Observational retrospective study of UK national success, risks and costs for 319,105 IVF/ICSI and 30,669 IUI treatment cycles

ObjectiveTo compare success rates, associated risks and cost-effectiveness between intrauterine insemination (IUI) and in vitro fertilisation (IVF). DesignRetrospective observational study. SettingThe UK from 2012 to 2016. ParticipantsData from Human Fertilisation and Embryology Authority’s freedom of information request for 2012–2016 for IVF/ICSI (intracytoplasmic sperm injection)and IUI as practiced in 319 105 IVF/ICSI and 30 669 IUI cycles. Direct-cost calculations for maternal and neonatal...

BMJ Open Current Issue

2h

Willingness, perceived barriers and motivators in adopting mobile applications for health-related interventions among older adults: a scoping review protocol

IntroductionThe world’s older population continues to grow at an unprecedented rate. An ageing population poses a great challenge to our healthcare system that requires new tool to tackle the complexity of health services as well as the increasing expenses. Mobile health applications (mHealth app) is seen to have the potential to address these challenges, alleviating burdens on the healthcare system and enhance the quality of life for older adults. Despite the numerous benefits of mHealth apps, relatively...

BMJ Open Current Issue

2h

Psychometric validation of a Patient-Centred Quality of Cancer Care Questionnaire in Mexico

ObjectivesTo develop and validate a Patient-Centred Quality of Cancer Care Questionnaire in Spanish (PCQCCQ-S) appropriate to the Mexican context. DesignPsychometric validation of a questionnaire. SettingTwo public oncology hospitals in Mexico City. Participants1809 patients with cancer aged ≥18 years. Source of informationCross-sectional survey. MethodsThe validation procedures comprised (1) content validity through a group of experts and patients; (2) item reduction and evaluation of the factor...

BMJ Open Current Issue

2h

Access and use of oxytocin for postpartum haemorrhage prevention: a pre-post study targeting the poorest in six Mesoamerican countries

ObjectivesHaemorrhage remains the leading cause of maternal mortality in Central America. The Salud Mesoamérica Initiative aims to reduce such mortality via performance indicators. Our objective was to assess the availability and administration of oxytocin, before and after applying Salud Mesoamérica Initiative interventions in the poorest health facilities across Central America. DesignPre-post study. Setting166 basic-level and comprehensive-level health facilities in Belize, Guatemala, Honduras,...

BMJ Open Current Issue

2h

Association between uterine contractions before elective caesarean section and transient tachypnoea of the newborn: a retrospective cohort study

ObjectiveWe evaluated the association between the presence of predelivery uterine contractions and transient tachypnoea of the newborn (TTN) in women undergoing an elective caesarean section. DesignA retrospective cohort study. SettingNational Hospital Organization Kofu National Hospital, which is a community hospital, between January 2011 and May 2019. ParticipantsThe study included 464 women who underwent elective caesarean section. The exclusion criteria were missing data, twin pregnancy,...

BMJ Open Current Issue

2h

Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM--CP): a study protocol

IntroductionChronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance. Exogenous melatonin is licensed to treat primary insomnia and there is some evidence for analgesic effects of melatonin. The aim of this study is to investigate the effects of oral melatonin (as Circadin) 2 mg at night in adults with severe non-malignant pain of at least 3 months’ duration. Methods and analysisWe will conduct a randomised double-blind placebo-controlled cross-over...

BMJ Open Current Issue

2h

Pain Squad+ smartphone app to support real-time pain treatment for adolescents with cancer: protocol for a randomised controlled trial

IntroductionPain negatively affects the health-related quality of life (HRQL) of adolescents with cancer. The Pain Squad+ smartphone-based application (app), has been developed to provide adolescents with real-time pain self-management support. The app uses a validated pain assessment and personalised pain treatment advice with centralised decision support via a registered nurse to enable real-time pain treatment in all settings. The algorithm informing pain treatment advice is evidence-based and...

BMJ Open Current Issue

2h

Qualitative exploration of the intersection between social influences and cultural norms in relation to the development of alcohol use behaviour during adolescence

ObjectivesFew contemporary studies have examined peer and social drivers of alcohol use during mid-adolescence. We sought to explore young people’s perspectives on socio-cultural influences relating to alcohol use behaviour during this period. DesignQualitative research study. MethodsSemi-structured one-to-one (n=25), paired (n=4) or triad (n=1) interviews and one focus group (n=6) were conducted with 30 young people aged 14 to 15 (13 males, 17 females) recruited from 4 schools, and 12 participants...

BMJ Open Current Issue

2h

Correction: Assessment of staffing needs for physicians and nurses at Upazila health complexes in Bangladesh using WHO workload indicators of staffing need (WISN) method

Joarder T, Tune SNBK, Nuruzzaman M, et al. Assessment of staffing needs for physicians and nurses at Upazila health complexes in Bangladesh using WHO workload indicators of staffing need (WISN) method. BMJ Open 2020;10:e035183. doi: 10.1136/bmjopen-2019-035183 This article was previously published with an error. Reference 29 is corrected as: Park CS-Y. Optimizing staffing, quality, and cost in home healthcare nursing: theory synthesis. J Adv Nurs 2017;73:1838–47.

BMJ Open Current Issue

17h

Correction: Effectiveness of internet-delivered cognitive behavioural therapy in reducing sickness absence among young employees with depressive symptoms: study protocol for a large-scale pragmatic randomised controlled trial

Kouvonen A, Mänty M, Harkko J, et al. Effectiveness of internet-delivered cognitive behavioural therapy in reducing sickness absence among young employees with depressive symptoms: study protocol for a large-scale pragmatic randomised controlled trial. BMJ Open 2019;9:e032119. doi: 10.1136/bmjopen-2019-032119 This article was previously published with errors. We found two small errors in description of the inclusion and exclusion criteria. First, the requirement of further 6 months job contract...

BMJ Open Current Issue

21h