Abstract The present work investigated the effect of camel's fetal fluids on a variety of bacterial and fungal pathogens. Ten samples of camel's amniotic and allantoic fluids were collected aseptically during parturition and their antimicrobial activities were evaluated by disc diffusion method and minimum inhibitory concentration (MIC) assay. The majority of tested pathogens were inhibited by both fluids up to 25% concentration. The fluids showed zones of inhibition ranging from...
02:00
Abstract Vibrio parahaemolyticus (VP) is a marine bacterium that opportunistically caused foodborne gastroenteritis in human and some diseases in marine animals. The isolated strain of V. parahaemolyticus WS001 from Samut Sakhon, Thailand has a presence of ldh (~ 450 bp) toxA (~ 333 bp) and toxB (~ 1269 bp) genes which showed pathogenicity in shrimp. This strain is suspected as low pathogenicity in human due to the lack of tdh and trh genes for encoding thermostable direct hemolysin...
Mon Mar 16, 2020 02:00
Abstract Xylella fastidiosa is a Gram-negative and nutritionally fastidious bacterial pathogen causing Pierce’s disease (PD) of grapevine and other plant diseases. X. fastidiosa strain ATCC 35879T which originated from Florida is the designated type strain for the species and for subsp. fastidiosa. In bacterial taxonomy, type strains preserve the characters of the original descriptions. Whole genome sequence of a type strain not only provides a standard reference for bacterial...
Mon Mar 16, 2020 02:00
Abstract The last decade has witnessed growth in scientific interest towards studying the biodiversity and ecology in extreme environments. Acid Mine Drainage (AMD), formed through the bio-oxidation of metal sulphides, is a typical extreme environment that is inhospitable to most life forms. Through the application of traditional culture-based molecular techniques, it has been established that AMD is home to a low diversity, specialized and novel microbial community that plays...
Mon Mar 16, 2020 10:43
Abstract For several decades, dirigent (DIR) domain-containing proteins have been assumed to be green lineage-specific, responsible for the defence response and lignan/lignin biosynthesis. Despite their high potential in terms of biotechnology and chemistry, to date there have been very few well-studied plant DIRs. However, recent achievements in sequencing technologies have allowed for discovery of DIR genes in bacteria. This prospective study suggests expansion of the focus...
Mon Mar 16, 2020 10:43
Abstract Together with the worldwide Washoku (traditional Japanese foods and drinks) boom, interest in sake, a traditional Japanese alcoholic drink, is increasing around the world. There are few scientific analyses and studies on the production of sake or the final product itself. We show the diversity of bacterial contaminants during sake production and investigated the effects of different ingredients on sake (for example, amino acids). The koji mold Aspergillus oryzae converts...
Mon Mar 16, 2020 10:43
Abstract Purpose High-grade spinal glioma (HGSG) is an extremely rare, malignant neoplasm insufficiently described in the literature. We sought to investigate the effect of epidemiological risk factors and treatment strategies on the prognosis of HGSGs using the National Cancer Database (NCDB). Methods Patients with diagnosis codes specific for HGSG...
02:00
Abstract Purpose MYC-driven medulloblastomas are highly aggressive childhood tumors with dismal outcomes and a lack of new treatment paradigms. We identified that targeting replication stress through WEE1 inhibition to suppress the S-phase replication checkpoint, combined with the attenuation of nucleotide synthesis with gemcitabine, is an effective strategy to induce apoptosis in MYC-driven medulloblastoma that could be rapidly translated...
Mon Mar 16, 2020 02:00
New Findings What is the central question of this study? We evaluated whether regional differences exist in nitric oxide synthase (NOS) dependent cutaneous vasodilatation and sweating during exercise‐heat stress in young men What is the main finding and its importance? Exercise‐induced increases in cutaneous vasodilatation and sweating were greater on the chest and upper back compared to the forearm, although the NOS contribution to cutaneous vasodilatation was similar across all regions....
07:35
New Findings It appears that the noradrenergic neurotransmitter system hastens central fatigue during prolonged exercise, a finding that coincides with a faster rate of increase in the rating of perceived exertion. Mental fatigue will affect several neurotransmitter systems, with presumably an important role for dopamine and adenosine, in multiple brain regions such as the prefrontal cortex and the anterior cingulate cortex Abstract In sports and exercise science fatigue...
Mon Mar 16, 2020 19:07
New Findings What is the central question of this study? Can antiarrhythmic drug effects on repolarization, conduction time and excitation wavelength in premature beats be determined by prior cardiac activation frequency? What is the main finding and its importance? In premature beats induced after a series of cardiac activations at the slow rate, antiarrhythmics prolong repolarization, but evoke little or no conduction delay, thus increasing the excitation wavelength, which indicates...
Mon Mar 16, 2020 19:07
Mon Mar 16, 2020 19:07
Abstract The association between obstructed müllerian duct anomalies and endometriosis has been well established and the pathogenesis is attributed to the theory of retrograde menstruation. However, this relationship with endometriosis is less clear in women with unobstructed müllerian duct anomalies and in those with rudimentary uterine structures that lack functioning endometrial tissue. This article reviews the embryology, genetics, pathophysiology, and American Society for...
02:00
Abstract Purpose To assess the clinical and imaging features of IgG4-RKD for understanding and diagnosis of this disease. Methods CT and MR images of 34 patients with IgG4-RKD were retrospectively analyzed by two radiologists in consensus. Results The serum IgG4 level was found...
Mon Mar 16, 2020 02:00
Abstract Psychological states can influence motor performance and learning. In Parkinson's disease (PD), placebo effects or expectancies for pharmacological treatment benefits are not uncommon, but little is known about whether self‐efficacy, beliefs about personal performance capabilities, may play a role in this population. To address this question, we investigated whether experimental manipulations designed to enhance self‐efficacy would benefit motor performance and learning in PD. A motor...
06:27
Journal of Neurotrauma, Ahead of Print.
Fri Mar 13, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Fri Mar 13, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Thu Mar 12, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Thu Mar 12, 2020 09:00
Abstract Due to its hemizygous inheritance and role in sex determination, the X chromosome is expected to play an important role in the evolution of sexual dimorphism, and to be enriched for sexually antagonistic genetic variation. By forcing the X chromosome to only be expressed in males over > 40 generations, we changed the selection pressures on the X to become similar to those experienced by the Y. This releases the X from any constraints arising from selection in females, and should lead...
04:52
You still might have to share yours sometimes. (Eduardo C.G. via Unsplash/)Your pup might like to snooze with their head on your shoes or doze on the cool tiles of your bathroom floor, but that’s no substitute for a real bed. Memory foam can help support their weary bones just like people beds, and soft and snuggly beds can help them feel comforted when you’re not around to lean on. If you try to keep your furry pal from hogging the blankets and snoring in your ear, a designated pet bed can also...
04:14
Stop using disposable cartridges and Earth-defiling plastic. (Supply via Unsplash/)Shaving tools are needlessly gendered, and for women often come with a pink tax, which jacks up the price for a nearly identical item simply because it’s packaged for women. All genders can skip the fuchsia marketing and reduce the waste of disposable and cartridge razors by choosing a safety razor or a straight razor with recyclable blades. Here are four great options for beginner and advanced shavers.Handsome bronze-colored...
04:07
It tastes even better if you’re running late for work. (Alex Chernenko via Unsplash/)The math on fancy espresso machines checks out if you use your machine frequently, but there’s still a substantial upfront investment. Fortunately, with these four espresso makers you don’t need to invest hundreds of dollars to get a decent shot. Add your own burr grinder and a milk frother, and make delicious coffee drinks at home without ceding your counter space to a machine you might only use a few times a month.Is...
04:03
If you've got an Android TV, you'll want to know how to use it to its full potential. (Google/)Android TV comes installed on a growing number of televisions (from manufacturers including Sony, TCL, and Sharp), and is also available on standalone devices including the Nvidia Shield TV. It’s particularly useful if you’ve already got other Google or Android devices, but many users may have only scratched the surface of what it can do.Dig a little deeper into the software and you’ll discover a variety...
Mon Mar 16, 2020 23:30
That space in front of the stage should be packed with fans. (Code Orange/)To an unfamiliar eye, the average a show from Pittsburgh-based metal outfit, Code Orange, looks like large-scale melee. As the band literally screams through their set, the audience yells, whips their hair, and climbs all over each other. The crowd is a fundamental part of any metal or hardcore band’s performance. Right now, however, social distancing stands in its way thanks to Coronavirus. Venues have limited capacities...
Mon Mar 16, 2020 20:56
How to catch feelings, but not coronavirus. (Pixabay/)Follow all of PopSci’s COVID-19 coverage here, including travel advice, pregnancy concerns, and the latest findings on the virus itself.Self-quarantine as a single person or a person who lives far from their significant other can be pretty lonely, especially while other folks spend their work-from-home hours snuggled up with the person they love.Still, it can be unnerving to be so close to someone who might’ve bumped into COVID-19 in the outside...
Mon Mar 16, 2020 19:30
You definitely don't need to carry signs like these around with you. (Oliver Hale/Unsplash/)Follow all of PopSci’s COVID-19 coverage here, including travel advice, pregnancy concerns, and the latest findings on the virus itself.In these dark and confusing times, hygiene is undergoing something of a renaissance.Since COVID-19 made landfall in the U.S. this January, disinfecting sprays and wipes have flown off shelves, triggering shortages nationwide as concerned citizens scramble to sanitize the countless...
Mon Mar 16, 2020 18:44
Warning: Contains puppies. And nude Founding Fathers. (Pexel/)2020 has been quite a year, and it’s only March. But while it’s important to pay attention to global events and follow evidence-based advice for, say, minimizing the spread of a dangerous new disease, it’s also important to find moments of peace and calm. If you’re having trouble disconnecting from the world’s stressors, take a leisurely digital stroll through these stories to amuse, relax, and distract your anxious brain.Step one: Look...
Mon Mar 16, 2020 17:06
This story originally featured on Motorcyclist.Half car, half motorcycle—three-wheelers like Vanderhall Motor Works’ Venice GT ($33,950) are a growing segment in the powersport world. Defined as both a reverse trike and autocycle, this vehicle category blends features of the two- and four-wheeled world for an experience like nothing else on the road.The Venice GT is powered by a General Motors-sourced 1,485cc inline-four. This LFV generation powertrain is used in Chevrolet’s 2016 and newer Malibu...
Mon Mar 16, 2020 15:59
The Vanderhall Motor Works Venice GT can be driven in California without a motorcycle endorsement. However, driver and passenger are required to wear a DOT-labeled helmet. (Adam Waheed/)We love the not so subtle styling touches of the wood-grain steering wheel and chrome bump shifter. (Adam Waheed/)Vanderhall Motor Works’ Venice GT simulates the driving experience of an open-wheel roadster. (Adam Waheed/)The Venice GT rolls on a set of 18-inch cast alloy wheels. Each wheel hides a single-piston hydraulic...
Mon Mar 16, 2020 15:44
Many increasing documents have proved that alternative polyadenylation (APA) events with different polyadenylation sites (PAS) contribute to posttranscriptional regulation. However, little is known about the detailed molecular features of PASs and its role in porcine fast and slow skeletal muscles through microRNAs (miRNAs) and RNA binding proteins (RBPs). In this study, we combined single-molecule real-time sequencing and Illumina RNA-seq datasets to comprehensively analyze polyadenylation in pigs....
Mon Mar 16, 2020 17:20
Recent comparisons between plant and animal viruses reveal many common principles that underlie how all viruses express their genetic material, amplify their genomes, and link virion assembly with replication. Cauliflower mosaic virus (CaMV) is not infectious for human beings. Here, we show that CaMV transactivator/viroplasmin protein (TAV) shares sequence similarity with and behaves like the human ribonuclease H1 (RNase H1) in reducing DNA/RNA hybrids detected with S9.6 antibody in HEK293T cells....
Mon Mar 16, 2020 17:20
Aims. Liver cancer is a multietiological disease that has multiple factors contributing to the hepatocarcinogenic process, e.g., hepatitis viruses, carcinogens, male sex, or metabolic factors. Notably, emerging evidence reported that gut microbiota is crucial to the pathogenesis of hepatocellular carcinoma (HCC) via activation of innate immunity. However, the effect of time to gut microbiota exposure after birth is unknown. Using a germ-free animal housing environment, instead of antibiotics, we...
Mon Mar 16, 2020 16:05
Estimation of the spread and advancement of Plasmodium falciparum artemisinin-resistant parasites can be done by probing polymorphisms in the kelch (Pfk13) domain (a validated molecular marker). This study aimed to provide baseline information for future artemisinin surveillance by analyzing the k13-propeller domain in P. falciparum field isolates collected from 24 study areas in 14 malaria hot spots of Odisha (previously Orissa) during July 2018-January 2019. A total of 178 P. falciparum mono infections...
Mon Mar 16, 2020 16:05
Breast cancer initiation is closely associated with cytokines that can change the inflammatory tumor microenvironment. Compounds extracted from plants have been explored for the possibility of cancer treatment in the recent decades. Berberine is an isoquinoline plant alkaloid with remarkable antioxidant and anti-inflammation roles, which is used in ethnic medicines, including traditional Chinese and North American medicine. In the present study, we investigated the effects of berberine on the malignant...
Mon Mar 16, 2020 16:05
Background. Oxidative stress is an important factor during age-related cataract formation. Apoptosis and autophagy induced by oxidative stress have been reported as key factors in age-related cataract. In our research, we investigated the role of let-7c-3p in the regulation of autophagy and apoptosis during the formation of age-related cataract. Material and Methods. Real-time PCR and western blot were employed to detect the expression of let-7c-3p in the tissues of age-related cataract. Human lens...
Mon Mar 16, 2020 14:05
The development of colorectal cancer (CRC) is a multistep process initiated by a benign polyp that has the potential to evolve into in situ carcinoma through the interactions between environmental and genetic factors. CRC incidence rates are constantly increased for young adult patients presenting an advanced tumor stage. The majority of CRCs arise from colonic adenomas originating from aberrant cell proliferation of colon epithelium. Endoscopic polypectomy represents a tool for early detection and...
Mon Mar 16, 2020 12:05
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