Abstract Multiple myeloma (MM) almost invariably progresses through novel therapies. Patients with quad-refractory MM (refractory to bortezomib, carfilzomib, lenalidomide, and pomalidomide) and penta-refractory MM (additional refractoriness to daratumumab) have few treatment options. Two chemotherapy regimens, bendamustine/prednisone (BP) and dexamethasone, cyclophosphamide, etoposide, and cisplatin (DCEP), are often used in quad- and penta-refractory MM, but there are limited...
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Abstract Aim: To measure histological villous atrophy and to clarify the diagnostic accuracy of endoscopic villous atrophy in gastrointestinal graft-versus-host disease. Methods: Data for patients who underwent upper and/or lower endoscopic examinations after hematopoietic stem cell transplantation were retrospectively collected. In study 1, group A included 56 patients in whom GI-GVHD was histologically confirmed and group B included 60 patients in whom GI-GVHD was not histologically...
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Information, Vol. 11, Pages 143: Tree-Like Distributed Computation Environment with Shapp Library Information doi: 10.3390/info11030143 Authors: Tomasz Gałecki Wiktor Bohdan Daszczuk Despite the rapidly growing computing power of computers, it is often insufficient to perform mass calculations in a short time, for example, simulation of systems for various sets of parameters, the searching of huge state spaces, optimization using ant or genetic algorithms, machine learning,...
Tue Mar 03, 2020 02:00
Applied Sciences, Vol. 10, Pages 1740: Motion-Based Design of Passive Damping Systems to Reduce Wind-Induced Vibrations of Stay Cables under Uncertainty Conditions Applied Sciences doi: 10.3390/app10051740 Authors: Javier Naranjo-Pérez Javier F. Jiménez-Alonso Iván M. Díaz Giuseppe Quaranta Andrés Sáez Stay cables exhibit both great slenderness and low damping, which make them sensitive to resonant phenomena induced by the dynamic character of external actions. Furthermore,...
Tue Mar 03, 2020 02:00
Remote Sensing, Vol. 12, Pages 823: Climatology Perspective of Sensitive Regimes and Active Regions of Aerosol Indirect Effect for Cirrus Clouds Over the Global Oceans Remote Sensing doi: 10.3390/rs12050823 Authors: Xuepeng Zhao Yangang Liu Fangqun Yu Andrew K. Heidinger Korak Saha Long-term satellite climate data records (CDRs) of clouds and aerosols are used to investigate the aerosol indirect effect (AIE) of cirrus clouds over the global oceans from a climatology...
Tue Mar 03, 2020 02:00
Diagnostics, Vol. 10, Pages 141: Novel Assessment of Urinary Albumin Excretion in Type 2 Diabetes Patients by Raman Spectroscopy Diagnostics doi: 10.3390/diagnostics10030141 Authors: Flores-Guerrero Muñoz-Morales Narea-Jimenez Perez-Fuentes Torres-Rasgado Ruiz-Vivanco Gonzalez-Viveros Castro-Ramos . Urinary albumin excretion remains the key biomarker to detect renal complications in type 2 diabetes. As diabetes epidemy increases, particularly...
Tue Mar 03, 2020 02:00
Cells, Vol. 9, Pages 604: Propranolol Suppresses the T-Helper Cell Depletion-Related Immune Dysfunction in Cirrhotic Mice Cells doi: 10.3390/cells9030604 Authors: Hung-Cheng Tsai Chien-Fu Hsu Chia-Chang Huang Shiang-Fen Huang Tzu-Hao Li Ying-Ying Yang Ming-Wei Lin Tzung-Yan Lee Chih-Wei Liu Yi-Hsiang Huang Ming-Chih Hou Han-Chieh Lin Bacterial translocation (BT) and splenomegaly contribute to cirrhosis-associated immune dysfunction (CAID)...
Tue Mar 03, 2020 02:00
Computation, Vol. 8, Pages 15: Machine-Learning Methods for Computational Science and Engineering Computation doi: 10.3390/computation8010015 Authors: Michael Frank Dimitris Drikakis Vassilis Charissis The re-kindled fascination in machine learning (ML), observed over the last few decades, has also percolated into natural sciences and engineering. ML algorithms are now used in scientific computing, as well as in data-mining and processing. In this paper, we provide a review...
Tue Mar 03, 2020 02:00
Diagnostics, Vol. 10, Pages 140: Clinical versus Ultrasound Measurements of Hyomental Distance Ratio for the Prediction of Difficult Airway in Patients with and without Morbid Obesity Diagnostics doi: 10.3390/diagnostics10030140 Authors: Petrișor Trancă Szabo Simon Prie Bodolea Purpose: To describe the correlation between clinically measured hyomental distance ratio (HMDRclin) and the ultrasound measurement (HMDRecho) in patients with and without morbid...
Tue Mar 03, 2020 02:00
Nanomaterials, Vol. 10, Pages 453: Shape Deformation in Ion Beam Irradiated Colloidal Monolayers: An AFM Investigation Nanomaterials doi: 10.3390/nano10030453 Authors: Lotito Karlušić Jakšić Tomić Luketić Müller Zambelli Fazinić Self-assembly of colloidal monolayers represents a prominent approach to the fabrication of nanostructures. The modification of the shape of colloidal particles is essential in order to enrich the variety of attainable patterns...
Tue Mar 03, 2020 02:00
IJGI, Vol. 9, Pages 148: GIScience Theory Based Assessment of Spatial Disparity of Geodetic Control Points Location ISPRS International Journal of Geo-Information doi: 10.3390/ijgi9030148 Authors: Elzbieta Bielecka Krzysztof Pokonieczny Sylwia Borkowska Geodetic networks provide a spatial reference framework for the positioning of any geographical feature in a common and consistent way. An even spatial distribution of geodetic control points assures good quality for subordinate...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1732: Transcriptome Analysis Reveals Long Intergenic Non-Coding RNAs Contributed to Intramuscular Fat Content Differences between Yorkshire and Wei Pigs International Journal of Molecular Sciences doi: 10.3390/ijms21051732 Authors: Qianqian Li Ziying Huang Wenjuan Zhao Mengxun Li Changchun Li Intramuscular fat (IMF) content is closely related to various meat traits, such as tenderness, juiciness, and flavor. The IMF content varies considerably...
Tue Mar 03, 2020 02:00
Remote Sensing, Vol. 12, Pages 822: An Improved Descalloping Method Combined With Imaging Parameters for GaoFen-3 ScanSAR Remote Sensing doi: 10.3390/rs12050822 Authors: Lihua Zhong Xiaolan Qiu Bing Han Yuxin Hu Due to the specific working mechanism of alternately transmitting and receiving signals between multiple adjacent swaths, scanning synthetic aperture radar (ScanSAR) will cause periodical wavelike modulation of the intensity image along azimuth direction, which...
Tue Mar 03, 2020 02:00
Viruses, Vol. 12, Pages 280: Lactococcus Ceduovirus Phages Isolated from Industrial Dairy Plants—from Physiological to Genomic Analyses Viruses doi: 10.3390/v12030280 Authors: Chmielewska-Jeznach Bardowski Szczepankowska Lactococcus Ceduovirus (formerly c2virus) bacteriophages are among the three most prevalent phage types reported in dairy environments. Phages from this group conduct a strictly lytic lifestyle and cause substantial losses during milk fermentation processes,...
Tue Mar 03, 2020 02:00
IJERPH, Vol. 17, Pages 1648: The Influence of Road Geometry on Vehicle Rollover and Skidding International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051648 Authors: Yanna Yin Huiying Wen Lu Sun Wei Hou This paper analyzes the influence of single and combined unfavorable road geometry on rollover and skidding risks of D-class mid-sized sport utility vehicles (SUVs) with front-wheel drive for roads with design speeds at 80 km/h. A closed-loop...
Tue Mar 03, 2020 02:00
Symmetry, Vol. 12, Pages 392: Influence of Ramped Wall Temperature and Ramped Wall Velocity on Unsteady Magnetohydrodynamic Convective Maxwell Fluid Flow Symmetry doi: 10.3390/sym12030392 Authors: Talha Anwar Poom Kumam Wiboonsak Watthayu Asifa This article provides a comprehensive analysis regarding effects of ramped wall temperature and ramped wall velocity on incompressible time-dependent magnetohydrodynamic flow of Maxwell fluid. The flow is due to free convection...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1737: Amino Acids 563–566 of the Na+/H+ Exchanger Isoform 1 C-Terminal Cytosolic Tail Prevent Protein Degradation and Stabilize Protein Expression and Activity International Journal of Molecular Sciences doi: 10.3390/ijms21051737 Authors: Xiuju Li Debajyoti Dutta Martin Jung Richard Zimmermann Larry Fliegel Isoform one of the mammalian Na+/H+ exchanger is a plasma membrane protein that is ubiquitously present in humans. It regulates intracellular...
Tue Mar 03, 2020 02:00
Applied Sciences, Vol. 10, Pages 1739: The Effectiveness of Embodied Pedagogical Agents and Their Impact on Students Learning in Virtual Worlds Applied Sciences doi: 10.3390/app10051739 Authors: Grivokostopoulou Kovas Perikos Over the last years, the successful integration of virtual reality in distance education contexts has led to the development of various frameworks related to the virtual learning approaches. 3D virtual worlds are an integral part of the landscape...
Tue Mar 03, 2020 02:00
Atmosphere, Vol. 11, Pages 252: Skill Assessment of an Atmosphere–Wave Regional Coupled Model over the East China Sea with a Focus on Typhoons Atmosphere doi: 10.3390/atmos11030252 Authors: Li Staneva Grayek Behrens Feng Yin This study performed several sensitivity experiments to investigate the impact of atmosphere–wave coupling on the simulated wind and waves over the East China Sea (ECS) with a focus on typhoon events. These experiments include...
Tue Mar 03, 2020 02:00
Water, Vol. 12, Pages 696: Using the Soil and Water Assessment Tool to Simulate the Pesticide Dynamics in the Data Scarce Guayas River Basin, Ecuador Water doi: 10.3390/w12030696 Authors: Cambien Gobeyn Nolivos Forio Arias-Hidalgo Dominguez-Granda Witing Volk Goethals Agricultural intensification has stimulated the economy in the Guayas River basin in Ecuador, but also affected several ecosystems. The increased use of pesticides poses a serious...
Tue Mar 03, 2020 02:00
JMSE, Vol. 8, Pages 169: A Probabilistic Model of Coastal Bluff-Top Erosion in High Latitudes Due to Thermoabrasion: A Case Study from Baydaratskaya Bay in the Kara Sea Journal of Marine Science and Engineering doi: 10.3390/jmse8030169 Authors: Mohammad Akhsanul Islam Raed Lubbad Mohammad Saud Afzal Arctic coastal erosion demands more attention as the global climate continues to change. Unlike those along low-latitude and mid-latitude, sediments along Arctic coastlines are...
Tue Mar 03, 2020 02:00
JMSE, Vol. 8, Pages 168: Comparison of Numerical Methods for Modeling the Wave Field Effects Generated by Individual Wave Energy Converters and Multiple Converter Wave Farms Journal of Marine Science and Engineering doi: 10.3390/jmse8030168 Authors: Cameron J. McNatt Aaron Porter Kelley Ruehl This numerical study compares the wave field generated by the spectral wave action balance code, SNL-SWAN, to the linear-wave boundary-element method (BEM) code, WAMIT. The objective...
Tue Mar 03, 2020 02:00
Remote Sensing, Vol. 12, Pages 821: Improved Winter Wheat Spatial Distribution Extraction Using A Convolutional Neural Network and Partly Connected Conditional Random Field Remote Sensing doi: 10.3390/rs12050821 Authors: Shouyi Wang Zhigang Xu Chengming Zhang Jinghan Zhang Zhongshan Mu Tianyu Zhao Yuanyuan Wang Shuai Gao Hao Yin Ziyun Zhang Improving the accuracy of edge pixel classification is crucial for extracting the winter wheat spatial distribution...
Tue Mar 03, 2020 02:00
Nutrients, Vol. 12, Pages 686: A randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study Nutrients doi: 10.3390/nu12030686 Authors: Arrigo F.G. Cicero Federica Fogacci Maddalena Veronesi Enrico Strocchi Elisa Grandi Elisabetta Rizzoli Andrea Poli Franca Marangoni Claudio Borghi The Beta-glucan Effects on Lipid...
Tue Mar 03, 2020 02:00
Sustainability, Vol. 12, Pages 1927: Application of Floating Aquatic Plants in Phytoremediation of Heavy Metals Polluted Water: A Review Sustainability doi: 10.3390/su12051927 Authors: Shafaqat Ali Zohaib Abbas Muhammad Rizwan Ihsan Elahi Zaheer İlkay Yavaş Aydın Ünay Mohamed M. Abdel-Daim May Bin-Jumah Mirza Hasanuzzaman Dimitris Kalderis Heavy-metal (HM) pollution is considered a leading source of environmental contamination. Heavy-metal pollution...
Tue Mar 03, 2020 02:00
Cells, Vol. 9, Pages 603: PPE51 Is Involved in the Uptake of Disaccharides by Mycobacterium tuberculosis Cells doi: 10.3390/cells9030603 Authors: Małgorzata Korycka-Machała Jakub Pawełczyk Paulina Borówka Bożena Dziadek Anna Brzostek Malwina Kawka Adrian Bekier Sebastian Rykowski Agnieszka B. Olejniczak Dominik Strapagiel Zbigniew Witczak Jarosław Dziadek We have recently found that selected thio-disaccharides possess bactericidal effects...
Tue Mar 03, 2020 02:00
Applied Sciences, Vol. 10, Pages 1737: 4-Hexylresorcinol Exhibits Different Characteristics to Estrogen Applied Sciences doi: 10.3390/app10051737 Authors: Yei-Jin Kang Ji-Hyeon Oh Hyun Seok You-Young Jo Dae-Won Kim Umberto Garagiola Je-Yong Choi Seong-Gon Kim 4-Hexylresorcinol (4HR) has been used as a food additive and antiseptic. The aim of this study was to evaluate whether the application of 4HR in breast cancer cells and ovariectomized rats showed...
Tue Mar 03, 2020 02:00
Sustainability, Vol. 12, Pages 1926: Assessment of the Health Effects of Heavy Metals Pollution of Agricultural Soils in the Iron Ore Mining Area of the Northern Piedmont of Mount Wutai, Shanxi Province, China Sustainability doi: 10.3390/su12051926 Authors: Dandan Wang Qinghai Xu Qingrong Zheng Liwei Wu We have measured the concentrations of toxic elements (Cd, Pb, As, and Hg) in 29 samples from agricultural soils in an iron ore mining area in the northern piedmont of...
Tue Mar 03, 2020 02:00
IJERPH, Vol. 17, Pages 1631: Examining the Relationship between Youth-Targeted Food Marketing Expenditures and the Demographics of Social Media Followers International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051631 Authors: Rummo Cassidy Wells Coffino Bragg : Background: To determine how many adolescents follow food/beverage brands on Instagram and Twitter, and examine associations between brands’ youth-targeted marketing...
Tue Mar 03, 2020 02:00
Molecules, Vol. 25, Pages 1139: Ultrasound-Assisted Extraction of Total Acetogenins from the Soursop Fruit by Response Surface Methodology Molecules doi: 10.3390/molecules25051139 Authors: Aguilar-Hernández Vivar-Vera García-Magaña González-Silva Pérez-Larios Montalvo-González The soursop fruit or Annona muricata (A. muricata) fruit is recognized by its bioactive compounds and acetogenins (ACG) are among the most important. The effect of ACGs, with greater...
Tue Mar 03, 2020 02:00
Sustainability, Vol. 12, Pages 1925: Fiscal Decentralization, Pollution and China’s Tourism Revenue Sustainability doi: 10.3390/su12051925 Authors: Shaolong Zeng Lingyun Gao Rui Shen Yingying Ma Haiping Li This paper focuses on the role of local governments in the development of tourism in China by examining 30 Chinese provinces from 2000 to 2018. The results of empirical research show that fiscal decentralization in China provides local governments with incentives...
Tue Mar 03, 2020 02:00
IJERPH, Vol. 17, Pages 1630: Comment on: Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051630 Authors: Hassan Šudomová In 2015, the Nobel Prize in Physiology or Medicine was awarded to Youyou Tu, for her discoveryof the natural anti‐malarial drug Artemisinin [...]
Tue Mar 03, 2020 02:00
Sustainability, Vol. 12, Pages 1924: Investigation into Creep Characteristics and Model of Recycled Construction and Demolition Waste Used in Embankment Filler Sustainability doi: 10.3390/su12051924 Authors: Zhe Li Shihao Yan Lulu Liu Jia Yang The creep deformation of recycled construction and demolition waste (CDW) filler is an important factor affecting road performance. In this paper, a series of laboratory tests, including a compaction test, sieving test, California...
Tue Mar 03, 2020 02:00
Applied Sciences, Vol. 10, Pages 1738: Removal of Cu(II) from Aqueous Solutions Using Amine-Doped Polyacrylonitrile Fibers Applied Sciences doi: 10.3390/app10051738 Authors: Aung Hong Park Lee : Polyacrylonitrile (PAN) fibers were prepared via electrospinning and were modified with diethylenetriamine (DETA) to fabricate surface-modified PAN fibers. The surface-modified PAN fibers were used to evaluate their adsorption capacity for the removal of Cu(II) from aqueous...
Tue Mar 03, 2020 02:00
IJERPH, Vol. 17, Pages 1629: Time-Cumulative Toxicity of Neonicotinoids: Experimental Evidence and Implications for Environmental Risk Assessments International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051629 Authors: Sánchez-Bayo Tennekes Our mechanistic understanding of the toxicity of chemicals that target biochemical and/or physiological pathways, such as pesticides and medical drugs is that they do so by binding to specific molecules. The...
Tue Mar 03, 2020 02:00
IJERPH, Vol. 17, Pages 1628: Participation and Performance Analysis in Children and Adolescents Competing in Time-Limited Ultra-Endurance Running Events International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051628 Authors: Scheer Di Gangi Villiger Rosemann Nikolaidis Knechtle Ultra-endurance running is of increasing popularity in the adult population, mainly due to master runners older than 35 years of age. However, youth...
Tue Mar 03, 2020 02:00
Sustainability, Vol. 12, Pages 1923: Socio-economic Study to Improve the Electrical Sustainability of the North Tower of Instituto Superior Técnico Sustainability doi: 10.3390/su12051923 Authors: Beatriz Durão João Paulo N. Torres Carlos A. F. Fernandes Ricardo A. Marques Lameirinhas In this paper, an autonomous photovoltaic system is going to be designed for the North Tower of Instituto Superior Técnico through the application of solar panels on its windows,...
Tue Mar 03, 2020 02:00
Healthcare, Vol. 8, Pages 53: Learning from a Feasibility Trial of a Simple Intervention: Is Research a Barrier to Service Delivery, or is Service Delivery a Barrier to Research? Healthcare doi: 10.3390/healthcare8010053 Authors: Frost Britten (1) Background: Applied health services research (AHSR) relies upon coordination across multiple organizational boundaries. Our aim was to understand how competing organizational and professional goals enhance or impede the conduct of...
Tue Mar 03, 2020 02:00
IJERPH, Vol. 17, Pages 1627: The Logic of Condom Use in Female Sex Workers in Bali, Indonesia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051627 Authors: Januraga Mooney-Somers Gesesew Ward Studies on human immunodeficiency virus (HIV) prevention practices of female sex workers often examine the use of condom as a single behaviour: using or not using condom. This study explores typologies of the logic of condom use as part...
Tue Mar 03, 2020 02:00
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