Τρίτη 3 Μαρτίου 2020


Lipopolysaccharide Inhibits Alpha Epithelial Sodium Channel Expression via MiR-124-5p in Alveolar Type 2  Epithelial Cells
Mesenchymal stem cells (MSCs) have been a potential strategy in the pretreatment of pulmonary diseases, while the mechanisms of MSCs-conditioned medium (MSCs-CM) involved with microRNAs on the regulation of lung ion transport are seldom reported. We investigated the role of miR-124-5p in lipopolysaccharide-involved epithelial sodium channel (ENaC) dysfunction and explored the potential target of miR-124-5p. We observed the lower expression of miR-124-5p after the administration of MSCs-CM, and the...
BioMed Research International
Tue Mar 03, 2020 15:50
Quantitative Diagnosis of Atrophic Gastritis by Probe-Based Confocal Laser Endomicroscopy
Aims. The aims of this study were to characterize nonatrophic and atrophic gastric mucosa under conventional endoscopy and probe-based confocal laser endomicroscopy (pCLE) modes and to define quantitative diagnostic parameters for these lesions under pCLE. Method. In phase I, 64 patients with gastric mucosal lesions diagnosed by gastrointestinal endoscopy were enrolled in the study. Normal mucosa and suspicious lesions were evaluated under normal white light imaging (WLI) and pCLE mode. Descriptive...
BioMed Research International
Tue Mar 03, 2020 15:50
Baseline Levels of Serum Progesterone and the First Trimester Pregnancy Outcome in Women with Threatened Abortion: A Retrospective Cohort Study
Objective. The relationship between serum progesterone and the first trimester pregnancy outcome of threatened abortion is still controversial. Therefore, we aimed to further study the association between these two parameters. Methods. The present study is an observational retrospective cohort study. A total of 726 participants who had threatened abortion from a hospital in Guangdong, China, were included in this study from 17th August 2011 to 30th October 2018. The exposure variable and the outcome...
BioMed Research International
Tue Mar 03, 2020 15:35
Percutaneous Endoscopic Transforaminal Discectomy versus Conventional Open Lumbar Discectomy for Upper Lumbar Disc Herniation: A Comparative Cohort Study
Background. Percutaneous endoscopic transforaminal discectomy (PETD) is regarded as a viable alternative option for upper lumbar disc herniation (LDH). However, few studies have evaluated PETD for upper LDH, and no study has compared the advantages of endoscopic procedures versus conventional surgery. The present study was aimed at comparing the surgical outcome and safety of PETD versus conventional open lumbar discectomy in the treatment of upper LDH. Methods. Data from 42 patients treated for...
BioMed Research International
Tue Mar 03, 2020 14:50
Effects of Four Kinds of Oxide Nanoparticles on Proteins in Extracellular Polymeric Substances of Sludge
Proteins are the most important component in sludge extracellular polymeric substances (EPS) and play a crucial role in the formation of sludge flocs, adsorption performance of sludge, and flocculation ability of sludge. This research is aimed at exploring the changes in proteins in EPS extracted from concentrated sludge after various nanoparticle (NP) treatments. The results showed that the protein content in EPS decreased by 40% after nanoalumina (Al2O3 NPs) treatment but increased at varying degrees...
BioMed Research International
Tue Mar 03, 2020 14:20
A Robust Signature Based on Autophagy-Associated LncRNAs for Predicting Prognosis in Lung Adenocarcinoma
Objective. To construct a predictive signature based on autophagy-associated lncRNAs for predicting prognosis in lung adenocarcinoma (LUAD). Materials and Methods. Differentially expressed autophagy genes (DEAGs) and differentially expressed lncRNAs (DElncRNAs) were screened between normal and LUAD samples at thresholds of and value
BioMed Research International
Tue Mar 03, 2020 13:20
A Framework for Automated and Objective Modification of Tubular Structures: Application to the Internal Carotid Artery
Abstract Patient‐specific medical image‐based computational fluid dynamics has been widely used to reveal fundamental insight into mechanisms of cardiovascular disease, for instance, correlating morphology to adverse vascular remodeling. However, segmentation of medical images is laborious, error‐prone, and a bottleneck in the development of large databases that are needed to capture the natural variability in morphology. Instead, idealized models, where morphological features are parameterized,...
International Journal for Numerical Methods in Biomedical Engineering
04:38
Aiber In-Flight Medical Emergency Response System
MIME Technologies, a startup originating at Aberdeen University in Scotland, unveiled the Aiber in-flight telemedicine system designed to be used by flight attendants to help stricken passengers. Using a tablet computer, flight attendants can communicate with physicians on the ground, transmitting observable symptoms, but also streaming data from sensors that can be stuck to the body of the victim. These can include heart rate, temperature, and respiration rate sensors, and the system includes...
Medgadget
00:06
On-X Ascending Aortic Prosthesis Cleared in EU
CryoLife, based in Kennesaw, Georgia, won EU regulatory clearance for the On-X Ascending Aortic Prosthesis (AAP) as a treatment option for people with poorly functioning aortic valves with a nearby ascending aortic aneurysm. The device, which combines a prosthetic valve and an ascending aortic prosthesis, can be implanted to address injured, damaged, or malfunctioning native or prosthetic valves. The valve of the On-X is made of pure pyrolitic carbon, which is a thromboresistant material...
Medgadget
Tue Mar 03, 2020 22:00
New HydroPICC Prevents Clogged Central Line Catheters
Access Vascular, based in Bedford, Massachusetts, won FDA clearance for the latest version of its HydroPICC anti-thrombogenic central line catheter. As with the original, which was cleared two years ago, the new device features Access’s unique “bulk-hydrophilic” material that prevents clogging by being rich in water while carrying a neutral surface charge. Proteins and other biomaterials tend not to stick to such surfaces and the material has been shown not to initiate a thrombosis cascade as it...
Medgadget
Tue Mar 03, 2020 19:17
FDA Clears First Pulse Oximeter to Measure Breathing Rate
Masimo just received the first FDA clearance for a fingertip pulse oximeter that can measure respiration rate. The MightySat Rx spot-check pulse oximeter includes a technology known as Respiration Rate from the Pleth (RRP) that makes it unnecessary to perform manual counts or use chest electrodes to measure respiration rate. The device can be used in the clinic, but is now also indicated for at-home use. In addition to respiration rate, it measures oxygen saturation, pulse rate, perfusion...
Medgadget
Tue Mar 03, 2020 18:48
Psychometric evaluation of a newly developed Elderly-Constipation Impact Scale
Background Chronic constipation is a common symptom among the elderly, and it may affect their quality of life (QoL). A lack of available research focused on the elderly means that this effect is not well understood. This study aimed to develop and validate a new scale (Elderly-Constipation Impact Scale (E-CIS)) to measure the impact of chronic constipation on QoL among the elderly. Methods A pool of items was generated...
PeerJ
Tue Mar 03, 2020 02:00
Evolutionary history of the Cameroon radiation of puddle frogs (Phrynobatrachidae: Phrynobatrachus), with descriptions of two critically endangered new species from the northern Cameroon Volcanic Line
The Cameroon Volcanic Line, a mountain chain located between West and Central Africa, is a region of numerous endemic diversifications, including of puddle frogs (Phrynobatrachus). This study reviews the phylogeny and taxonomy of puddle frogs of the “Cameroon radiation,” which is a clade containing mainly montane but also at least three lowland species. Molecular data revealed a novel evolutionary lineage from high altitudes in the northern part of the mountains. Puddle frogs from the new, minute-sized...
PeerJ
Tue Mar 03, 2020 02:00
A preliminary study of the effect of a high-salt diet on transcriptome dynamics in rat hypothalamic forebrain and brainstem cardiovascular control centers
Background High dietary salt intake is strongly correlated with cardiovascular (CV) diseases and it is regarded as a major risk factor associated with the pathogenesis of hypertension. The CV control centres in the brainstem (the nucleus tractus solitarii (NTS) and the rostral ventrolateral medulla (RVLM)) and hypothalamic forebrain (the subfornical organ, SFO; the supraoptic nucleus, SON and the paraventricular nucleus, PVN) have critical roles in regulating CV autonomic motor outflows,...
PeerJ
Tue Mar 03, 2020 02:00
Banat donkey, a neglected donkey breed from the central Balkans (Serbia)
The dominant donkey breed in the Balkans is the mid-sized Balkan donkey with a grey to chocolate coat color. Local breeders from Serbia, however, still maintain a few larger individuals of a lighter coat color, named Banat donkey, and speculate that they are descendants of a Spanish donkey heard that had been transferred to the Banat region by the Hapsburg Queen Maria Theresa in the XVIII century for a specific purpose, to work in local vineyards. We have previously found a unique nuclear gene-pool...
PeerJ
Tue Mar 03, 2020 02:00
Chronic arsenate exposure affects amphipod size distribution and reproduction
Arsenate (As V) is the predominant inorganic species of arsenic in oxic aquatic environments. Chronic water quality criteria for arsenate have not been established due to the scarcity of relevant studies on its impact on aquatic biota. We examined the acute and chronic effects of arsenate on the benthic amphipod Leptocheirus plumulosus, an important test organism for ecotoxicological studies. We determined that a concentration of 1,971 µg/L arsenate induced 50% mortality (LC50) in juveniles in 96-hr...
PeerJ
Tue Mar 03, 2020 02:00

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