Τρίτη 3 Μαρτίου 2020


MedWorm: Cancer & Oncology
Study to Clarify Radiation Benefits in Mesothelioma Patients
 
An upcoming phase III clinical trial involving the National Cancer Institute should clarify the still-debatable benefits of using radiotherapy in combination with aggressive surgery for patients with pleural mesothelioma. The trial will be the first multicenter, randomized study measuring both safety...
Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
 
Non–small cell lung cancer (NSCLC) is often characterized by mutually exclusive mutations in the epidermal growth factor receptor (EGFR) or the guanosine triphosphatase KRAS. We hypothesized that blocking EGFR palmitoylation, previously shown to inhibit EGFR activity, might alter downstream signaling...
‘Chasing a ghost’: dark chemical matter and the cause of colon cancer
 
Seven years ago, Jason Crawford, Ph.D., began chasing a ghost: a bacterial toxin named colibactin. Four years later he asked Seth Herzon, Ph.D., to join him. (Source: Yale Science and Health News)
Smilow Cancer Hospital: celebrating a decade of care
 
In October of 2009, the first patients walked into the new Smilow Cancer Hospital at Yale New Haven. Cancer care has not been the same since. (Source: Yale Science and Health News)
Experimental Drug May Prevent Chemotherapy Drug from Damaging the Heart
 
March 3, 2020—(BRONX, NY)—The commonly used chemotherapy drug doxorubicin can damage heart muscle, in some cases leading to severe or lethal heart failure. A new study led byAlbert Einstein College of Medicine researchers and involving zebrafish and mice suggests that the experimental drug BAI1 can prevent...
Use of PPIs Tied to Cognitive Issues in Breast Cancer Survivors
 
TUESDAY, March 3, 2020 -- Use of acid reflux drugs (proton pump inhibitors [PPIs]) during and after cancer treatment may be tied to impaired memory and concentration in breast cancer survivors, according to a study recently published in the Journal... (Source: Drugs.com - Pharma News)
'Optical tweezers' help in quest for better cancer treatments
 
(Michigan State University) In a groundbreaking new study, an interdisciplinary team of Michigan State University researchers has observed telomerase activity at a single-molecule level with unprecedented precision -- expanding our understanding of the vital enzyme and progressing toward better cancer...
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Radon is the second most common cause of lung cancer. Yet, there is no nationwide requirement to test for it. Here's why it's worth testing your house. (Source: CNN.com - Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
Nccmaid 2020 nccmaid 2020
 
Read clinically focused news coverage of key developments from NCCMAID 2020Medscape Oncology (Source: Medscape Today Headlines)
Simple blood is saving lives by detecting lung cancer years before symptoms show
 
Rebecca Allison, 69, and Shirley Dolan, 63, were both recipients of a revolutionary blood test - called the EarlyCDT-Lung test - that detected their lung cancer years before symptoms appeared. (Source: the Mail online | Health)
Strain of E Coli Linked to About 5% of Colorectal Cancer Strain of E Coli Linked to About 5% of Colorectal Cancer
 
A link between a genotoxin-producing strain of E coli and about 5% of colorectal cancer cases could offer novel clues as to how the cancer develops.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Surgical Approach Not Tied to Decision Regret After Prostatectomy
 
Functional and oncologic outcomes, autonomous decision - making, and follow - up time influence regret (Source: The Doctors Lounge - Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any...
Oncologists Are'Sacrificing Common Sense' in Pursuit of Innovation Oncologists Are'Sacrificing Common Sense' in Pursuit of Innovation
 
Dr Bishal Gyawali on how reaction to a recent ovarian cancer study reveals a troubling trend among oncologists of doubting negative results.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Drug Prices in US Continue to Soar; Are Profits Too High? Drug Prices in US Continue to Soar; Are Profits Too High?
 
Three studies and two editorials in Journal of the American Medical Association tackle the issue of the relentless rise in prices of new drugs and ask: Is the pharma industry making too much profit?Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
PCORI Board approves $150 million to fund large-scale patient-centered clinical studies
 
(Patient-Centered Outcomes Research Institute) The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors at its March 2, 2020 meeting approved up to $195 million for upcoming funding opportunities and $16 million for research projects comparing the most effective ways to treat a range...
Study can help identify cancer patients most likely to develop cachexia
 
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Researchers in Brazil analyzed 12 types of tumor and established a gene expression profile associated with cachexia, a potentially fatal syndrome characterized by severe weight loss and muscle wasting. (Source: EurekAlert! - Cancer)
Study reveals properties of cells fated to relapse in acute lymphoblastic leukemia
 
(St. Jude Children's Research Hospital) Researchers have found that genetically defined subpopulations of leukemia cells present at diagnosis have distinct characteristics that lead to relapse. (Source: EurekAlert! - Cancer)
Study: PFAS act similar to known cancer-causing chemicals
 
(Environmental Working Group) Scientists at the Environmental Working Group and Indiana University have for the first time conducted a review of 26 fluorinated chemicals, or PFAS, and found that all display at least one characteristic of known human carcinogens. (Source: EurekAlert! - Cancer)
Chemists inhibit a critical gear of cell immortality
 
(Northwestern University) Researchers have developed a promising molecular tool that targets and inhibits one of cell immortality's underlying gears: the enzyme telomerase. (Source: EurekAlert! - Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with...
Study suggests blocking immune T-cell regulator may help eliminate tumours
 
(eLife) Immune system T-cells are more able to destroy skin cancer cells when a T-cell regulator called SLAMF6 is missing, a new study in eLife shows. (Source: EurekAlert! - Cancer)
Imaging technique reveals 3D forces exerted by tiny cell clusters
 
(Brown University) A new technique for mapping the forces that clusters of cells exert on their surroundings could be useful for studying everything from tissue development to cancer metastasis. (Source: EurekAlert! - Cancer)
Blocking energy production in immune cells helps tumours escape treatment
 
(eLife) A small molecule that inhibits energy production in immune T-cells allows some tumours to escape treatment with an immunotherapy called PD-1 blockade therapy, says a study in mice published today in eLife. (Source: EurekAlert! - Cancer)MedWorm Message: If you are looking to buy something in the...
American Journal of Roentgenology names Andrew B. Rosenkrantz, MD next editor in chief
 
(American Roentgen Ray Society) The American Roentgen Ray Society announces Andrew B. Rosenkrantz of NYU has been named the next Editor in Chief of the American Journal of Roentgenology (AJR). Currently, Dr. Rosenkrantz is Assistant Editor for Genitourinary Imaging at AJR, a position he has held since...
Guidelines for BIA-ALCL Provide Additional Guidance for Recognition and Diagnosis
 
The new guidelines provide additional guidance for healthcare providers to better recognize and diagnose breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your...
Radiation therapy for colon cancer works better when specific protein blocked
 
(Washington University School of Medicine) Researchers at Washington University School of Medicine in St. Louis have identified a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut. (Source: EurekAlert! - Cancer)
FDA Grants Fast Track Designation to Tipifarnib to Treat Lymphoma
 
Kura Oncology ’s leading drug candidate, tipifarnib, was granted fast track designation by the FDA to treat adults of T-cell lymphomas. (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Starve a tumor, feed a cell: How cancers can resist drugs
 
(University of California - Irvine) With drug resistance a major challenge in the fight against cancer, a discovery by University of California, Irvine biologists could offer new approaches to overcoming the obstacle. Their research reveals that a mechanism enabling the diseased cells to scavenge dead...
Findings Show Resistance Mechanisms in Small Cell Lung Cancer
 
A study, published in Nature Cancer, demonstrates the quick and evolving revolutions of resistance mechanisms in small cell lung cancer. (Source: CancerNetwork)
Five-year survival improves for certain cancers in adolescent and young adults
 
(UNC Lineberger Comprehensive Cancer Center) The five-year survival rate for adolescents and young adults with cancer has significantly improved from 1975 to 2005 in the United States overall, but this was not the case for all cancers, according to a report in the Journal of the National Cancer Institute....
Immune cells may improve accuracy of predicting survival in colorectal cancer
 
(Mayo Clinic) The density of immune cells, called tumor infiltrating lymphocytes, when combined with analysis of tumor budding may serve as a method to more accurately predict survival in patients with stage III colon cancer. The findings, by a team of researchers led by Mayo Clinic gastroenterologist...
UNC researchers highlgiht promising signs for cancer treatment, still work to be done
 
A recent review of cancer survival rates over 30 years shows significant improvement in key areas – but researchers at UNC Chapel Hill found the improvement was largely absent from certain kinds of cancers. According to a new study in the Journal of the National Cancer Institute, the five-year survival...
Cancer survival rates improve for young adults
 
(Oxford University Press USA) A new study in the Journal of the National Cancer Institute finds improvements in five-year survival rates for all cancers in young adults. For some cancers, however, there has been little improvement since the 1970s. (Source: EurekAlert! - Medicine and Health)MedWorm Message:...
The CNIO discovers that rapamycin has harmful effects when telomeres are short
 
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) The CNIO shows that an anti-aging strategy that extends life in normal mice, the treatment with rapamycin, is harmful when mice have short telomeres.The team addresses for the first time the connections between two of the main biochemical processes...
NYU Abu Dhabi researchers design new technology for targeted cancer drug delivery
 
(New York University) A team of researchers at NYU Abu Dhabi has developed a biocompatible, biodegradable, and economical nanocarrier for safer and more effective delivery of anticancer drugs. Researchers demonstrate that the novel pH-responsive hybrid (i.e. multi-component) nanoparticles can be loaded...
Pancreatic Cancer Patients May Harbor Treatable Germline Mutations Pancreatic Cancer Patients May Harbor Treatable Germline Mutations
 
Germline mutations commonly found in individuals with pancreatic ductal adenocarcinoma (PDAC) may be treatable and should be identified as soon as possible, a comprehensive review suggests.Reuters Health Information (Source: Medscape Pathology Headlines)
Toxicity of Tumor Immune Checkpoint Inhibitors Toxicity of Tumor Immune Checkpoint Inhibitors
 
Are you aware of the potential adverse events associated with immune checkpoint inhibitors? Find out how to identify and manage these toxic effects.Translational Lung Cancer Research (Source: Medscape Today Headlines)
Docs lack consistency in breast cancer screening
 
Physicians aren't necessarily consistent when it comes to screening mammography...Read more on AuntMinnie.comRelated Reading: Do women over 75 need screening mammography? Are women with depression less likely to get mammograms? New European guidelines advise biennial screening at 45 German study...
KRAS Mutation and Primary Tumor Location, Survival in CRC KRAS Mutation and Primary Tumor Location, Survival in CRC
 
A study evaluating resected mCRC finds that right-sided lesions were a negative prognostic factor for disease-specific survival.Chinese Clinical Oncology (Source: Medscape Today Headlines)
FDA grants Breakthrough Therapy Designation for Roche ’s Esbriet (pirfenidone) in unclassifiable interstitial lung disease
 
Basel, 3 March 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation (BTD) to Esbriet ® (pirfenidone) for adults with unclassifiable interstitial lung disease (uILD). The designation was granted based on...
Training needed to use mammo for lung cancer awareness
 
Directors of mammography screening programs are interested in raising awareness...Read more on AuntMinnie.comRelated Reading: Education affects follow-up for CT lung screening exams Is shared decision-making CT lung screening's Trojan horse? Global lung cancer death rates for women to increase Smokers...
More cancer cases in Canada projected as aging population grows, with lung cancer still deadliest form: study
 
Nearly half of Canadians are expected to be diagnosed with cancer at some point in their lifetime. (Source: CBC | Health)
Hormone therapy, long shunned for a possible breast cancer link, is now seen as a short-term treatment for menopause symptoms
 
Researchers say fear of hormones for hot flashes, mental fogginess and libido problems was a misreading of a landmark 2002 study (Source: Washington Post: To Your Health)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the...
Sleepy Seniors Have Higher Health Risks
 
MONDAY, March 2, 2020 -- If you're over 65 and sleeping well at night, yet find yourself nodding off during the day, you may have a higher risk of developing new medical conditions like diabetes and cancer. New research found that people who were... (Source: Drugs.com - Daily MedNews)MedWorm Message:...
Sharp Climb in Weight Gain With Breast Cancer
 
Sharp Climb in Weight Gain After Breast Cancer Diagnosis (Source: eMedicineHealth.com)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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