Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης

A horse and a zebra: an atypical clinical picture including Guillain-Barré syndrome, recurrent fever and mesenteric lymphadenopathy caused by two concomitant infections

Abstract Background While Campylobacter jejuni represents the most common cause of bacterial gastroenteritis, Yersinia pseudotuberculosis infections are very rarely diagnosed in adults. Case We report on a previously healthy patient who presented several times at our hospital with fever, Guillain-Barré syndrome, recurrent abdominal symptoms and distinct...

An unusual clinical presentation of necrotizing fasciitis

Tue Mar 03, 2020 02:00

Controversies in the therapeutic approach to congenital cytomegalovirus infection

Tue Mar 03, 2020 02:00

Abstract Treatment of congenital cytomegalovirus infection is mandatory in cases with severe systemic and/or neurological involvement. However, some patients are paucisymptomatic, with very subtle systemic manifestations and/or minimal brain alterations. Current international guidelines do not clearly state whether these children should be treated, and this decision is not straightforward for clinicians. Of a small series of six infants with congenital cytomegalovirus infection...

Screening for invasive fungal disease using non‐culture‐based assays among inpatients with advanced HIV disease at a large academic hospital in South Africa

Tue Mar 03, 2020 02:00

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Mycoses

Abstract Introduction Despite widespread access to antiretroviral therapy (ART), the burden of advanced HIV disease in South Africa is high. This translates into an increased risk of AIDS‐related opportunistic infections, including invasive mycoses. Methods Using a limited number of non‐culture‐based diagnostic assays, we aimed to determine the prevalence of invasive mycoses and tuberculosis among hospitalised adults with very advanced HIV (CD4 counts <100 cells/µl) at a large...

Mycoses

04:27

Fluconazole‐resistant Candida parapsilosis strains with a Y132F substitution in the ERG11 gene causing invasive infections in a neonatal unit, South Africa

Abstract Introduction The prevalence of azole resistance in C. parapsilosis is very low in most parts of the world. However, South Africa has reported an exceptionally high prevalence of azole resistance in C. parapsilosis strains isolated from candidaemia cases. We aimed to determine the possible molecular mechanisms of fluconazole resistance in C. parapsilosis isolates obtained through surveillance at a large neonatal unit at a South African academic hospital. Methods We sequenced...

Mycoses

04:27

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Upregulation of Myeloid Zinc Finger 1 in DRG via Regulating MMP-2/9 and Kv 1.2 Expression Contributes to CFA-induced Inflammatory Pain

Publication date: Available online 3 March 2020Source: NeuroscienceAuthor(s): Qin Niu, Fei Xing, Han-Wen Gu, Liying Bai, Jian Zhang, Jing-Jing Yuan, Yuan-Yuan Mao, Zhi-Song Li, Wei Zhang, Ji-Tian Xu

Integrating somatosensory information over time

Tue Mar 03, 2020 13:43

Publication date: Available online 3 March 2020Source: NeuroscienceAuthor(s): Raúl Hernández-Pérez, Eduardo Rojas-Hortelano, Victor de Lafuente

Electrophysiological evidences for the rotational uncertainty effect in the hand mental rotation: an ERP and ERS/ERD study

Tue Mar 03, 2020 13:43

Publication date: Available online 3 March 2020Source: NeuroscienceAuthor(s): Lingxiao Yu, Xu Wang, Yuanyuan Lyu, Li Ding, Jie Jia, Shanbao Tong, Xiaoli Guo

Profile of pathogenic proteins and microRNAs in plasma-derived extracellular vesicles in Alzheimer’s disease: A pilot study

Tue Mar 03, 2020 13:43

Publication date: Available online 3 March 2020Source: NeuroscienceAuthor(s): Fang Li, Xin-Yu Xie, Xia-Fei Sui, Peng Wang, Zhu Chen, Jin-Biao Zhang

Tue Mar 03, 2020 13:43

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The CUL4B-miR-372/373-PIK3CA-AKT axis regulates metastasis in bladder cancer

Oncogene, Published online: 03 March 2020; doi:10.1038/s41388-020-1236-1The CUL4B-miR-372/373-PIK3CA-AKT axis regulates metastasis in bladder cancer (Source: Oncogene)

Alterations of T-cell-mediated immunity in acute myeloid leukemia

Tue Mar 03, 2020 00:00

Oncogene, Published online: 03 March 2020; doi:10.1038/s41388-020-1239-yAlterations of T-cell-mediated immunity in acute myeloid leukemia (Source: Oncogene)

Gastric cancer: genome damaged by bugs

Tue Mar 03, 2020 00:00

Oncogene, Published online: 02 March 2020; doi:10.1038/s41388-020-1241-4Gastric cancer: genome damaged by bugs (Source: Oncogene)

Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition

Mon Mar 02, 2020 00:00

Oncogene, Published online: 02 March 2020; doi:10.1038/s41388-020-1235-2Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition (Source: Oncogene)

Modeling clear cell renal cell carcinoma and therapeutic implications

Mon Mar 02, 2020 00:00

Oncogene, Published online: 02 March 2020; doi:10.1038/s41388-020-1234-3Modeling clear cell renal cell carcinoma and therapeutic implications (Source: Oncogene)