamins B12 and folic acid for its metabolism. Vitamins B12 and folic acid deficiencies lead to hyperhomocysteinemia (HHcy, elevated Hcy), which is linked to the development of diabetic retinopathy...
Tue Mar 03, 2020 02:00
Biomolecules, Vol. 10, Pages 389: Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases Biomolecules doi: 10.3390/biom10030389 Authors: Hara Niwa Noguchi Kanayama Niwa Matsuo Hatano Tomita Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological activities in various organs, including cell proliferation, apoptotic regulation, inflammation, fibrosis, and host defense. Galectin-3 is predominantly...
Tue Mar 03, 2020 02:00
Biomolecules, Vol. 10, Pages 391: Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts
Biomolecules, Vol. 10, Pages 391: Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts Biomolecules doi: 10.3390/biom10030391 Authors: Teil Arotcarena Faggiani Laferriere Bezard Dehay Parkinson’s Disease (PD) is characterized both by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These Lewy Bodies contain the aggregated α-synuclein (α-syn) protein,...
Tue Mar 03, 2020 02:00
Biomolecules, Vol. 10, Pages 388: TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy Biomolecules doi: 10.3390/biom10030388 Authors: Heo Lee Tetraspanin 8 (TSPAN8) is a member of the tetraspanin superfamily that forms TSPAN8-mediated protein complexes by interacting with themselves and other various cellular signaling molecules. These protein complexes help build tetraspanin-enriched microdomains (TEMs) that efficiently mediate intracellular...
Tue Mar 03, 2020 02:00
Biomolecules, Vol. 10, Pages 390: Altered Plasma Acylcarnitines and Amino Acids Profile in Spinocerebellar Ataxia Type 7 Biomolecules doi: 10.3390/biom10030390 Authors: Nambo-Venegas Valdez-Vargas Cisneros Palacios-González Vela-Amieva Ibarra-González Cerecedo-Zapata Martínez-Cruz Cortés Reyes-Grajeda Magaña Spinocerebellar ataxia type 7 (SCA7), a neurodegenerative disease characterized by cerebellar ataxia and retinal degeneration, is caused...
Tue Mar 03, 2020 02:00
Biosensors, Vol. 10, Pages 21: The Growing Interest in Development of Innovative Optical Aptasensors for the Detection of Antimicrobial Residues in Food Products Biosensors doi: 10.3390/bios10030021 Authors: Valérie Gaudin The presence of antimicrobial residues in food-producing animals can lead to harmful effects on the consumer (e.g., allergies, antimicrobial resistance, toxicological effects) and cause issues in food transformation (i.e., cheese, yogurts production). Therefore,...
Tue Mar 03, 2020 02:00
Biosensors, Vol. 10, Pages 20: Surface Probe Linker with Tandem Anti-Fouling Properties for Application in Biosensor Technology Biosensors doi: 10.3390/bios10030020 Authors: Spagnolo Franier Hianik Thompson This paper describes the anti-fouling capability of the novel monolayer-forming surface linker 3-(3-(trichlorosilylpropyloxy) propanoyl chloride (MEG-Cl). This compound was successfully attached to quartz crystal surfaces which are employed in an electromagnetic...
Tue Mar 03, 2020 02:00
Abstract Spinocerebellar ataxias (SCA) constitute of a group of degenerative and progressive disorders that can be identified on a molecular and cellular basis. Along with histological changes, the clinical presentation of SCA differs between subtypes. In addition to basic cerebellar dysfunction symptoms, patients with SCA develop gait ataxia, dysphagia, dysarthria, oculomotor disturbances, pyramidal and extrapyramidal disease signs, rigidity, bradycardia, sensory deficits, and...
Tue Mar 03, 2020 02:00
Related ArticlesSpecial Issue Preface. Dev Dyn. 2020 Mar;249(3):269 Authors: PMID: 32119766 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 15:34
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