Summary Background Psychological stress is commonly cited as a risk factor for melanoma, but clinical evidence is limited. Objectives This study aimed to evaluate the association between partner bereavement and (i) first‐time melanoma diagnosis and (ii) mortality in patients with melanoma. Methods We conducted two cohort studies using data from the U.K. Clinical Practice Research Datalink (1997–2017) and Danish nationwide registries (1997–2016). In study 1, we compared...
07:24
Abstract Background Real‐world biologic drug survival is an important proxy measure for effectiveness. Predictors of drug survival may help patients with psoriasis choose between biologic therapies. Objectives 1. To assess the relative drug survival of adalimumab, ustekinumab and secukinumab in patients with psoriasis; 2. To investigate for predictors for biologic drug survival. Methods A prospective cohort study was performed in the British Association of Dermatologists...
Tue Mar 03, 2020 16:17
Abstract Purpose of Review The purpose of this review is to provide an overview of the use of certolizumab pegol (Cimzia®, UCB S.A.) for psoriasis and psoriatic arthritis and summarize important findings. Recent Findings Three pivotal phase three clinical trials CIMPASI-1, CIMPASI-2, and CIMPACT have demonstrated efficacy and safety of certolizumab pegol...
Tue Mar 03, 2020 02:00
Abstract Purpose of Review This review aims to understand how Australia compares internationally in the practice of teledermatology for the diagnosis and management of skin cancer, and in the process, ascertain the robustness of the evidence for teledermatology, as well as identify its limitations and current difficulties for its adoption in Australia. Recent Findings ...
Tue Mar 03, 2020 02:00
Tue Mar 03, 2020 14:34
Tue Mar 03, 2020 14:34
Tue Mar 03, 2020 14:34
Abstract Vitiligo is an autoimmune skin disease that has a major impact on the quality of life of patients. However, a nationwide study of the association between vitiligo and the incidence of inclusive psychiatric diseases has not been conducted in the Asian population. Therefore, this study aimed to analyze the association between vitiligo and the risk of psychiatric disorders using a nationwide database in Taiwan. Data were collected from the National Health Insurance Research Database of Taiwan...
Tue Mar 03, 2020 14:34
Abstract The presence of eczema and elevated IgE in pediatric patients does not always indicate atopic dermatitis. Rare genodermatoses may share this clinical presentation and should be considered in the differential diagnosis for patients with congenital immunodeficiency and severe refractory dermatitis. We describe a case of severe dermatitis, allergies, and metabolic wasting syndrome, due to a novel mutation in DSG1 gene, an additional example of this uncommon genetic disorder of desmosome function.
05:33
Abstract Background/Objectives Hidradenitis suppurativa is a chronic, painful, debilitating disease that may present in the pediatric years. Overweight and obesity are believed to worsen disease severity, but many patients do not receive counseling regarding weight control. The objective of this study is to examine the percentage of hidradenitis suppurativa patients who receive weight counseling as a part of their disease management and which specialties primarily care for these patients. ...
05:33
Abstract Infectious panniculitis from hematogenous spread is uncommon and usually occurs in immunocompromised patients. Dissemination of gram‐positive organisms to the subcutaneous tissue is rare with only several reports of disseminated panniculitis caused by Streptococcal species. We report a case of an immunocompetent 2‐year‐old boy presenting with diffuse neutrophilic panniculitis arising from methicillin‐resistant Staphylococcus aureus septicemia. This case represents a highly atypical manifestation...
05:33
Abstract Objective To characterize the clinical and histologic presentation of reactive granulomatous dermatitis (RGD) in the pediatric population. Methods In this multicenter retrospective chart review, 7 pediatric patients with biopsy‐proven RGD were identified. Photographs, histology reports, and clinical course were reviewed to discover patterns in demographics, comorbid conditions, autoimmune sequelae, drug exposures, infections, morphology, and histologic features. Results Overall,...
05:33
Abstract Background Molluscum contagiosum (MC) is a common skin infection in the pediatric age group. The infection is self‐limited and manifests as discrete, umbilicated skin‐colored papules on any skin surface of the body. At times, complications such as local dermatitis and swelling, erythema, and pus formation may appear. These signs of inflammation are commonly presumed to represent bacterial infection. Methods This multicenter study was a retrospective analysis of data collected on...
05:33
Abstract Good sun‐safety practice includes wearing sun‐protective hats that must meet defined photoprotective criteria such as the 2017 Australian/New Zealand standard (AS/NZS 4399:2017). This study investigated the availability of sun‐safe hats during a three‐day cross‐sectional survey in November 2019 by visiting every shop in a single large multi‐store shopping complex in Australia. Hats were categorised according to whether the target customer was an adult or child prior to the assessment of...
04:26
Abstract In the present work we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and T98G spheroids as shown by flow cytometry on the single cell level. Moreover, cerco is efficiently internalized by cells throughout the spheroid as shown by confocal microscopy, for all three cell lines. Despite their higher cerco uptake, U87 spheroids show the least vulnerability...
04:26
Abstract Predicting the extent of necrosis in photodynamic therapy (PDT) is critical to ensure that the whole tumor is treated but vital structures, such as major blood vessels in the vicinity of the tumor, are spared. The models developed for clinical planning rely on empirical parameters that change with the nature of the photosensitizer and the target tissue. This work presents an in vivo study of the necrosis in the livers of rats due to PDT with a bacteriochlorin photosensitizer named redaporfin...
04:26
Abstract Introduction Peripheral nerve injury (PNI) can lead to sensory and/or motor impairment. As a treatment photobiomodulation (PBM) has demonstrated positive effects in terms of the maintenance of muscle activation and trophism. Methods Wistar rats were divided into five groups: control, injury, injury+PBM, injury+PBMn (irradiation over injured nerve), injury+PBMm (irradiation over affected muscle) and injury+PBMnm (irradiation over nerve and muscle). The left sciatic nerve was submitted...
04:26
Abstract Hexyl aminolevulinate (HAL) is a lipophilic derivative of 5‐aminolevulinic acid (5‐ALA) and can induce more protoporphyrin IX (PpIX) formation and stronger fluorescence intensity (FI) than 5‐ALA, which will greatly facilitate photodynamic diagnosis and therapy. The main drawback of HAL is its low solubility in neutral aqueous media. In this study, surfactants were used to increase HAL solubility in the cell culture medium and serum, followed by in vitro fluorescence formation measurement...
04:26
Abstract Tattoo colourants decompose under solar radiation and when exposed to laser light for their removal, leading to the accumulation in the dermis of toxic products. Aim of this study was to develop lipid microparticles (LMs) loaded with the colourant, Acid Red 87 (C.I. 45380) used in tattoo inks, and to investigate the effect of this system on the photostability of the colourant under simulated sunlight or laser irradiation. LMs loaded with C.I. 45380 were prepared by melt emulsification using...
04:26
Abstract Mammalian sirtuins (SIRTs 1‐7), are a family of NAD+‐dependent deacetylases with distinct subcellular localization and biological functions that regulate various important cellular processes. Among these, SIRTs ‐3, ‐4, and ‐5 are located in the mitochondria and have been implicated in caloric restriction, oxidative stress, aging, and various human diseases. Emerging evidence has found dysregulation of mitochondrial sirtuins in multiple dermatological conditions, including responses to ultraviolet...
04:26
Abstract Peritoneal carcinomatosis (PC) can occur as an advanced consequence of multiple primary malignancies. Surgical resection, radiation, or systemic interventions alone have proven inadequate for this aggressive cancer presentation, since PC still has a poor survival profile. Photodynamic therapy (PDT), in which photosensitive drugs are exposed to light to generate cytotoxic reactive oxygen species, may be an ideal treatment for PC because of its ability to deliver treatment to a depth appropriate...
04:26
Abstract This paper deals with the effect of photobiomodulation (PBM) on Daphnia magna S. and their sensitivity to cadmium sulfate, a known high toxic pollutant. In a first series of experiments, the effect of different He‐Ne laser fluences irradiation (range 0.9‐4,300 mJ/cm2) on the fertility of both parent and filial generations (F1‐F3) of the crustacean was studied. It was found that PBM in some cases significantly influenced the fertility of both irradiated crustaceans and their non‐irradiated...
04:26
Abstract Ultraviolet (UV) radiation is among the most prevalent environmental factors that influence human health and disease. Even one hour of UV irradiation extensively damages the genome. To cope with resulting deleterious DNA lesions, cells activate a multitude of DNA damage response pathways, including DNA repair. Strikingly, UV‐induced DNA damage formation and repair are affected by chromatin state. When cells enter S phase with these lesions, a distinct mutation signature is created via error‐prone...
04:26
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