IJNS, Vol. 6, Pages 16: Reducing False-Positive Results in Newborn Screening Using Machine Learning International Journal of Neonatal Screening doi: 10.3390/ijns6010016 Authors: Gang Peng Yishuo Tang Tina M. Cowan Gregory M. Enns Hongyu Zhao Curt Scharfe Newborn screening (NBS) for inborn metabolic disorders is a highly successful public health program that by design is accompanied by false-positive results. Here we trained a Random Forest machine learning classifier on...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 683: Influence of Bone Marrow-Derived Mesenchymal Stem Cell Therapy on Oxidative Stress Intensity in Minimally Conscious State Patients Journal of Clinical Medicine doi: 10.3390/jcm9030683 Authors: Katarzyna Jezierska-Wozniak Emilia Sinderewicz Wioleta Czelejewska Pawel Wojtacha Monika Barczewska Wojciech Maksymowicz Neurological disorders, including minimally conscious state (MCS), may be associated with the presence of high concentrations of reactive...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 681: Breast Density Notification: An Australian Perspective Journal of Clinical Medicine doi: 10.3390/jcm9030681 Authors: Ingman Richards Street Carter Rickard Stone Dasari Breast density, also known as mammographic density, refers to white and bright regions on a mammogram. Breast density can only be assessed by mammogram and is not related to how breasts look or feel. Therefore, women will only know their breast density if they are notified...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 682: MSC Based Therapies—New Perspectives for the Injured Lung Journal of Clinical Medicine doi: 10.3390/jcm9030682 Authors: Judith Behnke Sarah Kremer Tayyab Shahzad Cho-Ming Chao Eva Böttcher-Friebertshäuser Rory E. Morty Saverio Bellusci Harald Ehrhardt Chronic lung diseases pose a tremendous global burden. At least one in four people suffer from severe pulmonary sequelae over the course of a lifetime. Despite substantial improvements in therapeutic...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 678: Artificial Intelligence in Acute Kidney Injury Risk Prediction Journal of Clinical Medicine doi: 10.3390/jcm9030678 Authors: Joana Gameiro Tiago Branco José António Lopes Acute kidney injury (AKI) is a frequent complication in hospitalized patients, which is associated with worse short and long-term outcomes. It is crucial to develop methods to identify patients at risk for AKI and to diagnose subclinical AKI in order to improve patient outcomes. The advances...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 676: Additional Value of Machine-Learning Computed Tomographic Angiography-Based Fractional Flow Reserve Compared to Standard Computed Tomographic Angiography Journal of Clinical Medicine doi: 10.3390/jcm9030676 Authors: Dirk Lossnitzer Leonard Chandra Marlon Rutsch Tobias Becher Daniel Overhoff Sonja Janssen Christel Weiss Martin Borggrefe Ibrahim Akin Stefan Pfleger Stefan Baumann Background: Machine-learning-based computed-tomography-derived...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 680: Early Aspirin Discontinuation Following Acute Coronary Syndrome or Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9030680 Authors: Paul Guedeney Jules Mesnier Sabato Sorrentino Farouk Abcha Michel Zeitouni Benoit Lattuca Johanne Silvain Salvatore De De Rosa Ciro Indolfi Jean-Philippe Collet Mathieu Kerneis Gilles Montalescot The...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 677: Standard Versus Ultrasound-Guided Cannulation of the Femoral Artery in Patients Undergoing Invasive Procedures: A Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9030677 Authors: Sabato Sorrentino Phong Nguyen Nadia Salerno Alberto Polimeni Jolanda Sabatino Angela Makris Annemarie Hennessy Gennaro Giustino Carmen Spaccarotella Annalisa Mongiardo Salvatore De De Rosa Craig Juergens Ciro Indolfi...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 679: Molecular Genetics of Niemann–Pick Type C Disease in Italy: An Update on 105 Patients and Description of 18 NPC1 Novel Variants Journal of Clinical Medicine doi: 10.3390/jcm9030679 Authors: Andrea Dardis Stefania Zampieri Cinzia Gellera Rosalba Carrozzo Silvia Cattarossi Paolo Peruzzo Rosalia Dariol Annalisa Sechi Federica Deodato Claudio Caccia Daniela Verrigni Serena Gasperini Agata Fiumara Simona Fecarotta Miryam Carecchio...
Tue Mar 03, 2020 02:00
JCM, Vol. 9, Pages 675: Combining Immune Checkpoint Inhibitors with Anti-Angiogenic Agents Journal of Clinical Medicine doi: 10.3390/jcm9030675 Authors: Paola Ciciola Priscilla Cascetta Cataldo Bianco Luigi Formisano Roberto Bianco Immunotherapy has recently emerged as a novel strategy for treating different types of solid tumors, with promising results. However, still a large fraction of patients do not primarily respond to such approaches, and even responders sooner or...
Tue Mar 03, 2020 02:00
JDB, Vol. 8, Pages 5: The Hox Gene egl-5 Acts as a Terminal Selector for VD13 Development via Wnt Signaling Journal of Developmental Biology doi: 10.3390/jdb8010005 Authors: Meagan Kurland Bryn O’Meara Dana K. Tucker Brian D. Ackley Nervous systems are comprised of diverse cell types that differ functionally and morphologically. During development, extrinsic signals, e.g., growth factors, can activate intrinsic programs, usually orchestrated by networks of transcription factors....
Tue Mar 03, 2020 02:00
Medicina, Vol. 56, Pages 108: The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer Medicina doi: 10.3390/medicina56030108 Authors: Nicolae Bacalbasa Irina Balescu Mihaela Vilcu Simona Dima Camelia Diaconu Laura Iliescu Alexandru Filipescu Mihai Dimitriu Iulian Brezean Background and objectives: To identify the risk factors for para-aortic lymph node metastases in cases with presumed early stage ovarian cancer. Materials and methods:...
Tue Mar 03, 2020 02:00
Medicina, Vol. 56, Pages 107: Pre-Treatment and Post-Treatment Demodex Densities in Patients under Immunosuppressive Treatments Medicina doi: 10.3390/medicina56030107 Authors: Hacer Keles Esra Pancar Yuksel Fatma Aydin Nilgun Senturk Background and Objectives: Demodex species are common obligatory parasites and normally present in low number in human beings. Immunosuppression was suggested to be associated with increased density of Demodex mites. Systemic glucocorticoids, cyclosporine,...
Tue Mar 03, 2020 02:00
MPs, Vol. 3, Pages 21: A Rapid and High Throughput MIC Determination Method to Screen Uranium Resistant Microorganisms Methods and Protocols doi: 10.3390/mps3010021 Authors: Meenakshi Agarwal Rajesh Singh Rathore Ashvini Chauhan The assessment of minimum inhibitory concentration (MIC) is a conventional technique used for the screening of microbial resistance against antibiotics, biocides, and contaminants such as heavy metals. However, as part of our ongoing work, we have observed...
Tue Mar 03, 2020 02:00
Microorganisms, Vol. 8, Pages 362: Yeast Associated with Rice Phylloplane and Their Contribution to Control of Rice Sheath Blight Disease Microorganisms doi: 10.3390/microorganisms8030362 Authors: Parichat Into Pannida Khunnamwong Sasitorn Jindamoragot Somjit Am-in Wanwilai Intanoo Savitree Limtong The phylloplane is an important habitat for yeasts and these yeasts may have antagonistic activities against pathogens and could be used as biocontrol agents. To investigate...
Tue Mar 03, 2020 02:00
Microorganisms, Vol. 8, Pages 361: Eukaryotic Cell Permeabilisation to Identify New Putative Chlamydial Type III Secretion System Effectors Secreted within Host Cell Cytoplasm Microorganisms doi: 10.3390/microorganisms8030361 Authors: Carole Kebbi-Beghdadi Ludovic Pilloux Virginie Martin Gilbert Greub Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital...
Tue Mar 03, 2020 02:00
Microorganisms, Vol. 8, Pages 360: Inactivation of Shiga Toxin-Producing Escherichia coli in Refrigerated and Frozen Meatballs Using High Pressure Processing Microorganisms doi: 10.3390/microorganisms8030360 Authors: Anna C. S. Porto-Fett Armitra Jackson-Davis Lamin S. Kassama Marciauna Daniel Michelle Oliver YangJin Jung John B. Luchansky High pressure processing (HPP) was evaluated to inactivate Shiga toxin-producing Escherichia coli (STEC) in raw meatballs. Ground...
Tue Mar 03, 2020 02:00
Microorganisms, Vol. 8, Pages 359: TonB-Dependent Transporters in Sphingomonads: Unraveling Their Distribution and Function in Environmental Adaptation Microorganisms doi: 10.3390/microorganisms8030359 Authors: Devyani Samantarrai Annapoorni Lakshman Sagar Ramurthy Gudla Dayananda Siddavattam TonB-dependent transport system plays a critical role in the transport of nutrients across the energy-deprived outer membrane of Gram-negative bacteria. It contains a specialized outer...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1137: High Surface Reactivity and Biocompatibility of Y2O3 NPs in Human MCF-7 Epithelial and HT-1080 FibroBlast Cells Molecules doi: 10.3390/molecules25051137 Authors: Akhtar Ahamed Alrokayan Ramamoorthy Alaizeri This study aimed to generate a comparative data on biological response of yttrium oxide nanoparticles (Y2O3 NPs) with the antioxidant CeO2 NPs and pro-oxidant ZnO NPs. Sizes of Y2O3 NPs were found to be in the range of 35±10...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1130: Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis Molecules doi: 10.3390/molecules25051130 Authors: Bocheńska Gabig-Cimińska Sphingolipids (SLs), which have structural and biological responsibilities in the human epidermis, are importantly involved in the maintenance of the skin barrier and regulate cellular processes, such as the proliferation, differentiation and apoptosis of keratinocytes (KCs). As many dermatologic...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1136: Recent Modification Strategies of MoS2 for Enhanced Electrocatalytic Hydrogen Evolution Molecules doi: 10.3390/molecules25051136 Authors: Meng Chen Gao Zhao Kong Lin Chen Li Zhou Molybdenum disulfide (MoS2) has been recognized as one of the most promising catalysts to replace Pt for hydrogen evolution reaction (HER) electrocatalysis because of the elemental abundance, excellent catalytic potential, and stability. However,...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1135: A Supramolecular Approach to Structure-Based Design with A Focus on Synthons Hierarchy in Ornithine-Derived Ligands: Review, Synthesis, Experimental and in Silico Studies Molecules doi: 10.3390/molecules25051135 Authors: Bojarska Remko Breza Madura Kaczmarek Zabrocki Wolf The success of innovative drugs depends on an interdisciplinary and holistic approach to their design and development. The supramolecular architecture of living...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1134: Encapsulation Systems for Antimicrobial Food Packaging Components: An Update Molecules doi: 10.3390/molecules25051134 Authors: Becerril Nerín Silva Antimicrobially active packaging has emerged as an effective technology to reduce microbial growth in food products increasing both their shelf-life and microbial safety for the consumer while maintaining their quality and sensorial properties. In the last years, a great effort has been made to develop...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1133: Development of New Canned Chub Mackerel Products Incorporating Edible Seaweeds—Influence on the Minerals and Trace Elements Composition Molecules doi: 10.3390/molecules25051133 Authors: Vieira Soares Machado Oliva-Teles Correia João Ramalhosa Carvalho Domingues Antunes Morais Delerue-Matos This study aimed to develop new canned chub mackerel products incorporating edible seaweeds (Ascophyllum nodosum, Fucus spiralis,...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1132: Special Issue: "New Trends in Membrane Preparation and Applications"
Molecules, Vol. 25, Pages 1132: Special Issue: "New Trends in Membrane Preparation and Applications" Molecules doi: 10.3390/molecules25051132 Authors: Figoli This Special Issue aims to provide a collection of recent advancements in the field of membrane science [...]
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1131: Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities Molecules doi: 10.3390/molecules25051131 Authors: Oihana Gordobil Paula Olaizola Jesus M. Banales Jalel Labidi The growing concern about the environmental impact and human health risk related to the excessive use of synthetic ingredients in cosmetics and topical formulations calls for the exploration...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1139: Ultrasound-Assisted Extraction of Total Acetogenins from the Soursop Fruit by Response Surface Methodology Molecules doi: 10.3390/molecules25051139 Authors: Aguilar-Hernández Vivar-Vera García-Magaña González-Silva Pérez-Larios Montalvo-González The soursop fruit or Annona muricata (A. muricata) fruit is recognized by its bioactive compounds and acetogenins (ACG) are among the most important. The effect of ACGs, with greater importance...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1129: Evaluation of Volatile Compounds in Milks Fermented Using Traditional Starter Cultures and Probiotics Based on Odor Activity Value and Chemometric Techniques Molecules doi: 10.3390/molecules25051129 Authors: Li Zhang Si Mi Ruobing Liu Yaxin Sang Xianghong Wang The volatile components of milks fermented using traditional starter cultures (Streptococcus thermophilus and Lactobacillus bulgaricus) and probiotics (Lactobacillus lactis, Lactobacillus...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1128: Editorial to the Special Issue–“Natural Products and Drug Discovery”
Molecules, Vol. 25, Pages 1128: Editorial to the Special Issue–“Natural Products and Drug Discovery” Molecules doi: 10.3390/molecules25051128 Authors: Pinarosa Avato Natural products hold a prominent position in the discovery and development of many drugs used nowadays, with diverse indications for human and animal health [...]
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1127: Influence of Polymer Charge on the Localization and Dark- and Photo-Induced Toxicity of a Potential Type I Photosensitizer in Cancer Cell Models Molecules doi: 10.3390/molecules25051127 Authors: Mikael Lindgren Odrun A. Gederaas Monica Siksjø Tom A. Hansen Lena Chen Bastien Mettra Chantal Andraud Cyrille Monnereau A current trend within photo-dynamic therapy (PDT) is the development of molecular systems targeting hypoxic tumors. Thus,...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1124: Synthesis and Bioactivity Assessment of Novel Spiro Pyrazole-Oxindole Congeners Exhibiting Potent and Selective in vitro Anticancer Effects Molecules doi: 10.3390/molecules25051124 Authors: Heba M. Abo-Salem Amr Nassrallah Ahmed A.F. Soliman Manal S. Ebied Mohamed E. Elawady Sayeda A. Abdelhamid Eslam R. El-Sawy Yazeed A. Al-Sheikh Mourad A. M. Aboul-Soud The present work aims to design and synthesize novel series of spiro pyrazole-3,3’-oxindoles...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1126: Middle Eastern Plant Extracts: An Alternative to Modern Medicine Problems Molecules doi: 10.3390/molecules25051126 Authors: Disha Varijakzhan Chou-Min Chong Aisha Abushelaibi Kok-Song Lai Swee-Hua Erin Lim Middle Eastern countries are primarily known for their dry sand deserts; however, they have a wider physiographic range which includes upland plateau and mountain ranges. The Middle East is home to various types of plants, such as Phoenix...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1125: Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S Ribosomal Particles Followed by Cryo-Electron Microscopy Molecules doi: 10.3390/molecules25051125 Authors: Ramtin Shayan Dana Rinaldi Natacha Larburu Laura Plassart Stéphanie Balor David Bouyssié Simon Lebaron Julien Marcoux Pierre-Emmanuel Gleizes Célia Plisson-Chastang Assembly of eukaryotic ribosomal subunits is a very complex and sequential process that starts...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1119: Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study Molecules doi: 10.3390/molecules25051119 Authors: Iannotti De Maio Panza Appendino Taglialatela-Scafati De Petrocellis Amodeo Vitale Phytocannabinoids (pCBs) are a large family of meroterpenoids isolated from the plant Cannabis sativa. Δ9-Tetrahydrocannabinol...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1122: Fish By-Product Use as Biostimulants: An Overview of the Current State of the Art, Including Relevant Legislation and Regulations within the EU and USA Molecules doi: 10.3390/molecules25051122 Authors: Moses Madende Maria Hayes Crop production systems have adopted cost-effective, sustainable and environmentally friendly agricultural practices to improve crop yields and the quality of food derived from plants. Approaches such as genetic selection and...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1120: Building and Testing PPARγ Therapeutic ELB00824 with an Improved Therapeutic Window for Neuropathic Pain Molecules doi: 10.3390/molecules25051120 Authors: Westlund Zhang Effective, non-addictive therapeutics for chronic pain remain a critical need. While there are several potential therapeutics that stimulate anti-inflammatory mechanisms to restore homeostasis in the spinal dorsal horn microenvironment, the effectiveness of drugs for neuropathic pain...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1117: Citrus Auraptene Induces Expression of Brain-Derived Neurotrophic Factor in Neuro2a Cells Molecules doi: 10.3390/molecules25051117 Authors: Furukawa Washimi Hara Yamaoka Okuyama Sawamoto Nakajima (1) Background: Our published data have indicated that 1) auraptene (AUR), a citrus ingredient, has neuroprotective effects on the mouse brain, owing to its ability to suppress inflammation, such as causing a reduction in hyperactivation...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1123: Physicochemical and Digestion Properties of Potato Starch Were Modified by Complexing with Grape Seed Proanthocyanidins Molecules doi: 10.3390/molecules25051123 Authors: Zirui Zhang Jinhu Tian Haitian Fang Huiling Zhang Xiangli Kong Dongmei Wu Jiaqi Zheng Donghong Liu Xingqian Ye Shiguo Chen Dietary intake of potato starch could induce a dramatic increase in blood glucose and is positively associated with chronic metabolic diseases...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1121: Thermodynamic and Spectroscopic Studies of the Complexes Formed in Tartaric Acid and Lanthanide(III) Ions Binary Systems Molecules doi: 10.3390/molecules25051121 Authors: Michal Zabiszak Martyna Nowak Zbigniew Hnatejko Jakub Grajewski Kazuma Ogawa Malgorzata T. Kaczmarek Renata Jastrzab Binary complexes of tartaric acid with lanthanide(III) ions were investigated. The studies have been performed in aqueous solution using the potentiometric...
Tue Mar 03, 2020 02:00
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